Solid-Phase Synthesis of 4-Arylazetidin-2-ones via Suzuki and Heck Cross-Coupling Reactions

Journal of Organic Chemistry

Volumn 62, Issue 22, 1997, Pages 7820-7826

  Ruhland, Beatrice ^a   Bombrun, Agnes ^a   Gallop, Mark A ^a  

^a AFFYMAX RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 0001083115     PISSN: 00223263     EISSN: None     Source Type: Journal    
DOI: 10.1021/jo9711854     Document Type: Article

References (31)

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23. 3 in DMF for 24 h under a nitrogen atmosphere proved largely unsuccessful. Analysis of the crude by HPLC (λ = 254 nm and λ = 280 nm) showed 13% of 4-phenylbenzoic acid and 87% of unreacted 4-iodobenzoic acid.
24. 6) δ: 8.0-6.8 (m, 24H), 5.8 (d, 1H), 5.7 (d, 1H), 5.65 (d, 1 H), 5.55 (d, 1 H), 4.6 (q, 1 H), 4.2 (q, 1 H), 1.6 (d, 3 H), 1.2 (d, 3 H).
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27. 6) δ: 7.28-7.22 (m, 3H), 6.98-6.88 (m, 2H), 4.5 (q, J = 7.3 Hz, 1H), 4.4 (s, 2H), 1.4 (d, J = 7.3 Hz, 3H). Equation presented.
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