Osteopontin-dependent CD44v6 expression and cell adhesion in HepG2 cells

Carcinogenesis

Volumn 24, Issue 12, 2003, Pages 1871-1878

  Gao, Chengjiang ^a   Guo, Hongtao ^a   Downey, Laura ^a   Marroquin, Carlos ^a   Wei, Junping ^a   Kuo, Paul C ^a  

^a DUKE UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ARGINYLGLYCYLASPARTIC ACID; CD44V6 ANTIGEN; HERMES ANTIGEN; HYALURONIC ACID; ISOPROTEIN; MEMBRANE ANTIGEN; MESSENGER RNA; OSTEOPONTIN; PROTEIN TYROSINE KINASE; TUMOR MARKER; VITRONECTIN RECEPTOR;

ANTIGEN EXPRESSION; ARTICLE; CANCER CELL CULTURE; CANCER GROWTH; CELL ADHESION; CELL FUNCTION; CELL IMMORTALIZATION; CELL STIMULATION; CELL STRAIN HEPG2; CONCENTRATION RESPONSE; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME INHIBITION; HUMAN; HUMAN CELL; IN VITRO STUDY; LIVER CELL CARCINOMA; METASTASIS; NUCLEOTIDE SEQUENCE; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN INTERACTION; PROTEIN SYNTHESIS; SIGNAL TRANSDUCTION; SOLUBILITY; STEADY STATE; TIME; TUMOR PROMOTION; UPREGULATION; WESTERN BLOTTING;

ANTIGENS, CD44; BLOTTING, NORTHERN; BLOTTING, WESTERN; CARCINOMA, HEPATOCELLULAR; CELL ADHESION; CELL DIVISION; CELL LINE; CELL MOVEMENT; COLLAGEN; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG COMBINATIONS; ELECTROPHORESIS, POLYACRYLAMIDE GEL; GLYCOPROTEINS; HUMANS; HYALURONIC ACID; IMMUNOBLOTTING; INTEGRIN ALPHAVBETA3; LAMININ; OLIGOPEPTIDES; OSTEOPONTIN; PROTEIN ISOFORMS; PROTEOGLYCANS; RNA; RNA, MESSENGER; SIALOGLYCOPROTEINS; SIGNAL TRANSDUCTION; TIME FACTORS; UP-REGULATION;

EID: 0348143264     PISSN: 01433334     EISSN: None     Source Type: Journal    
DOI: 10.1093/carcin/bgg139     Document Type: Article

References (24)

1. Denhardt,D.T., Giachelli,C.M. and Rittling S.R. (2001) Role of osteopontin in cellular signaling and toxicant injury. Annu. Rev. Pharmacol. Toxicol., 41, 723-749.
2. Agrawal,D., Chen,T., Irby,R., Quackenbush,J., Chambers,A.F., Szabo,M., Cantor,A., Coppola,D. and Yeatman,T.J. (2002) Osteopontin identified as lead marker of colon cancer progression, using pooled sample expression profiling. J. Natl Cancer Inst., 94, 513-521.
3. Medico,E., Gentile,A., Lo,C.C., Williams,T.A., Gambarotta,G., Trusolino,L. and Comoglio,P.M. (2001) Osteopontin is an autocrine mediator of hepatocyte growth factor-induced invasive growth. Cancer Res., 61, 5861-5868.
4. Weber,G.F. (2001) The metastasis gene osteopontin: a candidate target for cancer therapy. Biochim. Biophys. Acta, 1552, 61-85.
5. Oates,A.J,. Barraclough,R. and Rudland,P.S. (1997) The role of osteopontin in tumorigenesis and metastasis. Invasion Metastasis, 17, 1-15.
6. Gotoh,M., Sakamoto,M., Kanetaka,K., Chuuma,M. and Hirohashi,S. (2002) Overexpression of osteopontin in hepatocellular carcinoma. Pathol. Int., 52, 19-24.
7. Harn,H.J., Ho,L.I., Yu,C.P., Wang,M.W., Lee,H.S., Lin,J.J., Lee,W.H., Isola,N.R. and Cooper,D.L. (1994) The variant mRNA isoform of human metastasis gene (CD44V) detected in the cell lines of human hepatocellular carcinoma. Biochem. Mol. Biol. Int., 32, 233-238.
8. Ye,Q.H., Qin,L.X., Forgues,M. et al. (2003) Predicting hepatitis B virus-positive metastatic hepatocellular carcinomas using gene expression profiling and supervised machine learning. Nature Med., 9, 416-423.
9. Goodison,S., Urquidi,V. and Tarin,D. (1999) CD44 cell adhesion molecules. Mol. Pathol., 52, 189-196.
10. Rudzki,Z. and Jothy,S. (1997) CD44 and the adhesion of neoplastic cells. Mol. Pathol., 50, 57-71.
11. Endo,K. and Terada,T. (2000) Protein expression of CD44 (standard and variant isoforms) in hepatocellular carcinoma: relationships with tumor grade, clinicopathologic parameters, p53 expression and patient survival. J. Hepatol., 32, 78-84.
12. Ponta,H., Sherman,L. and Herrlich,P.A. (2003) CD44: from adhesion molecules to signalling regulators. Nature Rev. Mol. Cell Biol., 4, 33-45.
13. Barbour,A.P., Reeder,J.A., Walsh,M.D., Fawcett,J., Antalis,T.M. and Gotley,D.C. (2003) Expression of the CD44v2-10 isoform confers a metastatic phenotype: importance of the heparan sulfate attachment site CD44v3. Cancer Res., 63, 887-892.
14. Fedarko,N.S., Jain,A., Karadag,A., Van,E.M. and Fisher,L.W. (2001) Elevated serum bone sialoprotein and osteopontin in colon, breast, prostate and lung cancer. Clin. Cancer Res., 7, 4060-4066.
15. Hu,N.W., Zhang,H.M., Hu,X.D., Li,M.T., Zhang,T., Zhou,L.J. and Liu,X.G. (2003) Protein synthesis inhibition blocks the late-phase LTP of C-fiber evoked field potentials in rat spinal dorsal horn. J. Neurophysiol., 89, 2354-2359.
16. Leclerc,G.J., Leclerc,G.M. and Barredo,J.C. (2002) Real-time RT-PCR analysis of mRNA decay: half-life of beta-actin mRNA in human leukemia CCRF-CEM and Nalm-6 cell lines. Cancer Cell Int., 2, 1.
17. Weber,G.F., Zawaideh,S., Hikita,S., Kumar,V.A., Cantor,H. and Ashkar,S. (2002) Phosphorylation-dependent interaction of osteopontin with its receptors regulates macrophage migration and activation. J. Leukoc. Biol., 72, 752-761.
18. Denhardt,D.T., Noda,M., O'Regan,A.W., Pavlin,D. and Berman,J.S. (2001) Osteopontin as a means to cope with environmental insults: regulation of inflammation, tissue remodeling and cell survival. J. Clin. Invest., 107, 1055-1061.
19. Mathew,J., Hines,J.E., Obafunwa,J.O., Burr,A.W., Toole,K. and Burt,A.D. (1996) CD44 is expressed in hepatocellular carcinomas showing vascular invasion. J. Pathol., 179, 74-79.
20. Weber,G.F., Ashkar,S. and Cantor,H. (1997) Interaction between CD44 and osteopontin as a potential basis for metastasis formation. Proc. Assoc. Am. Physicians, 109, 1-9.
21. Katagiri,Y.U., Sleeman,J., Fujii,H. et al. (1999) CD44 variants but not CD44s cooperate with beta1-containing integrins to permit cells to bind to osteopontin independently of arginine-glycine-aspartic acid, thereby stimulating cell motility and chemotaxis. Cancer Res., 59, 219-226.
22. Chellaiah,M.A., Biswas,R.S., Rittling,S.R., Denhardt,D.T. and Hruska,K.A. (2003) Rho-dependent Rho kinase activation increases CD44 surface expression and bone resorption in osteoclasts. J. Biol. Chem., 278, 29086-29097.
23. Chellaiah,M.A., Kizer,N., Biswas,R., Alvarez,U., Strauss-Schoenberger,J., Rifas,L., Rittling,S.R., Denhardt,D.T. and Hruska,K.A. (2003) Osteopontin deficiency produces osteoclast dysfunction due to reduced CD44 surface expression. Mol. Biol. Cell, 14, 173-189.
24. Chellaiah,M.A. and Hruska,K.A. (2003) The integrin alpha(v)beta(3) and CD44 regulate the actions of osteopontin on osteoclast motility. Calcif. Tissue Int., 72, 197-205.