Immobilisation of GM-CSF onto particulate vaccine carrier systems

International Journal of Pharmaceutics

Volumn 269, Issue 1, 2004, Pages 259-265

  Mandal, Barnali ^a   Kempf, Martina ^a   Merkle, Hans P ^a   Walter, Elke ^a  

^a ETH ZURICH   (Switzerland)

Author keywords

Adjuvant; GM CSF; Immobilisation; Microparticulates; Poly(D,L lactide co glycolide) (PLGA); Vaccines

Indexed keywords

ALUMINUM HYDROXIDE; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; POLYGLACTIN; VACCINE;

ADSORPTION; ARTICLE; CONTROLLED STUDY; DRUG DELIVERY SYSTEM; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; PH MEASUREMENT; PHYSICAL CHEMISTRY; PRIORITY JOURNAL; VACCINE PRODUCTION;

EID: 0346787818     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2003.09.023     Document Type: Article

References (36)

1. Basak S.K., Harui A., Stolina M., Sharma S., Mitani K., Dubinett S.M., Roth M.D. Increased dendritic cell number and function following continuous in vivo infusion of granulocyte macrophage-colony-stimulating factor and interleukin-4. Blood. 99:2002;2869-2879.
2. Bernfield M., Kokenyesi R., Kato M., Hinkes M.T., Spring J., Gallo R.L., Lose E.J. Biology of the syndecans: a family of transmembrane heparan sulfate proteoglycans. Ann. Rev. Cell Biol. 8:1992;365-393.
3. Brown C.D., Kreilgaard L., Nakakura M., Caram-Lelham N., Pettit D.K., Gombotz W.R., Hoffman A.S. Release of PEGylated granulocyte-macrophage colony-stimulating factor from chitosan/glycerol films. J. Control. Rel. 72:2001;35-46.
4. Chang M.F., White J.L., Nail S.L., Hem S.L. Role of the electrostatic attractive force in the adsorption of proteins by aluminum hydroxide adjuvant. PDA J. Pharm. Sci. Technol. 51:1997;25-29.
5. Chang M., Shi Y., Nail S.L., HogenEsch H., Adams S.B., White J.L., Hem S.L. Degree of antigen adsorption in the vaccine or interstitial fluid and its effect on the antibody response in rabbits. Vaccine. 19:2001;2884-2889.
6. Chen Y., Lin S.M., Lai H.S., Tseng S.H., Chen W.J. Effects of irradiated tumor vaccine and continuous localized infusion of granulocyte-macrophage colony-stimulating factor on neuroblastomas in mice. J. Pediatr. Surg. 37:2002;1298-1304.
7. Faraasen S., Vörös J., Csucs G., Textor M., Merkle H.P., Walter E. Ligand-specific targeting of microspheres to phagocytes by surface modification with poly(L-lysine)-grafted poly(ethylene glycol) conjugate. Pharm. Res. 20:2003;235-243.
8. Flarend R.E., Hem S.L., White J.L., Elmore D., Suckow M.A., Rudy A.C., Dandashli E.A. In vivo absorption of aluminium-containing vaccine adjuvants using 26Al. Vaccine. 15:1997;1314-1318.
9. Gasson J.C. Molecular physiology of granulocyte-macrophage colony-stimulating factor. Blood. 77:1991;1131-1145.
10. Gombotz, W., Pettit, D., OPankey, S., Lawter, J.R., Huang, W.J., 1995. Prolonged release of GM-CSF. US Patent 5,942,253 (4 August).
11. Harrison R.A., Richards A., Laing G.D., Theakston R.D. Simultaneous GeneGun immunisation with plasmids encoding antigen and GM-CSF: significant enhancement of murine antivenom IgG1 titres. Vaccine. 20:2002;1702-1706.
12. Hubell, J.A., Schense, J.C., Sakiyam-Elbert, S.E., 2000. Growth factor modified protein matrices for tissue engineering. International Patent WO 01/83522 A2 (8 November).
13. Johansen P., Men Y., Merkle H.P., Gander B. Revisiting PLA/PLGA microspheres: an analysis of their potential in parenteral vaccination. Eur. J. Pharm. Biopharm. 50:2000;129-146.
14. Kazzaz J., Neidleman J., Singh M., Ott G., O'Hagan D.T. Novel anionic microparticles are a potent adjuvant for the induction of cytotoxic T lymphocytes against recombinant p55 gag from HIV-1. J. Control. Rel. 67:2000;347-356.
15. Kumar S., Villinger F., Oakley M., Aguiar J.C., Jones T.R., Hedstrom R.C., Gowda K., Chute J., Stowers A., Kaslow D.C., Thomas E.K., Tine J., Klinman D., Hoffman S.L., Weiss W.W. A DNA vaccine encoding the 42 kDa C-terminus of merozoite surface protein 1 of Plasmodium falciparum induces antibody, interferon-gamma and cytotoxic T cell responses in rhesus monkeys: immuno-stimulatory effects of granulocyte macrophage-colony stimulating factor. Immunol. Lett. 81:2002;13-24.
16. Luck M., Pistel K.F., Li Y.X., Blunk T., Muller R.H., Kissel T. Plasma protein adsorption on biodegradable microspheres consisting of poly(D,L-lactide-co-glycolide), poly(L-lactide) or ABA triblock copolymers containing poly(oxyethylene) - influence of production method and polymer composition. J. Control. Rel. 55:1998;107-120.
17. Meinel L., Illi O.E., Zapf J., Malfanti M., Peter Merkle H., Gander B. Stabilizing insulin-like growth factor-I in poly(D,L-lactide-co-glycolide) microspheres. J. Control. Rel. 70:2001;193-202.
18. Modrowski D., Lomri A., Marie P.J. Glycosaminoglycans bind granulocyte-macrophage colony-stimulating factor and modulate its mitogenic activity and signaling in human osteoblastic cells. J. Cell. Physiol. 177:1998;187-195.
19. Morrissey P.J., Bressler L., Park L.S., Alpert A., Gillis S. Granulocyte-macrophage colony-stimulating factor augments the primary antibody response by enhancing the function of antigen-presenting cells. J. Immunol. 139:1987;1113-1119.
20. Müller M., Vörös J., Csucs G., Walter E., Danuser G., Textor M., Merkle H.P., Spencer N.D. Surface modification of PLGA microspheres. J. Biomed. Mater. Res. 66A:2003;55-61.
21. Ou-Yang P., Hwang L.H., Tao M.H., Chiang B.L., Chen D.S. Co-delivery of GM-CSF gene enhances the immune responses of hepatitis C viral core protein-expressing DNA vaccine: role of dendritic cells. J. Med. Virol. 66:2002;320-328.
22. Pettit D.K., Lawter J.R., Huang W.J., Pankey S.C., Nightlinger N.S., Lynch D.H., Schuh J.A., Morrissey P.J., Gombotz W.R. Characterization of poly(glycolide-co-D,L-lactide)/poly(D,L-lactide) microspheres for controlled release of GM-CSF. Pharm. Res. 14:1997;1422-1430.
23. Sallusto F., Cella M., Danieli C., Lanzavecchia A. Dendritic cells use macropinocytosis and the mannose receptor to concentrate macromolecules in the major histocompatibility complex class II compartment: downregulation by cytokines and bacterial products. J. Exp. Med. 182:1995;389-400.
24. Seeber S.J., White J.L., Hem S.L. Solubilization of aluminum-containing adjuvants by constituents of interstitial fluid. J. Parent. Sci. Technol. 45:1991;156-159.
25. Shirodkar S., Hutchinson R.L., Perry D.L., White J.L., Hem S.L. Aluminum compounds used as adjuvants in vaccines. Pharm. Res. 7:1990;1282-1288.
26. Singh M., Vajdy M., Gardner J., Briones M., O'Hagan D. Mucosal immunization with HIV-1 gag DNA on cationic microparticles prolongs gene expression and enhances local and systemic immunity. Vaccine. 20:2001;594-602.
27. Sun X., Hodge L.M., Jones H.P., Tabor L., Simecka J.W. Co-expression of granulocyte-macrophage colony-stimulating factor with antigen enhances humoral and tumor immunity after DNA vaccination. Vaccine. 20:2002;1466-1474.
28. Thiele L., Roten-Rutishauser B., Jilek S., Wunderli-Allensbach H., Merkle H.P., Walter E. Evaluation of particle uptake in human blood monocyte-derived cells in vitro. Does phagocytosis activity of dendritic cells measure up with macrophages? J. Control. Rel. 76:2001;59-71.
29. Venkataprasad N., Coombes A.G., Singh M., Rohde M., Wilkinson K., Hudecz F., Davis S.S., Vordermeier H.M. Induction of cellular immunity to a mycobacterial antigen adsorbed on lamellar particles of lactide polymers. Vaccine. 17:1999;1814-1819.
30. Walter E., Merkle H.P. Microparticle-mediated transfection of non-phagocytic cells in vitro. J. Drug Target. 10:2002;11-21.
31. Walter E., Moelling K., Pavlovic J., Merkle H.P. Microencapsulation of DNA using poly(D,L-lactide-co-glycolide): stability issues and release characteristics. J. Control. Rel. 61:1999;361-374.
32. Walter E., Dreher D., Kok M., Thiele L., Kiama S.G., Gehr P., Merkle H.P. Hydrophilic poly(D,L-lactide-co-glycolide) microspheres for the delivery of DNA to human-derived macrophages and dendritic cells. J. Control. Rel. 76:2001;149-168.
33. Wang J., Zganiacz A., Xing Z. Enhanced immunogenicity of BCG vaccine by using a viral-based GM-CSF transgene adjuvant formulation. Vaccine. 20:2002;2887-2898.
34. Wee S., Gombotz W.R. Protein release from alginate matrices. Adv. Drug Deliv. Rev. 31:1998;267-285.
35. Wettreich A., Sebollela A., Carvalho M.A., Azevedo S.P., Borojevic R., Ferreira S.T., Coelho-Sampaio T. Acidic pH modulates the interaction between human granulocyte-macrophage colony-stimulating factor and glycosaminoglycans. J. Biol. Chem. 274:1999;31468-31475.
36. Yei S., Bartholomew R.M., Pezzoli P., Gutierrez A., Gouveia E., Bassett D., Soo Hoo W., Carlo D.J. Novel membrane-bound GM-CSF vaccines for the treatment of cancer: generation and evaluation of mbGM-CSF mouse B16F10 melanoma cell vaccine. Gene Ther. 9:2002;1302-1311.