Naringin suppresses the mitogenic effect of lysophosphatidylcholine on vascular smooth muscle cells

Nutrition Research

Volumn 23, Issue 12, 2003, Pages 1671-1683

  Kim, Sang Hyun ^a   Zo, Joo Hee ^a   Kim, Myung A ^a   Hwang, Kyoung Kook ^b   Chae, In Ho ^b   Kim, Hyo Soo ^b   Kim, Cheol Ho ^b   Sohn, Dae Won ^b   Oh, Byung Hee ^b   Lee, Myoung Mook ^b   Park, Young Bae ^b  

^a Seoul National University Boramae Hospital   (South Korea)

^b Seoul National University Hospital   (South Korea)

Author keywords

Lysophosphatidylcholine; Mitogenic effect; Naringin; Vascular smooth muscle cells

Indexed keywords

3 (4,5 DIMETHYL 2 THIAZOLYL) 2,5 DIPHENYLTETRAZOLIUM BROMIDE; AURANTIIN; BROMINE DERIVATIVE; CELL ADHESION MOLECULE; LOW DENSITY LIPOPROTEIN; LYSOPHOSPHATIDYLCHOLINE; NITRIC OXIDE; THYMIDINE; TRITIUM;

ANIMAL CELL; ANTIINFLAMMATORY ACTIVITY; AORTA; ARTICLE; ATHEROGENESIS; CELL CULTURE; CELL PROLIFERATION; CELL PROTECTION; CONCENTRATION RESPONSE; CONTROLLED STUDY; CULTURE MEDIUM; DNA REPLICATION; DRUG EFFECT; DRUG SCREENING; MITOGENESIS; NONHUMAN; OXIDATION; PRIORITY JOURNAL; RAT; RAT STRAIN; SMOOTH MUSCLE FIBER; VASCULAR SMOOTH MUSCLE;

CITRUS; VITACEAE;

EID: 0346992279     PISSN: 02715317     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.nutres.2003.08.001     Document Type: Article

References (27)

1. Limmaset B, Douchen CL, Dore JC, et al. Effects of flavonoids on the release of reactive oxygen species by stimulated human neutrophils. Biochem Pharmacol 1993;46:1257-71.
2. Calomme M, Pieters L, Vlierinck A, et al. Inhibition of bacterial mutagenesis by citrus flavonoids. Planta Medica 1996;62:222-6.
3. So FV, Guthrie N, Chambers AF, et al. Inhibition of human breast cancer cell proliferation and delay of mammary tumorigenesis by flavonoids and citrus juices. Nutr Cancer 1996;26:167-81.
4. Le Marchand L, Murphy SP, Hankin JH, et al. Intake of flavonoids and lung cancer. J Natl Cancer Inst 2000;92(2):154-60.
5. Gordon PB, Holen I, Seglen PO. Protection by naringin and some other flavonoids of hepatocytic autophagy and endocytosis against inhibition by okadaic acid. J Biol Chem 1995;270(11):5830-8.
6. Kawaguchi K, Kikuchi S, Hasegawa H, et al. Suppression of lipopolysaccharide-induced tumor necrosis factor release and liver injury in mice by naringin. Eur J Pharmacol 1999;368(2):245-50.
7. Shin YW, Bok SH, Jeong TS, Bae KH, Jeoung NH, Choi MS, Lee SH, Park YB. Hypocholesterolemic effect of naringin associated with hepatic cholesterol regulating enzyme changes in rats. Int J Vitam Nutr Res 1999;69(5):341-7.
8. Choe SC, Kim HS, Jeong TS, et al. Naringin has an anti-atherogenic effect with the inhibition of intracellular adhesion molecule-1 in hypercholesterolemic rabbits. J Cardiovasc Pharm 2001;38:947-55.
9. 2 activity of apolipoprotein B100. Proc Natl Acad Sci USA 1990;87:9741-5.
10. Liao JK, Shin WS, Lee WY, et al. Oxidized low-density lipoprotein decreases the expression of endothelial nitric oxide synthase. J Biol Chem 1995;270(1):319-24.
11. Kugiyama K, Kerns SA, Morrisett JD, et al. Impairment of endothelium-dependent arterial relaxation by lysolecithin in modified low-density lipoproteins. Nature 1990;344:160-2.
12. Kume N, Cybulsky MI, Gimbrone MA. Lysophosphatidylcholine, a component of atherogenic lipoproteins, induces mononuclear leukocyte adhesion molecules in cultured human and rabbit arterial endothelial cells. J Clin Invest 1992;90:1138-44.
13. Murohara T, Scalia R, Lefer AM. Lysophosphatidylcholine promotes P-selectin expression in platelets and endothelial cells. Circ Rec 1996;78:780-9.
14. Quinn MT, Parthasarathy S, Steinberg D. Lysophosphatidylcholine: a chemotactic factor for human monocytes and its potential role in atherogenesis. Proc Natl Acad Sci USA 1988;85:2805-9.
15. Yui S, Sasaki T, Miyazaki A, et al. Induction of murine macrophage growth by modified LDLs. Arterioscl Thromb 1993;13:331-7.
16. Sakai M, Miyazaki A, Hakamata H, et al. Lysophosphatidylcholine potentiates the mitogenic activity modified LDL for human monocyte-derived macrophages. Arterioscl Thromb Vas 1996;16:600-5.
17. Watanabe T, Pakala R, Koba S, et al. Lysophosphatidylcholine and reactive oxygen species mediate the synergistic effect of mildly oxidized LDL with serotonin on vascular smooth muscle cell proliferation. Circulation 2001;103(10):1440-5.
18. Miyake Y, Yamamoto K, Tsujihara N, et al. Protective effects of lemon flavonoids on oxidative stress in diabetic rats. Lipids 1998;33:689-95.
19. Tsai SH, Lin-Shiau SY, Lin JK. Suppression of nitric oxide synthase and the down-regulation of NF-κB in macrophages by resveratrol. Br J Pharmcol 1999;126:673-80.
20. Herrera MD, Maruenda E. Effect of naringin and naringenin on contractions induced by noradrenaline in rat vas deferens-Evidence for postsynaptic alpha-2 adrenergic receptor. Gen Pharmac 1993;24(3):739-42.
21. Melzig MF, Loose R. Inhibition of lipopolysaccharide-induced endothelial cytotoxicity by selected flavonoids. Planta Medica 1998;64:397-9.
22. Mohands N, Wyatt J, Mel SF, et al. Lipid translocation across the human erythrocyte membrane: regulatory factors. J Biol Chem 1982;257:6537-43.
23. Oishi K, Raynor RL, Charp PA, et al. Regulation of protein kinase C by lysophosphatidylcholine: potential role in signal transduction. J Biol Chem 1988;263:6865-71.
24. Hattori Y, Banba N, Gross SS, et al. Glycated serum albumin-induced nitric oxide production in vascular smooth muscle cells by nuclear factor kappa B-dependent transcriptional activation of inducible nitric oxide synthase. Biochem Bioph Res Co 1999;259:128-32.
25. Katsuyama K, Shichri M, Marumo F, et al. NO inhibits cytokine-induced iNOS expression and NF-KB activation by interfering with phosphorylation and degradation of IκB-α. Arterioscl Thromb Vasc 1998; 18:1796-802.
26. Pahan K, Sheikh FG, Namboodiri AMS, et al. Lovastatin and phenylacetate inhibit the induction of nitric oxide synthase and cytokines in rat primary astrocytes, microglia, macrophages. J Clin Invest 1997;100: 2671-9.
27. Bustos C, Hernandez-Presa MA, Ortego M, et al. HMG-CoA reductase inhibition by atorvastatin reduces neointimal inflammation in a rabbit model of atherosclerosis. J Am Coll Cardiol 1998;32:2057-64.