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Volumn 30, Issue 4, 2003, Pages 307-313

Progress in Clinical Neurosciences: Therapeutic Hypothermia in Severe Traumatic Brain Injury

Author keywords

[No Author keywords available]

Indexed keywords

BRAIN INJURY; BRAIN PROTECTION; CLINICAL TRIAL; DISEASE SEVERITY; HUMAN; INDUCED HYPOTHERMIA; MORBIDITY; MORTALITY; NONHUMAN; PRIORITY JOURNAL; REVIEW; TEMPERATURE SENSITIVITY; TREATMENT OUTCOME; WARMING;

EID: 0347990741     PISSN: 03171671     EISSN: None     Source Type: Journal    
DOI: 10.1017/S0317167100003000     Document Type: Review
Times cited : (7)

References (50)
  • 1
    • 0003047572 scopus 로고    scopus 로고
    • Epidemiology of brain injury
    • Cooper PR, Golfinos JG, (Eds). New York: McGraw-Hill
    • Kraus J, McArthur D. Epidemiology of brain injury. In: Cooper PR, Golfinos JG, (Eds). Head Injury. New York: McGraw-Hill, 2000:1-26.
    • (2000) Head Injury , pp. 1-26
    • Kraus, J.1    McArthur, D.2
  • 2
    • 0002826605 scopus 로고
    • Observations on generalized refrigeration in cases of severe cerebral trauma
    • Fay T. Observations on generalized refrigeration in cases of severe cerebral trauma. Assoc Res Nerv Ment Dis Proc 1943;24:611-619.
    • (1943) Assoc Res Nerv Ment Dis Proc , vol.24 , pp. 611-619
    • Fay, T.1
  • 3
    • 0026018681 scopus 로고
    • Marked protection by moderate hypothermia after experimental traumatic brain injury
    • Clifton GL, Jiang JY, Lyeth BG, et al. Marked protection by moderate hypothermia after experimental traumatic brain injury. J Cereb Blood Flow Metab 1991;11:114-121.
    • (1991) J Cereb Blood Flow Metab , vol.11 , pp. 114-121
    • Clifton, G.L.1    Jiang, J.Y.2    Lyeth, B.G.3
  • 4
    • 0027759679 scopus 로고
    • Therapeutic hypothermia is cytoprotective without attenuating the traumatic brain injury-induced elevations in interstitial concentrations of aspartate and glutamate
    • Palmer AM, Marion DW, Botscheller ML, Redd EE. Therapeutic hypothermia is cytoprotective without attenuating the traumatic brain injury-induced elevations in interstitial concentrations of aspartate and glutamate. J Neurotrauma 1993;10:363-372.
    • (1993) J Neurotrauma , vol.10 , pp. 363-372
    • Palmer, A.M.1    Marion, D.W.2    Botscheller, M.L.3    Redd, E.E.4
  • 5
    • 0027172791 scopus 로고
    • Hypothermia blunts acetylcholine increase in CSF of traumatically brain injured rats
    • Lyeth BG, Jiang JY, Robinson SE, Guo H, Jenkins LW. Hypothermia blunts acetylcholine increase in CSF of traumatically brain injured rats. Mol Chem Neuropathol 1993;18:247-256.
    • (1993) Mol Chem Neuropathol , vol.18 , pp. 247-256
    • Lyeth, B.G.1    Jiang, J.Y.2    Robinson, S.E.3    Guo, H.4    Jenkins, L.W.5
  • 6
    • 0027955529 scopus 로고
    • Photothrombotic infarction triggers multiple episodes of cortical spreading depression in distant brain regions
    • Dietrich WD, Feng ZC, Leistra H, Watson BD, Rosenthal M. Photothrombotic infarction triggers multiple episodes of cortical spreading depression in distant brain regions. J Cereb Blood Flow Metab 1994;14:20-28.
    • (1994) J Cereb Blood Flow Metab , vol.14 , pp. 20-28
    • Dietrich, W.D.1    Feng, Z.C.2    Leistra, H.3    Watson, B.D.4    Rosenthal, M.5
  • 7
    • 0029100471 scopus 로고
    • Posttraumatic brain hypothermia provides protection from sensorimotor and cognitive behavioral deficits
    • Bramlett HM, Green EJ, Dietrich WD, et al. Posttraumatic brain hypothermia provides protection from sensorimotor and cognitive behavioral deficits. J Neurotrauma 1995;12:289-298.
    • (1995) J Neurotrauma , vol.12 , pp. 289-298
    • Bramlett, H.M.1    Green, E.J.2    Dietrich, W.D.3
  • 8
    • 0031703674 scopus 로고    scopus 로고
    • Effects of mild (33 degrees C) and moderate (29 degrees C) hypothermia on cerebral blood flow and metabolism, lactate, and extracellular glutamate in experimental head injury
    • Mori K, Maeda M, Miyazaki M, Iwase H. Effects of mild (33 degrees C) and moderate (29 degrees C) hypothermia on cerebral blood flow and metabolism, lactate, and extracellular glutamate in experimental head injury. Neurol Res 1998;20:719-726.
    • (1998) Neurol Res , vol.20 , pp. 719-726
    • Mori, K.1    Maeda, M.2    Miyazaki, M.3    Iwase, H.4
  • 9
    • 0031979517 scopus 로고    scopus 로고
    • Moderate hypothermia for 48 hours after temporary epidural brain compression injury in a canine outcome model
    • Ebmeyer U, Safar P, Radovsky A, et al. Moderate hypothermia for 48 hours after temporary epidural brain compression injury in a canine outcome model. J Neurotrauma 1998;15:323-336.
    • (1998) J Neurotrauma , vol.15 , pp. 323-336
    • Ebmeyer, U.1    Safar, P.2    Radovsky, A.3
  • 10
    • 0027216844 scopus 로고
    • The effect of resuscitative moderate hypothermia following epidural brain compression on cerebral damage in a canine outcome model
    • Pomeranz S, Safar P, Radovsky A, et al. The effect of resuscitative moderate hypothermia following epidural brain compression on cerebral damage in a canine outcome model. J Neurosurg 1993;79:241-251.
    • (1993) J Neurosurg , vol.79 , pp. 241-251
    • Pomeranz, S.1    Safar, P.2    Radovsky, A.3
  • 12
    • 0032740111 scopus 로고    scopus 로고
    • Secondary hypoxia following moderate fluid percussion brain injury in rats exacerbates sensorimotor and cognitive deficits
    • Bramlett HM, Dietrich WD, Green EJ. Secondary hypoxia following moderate fluid percussion brain injury in rats exacerbates sensorimotor and cognitive deficits. J Neurotrauma 1999;16:1035-1047.
    • (1999) J Neurotrauma , vol.16 , pp. 1035-1047
    • Bramlett, H.M.1    Dietrich, W.D.2    Green, E.J.3
  • 13
    • 0035169495 scopus 로고    scopus 로고
    • Posttraumatic hypothermia is neuroprotective in a model of traumatic brain injury complicated by a secondary hypoxic insult
    • Matsushita Y, Bramlett HM, Alonso O, Dietrich WD. Posttraumatic hypothermia is neuroprotective in a model of traumatic brain injury complicated by a secondary hypoxic insult. Crit Care Med 2001;29:2060-2066.
    • (2001) Crit Care Med , vol.29 , pp. 2060-2066
    • Matsushita, Y.1    Bramlett, H.M.2    Alonso, O.3    Dietrich, W.D.4
  • 14
    • 0033039882 scopus 로고    scopus 로고
    • Neuroprotective effect of hypothermia on neuronal injury in diffuse traumatic brain injury coupled with hypoxia and hypotension
    • Yamamoto M, Marmarou CR, Stiefel MF, Beaumont A, Marmarou A. Neuroprotective effect of hypothermia on neuronal injury in diffuse traumatic brain injury coupled with hypoxia and hypotension. J Neurotrauma 1999;16:487-500.
    • (1999) J Neurotrauma , vol.16 , pp. 487-500
    • Yamamoto, M.1    Marmarou, C.R.2    Stiefel, M.F.3    Beaumont, A.4    Marmarou, A.5
  • 15
    • 0033806192 scopus 로고    scopus 로고
    • No long-term benefit from hypothermia after severe traumatic brain injury with secondary insult in rats
    • Robertson CL, Clark RS, Dixon CE, et al. No long-term benefit from hypothermia after severe traumatic brain injury with secondary insult in rats. Crit Care Med 2000;28:3218-3223.
    • (2000) Crit Care Med , vol.28 , pp. 3218-3223
    • Robertson, C.L.1    Clark, R.S.2    Dixon, C.E.3
  • 16
    • 0001578114 scopus 로고
    • Effect of body temperature change on cerebral oxygen consumption of the intact monkey
    • Bering E. Effect of body temperature change on cerebral oxygen consumption of the intact monkey. Am J Physiol 1961;200:417-419.
    • (1961) Am J Physiol , vol.200 , pp. 417-419
    • Bering, E.1
  • 17
    • 0026754608 scopus 로고
    • 31P spectroscopy study of the effect of temperature on ischemic brain injury
    • 31P spectroscopy study of the effect of temperature on ischemic brain injury. Can J Neurol Sci 1992;19:317-325.
    • (1992) Can J Neurol Sci , vol.19 , pp. 317-325
    • Sutherland, G.R.1    Peeling, J.2    Sutherland, E.3
  • 18
    • 0032927988 scopus 로고    scopus 로고
    • Hypothermia: Depression of tricarboxylic acid cycle flux and evidence for pentose phosphate shunt upregulation
    • Kaibara T, Sutherland GR, Colbourne F, Tyson RL. Hypothermia: depression of tricarboxylic acid cycle flux and evidence for pentose phosphate shunt upregulation. J Neurosurg 1999;90:339-347.
    • (1999) J Neurosurg , vol.90 , pp. 339-347
    • Kaibara, T.1    Sutherland, G.R.2    Colbourne, F.3    Tyson, R.L.4
  • 19
    • 0036168990 scopus 로고    scopus 로고
    • Effect of hypothermia on brain tissue oxygenation in patients with severe head injury
    • Gupta AK, Al-Rawi PG, Hutchinson PJ, Kirkpatrick PJ. Effect of hypothermia on brain tissue oxygenation in patients with severe head injury. Br J Anaesth 2002;88:188-192.
    • (2002) Br J Anaesth , vol.88 , pp. 188-192
    • Gupta, A.K.1    Al-Rawi, P.G.2    Hutchinson, P.J.3    Kirkpatrick, P.J.4
  • 20
    • 0029112937 scopus 로고
    • Detection of free radical activity during transient global ischemia and recirculation: Effects of intraischemic brain temperature modulation
    • Globus MY-T, Busto R, Lin B, Schnippering H, Ginsberg MD. Detection of free radical activity during transient global ischemia and recirculation: effects of intraischemic brain temperature modulation. J Neurochem 1995;65:1250-1256.
    • (1995) J Neurochem , vol.65 , pp. 1250-1256
    • Globus, M.Y.-T.1    Busto, R.2    Lin, B.3    Schnippering, H.4    Ginsberg, M.D.5
  • 21
    • 0031046699 scopus 로고    scopus 로고
    • Effects of mild hypothermia on cerebral blood flow-independent changes in cortical extracellular levels of amino acids following contusion trauma in the rat
    • Koizumi H, Fujisawa H, Ito H, et al. Effects of mild hypothermia on cerebral blood flow-independent changes in cortical extracellular levels of amino acids following contusion trauma in the rat. Brain Res 1997;747:304-312.
    • (1997) Brain Res , vol.747 , pp. 304-312
    • Koizumi, H.1    Fujisawa, H.2    Ito, H.3
  • 22
    • 0033738884 scopus 로고    scopus 로고
    • Neurochemical monitoring in the management of severe head-injured patients with hypothermia
    • Yamaguchi S, Nakahara K, Miyagi T, Tokutomi T, Shigemori M. Neurochemical monitoring in the management of severe head-injured patients with hypothermia. Neurol Res 2000;22:657-664.
    • (2000) Neurol Res , vol.22 , pp. 657-664
    • Yamaguchi, S.1    Nakahara, K.2    Miyagi, T.3    Tokutomi, T.4    Shigemori, M.5
  • 23
    • 0031045652 scopus 로고    scopus 로고
    • Treatment of traumatic brain injury with moderate hypothermia
    • Marion DW, Penrod LE, Kelsey SF, et al. Treatment of traumatic brain injury with moderate hypothermia. N Engl J Med 1997;336:540-546.
    • (1997) N Engl J Med , vol.336 , pp. 540-546
    • Marion, D.W.1    Penrod, L.E.2    Kelsey, S.F.3
  • 24
    • 0036180777 scopus 로고    scopus 로고
    • Relationship between brain temperature, brain chemistry and oxygen delivery after severe human head injury: The effect of mild hypothermia
    • Soukup J, Zauner A, Doppenberg EM, et al. Relationship between brain temperature, brain chemistry and oxygen delivery after severe human head injury: the effect of mild hypothermia. Neurol Res 2002;24:161-168.
    • (2002) Neurol Res , vol.24 , pp. 161-168
    • Soukup, J.1    Zauner, A.2    Doppenberg, E.M.3
  • 25
    • 0032696982 scopus 로고    scopus 로고
    • Little benefit from mild hypothermia therapy for severely head injured patients with low intracranial pressure
    • Shiozaki T, Kato A, Taneda M, et al. Little benefit from mild hypothermia therapy for severely head injured patients with low intracranial pressure. J Neurosurg 1999;91:185-191.
    • (1999) J Neurosurg , vol.91 , pp. 185-191
    • Shiozaki, T.1    Kato, A.2    Taneda, M.3
  • 26
    • 0035954325 scopus 로고    scopus 로고
    • The Monro-Kellie hypothesis: Applications in CSF volume depletion
    • Mokri B. The Monro-Kellie hypothesis: applications in CSF volume depletion. Neurology 2001;56:1746-1748.
    • (2001) Neurology , vol.56 , pp. 1746-1748
    • Mokri, B.1
  • 27
    • 0001580427 scopus 로고
    • General hypothermia for experimental intracardiac surgery
    • Bigelow WG, Callaghan JC, Hopps JA. General hypothermia for experimental intracardiac surgery. Ann Surg 1950;132:531-537.
    • (1950) Ann Surg , vol.132 , pp. 531-537
    • Bigelow, W.G.1    Callaghan, J.C.2    Hopps, J.A.3
  • 28
    • 0002645528 scopus 로고
    • Brain volume and cerebrospinal fluid pressure during hypothermia
    • Rosomoff H. Brain volume and cerebrospinal fluid pressure during hypothermia. Am J Physiol 1955;183:19.
    • (1955) Am J Physiol , vol.183 , pp. 19
    • Rosomoff, H.1
  • 29
    • 0000941195 scopus 로고
    • Experimental study of the effects of hypothermia on local brain injury
    • Laskowski E. Experimental study of the effects of hypothermia on local brain injury. Neurology 1960;10:499-505.
    • (1960) Neurology , vol.10 , pp. 499-505
    • Laskowski, E.1
  • 30
    • 0030027456 scopus 로고    scopus 로고
    • Mild pre- and posttraumatic hypothermia attenuates blood-brain barrier damage following controlled cortical impact in the rat
    • Smith SL, Hall ED. Mild pre- and posttraumatic hypothermia attenuates blood-brain barrier damage following controlled cortical impact in the rat. J Neurotrauma 1996;13:1-9.
    • (1996) J Neurotrauma , vol.13 , pp. 1-9
    • Smith, S.L.1    Hall, E.D.2
  • 31
    • 0028982742 scopus 로고
    • Interleukin-1 receptor antagonist inhibits neuronal damage caused by fluid percussion injury in the rat
    • Toulmond S, Rothwell NJ. Interleukin-1 receptor antagonist inhibits neuronal damage caused by fluid percussion injury in the rat. Brain Res 1995;671:261-266.
    • (1995) Brain Res , vol.671 , pp. 261-266
    • Toulmond, S.1    Rothwell, N.J.2
  • 32
    • 0031044864 scopus 로고    scopus 로고
    • Adult nestin-expressing subependymal cells differentiate to astrocytes in response to brain injury
    • Holmin S, Almqvist P, Lendahl U, Mathiesen T. Adult nestin-expressing subependymal cells differentiate to astrocytes in response to brain injury. Eur J Neurosci 1997;9:65-75.
    • (1997) Eur J Neurosci , vol.9 , pp. 65-75
    • Holmin, S.1    Almqvist, P.2    Lendahl, U.3    Mathiesen, T.4
  • 33
    • 0029071410 scopus 로고
    • Hypothermia attenuates the normal increase in interleukin 1β RNA and nerve growth factor following traumatic brain injury in the rat
    • Goss JR, Styren SD, Miller PD, et al. Hypothermia attenuates the normal increase in interleukin 1β RNA and nerve growth factor following traumatic brain injury in the rat. J Neurotrauma 1995;12:159-167.
    • (1995) J Neurotrauma , vol.12 , pp. 159-167
    • Goss, J.R.1    Styren, S.D.2    Miller, P.D.3
  • 34
    • 0031310082 scopus 로고    scopus 로고
    • The relationship between brain temperature and neutrophil accumulation after traumatic brain injury in rats
    • Whalen MJ, Carlos TM, Clark RS, et al. The relationship between brain temperature and neutrophil accumulation after traumatic brain injury in rats. Acta Neurochir Suppl (Wien) 1997;70:260-261.
    • (1997) Acta Neurochir Suppl (Wien) , vol.70 , pp. 260-261
    • Whalen, M.J.1    Carlos, T.M.2    Clark, R.S.3
  • 35
    • 0034063154 scopus 로고    scopus 로고
    • Importance of posttraumatic hypothermia and hyperthermia on the inflammatory response after fluid percussion brain injury: Biochemical and immunocytochemical studies
    • Chatzipanteli K, Alonso OF, Kraydieh S, Dietrich WD. Importance of posttraumatic hypothermia and hyperthermia on the inflammatory response after fluid percussion brain injury: biochemical and immunocytochemical studies. J Cereb Blood Flow Metab 2000;20:531-542.
    • (2000) J Cereb Blood Flow Metab , vol.20 , pp. 531-542
    • Chatzipanteli, K.1    Alonso, O.F.2    Kraydieh, S.3    Dietrich, W.D.4
  • 36
    • 0031834799 scopus 로고    scopus 로고
    • Specific inhibition of apoptosis after cold-induced brain injury by moderate postinjury hypothermia
    • Xu R-X, Nakamura T, Nagao S, et al. Specific inhibition of apoptosis after cold-induced brain injury by moderate postinjury hypothermia. Neurosurgery 1998;43:107-114.
    • (1998) Neurosurgery , vol.43 , pp. 107-114
    • Xu, R.-X.1    Nakamura, T.2    Nagao, S.3
  • 37
    • 0031843505 scopus 로고    scopus 로고
    • Posttraumatic hypothermia in the treatment of axonal damage in an animal model of traumatic axonal injury
    • Koizumi H, Povlishock JT. Posttraumatic hypothermia in the treatment of axonal damage in an animal model of traumatic axonal injury. J Neurosurg 1998;89:303-309.
    • (1998) J Neurosurg , vol.89 , pp. 303-309
    • Koizumi, H.1    Povlishock, J.T.2
  • 38
    • 0034859561 scopus 로고    scopus 로고
    • Exacerbation of traumatically induced axonal injury by rapid posthypothermic rewarming and attenuation of axonal change by cyclosporin A
    • Suehiro E, Povlishock JT. Exacerbation of traumatically induced axonal injury by rapid posthypothermic rewarming and attenuation of axonal change by cyclosporin A. J Neurosurg 2001;94:493-498.
    • (2001) J Neurosurg , vol.94 , pp. 493-498
    • Suehiro, E.1    Povlishock, J.T.2
  • 39
    • 0023554153 scopus 로고
    • Small differences in intraischemic brain temperature critically determine the extent of ischemic neuronal injury
    • Busto R, Dietrich WD, Globus MY-T, et al. Small differences in intraischemic brain temperature critically determine the extent of ischemic neuronal injury. J Cereb Blood Flow Metab 1987;7:729-738.
    • (1987) J Cereb Blood Flow Metab , vol.7 , pp. 729-738
    • Busto, R.1    Dietrich, W.D.2    Globus, M.Y.-T.3
  • 40
    • 0018129225 scopus 로고
    • Ischaemic brain damage in fatal non-missile head injuries
    • Graham DI, Adams JH, Doyle D. Ischaemic brain damage in fatal non-missile head injuries. J Neurol Sci 1978;39:213-234.
    • (1978) J Neurol Sci , vol.39 , pp. 213-234
    • Graham, D.I.1    Adams, J.H.2    Doyle, D.3
  • 41
    • 0026779821 scopus 로고
    • Ultra-early evaluation of regional cerebral blood flow in severely head-injured patients using xenon-enhanced computerized tomography
    • Bouma GJ, Muizelaar JP, Stringer WA, et al. Ultra-early evaluation of regional cerebral blood flow in severely head-injured patients using xenon-enhanced computerized tomography. J Neurosurg 1992;77:360-368.
    • (1992) J Neurosurg , vol.77 , pp. 360-368
    • Bouma, G.J.1    Muizelaar, J.P.2    Stringer, W.A.3
  • 42
    • 0027223871 scopus 로고
    • Effect of mild hypothermia on uncontrolled intracranial hypertension after severe head injury
    • Shiozaki T, Sugimoto H, Taneda M, et al. Effect of mild hypothermia on uncontrolled intracranial hypertension after severe head injury. J Neurosurg 1993;79:363-368.
    • (1993) J Neurosurg , vol.79 , pp. 363-368
    • Shiozaki, T.1    Sugimoto, H.2    Taneda, M.3
  • 43
    • 0027440467 scopus 로고
    • A phase II study of moderate hypothermia in severe brain injury
    • Clifton GL, Allen S, Barrodale P, et al. A phase II study of moderate hypothermia in severe brain injury. J Neurotrauma 1993;10:263-271.
    • (1993) J Neurotrauma , vol.10 , pp. 263-271
    • Clifton, G.L.1    Allen, S.2    Barrodale, P.3
  • 44
    • 0034859173 scopus 로고    scopus 로고
    • A multicenter prospective randomized controlled trial of the efficacy of mild hypothermia for severely head injured patients with low intracranial pressure
    • Mild Hypothermia Study Group in Japan
    • Shiozaki T, Hayakata T, Taneda M, et al. A multicenter prospective randomized controlled trial of the efficacy of mild hypothermia for severely head injured patients with low intracranial pressure. Mild Hypothermia Study Group in Japan. J Neurosurg 2001;94:50-54.
    • (2001) J Neurosurg , vol.94 , pp. 50-54
    • Shiozaki, T.1    Hayakata, T.2    Taneda, M.3
  • 45
    • 0034517886 scopus 로고    scopus 로고
    • 2 production after traumatic brain injury in humans
    • 2 production after traumatic brain injury in humans. Crit Care Med 2000;28:3902-3906.
    • (2000) Crit Care Med , vol.28 , pp. 3902-3906
    • Aibiki, M.1    Maekawa, S.2    Yokono, S.3
  • 46
    • 0034432834 scopus 로고    scopus 로고
    • Effect of long-term mild hypothermia therapy in patients with severe traumatic brain injury: 1-Year follow-up review of 87 cases
    • Jiang J, Yu M, Zhu C. Effect of long-term mild hypothermia therapy in patients with severe traumatic brain injury: 1-year follow-up review of 87 cases. J Neurosurg 2000;93:546-549.
    • (2000) J Neurosurg , vol.93 , pp. 546-549
    • Jiang, J.1    Yu, M.2    Zhu, C.3
  • 47
    • 0035931948 scopus 로고    scopus 로고
    • Lack of effect of induction of hypothermia after acute brain injury
    • Clifton GL, Miller ER, Choi SC, et al. Lack of effect of induction of hypothermia after acute brain injury. N Engl J Med 2001;344:556-563.
    • (2001) N Engl J Med , vol.344 , pp. 556-563
    • Clifton, G.L.1    Miller, E.R.2    Choi, S.C.3
  • 48
    • 0034766710 scopus 로고    scopus 로고
    • Intercenter variance in clinical trials of head trauma - Experience of the National Acute Brain Injury Study: Hypothermia
    • Clifton GL, Choi SC, Miller ER, et al. Intercenter variance in clinical trials of head trauma - experience of the National Acute Brain Injury Study: Hypothermia. J Neurosurg 2001;95:751-755.
    • (2001) J Neurosurg , vol.95 , pp. 751-755
    • Clifton, G.L.1    Choi, S.C.2    Miller, E.R.3
  • 50
    • 0035931962 scopus 로고    scopus 로고
    • Hypothermia for traumatic brain injury - A good idea proved ineffective
    • Narayan RK. Hypothermia for traumatic brain injury - a good idea proved ineffective. N Engl J Med 2001;344:602-603.
    • (2001) N Engl J Med , vol.344 , pp. 602-603
    • Narayan, R.K.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.