The Tsukuba hypertensive mouse (transgenic mouse carrying human genes for both renin and angiotensinogen) as a model of human malignant hypertension: Development of lesions and morphometric analysis

Virchows Archiv

Volumn 432, Issue 2, 1998, Pages 169-175

  Shimokama, Tatsuro ^a   Haraoka, Seij ^a   Horiguchi, Hisashi ^a   Sugiyama, Fumihiro ^a   Murakami, Kazuo ^a   Watanabe, Teruo ^a  

^a UNIVERSITY OF TSUKUBA   (Japan)

Author keywords

Hypertension; Juxtaglomerular apparatus; Malignant nephrosclerosis; Renin angiotensin system; Transgenic mouse

Indexed keywords

ANGIOTENSIN; ANGIOTENSINOGEN; RENIN;

ANIMAL MODEL; ANIMAL TISSUE; ARTERITIS; ARTICLE; CONTROLLED STUDY; EPITHELIUM CELL; FEMALE; GLOMERULOSCLEROSIS; IMMUNOHISTOCHEMISTRY; JUXTAGLOMERULAR APPARATUS; KIDNEY INJURY; MALE; MALIGNANT HYPERTENSION; MESANGIUM CELL; MORPHOMETRICS; MOUSE; NONHUMAN; PRIORITY JOURNAL; RENIN ANGIOTENSIN ALDOSTERONE SYSTEM; TRANSGENIC MOUSE;

ANIMALS; ARTERITIS; BLOOD PRESSURE; DISEASE MODELS, ANIMAL; ENDOTHELIUM; FEMALE; GLOMERULOSCLEROSIS, FOCAL SEGMENTAL; HUMANS; HYPERTENSION; JUXTAGLOMERULAR APPARATUS; KIDNEY GLOMERULUS; MALE; MICE; MICE, TRANSGENIC; MUSCLE, SMOOTH, VASCULAR; RENIN-ANGIOTENSIN SYSTEM;

EID: 0031944871     PISSN: 09456317     EISSN: None     Source Type: Journal    
DOI: 10.1007/s004280050152     Document Type: Article

References (30)

1. Baba N, Shimokama T, Watanabe T (1993) Effects of hypercholesterolemia on initial and chronic phases of rat nephrotoxic serum nephritis: development of focal segmental glomerulosclerosis, analogous to atherosclerosis. Virchows Arch [B] 64: 97-105
2. Barajas L, Salido EC (1994) Pathology of the juxtaglomerular apparatus. In: Tisher CC, Brenner BM (eds) Renal pathology with clinical and functional correlations. Lippincott, Philadelphia, pp 948-978
3. Bohle A, Gaertner H-V, Laberke H-G, Kruck F (1989) The kidney. Structure and function. Schattauer, Stuttgart New York, pp 370-395
4. Dzau VJ, Re R (1994) Tissue angiotensin system in cardiovascular medicine: a paradigm shift? Circulation 89:458-470
5. Fukamizu A, Hatae T (1991) Human renin in transgenic mouse kidneys is localized in juxtaglomerular cells. Biochem J 278:601-603
6. Fukamizu A, Seo MS, Hatae T, Yokoyama M, Nomura T, Katuki M, Murakami K (1989) Tissue-specific expression of the human renin gene in transgenic mice. Biochem Biophys Res Commun 165:826-832
7. Fukamizu A, Sugimura K, Takimoto E, Sugiyama F, Seo MS, Takahashi S, Hatae T, Kajiwara N, Yagami K, Murakami K (1993) Chimeric renin-angiotensin system demonstrates sustained increase in blood pressure of transgenic mice carrying both human renin and human angiotensinogen genes. J Biol Chem 268:11617-11621
8. Ganten D, Hayduk K, Brecht HM, Boucher R, Genest J (1970) Evidence of renin release or production in splanchnic territory. Nature 226:551-552
9. Ganten D, Wagner J, Zeh K, Koeller M, Bader M, Michel JB, Paul M, Zimmermann F, Ruf P, Hilgenfeld U, Ganten U, Kaling M, Bachmann S, Mullins JJ, Murakami K (1992) Species-specificity of renin kinetics in transgenic rats harboring the human renin and angiotensinogen genes. Proc Natl Acad Sci USA 89:7806-7810
10. Goldstein MH, Wright JL, Churg J (1991) Vasculitis and hypertension. In: Churg A, Churg J (eds) Systemic vasculitides Igaku-Shoin, pp 359-372
11. Gorgas K (1978) Structure and innervation of the juxtaglomerular apparatus of the rat. (Advances in anatomy and cell biology, vol 54) Springer, Berlin Heidelberg New York
12. Greenberg DA (1993) Linkage ananlysis of "necessary" disease loci versus "susceptibility" loci. Am J Hum Genet 52: 135-143
13. Helmchen U, Ulrich OW (1994) Benign and malignant nephrosclerosis and renovascular disease. In: Tisher CC, Brenner BM (ed) Renal pathology, with clinical and functional correlations. Lippincott, Philadelphia, pp 1201-1236
14. Heptinstall RH (1992) Hypertension. I. Essential hypertension. In: Heptinstall RH (ed) Pathology of the kidney. Little Brown, Boston Toronto London, pp 951-1028
15. Jeunemaitr X, Soubrier F, Kotelevtsev YV, Lifton RP, Williams CS, Charru A, Hunt SC, Hopkins PN, Williams RR, Lalouel J, Corvol P (1992) Molecular basis of human hypertension: role of angiotensinogen. 71:169-180
16. Jones DB (1974) Arterial and glomerular lesions associated with severe hypertension. Lab Invest 31:303-313
17. Kincaid-Smith P (1991) Malignant hypertension. J Hypertens 9:893-899
18. Lilly L, Pratt R, Alexander RW, Larson D, Ellison K, Gimbrone M, Dzau V (1985) Renin expression by vascular endothelial cells in culture. Circ Res 57:312-318
19. Naftian AJ, Pratt RE, Dzau VJ (1989) Induction of platelet-derived growth factor A-chain and c-myc gene expression by angiotensin II in cultured rat vascular smooth muscle cells. J Clin Invest 83:1419-1424
20. Nakamura A, Johns EJ (1995) Renal nerves, renin and angiotensinogen gene expression in spontaneously hypertensive rats. Hypertension 25:581-586
21. Raij L, Azar S, Keane W (1984) Mesangial immune injury, hypertension, and progressive glomerular damage in Dahl rats. Kidney Int 26:137-143
22. Rapp JP, Wang SM, Dene H (1989) A genetic polymorphism in the renin gene of Dahl rats cosegregates with blood pressure. Science 243:542-544
23. Re R, Fallon J, Dzau V, Quay S, Harber E (1982) Renin synthesis by canine aortic smooth muscle cells in culture. Life Sci 30:99-106
24. Saye JA, Singer HA, Peach MJ (1984) Role of endothelium in conversion of angiotensin I to angiotensin II in rabbit aorta. Hypertension 6:216-221
25. Schricker K, Hamann M, Kaissling B, Kurtz A (1994) Role of the macula densa in the control of renal renin gene expression in two-kidney/one-rats. Pflugers Arch 427:42-46
26. Sigmund CD, Jones CA, Kane CM, Wu C, Lang JA, Gross KW (1992) Regulated tissue- and cell-specific expression of the human renin gene in transgenic mice. Circ Res 70:1070-1079
27. Takahashi S, Fukamizu A, Hasegawa T (1991) Expression of human angiotensinogen gene in transgenic mice and transfected cells. Biochem Biophys Res Commun 180:1103-1109
28. Thurston H, Swales JD, Bing RF, Hurst BC, Marks ES (1979) Vascular renin-like activity and blood pressure maintenance in the rat. Hypertension 1:643-649
29. Ward R (1990) Familial aggregation and genetic epidemiology of blood pressure. In: Laragh JH, Brenner BM (eds) Hypertension: pathophysiology, diagnosis and management. Raven Press, New York pp 81-100
30. Yamamoto J (1977) Role of renin-angiotensin system in experimental hypertension in rats: plasma renin and the antihypertensive effect of angiotensin II antagonist. Jpn Circ J 41:665-675