The AcbC protein from actinoplanes species is a C7-cyclitol synthase related to 3-dehydroquinate synthases and is involved in the biosynthesis of the α-glucosidase inhibitor acarbose

Journal of Biological Chemistry

Volumn 274, Issue 16, 1999, Pages 10889-10896

  Stratmann, Ansgar ^a,c   Mahmud, Taifo ^b   Lee, Sungsook ^b,d   Distler, Juergen ^a   Floss, Heinz G ^b   Piepersberg, Wolfgang ^a  

^a UNIVERSITY OF WUPPERTAL   (Germany)

^b UNIVERSITY OF WASHINGTON   (United States)

^c NOVARTIS PHARMA AG   (Switzerland)

^d Cerep Inc   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 EPI 5 EPI VALIOLONE 5 (HYDROXYMETHYL)CYCLOHEXANON 2,3,4,5 TETROL; 3 DEHYDROQUINATE SYNTHASE; ACARBOSE; ALPHA GLUCOSIDASE INHIBITOR; MANNOHEPTULOSE; PROTEIN ACBC; SYNTHETASE; THYMIDINE DIPHOSPHATE D GLUCOSE 4,6 DEHYDRATASE; THYMIDINE DIPHOSPHATE D GLUCOSE SYNTHASE; UNCLASSIFIED DRUG;

ACTINOPLANES; ARTICLE; BACTERIUM; CONTROLLED STUDY; CYCLIZATION; DNA SEQUENCE; DRUG SYNTHESIS; GENE CLUSTER; MOLECULAR CLONING; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; REACTION ANALYSIS; STREPTOMYCES LIVIDANS;

ACARBOSE; ACTINOMYCETALES; ALPHA-GLUCOSIDASES; AMINO ACID SEQUENCE; BACTERIAL PROTEINS; BASE SEQUENCE; CARBOHYDRATE SEQUENCE; CLONING, MOLECULAR; DNA PRIMERS; ENZYME INHIBITORS; INTRAMOLECULAR OXIDOREDUCTASES; MAGNETIC RESONANCE SPECTROSCOPY; MOLECULAR SEQUENCE DATA; MULTIGENE FAMILY; PHOSPHORUS-OXYGEN LYASES; SEQUENCE HOMOLOGY, AMINO ACID; SUBSTRATE SPECIFICITY; TRISACCHARIDES;

ACTINOPLANES; ACTINOPLANES SP.; ACTINOPLANES SP. 50/110; BACTERIA (MICROORGANISMS); EUKARYOTA; PROKARYOTA; STREPTOMYCES LIVIDANS;

EID: 0033574676     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.274.16.10889     Document Type: Article

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