Subsite specificities of granzyme M: A study of inhibitors and newly synthesized thiobenzyl ester substrates

Archives of Biochemistry and Biophysics

Volumn 422, Issue 1, 2004, Pages 9-22

  Rukamp, Brian J ^a   Kam, Chih Min ^a   Natarajan, Sudah ^a   Bolton, Brad W ^a   Smyth, Mark J ^b   Kelly, Janice M ^b   Powers, James C ^a  

^a GEORGIA INSTITUTE OF TECHNOLOGY   (United States)

^b PETER MACCALLUM CANCER CENTRE   (Australia)

Author keywords

Chymotrypsin; Enzyme; Granzyme M; GrzM; Inhibitors; Metase; Protease; Serine; Substrates; Thiobenzyl ester

Indexed keywords

3,4 DICHLOROISOCOUMARIN; ALANINE; AMINO ACID DERIVATIVE; ASPARTIC ACID; BENZYL DERIVATIVE; ENZYME; ENZYME INHIBITOR; ESTER; GRANZYME M; METHIONINE THIOBENZYL ESTER; N BENZYLOXYCARBONYLALANYL N (BETA TERT BUTYLSERYL)METHIONINE THIOBENZYL ESTER; N BENZYLOXYCARBONYLALANYL [N (GAMMA TERT BUTYLASPARTYL)]METHIONINE THIOBENZYL ESTER; N BENZYLOXYCARBONYLALANYLALANYLNETHIONINE THIOBENZYL ESTER; N BENZYLOXYCARBONYLALANYLASPARTYLMETHIONINE THIOBENZYL ESTER; N BENZYLOXYCARBONYLALANYLLYSYLMETHIONINE THIOBENZYL ESTER; N BENZYLOXYCARBONYLALANYLPHENYLMETHIONINE THIOBENZYL ESTER; N BENZYLOXYCARBONYLALANYLPROLYLMETHIONINE THIOBENZYL ESTER; N BENZYLOXYCARBONYLALANYLSERYLMETHIONINE THIOBENZYL ESTER; N BENZYLOXYCARBONYLPHENYLPROLYLMETHIONINE THIOBENZYL ESTER; N BENZYLOXYCARBONYLPROLYLPROLYLMETHIONINE THIOBENZYL ESTER; N BENZYLOXYCARBONYLSERYLPROLYLMETHIONINE THIOBENZYL ESTER; N BENZYLOXYCARBONYL[N (BETA TERT BUTYLSERYL)]PROLYLMETHIONINE THIOBENZYL ESTER; PEPTIDE; PROLINE; PROTEIN INHIBITOR; RECOMBINANT PROTEIN; SERINE; SERINE PROTEINASE; SERINE PROTEINASE INHIBITOR; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ARTICLE; DRUG EFFICACY; DRUG POTENCY; DRUG SCREENING; ENZYME INACTIVATION; ENZYME SPECIFICITY; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN FUNCTION; PROTEIN HYDROLYSIS; PROTEIN INTERACTION; PROTEIN ISOLATION; SYNTHESIS;

MURINAE;

EID: 0346690113     PISSN: 00039861     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.abb.2003.12.005     Document Type: Article

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