Effects of a mixture of polychlorinated biphenyls (Aroclor 1254) on the transcriptional activity of thyroid hormone receptor

Journal of Endocrinological Investigation

Volumn 26, Issue 10, 2003, Pages 972-978

  Bogazzi, F ^a   Raggi, F ^a   Ultimieri, F ^a   Russo, D ^a   Campomori, A ^a   McKinney, J D ^b   Pinchera, A ^a   Bartalena, L ^c   Martino, E ^a  

^a UNIVERSITY OF PISA   (Italy)

^b U S ENVIRONMENTAL PROTECTION AGENCY   (United States)

^c UNIVERSITY OF INSUBRIA   (Italy)

Author keywords

Aroclor; PCBs; Thyroid hormone; Thyroid hormone receptor

Indexed keywords

AROCLOR 1254; CHLORAMPHENICOL ACETYLTRANSFERASE; LIOTHYRONINE; MALATE DEHYDROGENASE (DECARBOXYLATING); POLYCHLORINATED BIPHENYL; THYROID HORMONE; THYROID HORMONE RECEPTOR; TRYPSIN;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DRUG EFFECT; ENDOCRINE DISEASE; ENZYME ACTIVITY; GEL MOBILITY SHIFT ASSAY; GENE MUTATION; GENETIC TRANSCRIPTION; GENETIC TRANSFECTION; HORMONE RECEPTOR INTERACTION; HORMONE RESPONSIVE ELEMENT; HORMONE SENSITIVITY; IN VITRO STUDY; MOLECULAR BIOLOGY; NONHUMAN; PLASMID; PROTEIN CONFORMATION; PROTEIN DEGRADATION; RAT; REPORTER GENE; RNA TRANSLATION; WILD TYPE;

EID: 0346998319     PISSN: 03914097     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF03348194     Document Type: Article

References (46)

1. McKinney JD, Waller CL. Molecular determinants of hormone mimicry: Halogenated aromatic hydrocarbon environmental agents. J Toxicol Environ Health 1998, 1: 27-58.
2. Safe S, Safe L, Mullin M. Polychlorinated biphenyls: Environmental occurrence and analysis. In: Safe S, Hutzinger O eds. Polychlorinated Biphenyls (PCBs): Mammalian and Environmental Toxicology. Berlin: Springer-Verlag 1987, 1-13.
3. Tilson HA, Jacobson JL, Rogan WJ. Polychlorinated biphenyls and the developing nervous system: Cross-species comparison. Neurotoxicology 1990, 13: 139-48.
4. Baccarelli A, Pesatori AC, Bertazzi PA. Occupational and environmental agents as endocrine disruptors: Experimental and human evidence. J Endocrinol Invest 2000, 23: 771-81.
5. McKinney JD, Waller CL. Polychlorinated biphenyls as hormonally active structural analogues. Environ Health Perspect 1994, 102: 290-7.
6. Emmett EA, Maroni M, Jefferys J, Schmith J, Levin BK, Alvares A. Studies of transformer repair workers exposed to PCBs: II. Results of clinical laboratory investigations. Am J Industr Med 1988, 14: 47-62.
7. Brucker-Davis F. Effects of environmental synthetic chemicals on thyroid function. Thyroid 1998, 8: 827-56.
8. DC, Wehler EK, Wesseling W, Koeman JH, Brouwer A. Alterations in rat brain thyroid hormone status following pre and postnatal exposure to polychlorinated biphenyls (Aroclor 1254). Toxicol Appl Pharmacol 1996, 136: 269-79.
9. Rickenbacher U, McKinney JD, Oatley SJ, Blake CCF. Structurally specific binding of halogenated biphenyls to thyroxine transport protein. J Med Chem 1986, 29: 641-8.
10. Bartalena L. Recent achievements in studies on thyroid hormone-binding proteins. Endocr Rev 1990, 11: 47-64.
11. Barter RA, Klaassen CD. UDP-glucuronosyltransferase inducers reduce thyroid hormone levels in rats by an extrathyroidal mechanism. Toxicol Appl Pharmacol 1992, 113: 36-42.
12. Goldey SE, Kehn LS, Lau C, Rehnberg GL, Crofton KM. Developmental exposure to polychlorinated biphenyls (aroclor 1254) reduces circulating thyroid hormone concentrations and causes hearing deficits in rats. Toxicol Appl Pharmacol 1995, 135: 77-88.
13. Ku LMJD, Sharma-Stokkermans M, Meserve LA. Thyroxine normalizes polychlorinated biphenyl (PCB) dose-related depression of choline acetyltransferase (ChAT) activity in hippocampus and basal forebrain of 15-day-old rats. Toxicology 1994, 94: 19-30.
14. Goldey ES, Crofton KM. Thyroxine replacement attenuates hypothyroxinemia, hearing loss, and motor deficits following developmental exposure to Aroclor 1254 in rats. Toxicol Sci 1998, 45: 94-105.
15. McKinney JD. Multifunctional receptor model for dioxin and related compound toxic action: Possible thyroid hormone responsive effector linked site. Environ Health Perspect 1989, 82: 323-36.
16. Cheek AO, Kow K, Chen J, McLachlan JA. Potential mechanisms of thyroid disruption in humans: Interaction of organochlorine compounds with receptor, transthyretin, and thyroxine binding globulin. Environ Health Perspect 1999, 107: 273-8.
17. Guo YL, Chen YC, Yu ML, Hsu CC. Early development of Yu-Cheng children born seven to twelve years after the Taiwan PCB outbreak. J Toxicol Environ Health 1994, 29: 2395-404.
18. Zoeller RT, Dowling LS, Vas AA. Developmental exposure to polychlorinated biphenyls exerts thyroid hormone-like effects on the expression of RC3/neurogranin and myelin basic protein messenger ribonucleic acids in the developing rat brain. Endocrinology 2000, 141: 181-9.
19. Desvergne B, Petty KJ, Nikodem VM. Functional characterization and receptor binding studies of the malic enzyme thyroid hormone response element. J Biol Chem 1991, 266: 1008-13.
20. Bogazzi F, Hudson LD, Nikodem VM. A novel heterodimerization partner for throid hormone receptor. J Biol Chem. 1994, 289: 11683-6.
21. Bogazzi F, Bartalena L, Brogioni S, et al. L-thyroxine directly affects expression of thyroid hormone-sensitive genes: Regulatory effect of RXRβ. Mol Cell Endocrinol 1997, 134: 23-31.
22. Bogazzi F, Bartalena L, Raggi F, Ultimieri F, Martino E. Pendrin does not increase sulfate uptake from mammalian COS-7 cells. J Endocrinol Invest 1999, 23: 170-2.
23. Bogazzi F, Bartalena L, Brogioni S, et al. Amiodarone antagonizes the effect of thyroid hormone at the molecular level. Eur J Endocrinol 2001, 145: 59-64.
24. Seed B, Sheen J-Y. A simple phase-extraction assay for chloamphenicol acetyltransferase activity. Gene 1988, 67: 271-7.
25. Ausubel FM, Brent R, Kingston RE, et al eds. Current Protocols in Molecular Biology. New York: Wiley and Sons. 1998.
26. Allan GF, Xiaohua L, Tsai SY, et al. Hormone and antihormone induce distinct conformational changes which are central to steroid receptor activation. J Biol Chem 1992, 267: 19513-20.
27. Ercan-Fang S, Schwartz HL, Oppenheimer JH. Isoform-specific 3,5,3′-triiodothyronine receptor binding capacity and messenger ribonucleic acid content in rat adeohypophysis: Effect of thyroidal state and comparison with extrapituitary tissues. Endocrinology 1996, 137: 3228-33.
28. Brouwer A, Morse DC, Lans MC, et al. Interactions of persistent environmental organohalides with the thyroid hormone system: Mechanisms and possible consequences for animal and human health. Toxicol Industr Health 1998, 14: 59-84.
29. Chauhan KR, Kodavanti PR, McKinney JD. Assessing the role of ortho-substitution on polychlorinated biphenyl binding to transthyretin, a thyroxine transport protein. Toxicol Appl Pharmacol 2000, 162: 10-21.
30. Porterfield SP. Vulnerability of the developing brain to thyroid abnormalities: Environmental insults to the thyroid system. Environ Health Perspect 1994, 102: 125-30.
31. Martino E, Bartalena L, Bogazzi F, Braverman LE. The effects of amiodarone on the thyroid. Endocr Rev 2001, 22: 240-54.
32. Bartalena L, Bogazzi F, Bravermann LE, Martino E. Effects of amiodarone administration during pregnancy on neonatal thyroid function and subsequent neurodevelopment. J Endocrinol Invest 2001, 24: 116-30.
33. Weiss RE, Refetoff S. Resistance to thyroid hormone. Rev Endocr Metab Disord 2000, 1: 97-108.
34. Jacobson JL, Jacobson SW. Association of prenatal exposure to an environmental contaminant with intellectual function in childhood. J Toxicol Clin Toxicol 2002, 40: 467-75.
35. Jacobson JL, Jacobson SW, Humphrey HE. Effects of exposure to PCBs and related compounds on growth and activity in children. Neurotoxicol Teratol 1990, 12: 319-26.
36. Jacobson JL, Jacobson SW. Breast-feeding and gender as moderators of teratogenic effects on cognitive development. Neurotoxicol Teratol 2002, 24: 349-58.
37. McKinney JD, Fannin R, Jordan S, Chae K, Rickenbacher U, Pedersen L. Polychlorinated biphenyls (PCBs) and related compound interactions with specific binding sites for thyroxine in rat liver nuclear extracts. J Med Chem 1987, 30: 79-86.
38. Cheung ENY, McKinney JD. Polybrominated naphthalenes and diiodobenzene in interactions with specific binding sites for 2,3,7,8-tetrachlorodibenzo-p-dioxin in rat liver cytosol. Mol Toxicol 1989, 1: 39-52.
39. Hahn ME, Goldstein JA, Linka P, Gasiewicz TA. Interaction of hexachlorobenzene with the receptor for 2,3,7,8-tetrachlorodibenzo-p-dioxin in vitro and in vivo. Arch Biochem Biophys 1989, 270: 344-55.
40. Kodavanti PRS, Ward TR, Derr-Yellin EC, et al. Congeners-specific distribution of polychlorinated biphenyls in brain regions, blood, liver, and fat of adult rats following repeated exposure to Aroclor 1254. Toxicol Appl Pharmacol 1998, 153: 199-210.
41. Shain W, Overmann SR, Wilson LR, Kostats J, Bush B. A congener analysis of polychlorinated biphenyls accumulating in rat pups after perinatal exposure. Arch Environ Contam Toxicol 1986, 15: 687-707.
42. Dewailly E, Mulvad G, Pedersen HS, et al. Concentration of organochlorines in human brain, liver and adipose tissue autopsy samples from Greenland. Environ Health Perspect 1999, 107: 823-8.
43. Kodavanti PRS, Tilson HA. Structure-activity relationships of potentially neurotoxic PCB congeners in the rat. Neurotoxicology 1997, 18: 423-38.
44. Bakker O, Van Beeren HC, Wiersinga WM. Desethylamiodarone is a noncompetitive inhibitor of the binding of thyroid hormone to the thyroid hormone β1-receptor protein. Endocrinology 1994, 134: 4665-70.
45. McDonnell DP, Clemm DL, Hermann T, Goldman ME, Pike Jw. Analysis of estrogen receptor function in vitro reveals three distinct classes of antiestrogens. Mol Endocrinol 1995, 9: 659-69.
46. Berger J, Bailey P, Biswas C, et al. Thiazolidinediones produce a conformational change in peroxisomal proliferator-activated receptor-γ: Binding and activation correlate with antidiabetic actions in db/db mice. Endocrinology 1996, 137: 4189-95.