Intrahepatic T cell survival versus death: Which one prevails and why?

Journal of Hepatology

Volumn 39, Issue 6, 2003, Pages 1070-1071

  Mehal, Wajahat Z ^a  

^a YALE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIUM LIPOPOLYSACCHARIDE; T LYMPHOCYTE ANTIGEN; TRANSFORMING GROWTH FACTOR BETA RECEPTOR;

ANTIGEN BINDING; APOPTOSIS; BINDING AFFINITY; CELL DEATH; CELL FUNCTION; CELL MATURATION; CELL SURVIVAL; CHRONIC HEPATITIS; CYTOKINE PRODUCTION; EDITORIAL; EFFECTOR CELL; HUMAN; IMMUNIZATION; LIVER CELL; LYMPHOCYTE SUBPOPULATION; MEMORY CELL; PHAGOCYTOSIS; PRIORITY JOURNAL; T LYMPHOCYTE ACTIVATION; VACCINATION; VIRUS HEPATITIS;

EID: 0346874202     PISSN: 01688278     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jhep.2003.10.005     Document Type: Editorial

References (9)

1. + T cells are found in the liver post-vaccination. J Hepatol 2003;39:910-917.
2. Cripse IN. Hepatic T cells and liver tolerance. Nat Rev Immunol 2003;3:51-62.
3. Mehal WZ, Azzaroli F, Crispe IN. Immunology of the healthy liver: old questions and new insights. Gastroenterology 2001;120:250-260.
4. Mehal WZ, Juedes AE, Crispe IN. Selective retention of activated CD8 + T cells by the normal liver. J Immunol 1999;163:3202-3210.
5. Hanon E, Stinchcombe JC, Saito M, Asquith BE, Taylor GP, Tanaka Y, et al. Fratricide among CD8(+) T lymphocytes naturally infected with human T cell lymphotropic virus type I. Immunity 2000;13:657-664.
6. Dennert G. Elimination of virus-specific cytotoxic T cells in the liver. Crit Rev Immunol 2002;22:1-11.
7. Russell JQ, Morrissette GJ, Weidner M, Vyas C, Aleman-Hoey D, Budd RC. Liver damage preferentially results from CD8(+) T cells triggered by high affinity peptide antigens. J Exp Med 1998;188:1147-1157.
8. Limmer A, Ohl J, Kurts C, Ljunggren HG, Reiss Y, Groettrup M, et al. Efficient presentation of exogenous antigen by liver endothelial cells to CD8 + T cells results in antigen-specific T-cell tolerance. Nat Med 2000;6:1348-1354.
9. Limmer A, Sacher T, Alferink J, Kretschmar M, Schonrich G, Nichterlein T, et al. Failure to induce organ-specific autoimmunity by breaking of tolerance: importance of the microenvironment. Eur J Immunol 1998;28:2395-2406.