Genetic variability of hepatitis A virus

Journal of General Virology

Volumn 84, Issue 12, 2003, Pages 3191-3201

  Costa Mattioli, Mauro ^a   Di Napoli, Anna ^b   Ferré, Virginie ^c   Billaudel, Sylviane ^c   Perez Bercoff, Raul ^b   Cristina, Juan ^d  

^a MCGILL UNIVERSITY   (Canada)

^b CNRS   (France)

^c UNIVERSITÉ DE NANTES   (France)

^d UNIVERSIDAD DE LA REPÚBLICA   (Uruguay)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIGENIC VARIATION; GENETIC RECOMBINATION; GENETIC VARIABILITY; GENOTYPE; HEPATITIS A VIRUS; INCIDENCE; MUTATION RATE; NONHUMAN; PRIORITY JOURNAL; REVIEW; SEROTYPE; VIRUS CLASSIFICATION; VIRUS IDENTIFICATION; VIRUS MUTATION; VIRUS SURVIVAL;

AMINO ACID SEQUENCE; ANTIGENIC VARIATION; CANADA; EPIDEMIOLOGY, MOLECULAR; EUROPE; EVOLUTION; GENOTYPE; HEPATITIS A; HEPATITIS A ANTIGENS; HEPATITIS A VIRUS, HUMAN; HUMANS; INCIDENCE; MOLECULAR SEQUENCE DATA; MUTATION; RECOMBINATION, GENETIC; RNA, VIRAL; SEQUENCE ALIGNMENT; SOUTH AMERICA; VARIATION (GENETICS);

HEPATITIS A VIRUS; RNA VIRUSES;

EID: 0348013200     PISSN: 00221317     EISSN: None     Source Type: Journal    
DOI: 10.1099/vir.0.19532-0     Document Type: Review

References (118)

1. Abuzwaida, A. R., Sidoni, M., Yoshida, C. F. & Schatzmayr, H. G. (1987). Seroepidemiology of hepatitis A and B in two urban communities of Rio de Janeiro, Brazil. Rev Inst Med Trop Sao Paulo 29, 219-223.
2. Apaire-Marchais, V., Robertson, B. H., Aubineau-Ferre, V., Le Roux, M. G., Leveque, F., Schwartzbrod, L. & Billaudel, S. (1995). Direct sequencing of hepatitis A virus strains isolated during an epidemic in France. Appl Environ Microbiol 61, 3977-3980.
3. Arauz-Ruiz, P., Sundqvist, L., Garcia, Z., Taylor, L., Visona, K., Norder, H. & Magnius, L. O. (2001). Presumed common source outbreaks of hepatitis A in an endemic area confirmed by limited sequencing within the VP1 region. J Med Virol 65, 449-456.
4. Baroudy, B. M., Ticehurst, J. R., Miele, T. A., Maizel, J. V., Jr, Purcell, R. H. & Feinstone, S. M. (1985). Sequence analysis of hepatitis A virus cDNA coding for capsid proteins and RNA polymerase. Proc Natl Acad Sci U S A 82, 2143-2147.
5. Beard, M. R., Cohen, L., Lemon, S. M. & Martin, A. (2001). Characterization of recombinant hepatitis A virus genomes containing exogenous sequences at the 2A/2B junction. J Virol 75, 1414-1426.
6. Brown, E. A., Jansen, R. W. & Lemon, S. M. (1989). Characterization of a simian hepatitis A virus (HAV): antigenic and genetic comparison with human HAV. J Virol 63, 4932-4937.
7. Brown, B. A., Oberste, M. S., Alexander, J. P., Jr, Kennett, M. L. & Pallansch, M. A. (1999). Molecular epidemiology and evolution of enterovirus 71 strains isolated from 1970 to 1998. J Virol 73, 9969-9975; erratum 74, 12003.
8. Brown, B. A., Kilpatrick, D. R., Oberste, M. S. & Pallansch, M. A. (2000). Serotype-specific identification of enterovirus 71 by PCR. J Clin Virol 16, 107-112; erratum 24, 211.
9. Bruisten, S. M., van Steenbergen, J. E., Pijl, A. S., Niesters, H. G., van Doornum, G. J. & Coutinho, R. A. (2001). Molecular epidemiology of hepatitis A virus in Amsterdam, the Netherlands. J Med Virol 63, 88-95.
10. Caro, V., Guillot, S., Delpeyroux, F. & Crainic, R. (2001). Molecular strategy for 'serotyping' of human enteroviruses. J Gen Virol 82, 79-91.
11. Casas, I., Palacios, G. F., Trallero, G., Cisterna, D., Freire, M. C. & Tenorio, A. (2001). Molecular characterization of human enteroviruses in clinical samples: comparison between VP2, VP1, and RNA polymerase regions using RT nested PCR assays and direct sequencing of products. J Med Virol 65, 138-148.
12. CDC (1999). Prevention of hepatitis A through active or passive immunization: recommendations of the Advisory Committee on Immunization Practices (ACIP). MMWR Recomm Rep 48, 1-37.
13. Ching, K. Z., Nakano, T., Chapman, L. E., Demby, A. & Robertson, B. H. (2002). Genetic characterization of wild-type genotype VII hepatitis A virus. J Gen Virol 83, 53-60.
14. Chironna, M., Grottola, A., Lanave, C., Villa, E., Barbuti, S. & Quarto, M. (2003). Genetic analysis of HAV strains recovered from patients with acute hepatitis from Southern Italy. J Med Virol 70, 343-349.
15. Chudy, M., Budek, I., Keller-Stanislawski, B., McCaustland, K. A., Neidhold, S., Robertson, B. H., Nubling, C. M., Seitz, R. & Lower, J. (1999). A new cluster of hepatitis A infection in hemophiliacs traced to a contaminated plasma pool. J Med Virol 57, 91-99.
16. Cianciara, J. (2000). Hepatitis A shifting epidemiology in Poland and Eastern Europe. Vaccine 18 (Suppl. 1), S68-S70.
17. Cohen, J. I., Rosenblum, B., Ticehurst, J. R., Daemer, R. J., Feinstone, S. M. & Purcell, R. H. (1987a). Complete nucleotide sequence of an attenuated hepatitis A virus: comparison with wild-type virus. Proc Natl Acad Sci U S A 84, 2497-2501.
18. Cohen, J. I., Ticehurst, J. R., Feinstone, S. M., Rosenblum, B. & Purcell, R. H. (1987b). Hepatitis A virus cDNA and its RNA transcripts are infectious in cell culture. J Virol 61, 3035-3039.
19. Costa-Mattioli, M., Ferré, V., Monpoeho, S., Garcia, L., Colina, R., Billaudel, S., Vega, I., Perez-Bercoff, R. & Cristina, J. (2001a). Genetic variability of hepatitis A virus in South America reveals heterogeneity and co-circulation during epidemic outbreaks. J Gen Virol 82, 2647-2652.
20. Costa-Mattioli, M., Monpoeho, S., Schvoerer, C., Besse, B., Aleman, M. H., Billaudel, S., Cristina, J. & Ferré, V. (2001b . Genetic analysis of hepatitis A virus outbreak in France confirms the co-circulation of subgenotypes 1a, 1b and reveals a new genetic lineage. J Med Virol 65, 233-240.
21. Costa-Mattioli, M., Cristina, J., Romero, H. & 12 other authors (2002). Molecular evolution of hepatitis A virus: a new classification based on the complete VP1 protein. J Virol 76, 9516-9525.
22. Costa-Mattioli, M., Ferré, V., Casane, D. & 7 other authors (2003). Evidence of recombination in natural populations of hepatitis A virus. Virology 311, 51-59.
23. Crevat, D., Crance, J. M., Chevrinais, A. M., Passagot, J., Biziagos, E., Somme, G. & Deloince, R. (1990). Monoclonal antibodies against an immunodominant and neutralizing epitope on hepatitis A virus antigen. Arch Virol 113, 95-98.
24. Cuervo, N. S., Guillot, S., Romanenkova, N., Combiescu, M., Aubert-Combiescu, A., Seghier, M., Caro, V., Crainic, R. & Delpeyroux, F. (2001). Genomic features of intertypic recombinant sabin poliovirus strains excreted by primary vaccinees. J Virol 75, 5740-5751.
25. Daemer, R. J., Feinstone, S. M., Gust, I. D. & Purcell, R. H. (1981). Propagation of human hepatitis A virus in African green monkey kidney cell culture: primary isolation and serial passage. Infect Immun 32, 388-393.
26. de Paula, V. S., Baptista, M. L., Lampe, E., Niel, C. & Gaspar, A. M. (2002). Characterization of hepatitis A virus isolates from sub-genotypes IA and IB in Rio de Janeiro, Brazil. J Med Virol 66, 22-27.
27. de Paula, V. S., Saback, F. L., Gaspar, A. M. & Niel, C. (2003). Mixed infection of a child care provider with hepatitis A virus isolates from subgenotypes IA and IB revealed by heteroduplex mobility assay. J Virol Methods 107, 223-228.
28. De Serres, G., Cromeans, T. L., Levesque, B. & 8 other authors (1999). Molecular confirmation of hepatitis A virus from well water: epidemiology and public health implications. J Infect Dis 179, 37-43.
29. Diaz, B. I., Sariol, C. A., Normann, A., Rodriguez, L. & Flehmig, B. (2001). Genetic relatedness of Cuban HAV wild-type isolates. J Med Virol 64, 96-103.
30. Divizia, M., Ruggeri, F., Hentschel, J., Flehmig, B., Pana, A. & Perez-Bercoff, R. (1986). Preliminary characterization of a fast-growing strain of human hepatitis A virus. Microbiologica 9, 269-278.
31. Domingo, E. & Holland, J. J. (1997). RNA virus mutations and fitness for survival. Annu Rev Microbiol 51, 151-178.
32. Domingo, E., Menendez-Arias, L. & Holland, J. J. (1997). RNA virus fitness. Rev Med Virol 7, 87-96.
33. Flehmig, B. (1980). Hepatitis A-virus in cell culture. I. Propagation of different hepatitis A-virus isolates in a fetal rhesus monkey kidney cell line (FrhK-4). Med Microbiol Immunol (Berl) 168, 239-248.
34. Frosner, G. G., Deinhardt, F., Scheid, R., Gauss-Muller, V., Holmes, N., Messelberger, V., Siegl, G. & Alexander, J. J. (1979). Propagation of human hepatitis A virus in a hepatoma cell line. Infection 7, 303-305.
35. Gaspar, A. M., Vitral, C. L., Yoshida, C. F. & Schatzmayr, H. G. (1992). Primary isolation of a Brazilian strain of hepatitis A virus (HAF-203) and growth in a primate cell line (FRhK-4). Braz J Med Biol Res 25, 697-705.
36. Gauss-Muller, V. & Kusov, Y. Y. (2002). Replication of a hepatitis A virus replicon detected by genetic recombination in vivo. J Gen Virol 83, 2183-2192.
37. Germinario, C., Lopalco, P. L., Chirona, M., Da Villa, G. & Chicanna, M. (2000). From hepatitis B to hepatitis A and B prevention: the Puglia (Italy) experience. Vaccine 18 (Suppl. 1), S83-S85.
38. Gmyl, A. P., Belousov, E. V., Maslova, S. V., Khitrina, E. V., Chetverin, A. B. & Agol, V. I. (1999). Nonreplicative RNA recombination in poliovirus. J Virol 73, 8958-8965.
39. Grinde, B., Stene-Johansen, K., Sharma, B., Hoel, T., Jensenius, M. & Skaug, K. (1997). Characterisation of an epidemic of hepatitis A virus involving intravenous drug abusers - infection by needle sharing? J Med Virol 53, 69-75.
40. Guillot, S., Caro, V., Cuervo, N., Korotkova, E., Combiescu, M., Persu, A., Aubert-Combiescu, A., Delpeyroux, F. & Crainic, R. (2000). Natural genetic exchanges between vaccine and wild poliovirus strains in humans. J Virol 74, 8434-8443.
41. Gust, I. D., Lehmann, N. I., Crowe, S., McCrorie, M., Locarnini, S. A. & Lucas, C. R. (1985). The origin of the HM175 strain of hepatitis A virus. J Infect Dis 151, 365-367.
42. Hadler, S. C., Webster, H. M., Erben, J. J., Swanson, J. E. & Maynard, J. E. (1980). Hepatitis A in day-care centers. A community-wide assessment. N Engl J Med 302, 1222-1227.
43. Haydon, D. T., Bastos, A. D., Knowles, N. J. & Samuel, A. R. (2001). Evidence for positive selection in foot-and-mouth disease virus capsid genes from field isolates. Genetics 157, 7-15.
44. Hirst, G. K. (1962). Genetic recombination with Newcastle virus, polioviruses and influenza. Cold Spring Harbor Symp Quant Biol 27, 303-308.
45. Hogle, J. M., Chow, M. & Filman, D. J. (1985). Three-dimensional structure of poliovirus at 2-9 Å resolution. Science 229, 1358-1365.
46. Hollinger, F. B. & Emerson, S. U. (2001). Hepatitis A virus. In Fields Virology, 4th edn, pp. 799-840. Edited by D. M. Knipe & P. M. Howley. New York: Lippincott Williams & Wilkins.
47. Hughes, J. V., Stanton, L. W., Tomassini, J. E., Long, W. J. & Scolnick, E. M. (1984). Neutralizing monoclonal antibodies to hepatitis A virus: partial localization of a neutralizing antigenic site. J Virol 52, 465-473.
48. Ina, Y. & Gojobori, T. (1994). Statistical analysis of nucleotide sequences of the hemagglutinin gene of human influenza A viruses. Proc Natl Acad Sci U S A 91, 8388-8392.
49. Jansen, R. W., Siegl, G. & Lemon, S. M. (1990). Molecular epidemiology of human hepatitis A virus defined by an antigen-capture polymerase chain reaction method. Proc Natl Acad Sci U S A 87, 2867-2871.
50. Jarvis, T. C. & Kirkegaard, K. (1992). Poliovirus RNA recombination: mechanistic studies in the absence of selection. EMBO J 11, 3135-3145.
51. Kew, O. M. & Nottay, B. K. (1984). Evolution of the oral poliovaccine strains in humans occurs by both mutation and intramolecular recombination. In Modern Approaches to Vaccines: Molecular and Chemical Basis of Virus Virulence and Immunogenicity, pp. 357-362. Edited by E. D. Lerner. Cold Spring Harbor, NY: Cold Spring Harbor Laboratory.
52. Kew, O., Morris-Glasgow, V., Landaverde, M. & 21 other authors (2002). Outbreak of poliomyelitis in Hispaniola associated with circulating type 1 vaccine-derived poliovirus. Science 296, 356-359.
53. Khanna, B., Spelbring, J. E., Innis, B. L. & Robertson, B. H. (1992). Characterization of a genetic variant of human hepatitis A virus. J Med Virol 36, 118-124.
54. Kirkegaard, K. & Baltimore, D. (1986). The mechanism of RNA recombination in poliovirus. Cell 47, 433-443.
55. Lai, M. M. (1992). RNA recombination in animal and plant viruses. Microbiol Rev 56, 61-79.
56. Ledinko, N. (1963). Genetic recombination with poliovirus type 1: studies of crosses between a normal horse serum-resistant mutant and several guanidine-resistant mutants of the same strain. Virology 20, 107-119.
57. Lemon, S. M., Chao, S. F., Jansen, R. W., Binn, L. N. & LeDuc, J. W. (1987). Genomic heterogeneity among human and nonhuman strains of hepatitis A virus. J Virol 61, 735-742.
58. Lemon, S. M., Murphy, P. C., Shields, P. A., Ping, L. H., Feinstone, S. M., Cromeans, T. & Jansen, R. W. (1991). Antigenic and genetic variation in cytopathic hepatitis A virus variants arising during persistent infection: evidence for genetic recombination. J Virol 65, 2056-2065.
59. Lenfant, C. (1994). From the National Institutes of Health. JAMA 272, 842.
60. Linemeyer, D. L., Menke, J. G., Martin-Gallardo, A., Hughes, J. V., Young, A. & Mitra, S. W. (1985). Molecular cloning and partial sequencing of hepatitis A viral cDNA. J Virol 54, 247-255.
61. Lipskaya, G. Y., Muzychenko, A. R., Kutitova, O. K., Maslova, S. V., Equestre, M., Drozdov, S. G., Bercoff, R. P. & Agol, V. I. (1991). Frequent isolation of intertypic poliovirus recombinants with serotype 2 specificity from vaccine-associated polio cases. J Med Virol 35, 290-296.
62. Liu, H. M., Zheng, D. P., Zhang, L. B., Oberste, M. S., Pallansch, M. A. & Kew, O. M. (2000). Molecular evolution of a type 1 wild-vaccine poliovirus recombinant during widespread circulation in China. J Virol 74, 11153-11161.
63. Martin, J., Samoilovich, E., Dunn, G. & 7 other authors (2002). Isolation of an intertypic poliovirus capsid recombinant from a child with vaccine-associated paralytic poliomyelitis. J Virol 76, 10921-10928.
64. Mateu, M. G., Camarero, J. A., Giralt, E., Andreu, D. & Domingo, E. (1995). Direct evaluation of the immunodominance of a major antigenic site of foot-and-mouth disease virus in a natural host. Virology 206, 298-306.
65. Matthews, R. E. (1979). The classification and nomenclature of viruses. Intervirology 11, 133-135.
66. Matthews, R. E. (1982). Classification and nomeclature of viruses. Intervirology 17, 1-199.
67. Mbayed, V. A., Sookoian, S., Alfonso, V. & Campos, R. H. (2002). Genetic characterization of hepatitis A virus isolates from Buenos Aires, Argentina. J Med Virol 68, 168-174.
68. McMinn, P., Lindsay, K., Perera, D., Chan, H. M., Chan, K. P. & Cardosa, M. J. (2001). Phylogenetic analysis of enterovirus 71 strains isolated during linked epidemics in Malaysia, Singapore, and Western Australia. J Virol 75, 7732-7738.
69. Mele, A., Rosmini, F., Zampieri, A. & Gill, O. N. (1986). Integrated epidemiological system for acute viral hepatitis in Italy (SEIEVA): description and preliminary results. Eur J Epidemiol 2, 300-304.
70. Melnick, J. L. (1992). Properties and classification of hepatitis A virus. Vaccine 10 (Suppl. 1), S24-S26.
71. Melnick, J. L. (1995). History and epidemiology of hepatitis A virus. J Infect Dis 171 (Suppl. 1), S2-S8.
72. Minor, P. D., John, A., Ferguson, M. & Icenogle, J. P. (1986). Antigenic and molecular evolution of the vaccine strain of type 3 poliovirus during the period of excretion by a primary vaccinee. J Gen Virol 67, 693-706.
73. Montano, A. (2002). Viral hepatitis in children: epidemiology and prophylaxis. Inst Hyg Mono Ser 2, 102-106 (in Spanish).
74. Nagy, P. D. & Simon, A. E. (1997). New insights into the mechanisms of RNA recombination. Virology 235, 1-9.
75. Nainan, O. V., Margolis, H. S., Robertson, B. H., Balayan, M. & Brinton, M. A. (1991). Sequence analysis of a new hepatitis A virus naturally infecting cynomolgus macaques (Macaca fascicularis). J Gen Virol 72, 1685-1689.
76. Nainan, O. V., Brinton, M. A. & Margolis, H. S. (1992). Identification of amino acids located in the antibody binding sites of human hepatitis A virus. Virology 191, 984-987.
77. Najarian, R., Caput, D., Gee, W., Potter, S. J., Renard, A., Merryweather, J., Van Nest, G. & Dina, D. (1985). Primary structure and gene organization of human hepatitis A virus. Proc Natl Acad Sci U S A 82, 2627-2631.
78. Norder, H., Bjerregaard, L. & Magnius, L. O. (2001). Homotypic echoviruses share aminoterminal VP1 sequence homology applicable for typing. J Med Virol 63, 35-44.
79. Oberste, M. S., Maher, K. & Pallansch, M. A. (1998). Complete sequence of echovirus 23 and its relationship to echovirus 22 and other human enteroviruses. Virus Res 56, 217-223.
80. Oberste, M. S., Maher, K., Kilpatrick, D. R. & Pallansch, M. A. (1999). Molecular evolution of the human enteroviruses: correlation of serotype with VP1 sequence and application to picornavirus classification. J Virol 73, 1941-1948.
81. Oberste, M. S., Maher, K., Flemister, M. R., Marchetti, G., Kilpatrick, D. R. & Pallansch, M. A. (2000). Comparison of classic and molecular approaches for the identification of untypeable enteroviruses. J Clin Microbiol 38, 1170-1174.
82. Oberste, M., Schnurr, D., Maher, K., al-Busaidy, S. & Pallansch, M. (2001). Molecular identification of new picornaviruses and characterization of a proposed enterovirus 73 serotype. J Gen Virol 82, 409-416.
83. Oberste, M. S., Maher, K. & Pallansch, M. A. (2002). Molecular phylogeny and proposed classification of the simian picornaviruses. J Virol 76, 1244-1251.
84. Ovchinnikov Iu, A., Sverdlov, E. D., Tsarev, S. A., Arsenian, S. G. & Rokhlina, T. O. (1985). Sequence of 3372 RNA nucleotide links in the hepatitis A virus coding for capsid VP4-VP1 and nonstructural proteins. Dokl Akad Nauk SSSR 285, 1014-1108 (in Russian).
85. Paul, A. V., Tada, H., von der Helm, K., Wissel, T., Kiehn, R., Wimmer, E. & Deinhardt, F. (1987). The entire nucleotide sequence of the genome of human hepatitis A virus (isolate MBB). Virus Res 8, 153-171.
86. Pierangeli, A., Bucci, M., Forzan, M., Pagnotti, P., Equestre, M. & Perez Bercoff, R. (1999). 'Primer alignment-and-extension': a novel mechanism of viral RNA recombination responsible for the rescue of inactivated poliovirus cDNA clones. J Gen Virol 80, 1889-1897.
87. Pina, S., Buti, M., Jardi, R., Clemente-Casares, P., Jofre, J. & Girones, R. (2001). Genetic analysis of hepatitis A virus strains recovered from the environment and from patients with acute hepatitis. J Gen Virol 82, 2955-2963.
88. Ping, L. H. & Lemon, S. M. (1992). Antigenic structure of human hepatitis A virus defined by analysis of escape mutants selected against murine monoclonal antibodies. J Virol 66, 2208-2216.
89. Ping, L. H., Jansen, R. W., Stapleton, J. T., Cohen, J. I. & Lemon, S. M. (1988). Identification of an immunodominant antigenic site involving the capsid protein VP3 of hepatitis A virus. Proc Natl Acad Sci U S A 85, 8281-8285.
90. Posada, D. & Crandall, K. A. (2001). Evaluation of methods for detecting recombination from DNA sequences: computer simulations. Proc Natl Acad Sci U S A 98, 13757-13762.
91. Rico-Hesse, R., Pallansch, M. A., Nottay, B. K. & Kew, O. M. (1987). Geographic distribution of wild poliovirus type 1 genotypes. Virology 160, 311-322.
92. Robertson, B. H. (2001). Viral hepatitis and primates: historical and molecular analysis of human and nonhuman primate hepatitis A, B, and the GB-related viruses. J Virol Hepat 8, 233-242.
93. Robertson, B. & Naiman, O. (1997). Genetic and antigenic variants of hepatitis A virus. In Viral Hepatitis and Liver Disease, pp. 14-18. Edited by G. Verme. Torino: Edizioni Minerva Medica.
94. Robertson, B. H., Khanna, B., Nainan, O. V. & Margolis, H. S. (1991). Epidemiologic patterns of wild-type hepatitis A virus determined by genetic variation. J Infect Dis 163, 286-292.
95. Robertson, B. H., Jansen, R. W., Khanna, B. & 10 other authors (1992). Genetic relatedness of hepatitis A virus strains recovered from different geographical regions. J Gen Virol 73, 1365-1377.
96. Robertson, B. H., Averhoff, F., Cromeans, T. L. & 8 other authors (2000). Genetic relatedness of hepatitis A virus isolates during a community-wide outbreak. J Med Virol 62, 144-150.
97. Ross, B. C. & Anderson, D. A. (1991). Characterization of hepatitis A virus capsid proteins with antisera raised to recombinant antigens. J Virol Methods 32, 213-220.
98. Rossmann, M. G., Arnold, E., Erickson, J. W. & 15 other authors (1985). Structure of a human common cold virus and functional relationship to other picornaviruses. Nature 317, 145-153.
99. Sanchez, G., Pinto, R. M., Vanaclocha, H. & Bosch, A. (2002). Molecular characterization of hepatitis A virus isolates from a transcontinental shellfish-borne outbreak. J Clin Microbiol 40, 4148-4155.
100. Sanchez, G., Bosch, A. & Pinto, R. M. (2003). Genome variability and capsid structural constraints of hepatitis A virus. J Virol 77, 452-459.
101. Santti, J., Hyypia, T., Kinnunen, L. & Salminen, M. (1999). Evidence of recombination among enteroviruses. J Virol 73, 8741-8749.
102. Schierup, M. H. & Hein, J. (2000). Consequences of recombination on traditional phylogenetic analysis. Genetics 156, 879-891.
103. Seibert, S. A., Howell, C. Y., Hughes, M. K. & Hughes, A. L. (1995). Natural selection on the gag, pol, and env genes of human immunodeficiency virus 1 (HIV-1). Mol Biol Evol 12, 803-813.
104. Stapleton, J. T. & Lemon, S. M. (1987). Neutralization escape mutants define a dominant immunogenic neutralization site on hepatitis A virus. J Virol 61, 491-498.
105. Stapleton, J. T., Jansen, R. & Lemon, S. M. (1985). Neutralizing antibody to hepatitis A virus in immune serum globulin and in the sera of human recipients of immune serum globulin. Gastroenterology 89, 637-642.
106. Stene-Johansen, K., Skaug, K., Blystad, H. & Grinde, B. (1998). A unique hepatitis A virus strain caused an epidemic in Norway associated with intravenous drug abuse. The Hepatitis A Study Group. Scand J Infect Dis 30, 35-38.
107. Tallo, T., Norder, H., Tefanova, V. & 9 other authors (2003). Sequential changes in hepatitis A virus genotype distribution in Estonia during 1994 to 2001. J Med Virol 70, 187-193.
108. Tanaka, J. (2000). Hepatitis A shifting epidemiology in Latin America. Vaccine 18 (Suppl. 1), S57-S60.
109. Tapia-Conyer, R., Santos, J. I., Cavalcanti, A. M., Urdaneta, E., Rivera, L., Manterola, A., Potin, M., Ruttiman, R. & Tanaka Kido, J. (1999). Hepatitis A in Latin America: a changing epidemiologic pattern. Am J Trop Med Hyg 61, 825-829.
110. Taylor, M. B. (1997). Molecular epidemiology of South African strains of hepatitis A virus: 1982-1996. J Med Virol 51, 273-279.
111. Ticehurst, J. R., Racaniello, V. R., Baroudy, B. M., Baltimore, D., Purcell, R. H. & Feinstone, S. M. (1983). Molecular cloning and characterization of hepatitis A virus cDNA. Proc Natl Acad Sci U S A 80, 5885-5889.
112. Ticehurst, J. C., Cohen, J. I. & Purcell, R. H. (1988). Analysis of molecular sequences demonstrates that hepatitis A virus (HAV) is a unique picornavirus. In Viral Hepatitis and Liver Disease, pp. 33-35. Edited by A. J. Zuckerman. New York: Alan R. Liss.
113. Tosh, C., Hemadri, D. & Sanyal, A. (2002). Evidence of recombination in the capsid-coding region of type A foot-and-mouth disease virus. J Gen Virol 83, 2455-2460.
114. Tsarev, S. A., Emerson, S. U., Balayan, M. S., Ticehurst, J. & Purcell, R. H. (1991). Simian hepatitis A virus (HAV) strain AGM-27: comparison of genome structure and growth in cell culture with other HAV strains. J Gen Virol 72, 1677-1683.
115. Venuti, A., Di Russo, C., del Grosso, N. & 13 other authors (1985). Isolation and molecular cloning of a fast-growing strain of human hepatitis A virus from its double-stranded replicative form. J Virol 56, 579-588.
116. Weitz, M. & Siegl, G. (1985). Variation among hepatitis A virus strains. I. Genomic variation detected by T1 oligonucleotide mapping. Virus Res 4, 53-67.
117. Worobey, M. & Holmes, E. C. (1999). Evolutionary aspects of recombination in RNA viruses. J Gen Virol 80, 2535-2543.
118. Worobey, M., Rambaut, A. & Holmes, E. C. (1999). Widespread intra-serotype recombination in natural populations of dengue virus. Proc Natl Acad Sci U S A 96, 7352-7357. f