Influence of hypoxia on nitric oxide synthase activity and gene expression in children with congenital heart disease: A novel pathophysiological adaptive mechanism

Circulation

Volumn 103, Issue 18, 2001, Pages 2272-2276

  Ferreiro, Carlos Regenga ^b   Chagas, Antonio Carlos Palandri ^a   Carvalho, Maria Helena Catelli ^a   Dantas, Ana Paula ^a   Jatene, Marcelo Biscegli ^b   De Souza, Luiz Carlos Bento ^b   Da Luz, Protásio Lemos ^a  

^a UNIVERSITY OF SÃO PAULO   (Brazil)

^b Heart Hosp Syrian Sanat Assoc   (Brazil)

Author keywords

Heart defects, congenital; Hypoxia; Nitric oxide synthase

Indexed keywords

NITRIC OXIDE SYNTHASE;

ADAPTATION; ARTICLE; CHILD; CLINICAL ARTICLE; CONGENITAL HEART DISEASE; CYANOTIC HEART DISEASE; ENZYME ACTIVITY; FEMALE; GENE EXPRESSION; GENE EXPRESSION REGULATION; HEART RIGHT ATRIUM; HEART SURGERY; HUMAN; HUMAN TISSUE; HYPOXIA; INFANT; MALE; PATHOPHYSIOLOGY; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

EID: 0035826707     PISSN: 00097322     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.CIR.103.18.2272     Document Type: Article

References (27)

1. Moncada S, Higgs A. The L-arginine-nitric oxide pathway. N Engl J Med. 1993;329:2002-2012.
2. Forstemann U, Closs EI, Pollock JS, et al. Nitric oxide synthase isozymes: characterization, purification, molecular cloning and functions. Hypertension. 1994;23(pt 2):1121-1131.
3. Nadaud S, Sobrier F. Molecular biology and molecular genetics of nitric oxide synthase genes. Clin Exp Hypertens. 1996;18:113-143.
4. Nathan C, Xie Q. Nitric oxide synthases: roles, tolls and controls. Cell. 1994;78:915-918.
5. Drexler H, Hayoz D, Munzel T, et al. Endothelial function in chronic congestive heart failure. Am J Cardiol. 1992;69:1596-1601.
6. Kubo SH, Rector TS, Bank AJ, et al. Lack of contribution of nitric oxide to basal vasomotor tone in chronic congestive heart failure. Am J Cardiol. 1994;74:1133-1136.
7. Wildhirt SM, Suzuki H, Horstman D, et al. Selective modulation of inducible nitric oxide synthase isozyme in myocardial infarction. Circulation. 1997;96:1616-1623.
8. Kitakaze M, Node K, Komamura K, et al. Evidence for nitric oxide generation in cardiac myocytes: its augmentation by hypoxia. J Mol Cell Cardiol. 1995;27:2149-2154.
9. McQuillan L, Leung GK, Marsden PA, et al. Hypoxia inhibits expression of eNOS via transcriptional and posttranslational mechanisms. Am J Physiol. 1994;267:H1921-H1927.
10. Archer LS, Freude KA, Shultz PJ. Effect of graded hypoxia on the induction and function of inducible nitric oxide synthase in rat mesangial cells. Circ Res. 1995;77:21-28.
11. Toporsian M, Govindaraju K, Mohammed N, et al. Downregulation of endothelial nitric oxide synthase in rat aorta after prolonged hypoxia in vivo. Circ Res. 2000;86:671-675.
12. McKee M, Scavone C, Nathanson JA. Nitric oxide, cGMP, and hormone regulation of active sodium transport. Proc Natl Acad Sci USA. 1994; 91:12056-12060.
13. Bradford M. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem. 1976;72:248-254.
14. Teng KS, Murthy JF, Kuemmerle JR, et al. Expression of endothelial nitric oxide synthase in human and rabbit gastrointestinal smooth muscle cells. Am J Physiol (Gastrointest Liver Physiol). 1998;275:G342-G351.
15. Chandel NS, Schumaker PT. Cellular oxygen sensing by mitochondria: old questions, new insight. J Appl Physiol. 2000;88:1880-1889.
16. Kuwahira I, Gonzalez NC, Heisler N, et al. Changes in regional blood flow distribution and oxygen supply during hypoxia in conscious rats. J Appl Physiol. 1993;74:211-214.
17. Cain SM. Oxygen delivery and uptake in dogs during anemic and hypoxic hypoxia. J Appl Physiol. 1977;42:228-234.
18. de Beider AJ, Radomski M, Why H, et al. Nitric oxide synthase activities in human myocardium. Lancet. 1993;341:84-85.
19. Heymes C, Vanderheyden M, Bronzwaer JGF, et al. Endomyocardial nitric oxide synthase and left ventricular preload reserve in dilated cardiomyopathy. Circulation. 1999;99:3009-3016.
20. Ikeda U, Shimada K. Nitric oxide and cardiac failure. Clin Cardiol. 1997;20:837-841.
21. Phelan MW, Faller DV. Hypoxia decreases constitutive nitric oxide synthase transcript and protein in cultured endothelial cells. J Cell Physiol. 1996;167:469-476.
22. Laufs U, La Fata VL, Liao JK. Inhibition of 3-hydroxy-3-methylglutaryl (HMG)-CoA reductase blocks hypoxia-mediated down-regulation of endothelial nitric oxide synthase. J Biol Chem. 1997;272:31725-31729.
23. Arnet UA, McMillan A, Dinerman JL, et al. Regulation of endothelial nitric-oxide synthase during hypoxia. J Biol Chem. 1996;271: 15069-15073.
24. Kacimi R, Long CS, Karliner JS. Chronic hypoxia modulates the interleukin-1β-stimulated inducible nitric oxide synthase pathway in cardiac myocytes. Circulation. 1997;96:1937-1943.
25. Jung F, Palmer L, Zhou N, et al. Hypoxic regulation of inducible nitric oxide synthase via hypoxia inducible factor-1 in cardiac myocytes. Circ Res. 2000;86:319-325.
26. Melillo G, Musso T, Sica A, et al. A hypoxia-responsive element mediates a novel pathway of activation of the inducible nitric oxide synthase promoter. J Exp Med. 1995;182:1683-1693.
27. Stamler JS. Redox signalling: nitrosylation and related target interactions of nitric oxide. Cell. 1994;78:931-936.