Lycopene attenuates arachidonic acid toxicity in HepG2 cells overexpressing CYP2E1

Biochemical and Biophysical Research Communications

Volumn 303, Issue 3, 2003, Pages 745-750

  Xu, Youqing ^a   Leo, Maria A ^a   Lieber, Charles S ^a  

^a MOUNT SINAI SCHOOL OF MEDICINE   (United States)

Author keywords

Anti oxidant; Arachidonic acid; Cytochrome P4502E1; HepG2 cells; Lycopene; Oxidative stress

Indexed keywords

ANTIOXIDANT; ARACHIDONIC ACID; CAROTENOID; CYTOCHROME P450 2E1; HYDROGEN PEROXIDE; LIPID; LYCOPENE; PLACEBO;

ANTIOXIDANT ACTIVITY; ARTICLE; CANCER CELL CULTURE; CELL PROTECTION; CELL TYPE; CONTROLLED STUDY; DRUG EFFECT; GENETIC TRANSFECTION; HEPATOMA CELL; HUMAN; HUMAN CELL; LIPID PEROXIDATION; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN EXPRESSION;

EID: 0037432604     PISSN: 0006291X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-291X(03)00404-2     Document Type: Article

References (38)

1. Lieber C.S. Microsomal ethanol-oxidizing system (MEOS): the first 30 years (1968-1998) - a review. Alcohol. Clin. Exp. Res. 23:1999;991-1007.
2. Lieber C.S. Alcohol and the liver: 1994 update. Gastroenterology. 106:1994;1085-1105.
3. Lieber C.S. Cytochrome P-4502E1: its physiological and pathological role. Physiol. Rev. 77:1997;517-543.
4. Takahashi H., Johansson H., French S.W. Effect of dietary fat composition on activities of the microsomal ethanol oxidizing system and ethanol-inducible cytochrome P450 (CYP2E1) in the liver of rats chronically fed ethanol. Pharmacol. Toxicol. 70:1992;347-351.
5. Nanji A.A., Zhao S., Lamb R.G., Sadrzadeh S.M.H., Dannenberg A.J., Waxman D.J. Changes in microsomal phospholipases and arachidonic acid in experimental alcoholic liver injury: relationship to cytochrome P4502E1 induction and conjugated diene formation. Alcohol. Clin. Exp. Res. 17:1993;598-603.
6. Nanji A.A., Zhao S., Sadzadeh S.M.H., Dannenberg A.J., Tahan S.R., Waxman D.J. Markedly enhanced cytochrome P4502E1 induction and lipid peroxidation is associated with severe liver injury in fish oil-ethanol-fed rats. Alchol. Clin. Exp. Res. 18:1994;1280-1285.
7. Dai Y., Rashba-Step J., Cederbaum A.I. Stable expression of human cytochrome P4502E1 in HepG2 cells: characterization of catalytic activities and production of reactive oxygen intermediates. Biochemistry. 32:1993;6928-6937.
8. Gerster H. The potential role of lycopene for human health. J. Am. Coll. Nutr. 16:1997;109-126.
9. Ribaya-Mercado J.D., Garmyn M., Gilchrest B.A., Russell R.M. Skin lycopene is destroyed preferentially over β-carotene during ultraviolet irradiation in humans. J. Nutr. 125(7):1995;1854-1859.
10. Matos H.R., Di Mascio P., Medeiros M.G.H. Protective effect of lycopene on lipid peroxidation and oxidative DNA damage in cell culture. Arch. Biochem. Biophys. 383(1):2000;56-59.
11. Riso P., Pinder A., Santangelo A., Porrini M. Does tomato consumption effectively increase the resistance of lymphocyte DNA to oxidative damage? Am. J. Clin. Nutr. 69:1999;712-718.
12. Yeh S., Hu M. Antioxidant and pro-oxidant effects of lycopene in comparison with β-carotene on oxidant-induced damage in Hs68 cells. J. Nutr. Biochem. 11(11-12):2000;548-554.
13. Chomczynski P., Sacchi N. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal. Biochem. 162:1987;156-159.
14. Koivisto T., Mishin V.M., Mak K.M., Cohen P.A., Lieber C.S. Induction of cytochrome P4502E1 by ethanol in rat Kupffer cells. Alcohol. Clin. Exp. Res. 20(2):1996;207-212.
15. Leammli U.K. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature. 227:1970;680-685.
16. Towbin H., Staehelin T., Gordon J. Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications. Proc. Natl. Acad. Sci. USA. 76:1979;4350-4354.
17. Tsutsumi M., Lasker J.M., Shimizu M., Rosman A.S., Lieber C.S. The intralobular distribution of ethanol-inducible P450IIE1 in rat and human liver. Hepatology. 10:1989;437-446.
18. Mishin V.M., Koivisto T., Lieber C.S. The determination of cytochrome P4502E1-dependent p-nitrophenol hydroxylation by high-performance liquid chromatography with electrochemical detection. Anal. Biochem. 233:1996;212-215.
19. Scudiero D.A., Shoemaker R.H., Paul K.D., Monks A. Evaluation of a soluble tetrazolium/formazan assay for cell growth and drug sensitivity in culture using human and other tumor cell lines. Cancer Res. 48:1988;4827-4833.
20. Thomas J.P., Geiger P.G., Girotti A.W. Lethal damage to endothelial cells by oxidized low density lipoprotein: role of selenoperoxidases in cytoprotection against lipid hydroperoxide- and iron-mediated reaction. J. Lipid Res. 34(3):1993;479-490.
21. Colell A., Garcia-Ruiz C., Miranda M., Ardite E., Mari M., Morales A., Corrales F., Kaplowitz N., Fernandez-Checa J.C. Selective glutathione depletion of mitochondria by ethanol sensitizes hepatocytes to tumor necrosis factor. Gastroenterology. 115:1998;1541-1551.
22. Chen Q., Galleano M., Cederbaum A.I. Cytotoxicity and apoptosis produced by arachidonic acid in HepG2 cells overexpressing human cytochrome P4502E1. J. Biol. Chem. 272(23):1997;14532-14541.
23. Lieber C.S. Ethanol metabolism, cirrhosis and alcoholism. Clin. Chim. Acta. 257:1997;59-84.
24. Brash A.R. Arachidonic acid as a bioactive molecule. J. Clin. Invest. 107(11):2001;1339-1345.
25. Seeds M.C., Bass D.A. Regulation and metabolism of arachidonic acid. Clin. Rev. Allergy Immunol. 17:1999;5-22.
26. Aleynik S.I., Leo M.A., Takeshige U., Aleynik M.K., Lieber C.S. Dilinoleoylphosphatildylcholine is the active antioxidant of polyenylphosphatidylcholine. J. Invest. Med. 47(9):1999;507-512.
27. Maziere C., Conte M.A., Degonville J., Ali D., Maziere J.C. Cellular enrichment with polyunsaturated fatty acids induces an oxidative stress and activates the transcription factors AP1 and NFkB. Biochem. Biophys. Res. Commun. 265:1999;116-122.
28. Vento R., D'Alessandro N., Giuliano M., Lanricella M., Carabillo M., Tesoriere G. Induction of apoptosis by arachidonic acid in human retinoblastoma Y79 cells: involvement of oxidative stress. Exp. Eye Res. 70:2000;503-517.
29. Hart C.M., Tolson J.K., Block E.R. Supplemental fatty acids alter lipid peroxidation and oxidant injury in endothelial cells. Am. J. Physiol. 260:1991;L481-L488.
30. Wagner B.A., Buettner G.R., Burns C.P. Free radical-mediated lipid peroxidation in cells: oxidizability is a function of cell lipid bis-allylic hydrogen content. Biochemistry. 33:1994;4449-4453.
31. Mikkelsen L., Hansen H.S., Grunnet N., Dich J. Cytoprotecive effect of tocopherols in hepatocytes cultured with polyunsaturated fatty acid. Lipids. 29:1994;369-372.
32. Wu D., Cederbaum A.I. Ethanol and arachidonic acid produce toxicity in hepatocytes from pyrazole-treated rats with high levels of CYP2E1. Mol. Cell. Biochem. 204:2000;157-167.
33. Wu D., Cederbaum A.I. Sodium salicylate increases CYP2E1 levels and enhances arachidonic acid toxicity in HepG2 cells and cultured rat hepatocytes. Mol. Pharmacol. 59:2001;795-805.
34. Rao A.V., Agarwal S. Bioavailability and in vivo antioxidant properties of lycopene from tomato products and their possible role in the prevention of cancer. Nutr. Cancer. 31(3):1998;199-203.
35. Stahl W., Junghans A., de Boer B., Driomina E.S., Briviba K., Sies H. Carotenoid mixtures protect multilamellar liposomes against oxidative damage: synergistic effect of lycopene and lutein. FEBS Lett. 427:1998;305-308.
36. Matsushima-Nishiwaki R., Shidoji Y., Nishiwaki S., Yamada T., Moriewaki H., Muto Y. Suppression by carotenoids of microcystin-induced morphological changes in mouse hepatocytes. Lipids. 30:1995;1029-1034.
37. Kotake-Nara E., Kushiro M., Zhang H., Sugawara T., Miyashita K., Nagao A. Carotenoids affect proliferation of human prostate cancer cells. J. Nutr. 131(12):2001;3303-3306.
38. Stahl W., Sies H. Lycopene: a biologically important carotenoid for human? Arch. Biochem. Biophys. 336(1):1996;1-9.