The α2A-Adrenergic Agonist Guanfacine Improves Visuomotor Associative Learning in Monkeys

Neuropsychopharmacology

Volumn 29, Issue 1, 2004, Pages 86-92

  Wang, Min ^a   Ji, Jin Zhao ^a   Li, Bao Ming ^a  

^a FUDAN UNIVERSITY   (China)

Author keywords

2A adrenoceptor; Guanfacine; Monkey; Visuomotor associative learning

Indexed keywords

ALPHA 2 ADRENERGIC RECEPTOR BLOCKING AGENT; ALPHA 2 ADRENERGIC RECEPTOR STIMULATING AGENT; ALPHA 2A ADRENERGIC RECEPTOR; GUANFACINE; IDAZOXAN;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; ERROR; EXPERIMENTATION; LEARNING; MALE; MONKEY; NONHUMAN; PRIORITY JOURNAL; STATISTICAL SIGNIFICANCE; STIMULUS RESPONSE; TASK PERFORMANCE; TEMPORAL CORTEX; VISUAL DISCRIMINATION; VISUOMOTOR COORDINATION;

ADRENERGIC ALPHA-AGONISTS; ADRENERGIC ALPHA-ANTAGONISTS; ANIMALS; ASSOCIATION LEARNING; BEHAVIOR, ANIMAL; DISCRIMINATION LEARNING; DOSE-RESPONSE RELATIONSHIP, DRUG; GUANFACINE; IDAZOXAN; MACACA MULATTA; PHOTIC STIMULATION; PSYCHOMOTOR PERFORMANCE; RECEPTORS, ADRENERGIC, ALPHA-2; STATISTICS, NONPARAMETRIC;

EID: 0346688564     PISSN: 0893133X     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.npp.1300278     Document Type: Article

References (36)

1. Arnsten AFT, Cai J-X, Goldman-Rakic PS (1988). The α-2 adrenergic agonist guanfacine improves memory in aged monkeys without sedative or hypotensive side effects: evidence for alpha-2 receptor subtypes. J Neurosci 8: 4287-4298.
2. 2-Adrenergic mechanisms in prefrontal cortex associated with cognitive decline in aged nonhuman primates. Science 230: 1273-1276.
3. Arnsten AFT, Leslie FM (1991). Behavioral and receptor binding analysis of the alpha-2 adrenergic agonist UK-14304 (5-bromo-6 [2-imidazoline-2-yl amino] quinoxaline): evidence for cognitive enhancement at an alpha-2 adrenoceptor subtype. Neuropharmacology 30: 1279-1289.
4. Arnsten AFT, Steere JC, Hunt RD (1996). The contribution of α-2 noradrenergic mechanisms to prefrontal cortical cognitive function: potential significance to Attention Deficit Hyperactivity Disorder. Arch Gen Psychiatry 53: 448-455.
5. Asaad WF, Rainer G, Miller EK (1998). Neural activity in the primate prefrontal cortex during associative learning. Neuron 21: 1399-1407.
6. Avery RA, Franowicz JS, Studholme C, van Dyck CH, Arnsten AFT (2000). The alpha-2A-adrenoceptor agonist, guanfacine, increases regional cerebral blood flow in dorsolateral prefrontal cortex of monkeys performing a spatial working memory task. Neuropsychopharmacololy 23: 240-249.
7. Bussey TJ, Wise SP, Murray EA (2001). The role of ventral and orbital prefrontal cortex in conditional visuomotor learning and strategy use in rhesus monkeys (Macaca mulatta). Behav Neurosci 115: 971-982.
8. Bussey TJ, Wise SP, Murray EA (2002). Interaction of ventral and orbital prefrontal cortex with inferotemporal cortex in conditional visuomotor learning. Behav Neurosci 116: 703-715.
9. Cai J-X, Ma Y-Y, Xu L, Hu X (1993). Reserpine impairs spatial working memory performance in monkeys: reversal by the α-2-adrenergic agonist clonidine. Brain Res 614: 191-196.
10. Chappell PB, Riddle MA, Scahill L, Lynch K, Schultz R, Arnsten AFT et al (1995). Guanfacine treatment of comorbid attention deficit hyperactivity disorder and Tourette's Syndrome: preliminary clinical experience. J Am Acad Child Adoles Psychiatry 34: 1140-1146.
11. Coull JT (1994). Pharmacological manipulations of the alpha 2-noradrenergic system: effects on cognition. Drugs Aging 5: 116-126.
12. Courtney SM, Ungerleider LG, Keil K, Haxby JV (1996). Object and spatial visual working memory activates separate neural system in human cortex. Cereb Cortex 6: 39-49.
13. Dias R, Robbins TW, Roberts AC (1996). Dissociation in prefrontal cortex of affective and attentional shifts. Nature 380: 69-72.
14. Goldman-Rakic PS (1996). Regional and cellular fractionation of working memory. Proc Natl Acad Sci USA 93: 13473-13480.
15. Franowicz JS, Kessler LE, Borja CMD, Kobilka BK, Limbird LE, Arnsten AFT (2002). Mutation of the α2A-adrenoceptor impairs working memory performance and annuls cognitive enhancement by guanfacine. J Neurosci 22: 8771-8777.
16. Horrigan JP, Barnhill LJ (1995). Guanfacine for treatment of Attention Deficit Hyperactivity Disorder in boys. J Child Adoles Psychopharmacol 5: 215-223.
17. Hunt RD, Arnsten AFT, Asbell MD (1995). An open trial of guanfacine in the treatment of attention deficit hyperactivity disorder. J Am Acad Child Adoles Psychiatry 34: 50-54.
18. Iversen S, Mishkin M (1970). Perseverative interference in monkeys following selective lesions of the inferior prefrontal convexity. Exp Brain Res 11: 376-386.
19. Jakala P, Sirvio J, Riekkinen M, Koivisto E, Kejonen K, Vanhanen M et al (1999). Guanfacine and clonidine, alpha 2-agonists, improve paired associates learning, but not delayed matching to sample, in humans. Neuropsychopharmacology 20: 119-130.
20. Li B-M, Inase M, Takashima T, Iijima T (1997). Neuronal activity in the inferior prefrontal cortex of the monkey during conditional visuomotor learning. Neurosci Res 21: S252.
21. Li B-M, Kubota K (1998). α2 adrenergic modulation of prefrontal cortical neuronal activity related to a visual discrimination task with GO and NO-GO performances in monkeys. Neurosci Res 31: 83-95.
22. Li B-M, Mao Z-M, Wang M, Mei Z-T (1999). Alpha-2 adrenergic modulation of prefrontal cortical neuronal activity related to spatial working memory in monkeys. Neuropsychopharmacology 21: 601-610.
23. Li B-M, Mei Z-T (1994). Delayed-response deficit induced by local injection of the alpha-2 adrenergic antagonist yohimbine into the dorsolateral prefrontal cortex in young adult monkeys. Behav Neural Biol 62: 34-139.
24. Mao Z-M, Arnsten AFT, Li B-M (1999). Local infusion of an α-1 adrenergic agonist into the prefrontal cortex impairs spatial working memory performance in monkeys. Biol Psychiatry 46: 1259-1265.
25. Murray EA, Bussey TJ, Wise SP (2000). Role of prefrontal cortex in a network for arbitrary visuomotor mapping. Exp Brain Res 133: 114-129.
26. Passingham RE, Toni I, Rushworth MFS (2000). Specialisation within the prefrontal cortex: the ventral prefrontal cortex and associative learning. Exp Brain Res 133: 103-113.
27. Rama P, Linnankoski I, Tanila H, Pertovaara A, Carlson S (1996). Medetomidine, atipamezole, and guanfacine in delayed response performance of aged monkeys. Pharmacol Biochem Behav 54: 1-7.
28. Ridley RM, Durnford LJ, Baker JA, Baker HF (1993). Cognitive inflexibility after archicortical and paleocortical prefrontal lesions in marmosets. Brain Res 628: 56-64.
29. Scahill L, Chappell PB, Kim YS, Schultz RT, Katsovich L, Shepherd E et al (2001). A placebo-controlled study of guanfacine in the treatment of children with tic disorders and attention deficit hyperactivity disorder. Am J Psychiatry 158: 1067-1074.
30. Steere JC, Arnsten AFT (1997). The α-2 noradrenergic receptor agonist guanfacine improves visual object discrimination reversal performance in aged rhesus monkeys. Behav Neurosci 111: 883-891.
31. Toni I, Passingham RE (1999). Prefrontal-basal ganglia pathways are involved in the learning of arbitrary visuomotor associations. Exp Brain Res 127: 19-32.
32. Toni I, Schluter ND, Josephs O, Friston K, Passingham RE (1999). Signal-, set-and movement-related activity in the human brain: an event-related fMRI study. Cereb Cortex 9: 35-49.
33. Wang M, Zhang H, Li B-M (2000). Deficit in conditional visuomotor learning by local infusion of bicuculline into the ventral prefrontal cortex in monkeys. Eur J Neurosci 12: 3787-3796.
34. Wilson FAW, O'Scalaidhe SP, Goldman-Rakic PS (1993). Dissociation of object and spatial processing domains in primate prefrontal cortex. Science 260: 1955-1957.
35. Wise SP (1996). Evolution of neuronal activity during conditional motor learning. In: Bloedel JR, Ebner TJ, Wise SP (eds) The Acquisition of Motor Behavior in Vertebrates. MIT Press: MA. pp 261-286.
36. Wise SP, Murray EA (2000). Arbitrary association between antecedents and actions. Trends Neurosci 23: 271-276.