Effect of epoxide hydrolase and glutathione S-tranferase genotypes on the induction of micronuclei and DNA damage by styrene-7,8-oxide in vitro

Mutation Research - Genetic Toxicology and Environmental Mutagenesis

Volumn 536, Issue 1-2, 2003, Pages 49-59

  Laffon, Blanca ^a   Pérez Cadahía, Beatriz ^a   Pásaro, Eduardo ^a   Méndez, Josefina ^a  

^a UNIVERSITY OF A CORUÑA   (Spain)

Author keywords

Comet assay; Epoxide hydrolase; Genetic polymorphisms; Glutathione S transferase; Micronucleus test; Styrene 7,8 oxide

Indexed keywords

DIMETHYL SULFOXIDE; DNA; EPOXIDE HYDROLASE; GLUTATHIONE TRANSFERASE; ISOPROTEIN; STYRENE OXIDE;

ADULT; ARTICLE; COMET ASSAY; CONTROLLED STUDY; DETOXIFICATION; DNA DAMAGE; DNA POLYMORPHISM; ENZYME ACTIVITY; EXON; FEMALE; GENOTOXICITY; GENOTYPE; HOMOZYGOSITY; HUMAN; HUMAN CELL; IN VITRO STUDY; LEUKOCYTE; MALE; MICRONUCLEUS TEST; NORMAL HUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN METABOLISM; WILD TYPE;

EID: 0347294693     PISSN: 13835718     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1383-5718(03)00034-2     Document Type: Article

References (40)

1. Seidegard J., Ekström G. The role of human glutathione transferases and epoxide hydrolases in the metabolism of xenobiotics. Environ. Health Perspect. 105:1997;791-799.
2. Hasset C., Aicher L., Sidhu J.S., Omiecinski J. Human microsomal epoxide hydrolase: genetic polymorphism and functional expression in vitro of amino acid variants. Hum. Mol. Genet. 3:1994;421-428.
3. Sarmanová J., Týnková L., Susová S., Gut I., Soucek P. Genetic polymorphisms of biotransformation enzymes: allele frequencies in the population of the Czech Republic. Pharmacogenetics. 10:2000;781-788.
4. Seidegard J., Pero R.W. The hereditary transmission of high glutathione transferase activity towards trans-stilbene oxide in human mononuclear leukocytes. Hum. Genet. 69:1985;66-68.
5. Miller R.R., Newhook R., Poole A. Styrene production, use and human exposure. Crit. Rev. Toxicol. 24:1994;S1-S10.
6. Rappaport S.M., Yeowell-O'Conell K., Bodell W., Yager J.W., Symanski E. An investigation of multiple biomarkers among workers exposed to styrene and styrene-7,8-oxide. Cancer Res. 56:1996;5410-5416.
7. Vodicka P., Koskinen M., Arand M., Oesch F., Hemminki K. Spectrum of styrene-induced DNA adducts: the relationship to other biomarkers and prospects in human biomonitoring. Mutat. Res. 511:2002;239-254.
8. Scott D., Preston R.J. A re-evaluation of the cytogenetic effects of styrene. Mutat. Res. 318:1994;175-203.
9. Laffon B., Pásaro E., Méndez J. Genotoxic effects of styrene-7,8-oxide in human white blood cells: comet assay in relation to the induction of sister-chromatid exchanges and micronuclei. Mutat. Res. 491:2001;163-172.
10. Laffon B., Pásaro E., Méndez J. DNA damage and repair in human leukocytes exposed to styrene-7,8-oxide measured by the comet assay. Toxicol. Lett. 126:2002;61-68.
11. Laffon B., Pásaro E., Méndez J. Effects of styrene-7,8-oxide over p53, p21, bcl-2 and bax expression in human lymphocyte cultures. Mutagenesis. 16:2001;127-132.
12. IARC, Some industrial chemicals, IARC monographs on the evaluation of carcinogenic risks to humans, International Agency for Research on Cancer 60, Lyon, 1994.
13. Sumner S.J., Fennell T.R. Review of the metabolic fate of styrene. Crit. Rev. Toxicol. 24:1994;S11-S33.
14. Fenech M. The cytokinesis-block micronucleus technique: a detailed description of the method and its application to genotoxicity studies in human populations. Mutat. Res. 285:1993;35-44.
15. Kirsch-Volders M., Sofuni T., Aardema M., Albertini S., Eastmond D., Fenech M., Ishidate M., Lorge E., Norppa H., Surrallés J., von der Hude W., Wakata A. Report from the in vitro micronucleus assay working group. Environ. Mol. Mutagen. 35:2000;167-172.
16. Singh N.P., McCoy M.T., Tice R.R., Schneider E.L. A simple technique for quantitation of low levels of DNA damage in individual cells. Exp. Cell Res. 175:1988;184-191.
17. Olive P.L., Banáth J.P., Durand R.E. Heterogeneity in radiation-induced DNA damage and repair in tumor and normal cells measured using the "comet" assay. Radiat. Res. 122:1990;86-94.
18. Smith C.A.D., Harrison D.J. Association between polymorphism in gene for microsomal epoxide hydrolase and susceptibility to emphysema. Lancet. 350:1997;630-633.
19. Saarikoski S.T., Voho A., Reinkainen M., Anttila S., Karjalainen A., Malaveille C., Vainio H., Husgafvel-Pursiainen K., Hirvonen A. Combined effect of polymorphic GST genes on individual susceptibility to lung cancer. Int. J. Cancer. 77:1998;516-521.
20. Korn M., Gfrörer W., Filser J.G., Kessler W. Styrene-7,8-oxide in blood of workers exposed to styrene. Arch. Toxicol. 68:1994;524-527.
21. Bolognesi C., Merlo F., Rabboni R., Valerio F., Abbondandolo A. Cytogenetic biomonitoring in traffic police workers: micronucleus test in peripheral blood lymphocytes. Environ. Mol. Mutagen. 30:1997;396-402.
22. Calvert G.M., Talaska G., Mueller C.A., Ammenheuser M.M., Au W.W., Fajen J.M., Fleming L.E., Briggle T., Ward E. Genotoxicity in workers exposed to methyl bromide. Mutat. Res. 417:1998;115-128.
23. Möller P., Knudsen L.E., Loft S., Wallin H. The comet assay as a rapid test in biomonitoring occupational exposure to DNA-damaging agents and effect of confounding factors. Cancer Epidemiol. Biomarkers Prev. 9:2000;1005-1015.
24. T.B.L. Kirkwood, DNA, mutations and aging, Mutat. Res. (Suppl.) (1988) 7-13.
25. Fenech M., Holland N., Chang W.P., Zeiger E., Bonassi S. The human micronucleus project - an international collaborative study on the use of the micronucleus technique for measuring DNA damage in humans. Mutat. Res. 428:1999;271-283.
26. Peace B.E., Succop P. Spontaneous micronucleus frequency and age: what are normal values? Mutat. Res. 425:1999;225-230.
27. Betti C., Davini T., Giannessi L., Loprieno N., Barale R. Microgel electrophoresis assay (comet test) and SCE analysis in human lymphocytes from 100 normal subjects. Mutat. Res. 307:1994;323-333.
28. Ali-Osman F., Akande O., Antoun G., Mao J.-X., Buolamwini J. Molecular cloning, characterization, and expression in Escherichia coli of full-length cDNAs of three human glutathione S-transferase Pi gene variants. J. Biol. Chem. 272:1997;10004-10012.
29. Vodicka P., Soucek P., Tates A.D., Dusinska M., Sarmanová J., Zamecnikova M., Vodickova L., Koskinen M., de Zwart F.A., Natarajan A.T., Hemminki K. Association between genetic polymorphism and biomarkers in styrene-exposed workers. Mutat. Res. 482:2001;89-103.
30. Van Goethem F., Lison D., Kirsch-Volders M. Comparative evaluation of the in vitro micronucleus test and the alkaline single cell electrophoresis assay for the detection of DNA damaging agents: genotoxic effects of cobalt powder. Mutat. Res. 392:1997;31-43.
31. Ollikainen T., Hirvonen A., Norppa H. Influence of GSTT1 genotype on sister chromatid exchange induction by styrene-7,8-oxide in cultured human lymphocytes. Environ. Mol. Mutagen. 31:1998;311-315.
32. Uusküla M., Järventaus H., Hirvonen A., Sorsa M., Norppa H. Influence of GSTM1 genotype on sister chromatid exchange induction by styrene-7,8-oxide and 1,2-epoxy-3-butene in cultured human lymphocytes. Carcinogenesis. 16:1995;947-950.
33. Shield A.J., Sanderson B.J.S. Role of glutathione S-transferase Mu (GSTM1) in styrene-7,8-oxide toxicity and mutagenicity. Environ. Mol. Mutagen. 37:2001;285-289.
34. Bernardini S., Hirvonen A., Järventaus H., Norppa H. Influence of GSTM1 and GSTT1 genotypes on sister chromatid exchange induction by styrene in cultured human lymphocytes. Carcinogenesis. 23:2002;893-897.
35. Laffon B., Pérez-Cadahía B., Pásaro E., Méndez J. Individual sensitivity to DNA damage induced by styrene in vitro: influence of cytochrome P450, epoxide hydrolase and glutathione S-transferase genotypes. Toxicology. 186:2003;131-141.
36. Ghittori S., Maestri L., Imbriani M., Capodaglio E., Cavalleri A. Urinary excretion of specific mercapturic acids in workers exposed to styrene. Am. J. Ind. Med. 31:1996;636-644.
37. De Palma G., Manini P., Mozzoni P., Andreoli R., Bergamaschi E., Cavazzini S., Franchini I., Mutti A. Polymorphism of xenobiotic-metabolizing enzymes and excretion of styrene-specific mercapturic acids. Chem. Res. Toxicol. 14:2001;1393-1400.
38. Haufroid V., Buchet J.P., Gsrdinal S., Ghittori S., Imbriani M., Hirvonen A., Lison D. Importance of genetic polymorphisms of drug-metabolizing enzymes for the interpretation of biomarkers of exposure to styrene. Biomarkers. 6:2001;236-249.
39. Zhang X., Chakrabarti S., Malick A.M., Richer C. Effects of different styrene metabolites on cytotoxicity, sister-chromatid exchanges and cell-cycle kinetics in human whole blood lymphocytes in vitro. Mutat. Res. 302:1993;213-218.
40. Laffon B., Pásaro E., Méndez J. Evaluation of genotoxic effects in a group of workers exposed to low levels of styrene. Toxicology. 171:2002;175-186.