A new 'traceless' solid-phase synthesis strategy: Synthesis of a benzimidazole library

Tetrahedron Letters

Volumn 40, Issue 14, 1999, Pages 2665-2668

  Huang, Wolin ^a   Scarborough, Robert M ^a  

^a MILLENNIUM PHARMACEUTICALS INC   (United States)

Author keywords

Benzimidazole; Combinatorial chemistry; Solid phase synthesis; Traceless

Indexed keywords

BENZIMIDAZOLE;

ARTICLE; CHEMICAL ANALYSIS; CHEMICAL BINDING; CHEMICAL REACTION; CHEMICAL STRUCTURE; DRUG SYNTHESIS; PHYSICAL PHASE; REACTION ANALYSIS; SOLID;

EID: 0033515847     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0040-4039(99)00293-2     Document Type: Article

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31. 6) data. IA: δ = 3.79 (s, 3 H), 5.64 (s, 2 H), 7.10 (d, J = 8 Hz, 1 H), 7.25 (s, 1 H), 7.36 (m, 5 H), 7.67 (d, J = 8 Hz, 1 H), 9.44 (s, 1 H); IB: δ = 3.79 (s, 3 H), 5.74 (s, 2 H), 7.07 (d, J = 8 Hz, 1 H), 7.26 (s, 1 H), 7.53 (d, J = 8 Hz, 2 H), 7.60 (d, J = 8 Hz, 1 H), 7.83 (d, J = 8 Hz, 2 H), 9.33 (s, 1 H); 1C: δ = 3.79 (s, 3 H), 3.80 (s, 3 H), 5.73 (s, 2 H), 7.07 (d, J = 8 Hz, 1 H), 7.25 (s, 1 H), 7.48 (d, J = 8 Hz, 2 H), 7.59 (d, J = 8 Hz, 1 H), 7.92 (d, J = 8 Hz, 2 H), 9.33 (s, 1 H).