Nuclear localization of the phosphatidylserine receptor protein via multiple nuclear localization signals

Experimental Cell Research

Volumn 293, Issue 1, 2004, Pages 154-163

  Cui, Ping ^a   Qin, Baoming ^a   Liu, Nan ^a   Pan, Guangjin ^a   Pei, Duanqing ^a,b  

^a TSINGHUA UNIVERSITY   (China)

^b UNIVERSITY OF MINNESOTA   (United States)

Author keywords

Apoptosis; Confocal microscopy; Inflammation; Nuclear localization signals; Nuclear protein; Phagocytosis; Phosphatidylserine; Phosphatidylserine receptor; Phospholipids; PSR

Indexed keywords

CELL SURFACE RECEPTOR; COMPLEMENTARY DNA; GREEN FLUORESCENT PROTEIN; HYBRID PROTEIN; MESSENGER RNA; PHOSPHATIDYLSERINE; PHOSPHATIDYLSERINE RECEPTOR; PHOTOPROTEIN; PROTEIN ANTIBODY; RECEPTOR PROTEIN;

ADENOCARCINOMA; AMINO ACID SEQUENCE; ANIMAL; ANIMAL CELL; ARTICLE; CELL CLONE; CELL LINE; CELL LYSATE; CELL NUCLEUS; CELL STRAIN 3T3; CONFOCAL MICROSCOPY; CYTOLOGY; DOG; ESCHERICHIA COLI; FLUORESCENT ANTIBODY TECHNIQUE; GENE DELETION; GENETIC CODE; GENETICS; HELA CELL; HUMAN; HUMAN CELL; IMMUNOFLUORESCENCE; KIDNEY; MALE; METABOLISM; MOLECULAR WEIGHT; MOUSE; NONHUMAN; NUCLEAR LOCALIZATION SIGNAL; NUCLEOTIDE SEQUENCE; PATHOLOGY; PRIORITY JOURNAL; PROSTATE TUMOR; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; SIGNAL TRANSDUCTION;

EID: 0346690073     PISSN: 00144827     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.yexcr.2003.09.023     Document Type: Article

References (23)

1. Savill J., Dransfield I., Gregory C., Haslett C. A blast from the past: clearance of apoptotic cells regulates immune responses. Nat. Rev., Immunol. 2:2002;965-975.
2. Nauta A.J., Daha M.R., Kooten C., Roos A. Recognition and clearance of apoptotic cells: a role for complement and pentraxins. Trends Immunol. 24:2003;148-154.
3. Williamson P., Schlegel R.A. Transbilayer phospholipid movement and the clearance of apoptotic cells. Biochim. Biophys. Acta. 1585:2002;53-63.
4. Fadok V.A., Chimini G. The phagocytosis of apoptotic cells. Semin. Immunol. 13:2001;365-372.
5. Balasubramanian K., Schroit A.J. Aminophospholipid asymmetry: a matter of life and death. Annu. Rev. Physiol. 65:2003;701-734.
6. Schlegel R.A., Williamson P. Phosphatidylserine, a death knell. Cell Death Differ. 8:2001;551-563.
7. Green D.R., Beere H.M. Apoptosis. Gone but not forgotten. Nature. 405:2000;28-29.
8. Fadok V.A., Bratton D.L., Rose D.M., Pearson A., Ezekewitz R.A., Henson P.M. A receptor for phosphatidylserine-specific clearance of apoptotic cells. Nature. 405:2000;85-90.
9. Vandivier R.W., Fadok V.A., Hoffmann P.R., Bratton D.L., Penvari C., Brown K.K., Brain J.D., Accurso F.J., Henson P.M. Elastase-mediated phosphatidylserine receptor cleavage impairs apoptotic cell clearance in cystic fibrosis and bronchiectasis. J. Clin. Invest. 109:2002;661-670.
10. Huynh M.L., Fadok V.A., Henson P.M. Phosphatidylserine-dependent ingestion of apoptotic cells promotes TGF-beta1 secretion and the resolution of inflammation. J. Clin. Invest. 109:2002;41-50.
11. Hoffmann P.R., deCathelineau A.M., Ogden C.A., Leverrier Y., Bratton D.L., Daleke D.L., Ridley A.J., Fadok V.A., Henson P.M. Phosphatidylserine (PS) induces PS receptor-mediated macropinocytosis and promotes clearance of apoptotic cells. J. Cell Biol. 155:2001;649-659.
12. Henson P.M., Bratton D.L., Fadok V.A. The phosphatidylserine receptor: a crucial molecular switch? Nat. Rev. Mol. Cell Biol. 2:2001;627-633.
13. Fadok V.A., Xue D., Henson P. If phosphatidylserine is the death knell, a new phosphatidylserine-specific receptor is the bellringer. Cell Death Differ. 8:2001;582-587.
14. Somersan S., Bhardwaj N. Tethering and tickling: a new role for the phosphatidylserine receptor. J. Cell Biol. 155:2001;501-504.
15. Fadok V.A., Bratton D.L., Henson P.M. Phagocyte receptors for apoptotic cells: recognition, uptake, and consequences. J. Clin. Invest. 108:2001;957-962.
16. Thomas G. Furin at the cutting edge: from protein traffic to embryogenesis and disease. Nat. Rev. Mol. Cell Biol. 3:2002;753-766.
17. Pei D., Weiss S.J. Furin-dependent intracellular activation of the human stromelysin-3 zymogen. Nature. 375:1995;244-247.
18. Pei D., Weiss S.J. Transmembrane-deletion mutants of the membrane-type matrix metalloproteinase-1 process progelatinase A and express intrinsic matrix-degrading activity. J. Biol. Chem. 271:1996;9135-9140.
19. Pei D., Kang T., Qi H. Cysteine array matrix metalloproteinase (CA-MMP)/MMP-23 is a type II transmembrane matrix metalloproteinase regulated by a single cleavage for both secretion and activation. J. Biol. Chem. 275:2000;33988-33997.
20. Gorlich D. Nuclear protein import. Curr. Opin. Cell Biol. 9:1997;412-419.
21. Blobel G. Unidirectional and bidirectional protein traffic across membranes. Cold Spring Harbor Symp. Quant. Biol. 60:1995;1-10.
22. Lieber T., Kidd S., Alcamo E., Corbin V., Young M.W. Antineurogenic phenotypes induced by truncated Notch proteins indicate a role in signal transduction and may point to a novel function for Notch in nuclei. Genes Dev. 7:1993;1949-1965.
23. Clissold P.M., Ponting C.P. JmjC: cupin metalloenzyme-like domains in jumonji, hairless and phospholipase A2beta. Trends Biochem. Sci. 26:2001;7-9.