Design and characterization of an oral delivery system for insulin administration

S.T.P. Pharma Sciences

Volumn 13, Issue 6, 2003, Pages 377-380

  Santiago, R M ^a   Fialho, S L ^a   Silva Cunha, A ^a  

^a FEDERAL UNIVERSITY OF MINAS GERAIS   (Brazil)

Author keywords

Enteral delivery; Granules; Hydroxypropyl cyclodextrin; Insulin; Microemulsions

Indexed keywords

2 HYDROXYPROPYL BETA CYCLODEXTRIN; ALGINIC ACID; CREMOPHOR; EUDRAGIT; INSULIN; MICROCRYSTALLINE CELLULOSE; MYRISTIC ACID ISOPROPYL ESTER;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG BIOAVAILABILITY; DRUG DELIVERY SYSTEM; DRUG DOSAGE FORM; DRUG FORMULATION; DRUG GRANULATION; DRUG RELEASE; DRUG SOLUTION; DRUG STABILITY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; IN VIVO STUDY; INSULIN TREATMENT; INTESTINE ABSORPTION; INTESTINE MUCOSA PERMEABILITY; MALE; MICROEMULSION; NONHUMAN; PH; RAT; SUSTAINED DRUG RELEASE;

EID: 0346271797     PISSN: 11571489     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (21)

1. TENJARLA S. - Microemulsions: an overview and pharmaceutical applications. - Crit. Rev. Ther. Drug Carrier Syst., 16, 461-521, 1999.
2. BAGWE R. P., KANICKY J. R., PALLA B. J., PATANJALI P. K., SHAH D. O. - Improved drug delivery using microemulsions: rationale, recent progress, and new horizons. - Crit. Rev. Ther. Drug Carrier Syst., 18, 77-140, 2001.
3. SAUDEK C.D. - Future developments in insulin delivery systems. - Diabetes Care, 16, 122-132, 1993.
4. IWANAGA K., ONO S., NARIOKA K., MORIMOTO K., KAKEMI M., YAMASHITA S., NANGO M., OKU N.-Oral delivery of insulin by using surface coating liposomes. Improvement of stability of insulin in GI tract. - Int. J. Pharm., 157, 73-80, 1997.
5. SILVA CUNHA A., CHÉRON M., GROSSIORD J.L., PUISIEUX F., SEILLER M. - w/o/w multiple emulsions of insulin containing a protease inhibitor and an absorption enhancer: Biological activity after oral administration to normal and diabetics rats. - Int. J. Pharm., 169, 33-44, 1998.
6. VAUTHIER C., SEILLER M., WEINGARTEN C., COUVREUR R - Contribution to the development of oral dosage form for insulin delivery. - STP Pharma Sci., 5, 391-396, 1999.
7. HOSNY E.A., AL-SHORA H.I., ELMAZAR M.M.A. - Oral delivery of insulin from enteric-coated capsules containing sodium salicylate: effect on relative hypoglycemia of diabetic beagle dogs. - Int. J. Pharm., 237, 71-76, 2002.
8. COURNARIE F., AUCHERE D., CHEVENNE D., LACOUR SEILLER M., VAUTHIER C. - Absorption and efficiency of insulin after oral administration of insulin-loaded nanocapsules in diabetic rats - Int. J. Pharm., 242, 325-328, 2002.
9. CHO Y.W., FLYNN M. - Oral delivery of insulin. - Lancet, 2, 1518-1519, 1989.
10. PATEL D.G., RITSCHEL W.A., CHALASANI P., RAO S. - Biological activity of insulin in microemulsion in mice. - J. Pharm. Sci., 80, 613-614, 1991.
11. RITSCHEL W.A. - Microemulsions form improved peptide absorption from gastrointestinal tract. - Methods Find. Exp. Clin. Pharmacol., 13, 205-220, 1993.
12. KRAELING M.E.K., RITSCHELW. A. - Development of a colonic release capsule dosage form and the absorption of insulin. - Methods Find Exp Clin Pharmacol., 14, 199-209, 1992.
13. SHAO Z., KRISHNAMOORTHY R., MITRA A.K. - Cyclodextrins as nasal absorption promoters of insulin: mechanistic evaluations. - Pharm. Res., 9, 1157-1163, 1992.
14. TOKIHIRO K., IRIE T., UEKAMA K. - Varying effects of cyclodextrin derivatives on aggregation and thermal behavior of insulin in aqueous solution. - Chem. Pharm. Bull., 45 (3), 525-531, 1997.
15. DOTSIKAS Y., LOUKAS Y.L. - Kinetic degradation study of insulin complexed with methyl-beta cyclodextrin. Confirmation of complexation with electrospray mass spectrometry and 1 H NMR. - J. Pharm. Biomed. Anal., 29, 487-494, 2002.
16. SCHIPPER N.G.M., ROMEIJN S.G., VERHOEF J.C., MERKUS F.W.H. - Nasal insulin delivery with dimethyl-β-cyclodextrin as an absorption enhancer in rabbits: powder more effective than liquid formulations. - Pharm. Res., 10, 682-686, 1993.
17. OLIVA A., FARIÑA J.B., LLABRÉS M. - Influence of temperature and shaking on stability of insulin preparations: degradation kinetics. - Int. J. Pharm., 143, 163-170, 1996.
18. SCHILING R.J., MITRA A.K. - Intestinal mucosal transport of insulin. - Int. J. Pharm., 62, 53-64, 1990.
19. The United States Pharmacopoeia 24 Ed. NF 19. (USP 24) -United States Pharmacopeial Convention Inc., Rockville, 2000, CD-Rom (Insight Publishing Productivity).
20. SORIANO I., EVORA C., LLABRÉS M. - Preparation and evaluation of insulin-loaded poly (DL-lactide) microspheres using an experimental design. - Int. J. Pharm., 142, 135-142, 1996.
21. CONSTANTINIDES P.P., SCALART J.P., LANCASTER C., MARCELLO J., MARKS G., ELLENS H., SMITH P.L. - Formulation and intestinal absorption enhancement evaluation of water-in-oil microemulsion incorporating medium-chain glycerides. - Pharm. Res., 11, 1385-1390, 1994.