Identification of MEK1 as a novel target for the treatment of neuropathic pain

British Journal of Pharmacology

Volumn 138, Issue 5, 2003, Pages 751-756

  Ciruela, A ^a   Dixon, A K ^a   Bramwell, S ^a,b   Gonzalez, M I ^a,c   Pinnock, R D ^a,d   Lee, K ^a,e  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^b PFIZER GLOBAL RESEARCH AND DEVELOPMENT   (United Kingdom)

^c GLAXOSMITHKLINE   (United Kingdom)

^d PFIZER INC   (United States)

^e UNIVERSITY OF WARWICK   (United Kingdom)

Author keywords

Allodynia; ERK; Gene expression; Hyperalgesia; Neuropathic pain

Indexed keywords

MITOGEN ACTIVATED PROTEIN KINASE 1; PD 198306; STREPTOZOCIN; UNCLASSIFIED DRUG;

ALLODYNIA; ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CENTRAL NERVOUS SYSTEM; CONTROLLED STUDY; DIABETIC NEUROPATHY; DOSE RESPONSE; DRUG EFFECT; DRUG MECHANISM; GENE EXPRESSION; HYBRIDIZATION; HYPERALGESIA; INTRAPLANTAR DRUG ADMINISTRATION; LUMBAR SPINAL CORD; MALE; NEUROPATHIC PAIN; NOCICEPTION; NONHUMAN; PRIORITY JOURNAL; RAT; STREPTOZOCIN DIABETES; SUPPRESSION SUBTRACTIVE HYBRIDIZATION; WESTERN BLOTTING;

ANIMALS; DIABETES MELLITUS, EXPERIMENTAL; DIABETIC NEUROPATHIES; DRUG DELIVERY SYSTEMS; FLUOROBENZENES; GENE EXPRESSION REGULATION, ENZYMOLOGIC; MALE; MAP KINASE KINASE 1; MAP KINASE SIGNALING SYSTEM; MITOGEN-ACTIVATED PROTEIN KINASE KINASES; PAIN MEASUREMENT; PROTEIN-SERINE-THREONINE KINASES; RATS; RATS, SPRAGUE-DAWLEY;

EID: 0037354490     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0705103     Document Type: Article

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