Structure-activity relationships by mass spectrometry: Identification of novel MMP-3 inhibitors

Bioorganic and Medicinal Chemistry

Volumn 12, Issue 1, 2004, Pages 37-44

  Ockey, Denise A ^a,d   Dotson, Jenna L ^a   Struble, Martin E ^a   Stults, John T ^b   Bourell, James H ^b   Clark, Kevin R ^c   Gadek, Thomas R ^a  

^a GENENTECH INC   (United States)

^b Protein Analytical Chemistry   (United States)

^c Small Molecule Pharmaceutical Sciences Genentech   (United States)

^d SUGEN INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

3 (4 METHYLBENZOYLAMINO)BENZOHYDROXAMIC ACID; 3 METHOXY N 4 TOLYLBENZAMIDE; 4 (4 METHOXYBENZOYLAMINO)BENZOHYDROXAMIC ACID; 4 CYANO N PHENETHYLBENZAMIDE; 4 CYANO N PHENYLBENZAMIDE; 4 METHOXY N 4 TOLYLBENZAMIDE; 4 METHOXY N PHENYLBENZAMIDE; 4 METHYL N PHENYLBENZAMIDE; CHROMOGENIC SUBSTRATE; CYCLOHEXYL 4 METHOXYBENZAMIDE; N (2 PHENETHYL) 4 METHOXYBENZAMIDE; N (4 CYANOPHENYL) 2 PHENYLACETAMIDE; N (4 CYANOPHENYL)BENZAMIDE; N (4 METHOXYPHENYL) 4 METHYLBENZAMIDE; N BENZYL 4 CYANOBENZAMIDE; STROMELYSIN; STROMELYSIN INHIBITOR; UNCLASSIFIED DRUG; [3 (4 METHOXYBENZOYLAMINO)PHENYL]ACETOHYDROXAMIC ACID; [3 (4 METHOXYBENZOYLAMINO)PHENYL]PROPANOHYDROXAMIC ACID; [3 (4 METHYLBENZOYLAMINO)PHENYL]ACETOHYDROXAMIC ACID; [3 (4 METHYLBENZOYLAMINO)PHENYL]PROPANOHYDROXAMIC ACID; [4 (4 METHOXYBENZOYLAMINO)PHENYL]ACETOHYDROXAMIC ACID; [4 (4 METHOXYBENZOYLAMINO)PHENYL]BUTANOHYDROXAMIC ACID; [4 (4 METHYLBENZOYLAMINO)PHENYL]ACETOHYDROXAMIC ACID;

ARTICLE; BINDING AFFINITY; BINDING SITE; DRUG BINDING; DRUG DETERMINATION; DRUG IDENTIFICATION; DRUG MECHANISM; DRUG PROTEIN BINDING; DRUG SCREENING; DRUG STRUCTURE; MASS SPECTROMETRY; MOLECULE; PROTEIN FUNCTION; PROTEIN TARGETING; STOICHIOMETRY; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS;

EID: 0347931976     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2003.10.053     Document Type: Article

References (15)

1. Ayed A., Krutchinsky A.N., Ens W., Standing K.G., Duckworth H.W. Rapid Comm. Mass Spec. 12:1998;339.
2. Rishton G.M. Drug Discovery Today. 2:1997;382.
3. Hajduk P.J., Gerfin T., Boehlen J.M., Marek D., Fesik S.W. J. Med. Chem. 42:1999;2315.
4. Loo J.A., Hu P., McConnel P., Mueller T., Sawyer T.K., Thanabal V. J. Am. Soc. Mass Spectrom. 8:1997;234.
5. Ayed A., Krutchinsky A.N., Ens W., Standing K.G., Duckwork H. J. Rapid Comm. Mass Spec. 12:1998;339.
6. Henion J.D., Li Y.T. J. Am. Chem. Soc. 113:1991;6294.
7. Loo JosephA. Int. J. Mass Spectrom. 200:2000;175.
8. Loo J.A., Hu P., McConnell P., Mueller T., Sawyer T.K., Thanabal V. J. Am. Soc. Mass. Spectrom. 8:1997;234.
9. Siuzdak G. Proc. Natl. Acad. Sci. 91:1994;11290.
10. Veenstra T.D. Biophysical Chemistry. 79:1999;63.
11. Sannes-Lowery K.A., Griffey R.H., Hofstadler S.A. Anal. Biochem. 280:2000;264.
12. Jørgensen T.J.D., Roepstroff P., Heck A.J.R. Anal. Chem. 70:1998;4427.
13. (b) [E]i=XE [E]0; [E·H]i=XE·H [E]0; [E·I]i= XE·I [E]0; [E·H·I]i=XE·H·I [E]0; X=relative intensity; E=enzyme; H=acetohydroxamic acid; I=fragment.
14. Holman C.M., Kan C.C., Gehring M.R., Van Wart H.E. Biochemistry. 38:1999;677.
15. Dhanara V., Ye Q.Z., Johnson L.L., Hupe D.J., Ortwine D.F., Dunbar J.B., Rubin J.R., Pavlovsky A., Humblet C., Blundell T.L. Structure. 4:1996;375.