Combining altered levels of effector transcripts in circulating T cells with a marker of endothelial injury is specific for active graft-versus-host disease

Bone Marrow Transplantation

Volumn 32, Issue 11, 2003, Pages 1077-1084

  Biedermann, Barbara C ^a,b   Tsakiris, D A ^b   Gregor, M ^b   Pober, J S ^c   Gratwohl, A ^b  

^a University Hospital Bruderholz   (Switzerland)

^b UNIVERSITY HOSPITAL BASEL   (Switzerland)

^c YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Cytotoxic; Endothelium; Fasligand; Graft versus host disease; Interferon type II; T lymphocytes; Vascular; von Willebrand factor

Indexed keywords

CD4 ANTIGEN; CD8 ANTIGEN; CYCLOPHOSPHAMIDE; CYCLOSPORIN A; ETOPOSIDE; FAS LIGAND; FLUDARABINE; GAMMA INTERFERON; MYCOPHENOLIC ACID 2 MORPHOLINOETHYL ESTER; PREDNISONE; THYMOCYTE ANTIBODY; VON WILLEBRAND FACTOR;

ADOLESCENT; ADULT; ALLOGENEIC STEM CELL TRANSPLANTATION; ARTICLE; CHRONIC DISEASE; CLINICAL ARTICLE; CONTROLLED STUDY; CYTOTOXIC T LYMPHOCYTE; EFFECTOR CELL; ENDOTHELIUM CELL; ENDOTHELIUM LESION; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; FLUORESCENCE ACTIVATED CELL SORTING; GENETIC TRANSCRIPTION; GRAFT VERSUS HOST REACTION; HEMATOLOGIC DISEASE; HUMAN; HUMAN CELL; LYMPHOCYTE COUNT; MALE; PHENOTYPE; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; RECIPIENT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SENSITIVITY AND SPECIFICITY; STATISTICAL ANALYSIS; STEM CELL TRANSPLANTATION; T LYMPHOCYTE ACTIVATION; T LYMPHOCYTE SUBPOPULATION; TARGET CELL; VASCULAR ENDOTHELIUM; VIRUS INFECTION;

BIOLOGICAL MARKERS; CASE-CONTROL STUDIES; ENDOTHELIUM, VASCULAR; FAS LIGAND PROTEIN; GRAFT VS HOST DISEASE; HEMATOPOIETIC STEM CELL TRANSPLANTATION; INTERFERON TYPE II; LYMPHOCYTE ACTIVATION; MEMBRANE GLYCOPROTEINS; MOLECULAR DIAGNOSTIC TECHNIQUES; RNA, MESSENGER; SENSITIVITY AND SPECIFICITY; SURVIVORS; T-LYMPHOCYTES, CYTOTOXIC; TRANSPLANTATION, HOMOLOGOUS; VON WILLEBRAND FACTOR;

EID: 0346752247     PISSN: 02683369     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bmt.1704258     Document Type: Article

References (19)

1. Majolino I, Saglio G, Scime R et al. High incidence of chronic GVHD after primary allogeneic peripheral blood stem cell transplantation in patients with hematologic malignancies. Bone Marrow Transplant 1996; 17: 555.
2. Socie G, Stone JV, Wingard JR et al. Long-term survival and late deaths after allogeneic bond marrow transplantation. Late Effects Working Committee of the International Bone Marrow Transplant Registry. N Engl J Med 1999; 341: 14.
3. Gratwohl A, Hermans J, Apperley J et al. Acute graft-versus-host disease: grade and outcome in patients with chronic myelogenous leukemia. Working Party Chronic Leukemia of the European Group for Blood and Marrow Transplantation. Blood 1995; 86: 813.
4. van den Brink MR, Burakoff SJ. Cytolytic pathways in haematopoietic stem-cell transplantation. Nat Rev Immunol 2002; 2: 273.
5. Roosnek E, Hogendijk S, Zawadynski S et al. The frequency of pretransplant donor cytotoxic T cell precursors with anti-host specificity predicts survival of patients transplanted with bone marrow from donors other than HLA-identical siblings. Transplantation 1993; 56: 691.
6. Mutis T, Gillespie G, Schrama E et al. Tetrameric HLA class I-minor histocompatibility antigen peptide complexes demonstrate minor histocompatibility antigen-specific cytotoxic T lymphocytes in patients with graft-versus-host disease. Nat Med 1999; 5: 839.
7. Biedermann BC, Sahner S, Gregor M et al. Endothelial injury mediated by cytotoxic T lymphocytes and loss of microvessels in chronic graft versus host disease. Lancet 2002; 359: 2078.
8. Shulman HM, Sullivan KM, Weiden PL et al. Chronic graft-versus-host syndrome in man. A long-term clinicopathologic study of 20 Seattle patients. Am J Med 1980; 69: 204.
9. Hamann D, Baars PA, Rep MH et al. Phenotypic and functional separation of memory and effector human CD8+ T cells. J Exp Med 1997; 186: 1407.
10. Biedermann BC, Pober JS. Human vascular endothelial cells favor clonal expansion of unusual alloreactive CTL. J Immunol 1999; 162: 7022.
11. Fitzpatrick DR, Shirley KM, McDonald LE et al. Distinct methylation of the interferon gamma (IFN-gamma) and interleukin 3 (IL-3) genes in newly activated primary CD8 + T lymphocytes: regional IFN-gamma promoter demethylation and mRNA expression are heritable in CD44(high)CD8 + T cells. J Exp Med 1998; 188: 103.
12. Callan MF, Tan L, Annels N et al. Direct visualization of antigen-specific CD8 + T cells during the primary immune response to Epstein-Barr virus in vivo. J Exp Med 1998; 187: 1395.
13. Busch DH, Pilip I, Pamer EG. Evolution of a complex T cell receptor repertoire during primary and recall bacterial infection. J Exp Med 1998; 188: 61.
14. Ogg GS, Jin X, Bonhoeffer S et al. Quantitation of HIV-1-specific cytotoxic T lymphocytes and plasma load of viral RNA. Science 1998; 279: 2103.
15. Callan MF, Fazou C, Yang H et al. CD8(+) T-cell selection, function, and death in the primary immune response in vivo. J Clin Invest 2000; 106: 1251.
16. Cerny A, McHutchison JG, Pasquinelli C et al. Cytotoxic T lymphocyte response to hepatitis C virus-derived peptides containing the HLA A2.1 binding motif. J Clin Invest 1995; 95: 521.
17. Strehlau J, Pavlakis M, Lipman M et al. Quantitative detection of immune activation transcripts as a diagnostic tool in kidney transplantation. Proc Natl Acad Sci USA 1997; 94: 695.
18. Starzl TE, Zinkernagel RM. Antigen localization and migration in immunity and tolerance. N Engl J Med 1998; 339: 1905.
19. Woywodt A, Streiber F, de Groot K et al. Circulating endothelial cells as markers for ANCA-associated small-vessel vasculitis. Lancet 2003; 361: 206.