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Volumn 55, Issue 5, 2003, Pages 675-682

Perspective of losigamone in epilepsy treatment

Author keywords

Antiepileptic drugs; Experimental models of epilepsy; Losigamone; Refractory epilepsy

Indexed keywords

4 AMINOPYRIDINE; ADD 137022; BICUCULLINE; BUTENOLIDE; CARBAMAZEPINE; CYTOCHROME P450 2A6; ETHOSUXIMIDE; FLUNITRAZEPAM; LAMOTRIGINE; LOSIGAMONE; MAGNESIUM ION; NICOTINE; PENTETRAZOLE; PHENYTOIN; PICROTOXIN; TERT BUTYLBICYCLOPHOSPHOROTHIOATE S 35; VALPROIC ACID; FURAN DERIVATIVE;

EID: 0346327433     PISSN: 12306002     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review
Times cited : (8)

References (55)
  • 1
    • 0027409231 scopus 로고
    • + current in pyramidal neurons from rat and cat sensorimotor cortex
    • + current in pyramidal neurons from rat and cat sensorimotor cortex. J. Neurosci., 1993, 13, 660-673.
    • (1993) J. Neurosci. , vol.13 , pp. 660-673
    • Alzheimer, C.1    Schwindt, P.C.2    Crill, W.E.3
  • 2
    • 0029963240 scopus 로고    scopus 로고
    • Ionic basis of spike after-depolarization and burst generation in adult rat hippocampal CA1 pyramidal cells
    • Azous R., Jensen M.S., Yaari Y.: Ionic basis of spike after-depolarization and burst generation in adult rat hippocampal CA1 pyramidal cells. J. Physiol., 1996, 492, 211-223.
    • (1996) J. Physiol. , vol.492 , pp. 211-223
    • Azous, R.1    Jensen, M.S.2    Yaari, Y.3
  • 3
    • 0035050624 scopus 로고    scopus 로고
    • Losigamone add-on therapy in partial epilepsy: A placebo-controlled study
    • Losigamone Study Group
    • Bauer J., Dienel A., Elger C.E., Losigamone Study Group: Losigamone add-on therapy in partial epilepsy: a placebo-controlled study. Acta Neurol. Scand., 2001, 103, 226-230.
    • (2001) Acta Neurol. Scand. , vol.103 , pp. 226-230
    • Bauer, J.1    Dienel, A.2    Elger, C.E.3
  • 4
    • 0031957398 scopus 로고    scopus 로고
    • Advances in the medical treatment of epilepsy
    • Bazil C.W., Pedley T.A.: Advances in the medical treatment of epilepsy. Annu. Rev. Med., 1998, 49, 135-162.
    • (1998) Annu. Rev. Med. , vol.49 , pp. 135-162
    • Bazil, C.W.1    Pedley, T.A.2
  • 6
    • 0034914046 scopus 로고    scopus 로고
    • Do we need any more new antiepileptic drugs?
    • Brodie M.J.: Do we need any more new antiepileptic drugs? Epilepsy Res., 2001, 45, 3-6.
    • (2001) Epilepsy Res. , vol.45 , pp. 3-6
    • Brodie, M.J.1
  • 8
    • 0345781183 scopus 로고
    • AO-33: A new tetronic acid derivative with anticonvulsant properties
    • 18th Int. Epilepsy Congress (Oct. 17-22, New Delhi) Abstr. 23
    • Chatterjee S.S., Klessing K., Stein U.: AO-33: a new tetronic acid derivative with anticonvulsant properties. 18th Int. Epilepsy Congress (Oct. 17-22, New Delhi), 1989, Abstr. 23.
    • (1989)
    • Chatterjee, S.S.1    Klessing, K.2    Stein, U.3
  • 9
    • 0029932350 scopus 로고    scopus 로고
    • Persistent sodium current in mammalian central neurons
    • Crill W.E.: Persistent sodium current in mammalian central neurons. Annu. Rev. Physiol., 1996, 58, 349-362.
    • (1996) Annu. Rev. Physiol. , vol.58 , pp. 349-362
    • Crill, W.E.1
  • 10
    • 0036850041 scopus 로고    scopus 로고
    • Polytherapy in epilepsy: The experimental evidence
    • Czuczwar S.J., Borowicz K.K.: Polytherapy in epilepsy: the experimental evidence. Epilepsy Res., 2002, 52, 15-23.
    • (2002) Epilepsy Res. , vol.52 , pp. 15-23
    • Czuczwar, S.J.1    Borowicz, K.K.2
  • 11
    • 0035073915 scopus 로고    scopus 로고
    • Felbamate, gabapentin and topiramate as adjuvant antiepileptic drugs in experimental models of epilepsy
    • Czuczwar S.J., Przesmycki K.: Felbamate, gabapentin and topiramate as adjuvant antiepileptic drugs in experimental models of epilepsy. Pol. J. Pharmacol., 2001, 53, 65-68.
    • (2001) Pol. J. Pharmacol. , vol.53 , pp. 65-68
    • Czuczwar, S.J.1    Przesmycki, K.2
  • 13
    • 0344316871 scopus 로고    scopus 로고
    • Losigamone: Comprehensive summary of safety and tolerability in volunteers
    • Dienel A., Biber A.: Losigamone: comprehensive summary of safety and tolerability in volunteers. Epilepsia, 1996, 37, Suppl. 4, 63-64.
    • (1996) Epilepsia , vol.37 , Issue.SUPPL. 4 , pp. 63-64
    • Dienel, A.1    Biber, A.2
  • 14
    • 0029149763 scopus 로고
    • Effects of the anticonvulsant losigamone and its isomers on the GABAA receptor system
    • Dimpfel W., Chatterjee S.S., Noldner M., Ticku M.K.: Effects of the anticonvulsant losigamone and its isomers on the GABAA receptor system. Epilepsia, 1995, 36, 983-989.
    • (1995) Epilepsia , vol.36 , pp. 983-989
    • Dimpfel, W.1    Chatterjee, S.S.2    Noldner, M.3    Ticku, M.K.4
  • 15
    • 0030948683 scopus 로고    scopus 로고
    • Losigamone decreases spontaneous synaptic activity in cultured hippocampal neurons
    • Draguhn A., Jungclaus M., Sokolowa S., Heinemann U.: Losigamone decreases spontaneous synaptic activity in cultured hippocampal neurons. Eur. J. Pharmacol., 1997, 325, 245-251.
    • (1997) Eur. J. Pharmacol. , vol.325 , pp. 245-251
    • Draguhn, A.1    Jungclaus, M.2    Sokolowa, S.3    Heinemann, U.4
  • 17
    • 0032797436 scopus 로고    scopus 로고
    • Preclinical evaluation of newly approved and potential antiepileptic drugs against cocaine-induced seizures
    • Gasior M., Ungard J.T., Witkin J.M.: Preclinical evaluation of newly approved and potential antiepileptic drugs against cocaine-induced seizures. J. Pharmacol. Exp. Ther., 1999, 290, 1148-1156.
    • (1999) J. Pharmacol. Exp. Ther. , vol.290 , pp. 1148-1156
    • Gasior, M.1    Ungard, J.T.2    Witkin, J.M.3
  • 18
    • 0035976512 scopus 로고    scopus 로고
    • The antiepileptic drug losigamone decreases the persistent Na+ current in rat hippocampal neurons
    • Gebhardt C., Breustedt J.M., Noldner M., Chatterjee S.S., Heinemann U.: The antiepileptic drug losigamone decreases the persistent Na+ current in rat hippocampal neurons. Brain Res., 2001, 920, 27-31.
    • (2001) Brain Res. , vol.920 , pp. 27-31
    • Gebhardt, C.1    Breustedt, J.M.2    Noldner, M.3    Chatterjee, S.S.4    Heinemann, U.5
  • 19
    • 0021922774 scopus 로고
    • Effects of anticonvulsants on spontaneous epileptiform activity which develops in the absence of chemical synaptic transmission in hippocampal slices
    • Heinemann U., Franceschetti S., Hamon B., Konnerth A., Yaari Y.: Effects of anticonvulsants on spontaneous epileptiform activity which develops in the absence of chemical synaptic transmission in hippocampal slices. Brain Res., 1985, 325, 349-352.
    • (1985) Brain Res. , vol.325 , pp. 349-352
    • Heinemann, U.1    Franceschetti, S.2    Hamon, B.3    Konnerth, A.4    Yaari, Y.5
  • 20
    • 0032754438 scopus 로고    scopus 로고
    • The anticonvulsant effects of the enantiomers of losigamone
    • Jones F.A., Davies J.A.: The anticonvulsant effects of the enantiomers of losigamone. Brit. J. Pharmacol., 1999, 128, 1223-1228.
    • (1999) Brit. J. Pharmacol. , vol.128 , pp. 1223-1228
    • Jones, F.A.1    Davies, J.A.2
  • 21
    • 0345781182 scopus 로고
    • Beta-Methoxybutenolide als potentielle Antikonvulsiva: Diastereoselektive Synthese und Strukturwirkungsbeziehungen
    • Int. Symposion: Dreidimensionale Struktur und Wirkung, Schliersee (Oct. 2-4)
    • Klessing K., Chatterjee S.S.: Beta-Methoxybutenolide als potentielle Antikonvulsiva: diastereoselektive Synthese und Strukturwirkungsbeziehungen. Int. Symposion: Dreidimensionale Struktur und Wirkung, Schliersee (Oct. 2-4), 1989.
    • (1989)
    • Klessing, K.1    Chatterjee, S.S.2
  • 22
    • 0347042591 scopus 로고    scopus 로고
    • Effect of antiepileptic drugs on synthesis of kynurenic acid in the rat cortical slices
    • 1
    • Kocki T., Urbańska E.U., Wielosz M., Turski W.A.: Effect of antiepileptic drugs on synthesis of kynurenic acid in the rat cortical slices. Pol. J. Pharmacol., 2003, 55, 1, 115.
    • (2003) Pol. J. Pharmacol. , vol.55 , pp. 115
    • Kocki, T.1    Urbańska, E.U.2    Wielosz, M.3    Turski, W.A.4
  • 23
    • 0025143308 scopus 로고
    • Effects of the tetronic acid derivatives AO33 (losigamone) and AO78 on epileptiform activity and on stimulus-induced calcium concentration changes in rat hippocampal slices
    • Kohr G., Heinemann U.: Effects of the tetronic acid derivatives AO33 (losigamone) and AO78 on epileptiform activity and on stimulus-induced calcium concentration changes in rat hippocampal slices. Epilepsy Res., 1990, 7, 49-58.
    • (1990) Epilepsy Res. , vol.7 , pp. 49-58
    • Kohr, G.1    Heinemann, U.2
  • 24
    • 0025275847 scopus 로고
    • Anticonvulsant properties of tetronic acid derivatives on picrotoxin-induced epileptiform activity in rat hippocampal slices
    • Kohr G., Heinemann U.: Anticonvulsant properties of tetronic acid derivatives on picrotoxin-induced epileptiform activity in rat hippocampal slices. Neurosci. Lett., 1990, 112, 43-47.
    • (1990) Neurosci. Lett. , vol.112 , pp. 43-47
    • Kohr, G.1    Heinemann, U.2
  • 25
    • 0006944943 scopus 로고    scopus 로고
    • Losigamone interactions with antiepileptic drugs in healthy volunteers
    • Kramer G., Wad N., Bredel-Geissler A., Dienel A., Biber A.: Losigamone interactions with antiepileptic drugs in healthy volunteers. Epilepsia, 1996, 37, Suppl. 4, 89.
    • (1996) Epilepsia , vol.37 , Issue.SUPPL. 4 , pp. 89
    • Kramer, G.1    Wad, N.2    Bredel-Geissler, A.3    Dienel, A.4    Biber, A.5
  • 26
    • 0034598762 scopus 로고    scopus 로고
    • Early identification of refractory epilepsy
    • Kwan P., Brodie M.J.: Early identification of refractory epilepsy. N. Engl. J. Med., 2000, 342, 314-319.
    • (2000) N. Engl. J. Med. , vol.342 , pp. 314-319
    • Kwan, P.1    Brodie, M.J.2
  • 27
    • 0031909953 scopus 로고    scopus 로고
    • Reduction of cortical pyramidal neuron excitability by the action of phenytoin on persistent Na+ current
    • Lampl I., Schwindt P., Crill W.: Reduction of cortical pyramidal neuron excitability by the action of phenytoin on persistent Na+ current. J. Pharmacol. Exp. Ther., 1998, 284, 228-237.
    • (1998) J. Pharmacol. Exp. Ther. , vol.284 , pp. 228-237
    • Lampl, I.1    Schwindt, P.2    Crill, W.3
  • 29
    • 0025847753 scopus 로고
    • The role of technical, biological and pharmacological factors in the laboratory evaluation of anticonvulsant drugs. IV. Protective indices
    • Löscher W, Nolting B.: The role of technical, biological and pharmacological factors in the laboratory evaluation of anticonvulsant drugs. IV. Protective indices. Epilepsy Res., 1991, 9, 1-10.
    • (1991) Epilepsy Res. , vol.9 , pp. 1-10
    • Löscher, W.1    Nolting, B.2
  • 30
    • 0036499726 scopus 로고    scopus 로고
    • Current status and future directions in the pharmacotherapy of epilepsy
    • Löscher W: Current status and future directions in the pharmacotherapy of epilepsy. Trends Pharmacol. Sci., 2002, 23, 113-118.
    • (2002) Trends Pharmacol. Sci. , vol.23 , pp. 113-118
    • Löscher, W.1
  • 32
    • 0033198253 scopus 로고    scopus 로고
    • High conductance sustained single-channel activity responsible for the low-threshold persistent Na(+) current in entorhinal cortex neurons
    • Magistretti J., Ragsdale D.S., Alonso A.: High conductance sustained single-channel activity responsible for the low-threshold persistent Na(+) current in entorhinal cortex neurons. J. Neurosci., 1999, 19, 7334-7341.
    • (1999) J. Neurosci. , vol.19 , pp. 7334-7341
    • Magistretti, J.1    Ragsdale, D.S.2    Alonso, A.3
  • 33
    • 0034189473 scopus 로고    scopus 로고
    • New anti-epileptic drugs for the 21st century
    • McCabe P.H.: New anti-epileptic drugs for the 21st century. Expert Opin. Pharmacother., 2000, 1, 633-674.
    • (2000) Expert Opin. Pharmacother. , vol.1 , pp. 633-674
    • McCabe, P.H.1
  • 36
    • 37948999677 scopus 로고
    • The structure and synthesis of fadyenolide, a new butenolide from piper fadyenii
    • Pelter A., Al-Bagati R., Hansel R., Dinter H., Burke B.: The structure and synthesis of fadyenolide, a new butenolide from piper fadyenii. Tetrahedron Lett., 1981, 22, 1545-1548.
    • (1981) Tetrahedron Lett. , vol.22 , pp. 1545-1548
    • Pelter, A.1    Al-Bagati, R.2    Hansel, R.3    Dinter, H.4    Burke, B.5
  • 38
    • 0032918385 scopus 로고    scopus 로고
    • Clinical aspects and biological bases of drug-resistant epilepsies
    • Regesta G., Tanganelli P.: Clinical aspects and biological bases of drug-resistant epilepsies. Epilepsy Res., 1999, 34, 109-122.
    • (1999) Epilepsy Res. , vol.34 , pp. 109-122
    • Regesta, G.1    Tanganelli, P.2
  • 39
    • 0027137896 scopus 로고
    • Some aspects of prognosis in the epilepsies: A review
    • Sander J.W.A.S.: Some aspects of prognosis in the epilepsies: a review. Epilepsia, 1993, 34, 1007-1016.
    • (1993) Epilepsia , vol.34 , pp. 1007-1016
    • Sander, J.W.A.S.1
  • 41
    • 0028815488 scopus 로고
    • Monotherapy versus polytherapy in epilepsy
    • Schmidt D., Gram L.: Monotherapy versus polytherapy in epilepsy. CNS Drugs, 1995, 3, 194-208.
    • (1995) CNS Drugs , vol.3 , pp. 194-208
    • Schmidt, D.1    Gram, L.2
  • 42
    • 0028819694 scopus 로고
    • Effects of losigamone on synaptic potentials and spike frequency habituation in rat entorhinal cortex and hippocampal CA1 neurones
    • Schmitz D., Gloveli T., Heinemann U.: Effects of losigamone on synaptic potentials and spike frequency habituation in rat entorhinal cortex and hippocampal CA1 neurones. Neurosci. Lett., 1995, 200, 141-143.
    • (1995) Neurosci. Lett. , vol.200 , pp. 141-143
    • Schmitz, D.1    Gloveli, T.2    Heinemann, U.3
  • 43
    • 0030857906 scopus 로고    scopus 로고
    • Late sodium channel openings underlying epileptiform activity are preferentially diminished by the anticonvulsant phenytoin
    • Segal M.M., Douglas A.F.: Late sodium channel openings underlying epileptiform activity are preferentially diminished by the anticonvulsant phenytoin. J. Neurophysiol., 1997, 77, 3021-3034.
    • (1997) J. Neurophysiol. , vol.77 , pp. 3021-3034
    • Segal, M.M.1    Douglas, A.F.2
  • 44
    • 0030833897 scopus 로고    scopus 로고
    • The effect of losigamone (AO-33) on electrical activity and excitatory amino acid release in mouse cortical slices
    • Srinivasan J., Richens A., Davies J.A.: The effect of losigamone (AO-33) on electrical activity and excitatory amino acid release in mouse cortical slices. Brit. J. Pharmacol., 1997, 122, 1490-1494.
    • (1997) Brit. J. Pharmacol. , vol.122 , pp. 1490-1494
    • Srinivasan, J.1    Richens, A.2    Davies, J.A.3
  • 45
    • 0026264936 scopus 로고
    • Losigamone
    • Eds. Pissani F., Perucca E., Avanzini G., Richens A., Elsevier, Amsterdam
    • Stein U., Messing K., Chatterjee S.S.: Losigamone. In: New Antiepileptic Drugs. Eds. Pissani F., Perucca E., Avanzini G., Richens A., Elsevier, Amsterdam, 1991, 129-133.
    • (1991) New Antiepileptic Drugs , pp. 129-133
    • Stein, U.1    Messing, K.2    Chatterjee, S.S.3
  • 46
    • 0002821824 scopus 로고
    • Potential antiepileptic drugs: Losigamone
    • Eds. Levy R.H., Mattson R.H., Meldrum B.S., Raven Press, New York
    • Stein U.: Potential antiepileptic drugs: losigamone. In: Antiepileptic Drugs. Eds. Levy R.H., Mattson R.H., Meldrum B.S., Raven Press, New York, 1995, 1025-1034.
    • (1995) Antiepileptic Drugs , pp. 1025-1034
    • Stein, U.1
  • 47
    • 0030729596 scopus 로고    scopus 로고
    • The influence of established and new antiepileptic drugs on visual perception. 1. A placebo-controlled, double-blind, single-dose study in healthy volunteers
    • Steinhoff B.J., Freudenthaler N., Paulus W.: The influence of established and new antiepileptic drugs on visual perception. 1. A placebo-controlled, double-blind, single-dose study in healthy volunteers. Epilepsy Res., 1997, 29, 35-47.
    • (1997) Epilepsy Res. , vol.29 , pp. 35-47
    • Steinhoff, B.J.1    Freudenthaler, N.2    Paulus, W.3
  • 50
    • 0029813840 scopus 로고    scopus 로고
    • Stereoselective metabolism of a new anticonvulsant drug candidate, losigamone, by human liver microsomes
    • Torchin C.D., McNeilly P.J., Kapetanovic I.M., Strong J.M., Kupferberg H.J.: Stereoselective metabolism of a new anticonvulsant drug candidate, losigamone, by human liver microsomes. Drug Metab. Disposition, 1996, 24, 1002-1008.
    • (1996) Drug Metab. Disposition , vol.24 , pp. 1002-1008
    • Torchin, C.D.1    McNeilly, P.J.2    Kapetanovic, I.M.3    Strong, J.M.4    Kupferberg, H.J.5
  • 51
    • 0033048374 scopus 로고    scopus 로고
    • Chiral high-performance liquid chromatographic analysis of enantiomers of losigamone, a new candidate antiepileptic drug
    • Torchin C.D., Yonekawa W.D., Kapetanovic I.M., Kupferberg H.J.: Chiral high-performance liquid chromatographic analysis of enantiomers of losigamone, a new candidate antiepileptic drug. J. Chromatogr. B - Bio. Med. Appl., 1999, 724, 101-108.
    • (1999) J. Chromatogr. B - Bio. Med. Appl. , vol.724 , pp. 101-108
    • Torchin, C.D.1    Yonekawa, W.D.2    Kapetanovic, I.M.3    Kupferberg, H.J.4
  • 53
    • 0028843385 scopus 로고
    • The effects of anticonvulsant agents on 4-aminopyridine-induced epileptiform activity in rat hippocampus in vitro
    • Yonekawa W.D., Kapetanovic I.M., Kupferberg H.J.: The effects of anticonvulsant agents on 4-aminopyridine-induced epileptiform activity in rat hippocampus in vitro. Epilepsy Res., 1995, 20, 137-150.
    • (1995) Epilepsy Res. , vol.20 , pp. 137-150
    • Yonekawa, W.D.1    Kapetanovic, I.M.2    Kupferberg, H.J.3
  • 54
    • 0026528920 scopus 로고
    • Comparison of the effects of losigamone and its isomers on maximal electroshock induced convulsions in mice and on three different patterns of low magnesium induced epileptiform activity in slices of the rat temporal cortex
    • Zhang C.L., Chatterjee S.S., Stein U., Heinemann U.: Comparison of the effects of losigamone and its isomers on maximal electroshock induced convulsions in mice and on three different patterns of low magnesium induced epileptiform activity in slices of the rat temporal cortex. Naunyn-Schmied. Arch. Pharmacol., 1992, 345, 85-92.
    • (1992) Naunyn-Schmied. Arch. Pharmacol. , vol.345 , pp. 85-92
    • Zhang, C.L.1    Chatterjee, S.S.2    Stein, U.3    Heinemann, U.4
  • 55
    • 0028068951 scopus 로고
    • Effects of NMDA- and AMPA-receptor antagonists on different forms of epileptiform activity in rat temporal cortex slices
    • Zhang C.L., Gloveli T., Heinemann U.: Effects of NMDA- and AMPA-receptor antagonists on different forms of epileptiform activity in rat temporal cortex slices. Epilepsia, 1994, 35, Suppl. 5, S68-S73.
    • (1994) Epilepsia , vol.35 , Issue.SUPPL. 5
    • Zhang, C.L.1    Gloveli, T.2    Heinemann, U.3


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