Iron Supplementation Does Not Affect the Susceptibility of LDL to Oxidative Modification in Women with Low Iron Status

Journal of Nutrition

Volumn 134, Issue 1, 2004, Pages 99-103

  Binkoski, Amy E ^a   Kris Etherton, Penny M ^a   Beard, John L ^a  

^a PENNSYLVANIA STATE UNIVERSITY   (United States)

Author keywords

Dietary fat; Ferritin; Iron; Lag time; LDL oxidation

Indexed keywords

FAT; FERRITIN; FERROUS SULFATE; FREE RADICAL; IRON; LOW DENSITY LIPOPROTEIN; PLACEBO; SATURATED FATTY ACID;

ADULT; ARTICLE; ATHEROGENESIS; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DIET; DIETARY INTAKE; DOUBLE BLIND PROCEDURE; FAT INTAKE; FEMALE; FERRITIN BLOOD LEVEL; HUMAN; IRON DEFICIENCY; IRON STORAGE; IRON THERAPY; LOW FAT DIET; NORMAL HUMAN; OXIDATION; OXIDATIVE STRESS; RANDOMIZED CONTROLLED TRIAL;

EID: 0346726184     PISSN: 00223166     EISSN: None     Source Type: Journal    
DOI: 10.1093/jn/134.1.99     Document Type: Article

References (25)

1. Sullivan, J. L. (1981) Iron and the sex difference in heart disease risk. Lancet 1: 1293-1294.
2. Salonen, J. T., Nyyssonen, K., Korpela, H., Tuomilehto, J., Seppanen, R. & Salonen, R. (1992) High stored iron levels are associated with excess risk of myocardial infarction in eastern Finnish men. Circulation 86: 803-811.
3. Magnusson, M. K., Sigfusson, N., Sigvaldason, H., Johannesson, G. M., Magnusson, S. & Thorgeirsson, G. (1994) Low iron-binding capacity as a risk factor for myocardial infarction. Circulation 89: 102-108.
4. Reunanen, A., Takkunen, H., Knekt, P., Seppanen, R. & Aromaa, A. (1995) Body iron stores, iron intake and coronary heart disease mortality. J. Intern. Med. 238: 223-230.
5. Ascherio, A., Rimm, E. B., Giovannucci, E., Willett, W. C. & Stampfer, M. J. (2001) Blood donations and risk of coronary heart disease in men. Circulation 103: 52-57.
6. Danesh, J. & Appleby, P. (1999) Coronary heart disease and iron status: meta-analyses of prospective studies. Circulation 99: 852-854.
7. Steinberg, D., Parthasarathy, S., Carew, T. E., Khoo, J. C. & Witztum, J. L. (1989) Beyond cholesterol. Modifications of low-density lipoprotein that increase its atherogenicity. N. Engl. J. Med. 320: 915-924.
8. Steinberg, D. (1997) Lewis A. Conner Memorial Lecture. Oxidative modification of. LDL and atherogenesis. Circulation 95: 1062-1071.
9. Berliner, J. A. & Heinecke, J. W. (1996) The role of oxidized lipoproteins in atherogenesis. Free Radic. Biol. Med. 20: 707-727.
10. Meyers, D. G. (2000) The iron hypothesis: does iron play a role in atherosclerosis? Transfusion 40: 1023-1029.
11. Biemond, P., van Eijk, H. G., Swaak, A. J. & Koster, J. F. (1984) Iron mobilization from ferritin by superoxide derived from stimulated polymorphonuclear leukocytes. Possible mechanism in inflammation diseases. J. Clin. Investig. 73; 1576-1579.
12. McCord, J. M. (1996) Effects of positive iron status at a cellular level. Nutr. Rev. 54: 85-88.
13. Derstine, J. L., Murray-Kolb, L. E., Yu-Poth, S., Hargrove, R. L., Kris-Etherton, P. M. & Beard, J. L. (2003) Iron status in association with cardiovascular disease risk in three controlled feeding studies Am. J. Clin. Nutr. 77: 56-62.
14. Yu-Poth, S., Etherton, T. D., Reddy, C. C., Pearson, T. A., Reed, R., Zhao, G., Jonnalagadda, S., Wan, Y. & Kris-Etherton, P. M. (2000) Lowering dietary saturated fat and total fat reduces the oxidative susceptibility of LDL in healthy men and women. J. Nutr. 130: 2228-2237.
15. McCarron, D. A., Oparil, S., Chait, A., Haynes, R. B., Kris-Etherton, P., Stern, J. S., Resnick, L. M., Clark, S., Morris, C. D., Hatton, D. C., Metz, J. A., McMahon, M., Holcomb, S., Snyder, G. W. & Pi-Sunyer, F. X. (1997) Nutritional management of cardiovascular risk factors. A randomized clinical trial. Arch. Intern. Med. 157: 169-177.
16. Redgrave, T. G., Roberts, D. C. & West, C. E. (1975) Separation of plasma lipoproteins by density-gradient ultracentrifugation. Anal. Biochem. 65: 42-49.
17. Lowry, O. H. Rosebrough, N. J., Farr, A. L. & Randall, R. J. (1951) Protein measurement with the Folin phenol reagent. J. Biol. Chem. 193: 265-275.
18. Esterbauer, H., Striegl, G., Puhl, H. & Rotheneder, M. (1989) Continuous monitoring of in vitro oxidation of human low density lipoprotein. Free Radic. Res. Commun. 6: 67-75.
19. Cook, J. D., Lipschitz, D. A., Miles, L. E. & Finch, C. A. (1974) Serum ferritin as a measure of iron stores in normal subjects. Am. J. Clin. Nutr. 27: 681-687.
20. Steinberg, D. (1997) Low density lipoprotein oxidation and its pathobiological significance. J. Biol. Chem. 272: 20963-20966.
21. Hargrove, R. L., Etherton, T. D., Pearson, T. A., Harrison, E. H. & Kris-Etherton, P. M. (2001) Low fat and high monounsaturated diets decrease human low density lipoprotein oxidative susceptibility in vitro. J. Nutr. 131: 1758-1763.
22. Salonen, J. T., Korpela, H., Nyyssonen, K., Porkkala, E., Tuomainen, T. P., Belcher, J. D., Jacobs, D. R., Jr. & Salonen, R. (1995) Lowering of body iron stores by blood letting and oxidation resistance of serum lipoproteins: a randomized crossover trial in male smokers. J. Intern. Med. 237: 161-168.
23. Kiechl, S., Willeit, J., Egger, G., Poewe, W. & Oberhollenzer, F. (1997) Body iron stores and the risk of carotid atherosclerosis: prospective results from the Bruneck study. Circulation 96: 3300-3307.
24. Klipstein-Grobusch, K., Koster, J. F., Grobbee, D. E., Lindemans, J., Boeing, H., Hofman, A. & Witteman, J. C. (1999) Serum ferritin and risk of myocardial infarction in the elderly: the Rotterdam Study. Am. J. Clin. Nutr. 69: 1231-1236.
25. Iribarren, C., Sempos, C. T., Eckfeldt, J. H. & Folsom, A. R. (1998) Lack of association between ferritin level and measures of LDL oxidation: the ARIC study. Atherosclerosis Risk in Communities. Atherosclerosis 139: 189-195.