The endothelin receptor antagonist ameliorates the hypertensive phenotypes of transgenic hypertensive mice with renin-angiotensin genes and discloses roles of organ specific activation of endothelin system in transgenic mice

Life Sciences

Volumn 74, Issue 9, 2004, Pages 1105-1118

  Maki, Shinichi ^a   Miyauchi, Takashi ^a   Kakinuma, Yoshihiko ^a,b   Sakai, Satoshi ^a   Kobayashi, Tsutomu ^a   Sugiyama, Fumihiro ^a   Fukamizu, Akiyoshi ^a   Goto, Katsutoshi ^a   Yamaguchi, Iwao ^a  

^a UNIVERSITY OF TSUKUBA   (Japan)

^b KOCHI MEDICAL SCHOOL   (Japan)

Author keywords

Endothelin; Endothelin receptor antagonist; Renin angiotensin system

Indexed keywords

3 (2 CARBOXYMETHOXY 4 METHOXYPHENYL) 1 (3,4 METHYLENEDIOXYPHENYL) 5 PROPOXY 2 INDANCARBOXYLIC ACID; ENDOTHELIN; ENDOTHELIN 1; ENDOTHELIN 2; ENDOTHELIN RECEPTOR; ENDOTHELIN RECEPTOR ANTAGONIST; MESSENGER RNA; PREPROENDOTHELIN 1; VASODILATOR AGENT;

ANIMAL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIBODY SPECIFICITY; ARTICLE; BLOOD PRESSURE; BLOOD VESSEL WALL; CONTROLLED STUDY; GENE EXPRESSION; GENETICS; HEART MUSCLE; HEART VENTRICLE HYPERTROPHY; HISTOLOGY; HYPERTENSION; KIDNEY; KIDNEY DISEASE; MALE; METABOLISM; MOUSE; NONHUMAN; PHENOTYPE; RENIN ANGIOTENSIN ALDOSTERONE SYSTEM; STATISTICAL SIGNIFICANCE; TRANSGENIC MOUSE; WILD TYPE;

MUS MUSCULUS;

EID: 0346996441     PISSN: 00243205     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.lfs.2003.07.034     Document Type: Article

References (46)

1. Bidani A.K., Griffin K.A., Plott W., Schwartz M.M. Renal ablation acutely transforms 'benign' hypertension to 'malignant' nephrosclerosis in hypertensive rats. Hypertension. 24:1994;309-316.
2. Dohi Y., Hahn A.W., Boulanger C.M., Buhler F.R., Luscher T.F. Endothelin stimulated by angiotensin II augments contractility of spontaneously hypertensive rat resistance arteries. Hypertension. 19:1992;131-137.
3. Dzau V.J. Multiple pathways of angiotensin production in the blood vessel wall: evidence, possibilities and hypotheses. Journal of Hypertension. 7:1989;933-936.
4. Emori T., Hirata Y., Ohta K., Shichiri M., Marumo F. Secretory mechanism of immunoreactive endothelin in cultured bovine endothelial cells. Biochemical & Biophysical Research Communications. 160:1989;93-100.
5. Fukamizu A., Sugimura K., Takimoto E., Sugiyama F., Seo M.S., Takahashi S.et al. Chimeric renin-angiotensin system demonstrates sustained increase in blood pressure of transgenic mice carrying both human renin and human angiotensinogen genes. Journal of Biological Chemistry. 268:1993;11617-11621.
6. Fukamizu A., Watanabe M., Inoue Y., Kon Y., Shimada S., Shiota N.et al. Cortical expression of the human angiotensinogen gene in the kidney of transgenic mice. Kidney International. 46:1994;1533-1535.
7. Gardiner S.M., Compton A.M., Kemp P.A., Bennett T. The effects of phosphoramidon on the regional haemodynamic responses to human proendothelin [1-38] in conscious rats. British Journal of Pharmacology. 103:1991;2009-2015.
8. Gomez-Garre D., Ruiz-Ortega M., Ortego M., Largo R., Lopez-Armada M.J., Plaza J.J.et al. Effects and interactions of endothelin-1 and angiotensin II on matrix protein expression and synthesis and mesangial cell growth. Hypertension. 27:1996;885-892.
9. Haber E., George C. Griffith lecture. The role of renin in normal and pathological cardiovascular homeostasis. Circulation. 54:1976;849-861.
10. Heagerty A.M. Angiotensin II: vasoconstrictor or growth factor? Journal of Cardiovascular Pharmacology. 18:1991;S14-S19.
11. Herizi A., Jover B., Bouriquet N., Mimran A. Prevention of the cardiovascular and renal effects of angiotensin II by endothelin blockade. Hypertension. 31:1998;10-14.
12. Hirata Y., Takagi Y., Fukuda Y., Marumo F. Endothelin is a potent mitogen for rat vascular smooth muscle cells. Atherosclerosis. 78:1989;225-228.
13. Hocher B., Liefeldt L., Thone-Reineke C., Orzechowski H.D., Distler A., Bauer C., Paul M. Characterization of the renal phenotype of transgenic rats expressing the human endothelin-2 gene. Hypertension. 28:1996;196-201.
14. Imai T., Hirata Y., Emori T., Yanagisawa M., Masaki T., Marumo F. Induction of endothelin-1 gene by angiotensin and vasopressin in endothelial cells. Hypertension. 19:1992;753-757.
15. Ishiye M., Umemura K., Uematsu T., Nakashima M. Angiotensin AT1 receptor-mediated attenuation of cardiac hypertrophy due to volume overload: involvement of endothelin. European Journal of Pharmacology. 280:1995;11-17.
16. Ito H., Hirata Y., Adachi S., Tanaka M., Tsujino M., Koike A.et al. Endothelin-1 is an autocrine/paracrine factor in the mechanism of angiotensin II-induced hypertrophy in cultured rat cardiomyocytes. Journal of Clinical Investigation. 92:1993;398-403.
17. Kai T., Sugimura K., Shimada S., Kurooka A., Takenaka T., Ishikawa K. Inhibitory effects of a subdepressor dose of L-158,809, an angiotensin II type 1 receptor antagonist, on cardiac hypertrophy and nephropathy via the activated human renin-angiotensin system in double toransgenic mice with hypertension. Japanese Circulation Journal. 62:1998;599-603.
18. Kai T., Shimada S., Kurooka A., Takenaka T., Ishikawa K. Tissue angiotensin II concentration in the heart and kidneys in transgenic Tsukuba hypertensive mice. Blood Pressure. 7:1998;61-63.
19. Karlsen F.M., Andersen C.B., Leyssac P.P., Holstein-Rathlou N.H. Dynamic autoregulation and renal injury in Dahl rats. Hypertension. 30:1997;975-983.
20. Katz A.M. Angiotensin II: hemodynamic regulator or growth factor? editorial Journal of Molecular & Cellular Cardiology. 22:1990;739-747.
21. Kobayashi T., Miyauchi T., Sakai S., Kobayashi M., Yamaguchi I., Goto K.et al. The expression of endothelin-1, ETA receptors, ETB receptors, endothelin-converting enzyme and the cellular distribution of endothelin-1 staining in the failing heart due to myocardial infarction in rats. Am J Physiol. 276:1999;H1197-H1206.
22. Kohno M., Horio T., Ikeda M., Yokokawa K., Fukui T., Yasunari K.et al. Angiotensin II stimulates endothelin-1 secretion in cultured rat mesangial cells. Kidney International. 42:1992;860-866.
23. Maeda S., Miyauchi T., Sakai S., Kobayashi T., Iemitsu M., Goto K.et al. Prolonged exercise causes an increase in endothelin-1 production in the heart of rats. American Journal of Physiology. 275:1998;H2105-H2112.
24. Maeda S., Miyauchi T., Kobayashi T., Goto K., Matsuda M. Exercise causes tissue-specific enhancement of endothelin-1 mRNA expression in internal organs. Journal of Applied Physiology. 85:1998;425-431.
25. Maki S., Miyauchi T., Sakai S., Kobayashi T., Maeda S., Takata Y.et al. Endothelin-1 expression in hearts of transgenic hypertensive mice overexpressing angiotensin II. Journal of Cardiovascular Pharmacology. 31:1998;S412-S416.
26. Mazzolai L., Nussberger J., Aubert J.F., Brunner D.B., Gabbiani G., Brunner H.R.et al. Blood pressure-independent cardiac hypertrophy induced by locally activated renin-angiotensin system. Hypertension. 31:1998;1324-1330.
27. Moreau P., d'Uscio L.V., Shaw S., Takase H., Barton M., Luscher T.F. Angiotensin II increases tissue endothelin and induces vascular hypertrophy: reversal by ET(A)-receptor antagonist. Circulation. 96:1997;1593-1597.
28. Pollock D.M., Opgenorth T.J. Evidence for endothelin-induced renal vasoconstriction independent of ETA receptor activation. American Journal of Physiology. 264:1993;R222-R226.
29. Raij L., Azar S., Keane W. Mesangial immune injury, hypertension, and progressive glomerular damage in Dahl rats. Kidney International. 26:1984;137-143.
30. Romero J.C., Knox F.G. Mechanisms underlying pressure-related natriuresis: the role of the renin-angiotensin and prostaglandin systems. State of the art lecture. Hypertension. 11:1988;724-738.
31. Rosenfeld J.B., Zabludowski J. The renin-angiotensin system, the kidney, and hypertension. Journal of Cardiovascular Pharmacology. 13:1989;S22-S26.
32. Sakai S., Miyauchi T., Kobayashi T., Yamaguchi I., Goto K., Sugishita Y. Altered expression of isoforms of myosin heavy chain mRNA in the failing rat heart is ameliorated by chronic treatment with an endothelin receptor antagonist. Journal of Cardiovascular Pharmacology. 31:1998;S302-S305.
33. Scott-Burden T., Resink T.J., Hahn A.W., Vanhoutte P.M. Induction of endothelin secretion by angiotensin II: effects on growth and synthetic activity of vascular smooth muscle cells. Journal of Cardiovascular Pharmacology. 17:1991;S96-100.
34. Shimokama T., Haraoka S., Horiguchi H., Sugiyama F., Murakami K., Watanabe T. The Tsukuba hypertensive mouse (transgenic mouse carrying human genes for both renin and angiotensinogen) as a model of human malignant hypertension: development of lesions and morphometric analysis. Virchows Archiv. 432:1998;169-175.
35. Shubeita H.E., McDonough P.M., Harris A.N., Knowlton K.U., Glembotski C.C., Brown J.H.et al. Endothelin induction of inositol phospholipid hydrolysis, sarcomere assembly, and cardiac gene expression in ventricular myocytes. A paracrine mechanism for myocardial cell hypertrophy. Journal of Biological Chemistry. 265:1990;20555-20562.
36. Su E.J., Lombardi D.M., Siegal J., Schwartz S.M. Angiotensin II induces vascular smooth muscle cell replication independent of blood pressure. Hypertension. 31:1998;1331-1337.
37. Sugaya T., Nishimatsu S., Tanimoto K., Takimoto E., Yamagishi T., Imamura K.et al. Angiotensin II type 1a receptor-deficient mice with hypotension and hyperreninemia. Journal of Biological Chemistry. 270:1995;18719-18722.
38. Sugiyama F., Haraoka S., Watanabe T., Shiota N., Taniguchi K., Ueno Y.et al. Acceleration of atherosclerotic lesions in transgenic mice with hypertension by the activated renin-angiotensin system. Laboratory Investigation. 76:1997;835-842.
39. Sung C.P., Arleth A.J., Storer B.L., Ohlstein E.H. Angiotensin type 1 receptors mediate smooth muscle proliferation and endothelin biosynthesis in rat vascular smooth muscle. Journal of Pharmacology & Experimental Therapeutics. 271:1994;429-437.
40. Takimoto E., Ishida J., Sugiyama F., Horiguchi H., Murakami K., Fukamizu A. Hypertension induced in pregnant mice by placental renin and maternal angiotensinogen. Science. 274:1996;995-998.
41. Tanimoto K., Sugiyama F., Goto Y., Ishida J., Takimoto E., Yagami K.et al. Angiotensinogen-deficient mice with hypotension. Journal of Biological Chemistry. 269:1994;31334-31337.
42. Unger T., Gohlke P., Paul M., Rettig R. Tissue renin-angiotensin systems: fact or fiction? Journal of Cardiovascular Pharmacology. 18:1991;S20-S25.
43. Wilkins F.C. Jr., Alberola A., Mizelle H.L., Opgenorth T.J., Granger J.P. Systemic hemodynamics and renal function during long-term pathophysiological increases in circulating endothelin. American Journal of Physiology. 268:1995;R375-R381.
44. Wolf G., Ziyadeh F.N., Zahner G., Stahl R.A. Angiotensin II is mitogenic for cultured rat glomerular endothelial cells. Hypertension. 27:1996;897-905.
45. Yamauchi-Kohno R., Miyauchi T., Hoshino T., Kobayashi T., Aihara H., Sakai S., Yabana H., Goto K., Sugishita Y., Murata S. Role of endothelin in deterioration of heart failure due to cardiomyopathy in hamsters: increase in endothelin-1 production in the heart and beneficial effect of endothelin A antagonist on survival and cardiac function. Circulation. 99:1999;2171-2176.
46. 2+ channels. Journal of Hypertension Supplement. 6:1988;S188-S191.