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When 2-amino-4-picoline was added to a biphasic system of phenol, 4,4′-dipyridyl, and 1-hexene, 2-amiono-4-picoline resided largely in the polar phase (phenol and 4,4′-dipyridyl). See Supporting Information.
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34
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0347726722
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note
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Because an excess amount of 5 was used in the reaction, such a small loss of 5 seems not to affect the reactivity.
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35
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0345834955
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note
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It was reported that the addition of benzoic acid improved the reactivity of hydroacylation. See ref 3b.
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0347726721
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note
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At every cycle, a significant amount of 5 was found in the nonpolar phase (more than 10% of the initial amount of 5).
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