메뉴 건너뛰기




Volumn 21, Issue 4-5, 2003, Pages 279-284

The biosynthesis and metabolism of acarbose in Actinoplanes sp. SE 50/110: A progress report

Author keywords

Glucosidase inhibitor; Acarbose biosynthesis; Actinoplanes; Carbophor

Indexed keywords

AMINO ACIDS; BIOSYNTHESIS; CHEMICAL BONDS; ENZYME INHIBITION; GENES; MALTOSE; METABOLISM; STARCH;

EID: 0347337767     PISSN: 10242422     EISSN: None     Source Type: Journal    
DOI: 10.1080/102424120310001614388     Document Type: Conference Paper
Times cited : (37)

References (22)
  • 1
    • 0018413311 scopus 로고
    • Inhibition of human intestinal α-glucoside hydrolases by a new complex oligosaccaride
    • Caspary, W.F. and Graf, S. (1979) "Inhibition of human intestinal α-glucoside hydrolases by a new complex oligosaccaride", Res. Exp. Med. 175, 1-6.
    • (1979) Res. Exp. Med. , vol.175 , pp. 1-6
    • Caspary, W.F.1    Graf, S.2
  • 2
    • 0034801568 scopus 로고    scopus 로고
    • Biosynthesis of the validamycins: Identification of the intermediates in the biosynthesis of validamycin A by Streptomyces hygroscopicus var. limoneus
    • Dong, H., Mahmud, T., Tornus, I., Lee, S. and Floss, H. G. (2001) "Biosynthesis of the validamycins: Identification of the intermediates in the biosynthesis of validamycin A by Streptomyces hygroscopicus var. limoneus", J. Am. Chem. Soc. 28, 2733-2742.
    • (2001) J. Am. Chem. Soc. , vol.28 , pp. 2733-2742
    • Dong, H.1    Mahmud, T.2    Tornus, I.3    Lee, S.4    Floss, H.G.5
  • 3
    • 0029764468 scopus 로고    scopus 로고
    • Acarbose 7-phosphotransferase from Actinoplanes sp.: Purification, properties, and possible physiological function
    • Drepper, A. and Pape, H. (1996) "Acarbose 7-phosphotransferase from Actinoplanes sp.: Purification, properties, and possible physiological function", J. Antibiot. 49, 664-668.
    • (1996) J. Antibiot. , vol.49 , pp. 664-668
    • Drepper, A.1    Pape, H.2
  • 4
    • 0029746222 scopus 로고    scopus 로고
    • Formation of acarbose phosphate by a cell-free extract from the acarbose producer Actinoplanes sp
    • Goeke, K., Drepper, A. and Pape, H. (1996) "Formation of acarbose phosphate by a cell-free extract from the acarbose producer Actinoplanes sp", J. Antibiotics 49, 661-663.
    • (1996) J. Antibiotics , vol.49 , pp. 661-663
    • Goeke, K.1    Drepper, A.2    Pape, H.3
  • 5
    • 0346827075 scopus 로고
    • Studies designed to localize the essential structural unit of glycoside-hydrolase inhibitors of the acarbose type
    • In: Creutzfeld, E., ed; (Excerpta Medica, Amsterdam)
    • Heiker, F.R., Böshagen, H., Junge, B., Müller, L. and Stoltefuß, J. (1981) "Studies designed to localize the essential structural unit of glycoside-hydrolase inhibitors of the acarbose type", In: Creutzfeld, E., ed, First International Symposium on Acarbose (Excerpta Medica, Amsterdam), pp 137-141.
    • (1981) First International Symposium on Acarbose , pp. 137-141
    • Heiker, F.R.1    Böshagen, H.2    Junge, B.3    Müller, L.4    Stoltefuß, J.5
  • 6
    • 0034938521 scopus 로고    scopus 로고
    • Identification, cloning, expression, and characterization of the extracellular acarbose-modifying glycosyltransferase, AcbD, from Actinoplanes sp. Strain SE50
    • Hemker, M., Stratmann, A., Goeke, K., Schröder, W., Lenz, J., Piepersberg, W. and Pape, H. (2001) "Identification, cloning, expression, and characterization of the extracellular acarbose-modifying glycosyltransferase, AcbD, from Actinoplanes sp. Strain SE50", J. Bacteriol. 183, 4484-4492.
    • (2001) J. Bacteriol. , vol.183 , pp. 4484-4492
    • Hemker, M.1    Stratmann, A.2    Goeke, K.3    Schröder, W.4    Lenz, J.5    Piepersberg, W.6    Pape, H.7
  • 7
    • 0029111794 scopus 로고
    • A cellulase/xylanase-negative mutant of Streptomyces lividans 1326 defective in cellobiose and xylobiose uptake is mutated in a gene encoding a protein homologous to ATP-binding proteins
    • Hurtubise, Y., Shareck, F., Kluepfel, D. and Morosoli, R. (1995) "A cellulase/xylanase-negative mutant of Streptomyces lividans 1326 defective in cellobiose and xylobiose uptake is mutated in a gene encoding a protein homologous to ATP-binding proteins", Mol Microbiol. 17, 367-377.
    • (1995) Mol Microbiol. , vol.17 , pp. 367-377
    • Hurtubise, Y.1    Shareck, F.2    Kluepfel, D.3    Morosoli, R.4
  • 9
    • 0033523256 scopus 로고    scopus 로고
    • Biosynthetic studies on the -glucosidase inhibitor acarbose in Actinoplanes sp.: 2-epi-5-epi-valiolone in the direct precursor of the valienamine moiety
    • Mahmud, T., Tornus, I., Egelkrout, E., Wolf, E., Uy. C., Floss, H. G. and Lee, S. (1999) "Biosynthetic studies on the -glucosidase inhibitor acarbose in Actinoplanes sp.: 2-epi-5-epi-valiolone in the direct precursor of the valienamine moiety", J. Am. Chem. Soc. 121, 6973-6978.
    • (1999) J. Am. Chem. Soc. , vol.121 , pp. 6973-6978
    • Mahmud, T.1    Tornus, I.2    Egelkrout, E.3    Wolf, E.4    Uy, C.5    Floss, H.G.6    Lee, S.7
  • 10
    • 0000143333 scopus 로고
    • Chemistry, biochemistry and therapeutic potenital of microbial (-glucosidase inhibitors)
    • In: Demain, A.L., Somkuti, G.A., Hunter-Creva, J.C. and Rossmore, H.W., eds; (Elsevier Science Publishers, Amsterdam)
    • Müller, L. (1989) "Chemistry, biochemistry and therapeutic potenital of microbial (-glucosidase inhibitors)", In: Demain, A.L., Somkuti, G.A., Hunter-Creva, J.C. and Rossmore, H.W., eds, Novel Microbial Products for Medicine and Agriculture (Elsevier Science Publishers, Amsterdam), pp 109-116.
    • (1989) Novel Microbial Products for Medicine and Agriculture , pp. 109-116
    • Müller, L.1
  • 11
    • 0008558197 scopus 로고    scopus 로고
    • Crystal structures of human pancreatic α-amylase in complex with carbohydrate and proteinaceous inhibitors
    • Nahoum, V., Roux, G., Anton, V., Rouge, P., Puigserver, A., Bischoff, H., Henrissat, B. and Payan, F. (2000) "Crystal structures of human pancreatic α-amylase in complex with carbohydrate and proteinaceous inhibitors", Biochem. J. 346, 201-208.
    • (2000) Biochem. J. , vol.346 , pp. 201-208
    • Nahoum, V.1    Roux, G.2    Anton, V.3    Rouge, P.4    Puigserver, A.5    Bischoff, H.6    Henrissat, B.7    Payan, F.8
  • 12
    • 0001855097 scopus 로고    scopus 로고
    • Molecular biology, biochemistry, and fermentation of aminoglycoside antibiotics
    • In: Strohl, W.R., ed; (Marcel-Dekker, New York)
    • Piepersberg, W. (1997) "Molecular biology, biochemistry, and fermentation of aminoglycoside antibiotics", In: Strohl, W.R., ed, Biotechnology of Industrial Antibiotics, 2nd edn (Marcel-Dekker, New York), pp 81-163.
    • (1997) Biotechnology of Industrial Antibiotics, 2nd edn , pp. 81-163
    • Piepersberg, W.1
  • 13
    • 84978696453 scopus 로고    scopus 로고
    • Aminoglycosides and sugar components in other secondary metabolites
    • In: Rehm, H.-J., Reed, G., Pühler, A. and Stadler, P., eds; 2nd edn (VCH-Verlagsgesellschaft, Weinheim)
    • Piepersberg, W. and Distler, J. (1997) "Aminoglycosides and sugar components in other secondary metabolites", In: Rehm, H.-J., Reed, G., Pühler, A. and Stadler, P., eds, Biotechnology, Vol. 7, 2nd edn (VCH-Verlagsgesellschaft, Weinheim), pp 397-488.
    • (1997) Biotechnology , pp. 397-488
    • Piepersberg, W.1    Distler, J.2
  • 15
    • 0347457848 scopus 로고    scopus 로고
    • Identifizierung eines Acarbose-Biosynthesegenclusters in Actinoplanes sp. und Charakterisierung ausgewählter Enzyme des Acarbose-Stoffwechsels
    • PhD thesis, University Wuppertal
    • Stratmann, A. (1997) Identifizierung eines Acarbose-Biosynthesegenclusters in Actinoplanes sp. und Charakterisierung ausgewählter Enzyme des Acarbose-Stoffwechsels. PhD thesis, University Wuppertal.
    • (1997)
    • Stratmann, A.1
  • 16
    • 0033574676 scopus 로고    scopus 로고
    • 7-cyclitol synthase related to 3-dehydroquinate synthases and is involved in the biosynthesis of the αgGlucosidase inhibitor acarbose
    • 7-cyclitol synthase related to 3-dehydroquinate synthases and is involved in the biosynthesis of the αgGlucosidase inhibitor acarbose", J. Biol. Chem. 274, 10889-10896.
    • (1999) J. Biol. Chem. , vol.274 , pp. 10889-10896
    • Stratmann, A.1    Mahmud, T.2    Lee, S.3    Distler, J.4    Floss, H.G.5    Piepersberg, W.6
  • 18
    • 0346827074 scopus 로고    scopus 로고
    • Acarbose-metabolism in Actinoplanes sp. SE50/110
    • PhD thesis, University Wuppertal
    • Thomas, H. (2001) Acarbose-metabolism in Actinoplanes sp. SE50/110. PhD thesis, University Wuppertal.
    • (2001)
    • Thomas, H.1
  • 20
    • 0037151092 scopus 로고    scopus 로고
    • Biosynthesis of the C(7)-cyclitol moiety of acarbose in Actinoplanes species SE50/110. 7-O-phosphorylation of the initial cyclitol precursor leads to proposal of a new biosynthetic pathway
    • Zhang, C.S., Stratmann, A., Block, O., Bruckner, R., Podeschwa, M., Altenbach, H.J., Wehmeier, U.F. and Piepersberg, W. (2002) "Biosynthesis of the C(7)-cyclitol moiety of acarbose in Actinoplanes species SE50/110. 7-O-phosphorylation of the initial cyclitol precursor leads to proposal of a new biosynthetic pathway", J. Biol. Chem. 277, 22853-22862.
    • (2002) J. Biol. Chem. , vol.277 , pp. 22853-22862
    • Zhang, C.S.1    Stratmann, A.2    Block, O.3    Bruckner, R.4    Podeschwa, M.5    Altenbach, H.J.6    Wehmeier, U.F.7    Piepersberg, W.8
  • 21
    • 0345270037 scopus 로고    scopus 로고
    • The acarbose-biosynthetic enzyme AcbO from Actinoplanes sp. SE 50/110 is a 2-epi-5-epi-valiolone-7-phosphate 2-epimerase
    • Zhang, C.Z., Podeschwa, M., Altenbach, H.J., Piepersberg, W. and Wehmeier, U.F. (2003a) "The acarbose-biosynthetic enzyme AcbO from Actinoplanes sp. SE 50/110 is a 2-epi-5-epi-valiolone-7-phosphate 2-epimerase", FEBS Lett. 540, 47-52.
    • (2003) FEBS Lett. , vol.540 , pp. 47-52
    • Zhang, C.Z.1    Podeschwa, M.2    Altenbach, H.J.3    Piepersberg, W.4    Wehmeier, U.F.5
  • 22
    • 0344838677 scopus 로고    scopus 로고
    • Identification of a 1-epi-valienol 7-kinase activity in the producer of acarbose, Actinoplanes sp. SE50/110
    • Zhang, C.Z., Podeschwa, M., Block, O., Altenbach, H.J., Piepersberg, W. and Wehmeier, U.F. (2003b) "Identification of a 1-epi-valienol 7-kinase activity in the producer of acarbose, Actinoplanes sp. SE50/110", FEBS Lett. 540, 53-57.
    • (2003) FEBS Lett. , vol.540 , pp. 53-57
    • Zhang, C.Z.1    Podeschwa, M.2    Block, O.3    Altenbach, H.J.4    Piepersberg, W.5    Wehmeier, U.F.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.