Preoperative Chemoradiation for Locally Advanced Rectal Cancer: Rationale, Technique, and Results of Treatment

Seminars in Surgical Oncology

Volumn 21, Issue 4, 2003, Pages 265-270

  Crane, Christopher H ^a   Skibber, John ^a  

^a UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

Author keywords

Chemoradiation; Mesorectal excision; Neoadjuvant therapy; Rectal cancer

Indexed keywords

ANTINEOPLASTIC AGENT;

ANASTOMOSIS; ANUS SPHINCTER; ARTICLE; CANCER CHEMOTHERAPY; CANCER RADIOTHERAPY; CANCER STAGING; CANCER SURGERY; CANCER SURVIVAL; COLOSTOMY; CONTROLLED STUDY; FOLLOW UP; HOSPITALIZATION; HUMAN; MAJOR CLINICAL STUDY; METASTASIS; MORBIDITY; PREOPERATIVE PERIOD; PRIORITY JOURNAL; RECTUM CARCINOMA; RECTUM RESECTION; SKIN CARE; SURGICAL TECHNIQUE; TREATMENT OUTCOME;

CHEMOTHERAPY, ADJUVANT; HUMANS; NEOADJUVANT THERAPY; PROGNOSIS; RADIOTHERAPY DOSAGE; RECTAL NEOPLASMS; SURVIVAL RATE;

EID: 0346753963     PISSN: 87560437     EISSN: None     Source Type: Journal    
DOI: 10.1002/ssu.10046     Document Type: Article

References (24)

1. Krook JE, Moertel CG, Gunderson LL, et al: Effective surgical adjuvant therapy for high-risk rectal carcinoma [see comments]. N Engl J Med 1991;324(11):709-715.
2. Prolongation of the disease-free interval in surgically treated rectal carcinoma. Gastrointestinal Tumor Study Group. N Engl J Med 1985; 312(23):1465-1472.
3. Minsky BD, Coia L, Haller D, et al: Treatment systems guidelines for primary rectal cancer from the 1996 Patterns of Care Study. Int J Radiat Oncol Biol Phys 1998;41(1):21-27.
4. Vauthey JN, Marsh RW, Zlotecki RA, et al: Recent advances in the treatment and outcome of locally advanced rectal cancer. Ann Surg 1999;229(5):745-752; discussion 752-754.
5. Rich TA, Skibber JM, Ajani JA, et al: Preoperative infusional chemoradiation therapy for stage T3 rectal cancer. Int J Radiat Oncol Biol Phys 1995;32(4):1025-1029.
6. Janjan NA, Khoo VS, Abbruzzese J, et al: Tumor downstaging and sphincter preservation with preoperative chemoradiation in locally advanced rectal cancer: the M. D. Anderson Cancer Center experience. Int J Radiat Oncol Biol Phys 1999;44(5):1027-1038.
7. Sauer R, Geman Rectal Cancer Group: Adjuvant verses neoadjuvant combined modality treatment for locally advanced rectal cancer: First results of the German Rectal Cancer Study (CAO/ ARO/AIO-94). Int J Radiat Oncol Biol Phys 2003;57:S124-S125.
8. Improved survival with preoperative radiotherapy in resectable rectal cancer. Swedish Rectal Cancer Trial. N Engl J Med 1997; 336(14):980-987.
9. O'Connell M, Martenson JA, Wieand HS, et al: Improving adjuvant therapy for rectal cancer by combining protracted-infusion fluorouracil with radiation therapy after curative surgery. N Engl J Med 1994;331(8):502-507.
10. Minsky BD, Conti JA, Huang Y, Knopf K: Relationship of acute gastrointestinal toxicity and the volume of irradiated small bowel in patients receiving combined modality therapy for rectal cancer. J Clin Oncol 1995;13(6):1409-1416.
11. Minsky BD: Sphincter preservation in rectal cancer-continued evidence of success [editorial, comment]. Int J Radiat Oncol Biol Phys 2000;46(2):267-268.
12. Adams DR, Blatchford GJ, Lin KM, et al: Use of preoperative ultrasound staging for treatment of rectal cancer. Dis Colon Rectum 1999;42(2):159-166.
13. Mohiuddin M, Regine WF, John WJ, et al: Preoperative chemoradiation in fixed distal rectal cancer: dose time factors for pathological complete response. Int J Radiat Oncol Biol Phys 2000; 46(4):883-888.
14. Janjan NA, Crane CH, Feig BW, et al: Prospective trial of preoperative concomitant boost radiotherapy with continuous infusion 5-fluorouracil for locally advanced rectal cancer. Int J Radiat Oncol Biol Phys 2000;47(3):713-718.
15. Mak AC, Rich TA, Schultheiss T, et al: Late complications of postoperative radiation therapy for cancer of the rectum and rectosigmoid. Int J Radiat Oncol Biol Phys 1994;28(3):597-603.
16. Hyams DM, Mamounas EP, Petrelli N, et al: A clinical trial to evaluate the worth of preoperative multimodality therapy in patients with operable carcinoma of the rectum: a progress report of National Surgical Breast and Bowel Project Protocol R-03. Dis Colon Rectum 1997;40(2):131-139.
17. Crane CH, Skibber JM, Feig BW, et al: Response to preoperative chemoradiation increases the use of sphincter-preserving surgery in patients with locally advanced low rectal carcinoma. Cancer 2003;97:517-524.
18. Meterissian S, Skibber J, Rich T, et al: Patterns of residual disease after preoperative chemoradiation in ultrasound T3 rectal carcinoma. Ann Surg Oncol 1994;1(2):111-116.
19. Janjan NA, Abbruzzese J, Pazdur R, et al: Prognostic implications of response to preoperative infusional chemoradiation in locally advanced rectal cancer. Radiother Oncol 1999;51(2):153-160.
20. Janjan NA, Khoo VS, Rich TA, et al: Locally advanced rectal cancer: surgical complications after infusional chemotherapy and radiation therapy. Radiology 1998;206(1):131-136.
21. Sanfilippo N, Crane C, Skibber J, et al: T4 rectal cancer treated with preoperative chemoradiation to the posterior pelvis followed by multivisceral resection: patterns of failure and limitations of treatment. Int J Radiat Oncol Biol Phys 2001;51(1):176-183.
22. O'Connell M, Laurie JA, Kahn M, et al: Prospectively randomized trial of postoperative adjuvant chemotherapy in patients with high-risk colon cancer. J Clin Oncol 1998;16(1):295-300.
23. Tepper JE, O'Connell MJ, Petroni GR, et al: Adjuvant postoperative fluorouracil-modulated chemotherapy combined with pelvic radiation therapy for rectal cancer: initial results of intergroup 0114. J Clin Oncol 1997;15(5):2030-2039.
24. Crane CH, Janjan NA, Abbruzzese JL, et al: Effective pelvic symptom control using initial chemoradiation in patients presenting with rectal cancer and synchronous metastases followed by aggressive multidisciplinary management. Int J Radiat Oncol Biol Phys 2001;49(1):107-116.