Prevention of autoantibody-mediated Graves'-like hyperthyroidism in mice with IL-4, a Th2 cytokine

Journal of Immunology

Volumn 170, Issue 7, 2003, Pages 3522-3527

  Nagayama, Yuji ^a   Mizuguchi, Hiroyuki ^b   Hayakawa, Takao ^b   Niwa, Masami ^a   McLachlan, Sandra M ^c   Rapoport, Basil ^c  

^a NAGASAKI UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b NATIONAL INSTITUTE OF HEALTH SCIENCES   (Japan)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOVIRUS VECTOR; AUTOANTIBODY; GAMMA INTERFERON; IMMUNOGLOBULIN G ANTIBODY; IMMUNOGLOBULIN G1; IMMUNOGLOBULIN G2A; INTERLEUKIN 12; INTERLEUKIN 4; THYROID STIMULATING IMMUNOGLOBULIN; THYROTROPIN; THYROTROPIN RECEPTOR; THYROXINE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIBODY PRODUCTION; ARTICLE; CELL STRAIN COS1; CONTROLLED STUDY; CYTOKINE PRODUCTION; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; GRAVES DISEASE; MOUSE; NONHUMAN; PRIORITY JOURNAL; SPLEEN CELL; TH1 CELL; TH2 CELL;

EID: 0347264749     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.170.7.3522     Document Type: Article

References (36)

1. Rees Smith, B., S. M. McLachlan, and J. Furmaniak. 1988. Autoantibodies to the thyrotropin receptor. Endocr. Rev. 9:106.
2. Rapoport, B., G. D. Chazenbalk, J. C. Jaume, and S. M. McLachlan. 1998. The thyrotropin (TSH) receptor: interaction with TSH and autoantibodies. Endocr. Rev. 19:673.
3. Yamada, T., A. Sato, I. Komiya, T. Nishimori, Y. Ito, A. Terao, S. Eto, and Y. Tanaka. 2000. An elevation of serum immunoglobulin E provides a new aspect of hyperthyroid Graves' disease. J. Clin. Endocrinol. Metab. 85:2775.
4. Coles, A., M. Wing, S. Smith, F. Coraddu, S. Greer, C. Taylor, A. Weetman, G. Hale, V. K. Chatterjee, H. Waldmann, and A. Compston. 1999. Pulsed monoclonal antibody treatment and autoimmune thyroid disease in multiple sclerosis. Lancet 354:1691.
5. Weetman, A. P. 2002. Cytokine and autoimmune thyroid disease. Hot. Thyroidol.
6. Davies, T. F. 1999. The thyroid immunology of the postpartum period. Thyroid 9:675.
7. Weetman, A. P., M. E. Yateman, P. A. Ealey, C. M. Black, C. B. Reimer, R. C. Williams, Jr., B. Shine, and N. J. Marshall. 1990. Thyroid-stimulating antibody activity between different immunoglobulin G subclasses. J. Clin. Invest. 86:723.
8. Shimojo, N., Y. Kohno, K. Yamaguchi, S. Kikuoka, A. Hoshioka, H. Niimi, A. Hirai, Y. Tamura, Y. Saito, L. D. Kohn, and K. Tahara. 1996. Induction of Graves-like disease in mice by immunization with fibroblasts transfected with the thyrotropin receptor and a class II molecule. Proc. Natl. Acad. Sci. USA 93:11074.
9. Costagliola, S., M. C. Many, J.-F. Dehef, J. Pohlenz, S. Refetoff, and G. Vassart. 2000. Genetic immunization of outbred mice with thyrotropin receptor cDNA provides a model of Graves' disease. J. Clin. Invest. 105:803.
10. Kita, M., L. Ahmad, R. C. Marians, H. Vlase, P. Unger, P. N. Graves, and T. F. Davies. 1999. Regulation and transfer of a murine model of thyrotropin receptor antibody mediated Graves' disease. Endocrinology 140:1392.
11. Yan, X.-M., J. Guo, P, Pichurin, K. Tanaka, J. C. Jaume, B. Rapoport, and S. M. McLachlan. 2000. Cytokines. IgG subclasses and costimulation in a mouse model of thyroid autoimmunity induced by injection of fibroblasts co-expressing MHC class II and thyroid autoantigens. Clin. Exp. Immunol. 122:170.
12. Costagliola, S., P. Rodien, M.-C. Many, M. Ludgate, and G. Vassart. 1998. Genetic immunization against the human thyrotropin receptor causes thyroiditis and allows production of monoclonal antibodies recognizing the native receptor. J. Immunol. 160:1458.
13. Pichurin, P., X.-M. Yan, L. Farilla, J. Guo, G. D. Chazenbalk, B, Rapoport, and S. M. McLachlan. 2001. Naked TSHR receptor DNA vaccination: a Th1 T cell response in which interferon-γ production, rather than antibody, dominates the immune response in mice, Endocrinology 142:3530.
14. Pichurin, P., O. Pichurina, G. D. Chazenbalk, C. Paras, C.-R. Chen, B. Rapoport, and S. M. McLachlan. 2002. Immune deviation away from Th1 in interferon-γ knock-out mice does not enhance TSH receptor antibody production following naked DNA vaccination. Endocrinology 143:1182.
15. Nagayama, Y., M. Kita-Furuyama, T. Ando, K. Nakao, H. Mizuguchi, T. Hayakawa, K. Eguchi, and M. Niwa. 2002. A novel murine model of Graves' hyperthyroidism with intramuscular injection of adenovirus expressing the thyrotropin receptor. J. Immunol. 168:2789.
16. Mizuguchi, H., and M. A. Kay. 1998. Efficient construction of a recombinant adenoviral vector by an improved in vitro ligation method. Hum. Gene Ther. 9:2577.
17. Mizuguchi, H., N. Koizumi, T. Hosono, N. Utoguchi, Y. Watanabe, M. A. Kay, and T. Hayakawa. 2001. A simplified system for constructing recombinant adenoviral vectors containing heterologous peptides in the HI loop of their fiber knob. Gene Ther. 8:730.
18. Obana, S., H. Miyazawa, E. Hara, T. Tamura, H. Nariuchi, M. Takata, S. Fujimoto, and H. Yamamoto. 1995. Induction of anti-tumor immunity by mouse tumor cells transfected with mouse interleukin-12 gene. Jpn. J. Med. Sci. Biol. 48:221.
19. Chazenbalk, G. D., J. C. Jaume, S. M. McLachlan, and B. Rapoport. 1997. Engineering the human thyrotropin receptor ectodomain from a non-secreted form to a secreted, highly immunoreactive glycoprotein that neutralizes autoantibodies in Graves' patients' sera. J. Biol. Chem. 272:18959.
20. Chazenbalk, G. D., S. M. McLachlan, P. Pichurin, and B. Rapoport. 2001. A "prion-like" shift between two conformational forms of a recombinant thyrotropin receptor A subunit module: purification and stabilization using chemical chaperones of the form reactive with Graves' autoantibodies. J. Clin. Endocrinol. Metab. 86:1287.
21. Nagayama, Y., S. M. McLachlan, B. Rapoport, and M. Niwa. 2002. A major role for non-MHC genes, but not for microorganisms, in a novel murine model of Graves' hyperthyroidism. Thyroid. In press.
22. Gessner, J. E., H. Heiken, A. Tamm, and R. E. Schmit. 1998. The IgG receptor family (FcγR). Ann. Hematol. 76:231.
23. Kita-Furuyama, M., Y. Nagayama, P. Pichurin, S. M. McLachlan, B. Rapoport, and K. Eguchi. 2002. Dendritic cells infected with adenovirus expressing the thyrotropin receptor induce Graves' hyperthyroidism in BALB/c mice. Clin. Exp. Immunol. 131:234.
24. Elson, C., and R. N. Baker. 2000. Helper T cells in antibody-mediated, organspecific autoimmunity. Curr. Opin. Immunol, 12:664.
25. Hill, M., D. Beeson, P. Moss, L. Jacobson, A. Bond, L. Corlett, J. Newsom-Davis, A. Vincent, and N. Willcox. 1999. Early-onset myasthenia gravis: a recurring T-cell epitope in the adult-specific acethyleholine receptor ε subunit presented by the susceptibility allele HLA-DR52a. Ann. Neurol. 5:224.
26. Theofilopoulos, A. N., and B. R. Lawson. 1999. Tumor necrosis factor and other cytokines in murine lupus. Ann. Rheum. Dis. 58:149.
27. Peng, S. L., J. Moslehi, and J. Craftt. 1997. Roles of interferon-γ and interleukin-4 in murine lupus. J. Clin. Invest. 99:1936.
28. Santiago, M.-L., L. Fossati, C. Jacquet, W. Muller, S. Izui, and L. Reininger. 1997. Interleukin-4 protects against a genetically linked lupus-like autoimmune syndrome. J. Exp. Med. 185:65.
29. Mossman, T. R., and R. L. Coffman. 1989. Th1 and Th2 cells: different patterns of lymphokine secretion lead to different functional properties. Annu. Rev. Immunol. 7:145.
30. H1 responses and resistance to Leishmania major in susceptible BALB/c mice. Nat. Immunol. 2:1054.
31. Rhodes, S. G., and S. Graham. 2002. Is timing important for cytokine polarization? Trends Immunol. 23:246.
32. Hogaboam, C. M., B. A. Vallance, A. Kumar, C. L. Addison, F. L. Graham, J. Gauldie, and S. Collins. 1997. Therapeutic effects of interleukin-4 gene transfer in experimental inflammatory bowel disease. J. Clin. Invest. 100:2766.
33. Fort, M., R. Lesley, N. Davidson, S. Menon, F. Brombacher, M. Leach, and D. Rennick. 2001. IL-4 exacerbates disease in a Th1 cell transfer model of colitis. J. Immunol. 166:293.
34. Cameron, M. J., G. A. Arreaza, L. Waldhauser, J. Gauldie, and T. L. Delovitch. 2000. Immunotherapy of spontaneous type 1 diabetes in nonobese diabetic mice by systemic interleukin-4 treatment employing adenovirus vector-mediated gene transfer. Gene Ther. 7:1840.
35. Radu. D. L., N. Noben-Trauth, J. Hu-Li, W. E. Paul, and C. A. Bona. 2000. A targeted mutation in the IL-4Rα gene protects mice against autoimmune diabetes. Proc. Natl. Acad. Sci. USA 97:12700.
36. Tonnetti, L., R. Spaccapedo, E. Cenci, A. Mencacci, P. Puccetti, R. L. Coffman, F. Bistoni, and L. Romani. 1995. Interleukin-4 and - 10 exacerbate candidiasis in mice. Eur. J. Immunol. 25:1559.