Roles of the Semaphorin Family in Immune Regulation

Advances in Immunology

Volumn 81, Issue , 2003, Pages 173-198

  Kumanogoh, Atsushi ^a   Kikutani, Hitoshi ^a  

^a OSAKA UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CD100 ANTIGEN; CD108 ANTIGEN; CD72 ANTIGEN; CELL PROTEIN; PROTEIN TIM; SEMAPHORIN; SEMAPHORIN 3A; SEMAPHORIN 4A; UNCLASSIFIED DRUG;

B LYMPHOCYTE DIFFERENTIATION; CELL ACTIVATION; DENDRITIC CELL; HUMAN; IMMUNOMODULATION; IMMUNOREGULATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; REVIEW; SIGNAL TRANSDUCTION; T LYMPHOCYTE;

EID: 0346252646     PISSN: 00652776     EISSN: None     Source Type: Book Series    
DOI: 10.1016/S0065-2776(03)81005-2     Document Type: Review

References (72)

1. Adachi, T., Flaswinkel, H., Yakura, H., Reth, M., and Tsubata, T. (1998). The B cell surface protein CD72 recruits the tyrosine phosphatase SHP-1 upon tyrosine phosphorylation. J. Immunol. 160, 4662-4665.
2. Aurandt, J., Vikis, H. G., Gutkind, J. S., Ahn, N., and Guan, K. L. (2002). The semaphorin receptor plexin-B1 signals through a direct interaction with the Rho-specific nucleotide exchange factor, LARG. Proc. Natl. Acad. Sci. USA 99, 12085-12090.
3. Banchereau, J., and Steinman, R. M. (1998). Dendritic cells and the control of immunity. Nature 392, 245-252.
4. Behar, O., Golden, J. A., Mashimo, H., Schoen, F. J., and Fishman, M. C. (1996). Semaphorin III is needed for normal patterning and growth of nerves, bones and heart. Nature 383, 525-528.
5. Billard, C., Delaire, S., Raffoux, E., Bensussan, A., and Boumsell, L. (2000). Switch in the protein tyrosine phosphatase associated with human CD100 semaphorin at terminal B-cell differentiation stage. Blood 95, 965-972.
6. Bougeret, C., Mansur, I. G., Dastot, H., Schmid, M., Mahouy, G., Bensussan, A., and Boumsell, L. (1992). Increased surface expression of a newly identified 150-kDa dimer early after human T lymphocyte activation. J. Immunol. 148, 318-323.
7. Burshtyn, D. N., Scharenberg, A. M., Wagtmann, N., Rajagopalan, S., Berrada, K., Yi, T., Kinet, J.-P., and Long, E. O. (1996). Recruitment of tyrosine phosphatase HCP by the killer cell inhibitor receptor. Immunity 4, 77-85.
8. Chen, H., He, Z., Bagri, A., and Tessier-Lavigne, M. (1998). Semaphorin-neuropilin interactions underlying sympathetic axon responses to class III semaphorins. Neuron 21, 1283-1290.
9. Comeau, M. R., Johnson, R., DuBose, R. F., Petersen, M., Gearing, P., VandenBos, T., Park, L., Farrah, T., Buller, R. M., Cohen, J. I. et al. (1998). A poxvirus-encoded semaphorin induces cytokine production from monocytes and binds to a novel cellular semaphorin receptor, VESPR. Immunity 8, 473-482.
10. Delaire, S., Billard, C., Tordjman, R., Chedotal, A., Elhabazi, A., Bensussan, A., and Boumsell, L. (2001). Biological activity of soluble CD100. II. Soluble CD100, similarly to H-SemaIII, inhibits immune cell migration. J. Immunol. 166, 4348-4354.
11. Delaire, S., Elhabazi, A., Bensussan, A., and Boumsell, L. (1998). CD100 is a leukocyte semaphorin. Cell Mol. Life Sci. 54, 1265-1276.
12. Doody, G. M., Justement, L. B., Delibrias, C. C., Matthews, R. J., Lin, J., Thomas, M. L., and Fearon, D. T. (1995). A role in B cell activation for CD22 and the protein tyrosine phosphatase SHP. Science 269, 242-244.
13. Elhabazi, A., Delaire, S., Bensussan, A., Boumsell, L., and Bismuth, G. (2001). Biological activity of soluble CD100. I. The extracellular region of CD100 is released from the surface of T lymphocytes by regulated proteolysis. J. Immunol. 166, 4341-4347.
14. Elhabazi, A., Lang, V., Herold, C., Freeman, G. J., Bensussan, A., Boumsell, L., and Bismuth, G. (1997). The human semaphorin-like leukocyte cell surface molecule CD100 associates with a serine kinase activity. J. Biol. Chem. 272, 23515-23520.
15. Ensser, A., and Fleckenstein, B. (1995). Alcelaphine herpesvirus type 1 has a semaphorin-like gene. J. Gen. Virol. 76, 1063-1067.
16. Furuyama, T., Inagaki, S., Kosugi, A., Noda, S., Saitoh, S., Ogata, M., Iwahashi, Y., Miyazaki, N., Hamaoka, T., and Tohyama, M. (1996). Identification of a novel transmembrane semaphorin expressed on lymphocytes. J. Biol. Chem. 271, 33376-33381.
17. Giger, R. J., and Kolodkin, A. L. (2001). Silencing the siren: guidance cue hierarchies at the CNS midline. Cell 105, 1-4.
18. Gordon, J. (1994). B-cell signalling via the C-type lectins CD23 and CD72. Immunol. Today 15, 411-417.
19. Gordon, J., Katira, A., Strain, A. J., and Gillis, S. (1991). Inhibition of interleukin 4-promoted CD23 production in human B lymphocytes by transforming growth factor-beta, interferons or anti-CD19 antibody is overridden on engaging CD40. Eur. J. Immunol. 21, 1917-1922.
20. Grunwald, I. C., and Klein, R. (2002). Axon guidance: receptor complexes and signaling mechanisms. Curr. Opin. Neurobiol, 12, 250-259.
21. Hall, K. T., Boumsell, L., Schultze, J. L., Boussiotis, V. A., Dorfman, D. M., Cardoso, A. A., Bensussan, A., Nadler, L. M., and Freeman, G. J. (1996). Human CD100, a novel leukocyte semaphorin that promotes B-cell aggregation and differentiation. Proc. Natl. Acad. Sci. USA A93, 11780-11785.
22. He, Z., and Tessier-Lavigne, M. (1997). Neuropilin is a receptor for the axonal chemorepellent Semaphorin III. Cell 90, 739-751.
23. Herold, C., Bismuth, G., Bensussan, A., and Boumsell, L. (1995). Activation signals are delivered through two distinct epitopes of CD100, a unique 150 kDa human lymphocyte surface structure previously defined by BB18 mAb. Int. Immunol. 7, 1-8.
24. Herold, C., Elhabazi, A., Bismuth, G., Bensussan, A., and Boumsell, L. (1996). CD100 is associated with CD45 at the surface of human T lymphocytes. Role in T cell homotypic adhesion. J. Immunol. 157, 5262-5268,
25. Holmes, S., Downs, A., Fosberry, A., Hayes, P., Michalovich, D., Murdoch, P., Moores, K., Fox, J., Deen, K., Pettman, G., Wattam, T., and Lewis, C. (2002). Sema7A is a Potent Monocyte Stimulator. Scand. J. Immunol, 56, 270-275.
26. Kitsukawa, T., Shimono, A., Kawakami, A., Kondoh, H., and Fujisawa, H. (1995). Overexpression of a membrane protein, neuropilin, in chimeric mice causes anomalies in the cardiovascular system, nervous system and limbs. Development 121, 4309-4318.
27. Kolodkin, A. L., Levengood, D. V., Rowe, E. G., Tai, Y. T., Giger, R. J., and Ginty, D. D. (1997). Neuropilin is a semaphorin III receptor. Cell 90, 753-762.
28. Kolodkin, A. L., Matthes, D. J., and Goodman, C. S. (1993). The semaphorin genes encode a family of transmembrane and secreted growth cone guidance molecules. Cell 75, 1389-1399.
29. Kolodkin, A. L., Matthes, D. J., O'Connor, T. P., Patel, N. H., Bentley, D., and Goodman, C. S. (1992). Fascilin IV: sequence, expression, and function during growth cone guidance in the grasshopper embryo. Neuron 9, 831-845.
30. Koppel, A. M., Feiner, L., Kobayashi, H., and Raper, J. A. (1997). A 70 amino acid region within the semaphorin domain activates specific cellular response of semaphorin family members. Neuron 19, 531-537.
31. Koppel, A. M., and Raper, J. A. (1998). Collapsin-1 covalently dimerizes, and dimerization is necessary for collapsing activity. J. Biol. Chem. 273, 15708-15713.
32. Kumanogoh, A., and Kikutani, H. (2001). The CD100-CD72 interaction: a novel mechanism of immune regulation. Trends Immunol. 22, 670-676.
33. Kumanogoh, A., Marukawa, S., Suzuki, K., Takegahara, N., Watanabe, C., Ch'ng, E., Ishida, I., Fujimura, H., Sakoda, S., Yoshida, K., and Kikutani, H. (2002a). Class IV semaphorin Sema4A enhances T-cell activation and interacts with Tim-2. Nature 419, 629-633.
34. Kumanogoh, A., Suzuki, K., Ch'ng, E., Watanabe, C., Marukawa, S., Takegahara, N., Ishida, I., Sato, T., Habu, S., Yoshida, K., and Kikutani, H. (2002b). Requirement for the lymphocyte semaphorin, CD100, in the induction of antigen-specific T cells and the maturation of dendritic cells. J. Immunol. 169, 1175-1181.
35. Kumanogoh, A., Watanabe, C., Lee, I., Wang, X., Shi, W., Araki, H., Hirata, H., Iwahori, K., Uchida, J., Yasui, T., Matsumoto, M., Yoshida, K., Yakura, H., Pan, C., Parnes, J. R., and Kikutani, H. (2000). Identification of CD72 as a lymphocyte receptor for the class IV semaphorin CD100: a novel mechanism for regulating B cell signaling. Immunity 13, 621-631.
36. Luo, Y., Raible, D., and Raper, J. A. (1993). Collapsin: a protein in brain that induces the collapse and paralysis of neuronal growth cones. Cell 75, 217-227.
37. Maestrini, E., Tamagnone, L., Longati, P., Cremona, O., Bione, S., Tamanini, F., Neel, B. G., Toniolo, D., and Comoglio, P. M. (1996), A family of transmembrane proteins with homology to the MET-hepatocyte growth factor receptor. Proc. Natl. Acad. Sci. USA 93, 674-678.
38. McIntire, J. J., Umetsu, S. E., Akbari, O., Potter, M., Kuchroo, V. K., Barsh, G. S., Freeman, G. J., Umetsu, D. T., and DeKruyff, R. H. (2001). Identification of Tapr (an airway hyperreactivity regulatory locus) and the linked Tim gene family, Nat. Immunol. 2, 1109-1116.
39. Monney, L., Sabatos, C. A., Gaglia, J. L., Ryu, A., Waldner, H., Chernova, T., Manning, S., Greenfield, E. A., Coyle, A. J., Sobel, R. A. et al. (2002). Th1-specific cell surface protein Tim-3 regulates macrophage activation and severity of an autoimmune disease. Nature 415, 536-541.
40. Mudad, R., Rao, N., Angelisova, P., Horejsi, V., and Telen, M. J. (1995). Evidence that CDw108 membrane protein bears the JMH blood group antigen. Transfusion 35, 566-570.
41. Nakayama, E., von Hoegen, I., and Parnes, J. R. (1989), Sequence of the Lyb-2 B-cell differentiation antigen defines a gene superfamily of receptors with inverted membrane orientation. Proc. Natl. Acad. Sci. USA 86, 1352-1356.
42. Pan, C., Baumgarth, N., and Parnes, J. R. (1999). CD72-deficient mice reveal nonredundant roles of CD72 in B cell development and activation. Immunity 11, 495-506.
43. Perrot, V., Vazquez-Prado, J., and Gutkind, J. S. (2002). Plexin B regulates Rho through the guanine nucleotide exchange factors Leukemia-associated RhoGEF (LARG) and PDZ-RhoGEF. J. Biol. Chem 277, 43115-43120.
44. Puschel, A. W., Adams, R. H., and Betz, H. (1995). Murine semaphorin D/collapsin is a member of a diverse gene family and creates domains inhibitory for axonal extension. Neuron 14, 941-948.
45. Raper, J. A. (2000). Semaphorins and their receptors in vertebrates and invertebrates. Curr. Opin. Neurobiol. 10, 88-94.
46. Sekido, Y., Bader, S., Latif, F., Chen, J. Y., Duh, F. M., Wei, M. H., Albanesi, J. P., Lee, C. C., Lerman, M. I., and Minna, J. D. (1996). Human semaphorins A(V) and IV reside in the 3p21.3 small cell lung cancer deletion region and demonstrate distinct expression patterns. Proc. Natl. Acad. Sci. USA 93, 4120-4125.
47. Semaphorin Nomenclature Committee (1999). Unified nomenclature for the semaphorins/collapsins. Cell 97, 551-552.
48. Shi, W., Kumanogoh, A., Watanabe, C., Uchida, J., Wang, X., Yasui, T., Yukawa, K., Ikawa, M., Okabe, M., Parnes, J. R., Yoshida, K., and Kikutani, H. (2000). The class IV semaphorin CD100 plays nonredundant roles in the immune system: defective B and T cell activation in CD100-deficient mice. Immunity 13, 633-642.
49. Soker, S., Takashima, S., Miao, H. Q., Neufeld, G., and Klagsbrun, M. (1998). Neuropilin-1 is expressed by endothelial and tumor cells as an isoform-specific receptor for vascular endothelial growth factor. Cell 92, 735-745.
50. Spriggs, M. K. (1999). Shared resources between the neural and immune systems: semaphorins join the ranks. Curr. Opin. Immunol. 11, 387-391.
51. Steward, O. (2002). Translating axon guidance cues. Cell 110, 537.
52. Subbarao, B., Morris, J., and Baluyut, A. R. (1988). Properties of anti-Lyb-2-mediated B-cell activation and the relationship between Lyb-2 molecules and receptors for B-cell stimulatory factor-1 on murine B lymphocytes. Cell Immunol. 112, 329-342.
53. Subbarao, B., and Mosier, D. E. (1984). Activation of B lymphocytes by monovalent anit-Lyb-2 antibodies. J. Exp. Med. 159, 1796-1801.
54. Takahashi, T., Fournier, A., Nakamura, F., Wang, L. H., Murakami, Y., Kalb, R. G., Fujisawa, H., and Strittmatter, S. M. (1999). Plexin-neuropilin-1 complexes form functional semaphorin-3A receptors. Cell 99, 59-69.
55. Takahashi, T., and Strittmatter, S. M. (2001). Plexina1 autoinhibition by the plexin sema domain. Neuron 29, 429-439.
56. Tamagnone, L., Artigiani, S., Chen, H., He, Z., Ming, G. I., Song, H., Chedotal, A., Winberg, M. L., Goodman, C. S., Poo, M., Tessier-Lavigne, M., and Comoglio, P. M. (1999). Plexins area large family of receptors for transmembrane, secreted, and GPI-anchored semaphorins in vertebrates. Cell 99, 71-80.
57. Tamagnone, L., and Comoglio, P. M. (2000), Signalling by semaphorin receptors: cell guidance and beyond. Trends Cell Biol. 10, 377-383.
58. Tessier-Lavigne, M., and Goodman, S. C. (1996). The molecular biology of axon guidance. Science 274, 1123-1133.
59. Tordjman, R., Lepelletier, Y., Lemarchandel, V., Cambot, M., Gaulard, P., Hermine, O., and Romeo, P. H. (2002). A neuronal receptor, neuropilin-1, is essential for the initiation of the primary immune response. Nat. Immunol. 3, 477-482.
60. van der Merwe, P. A., Bodian, D. L., Daenke, S., Linsley, P., and Davis, S. J. (1997), CD80 (B7-1) binds to both CD28 and CTLA-4 with a low affinity and very fast kinetics. J. Exp. Med. 185, 393-403.
61. Venkataraman, C., Lu, P. J., Buhl, A. M., Chen, C. S., Cambier, J. C., and Bondada, S. (1998a). CD72-mediated B cell activation involves recruitment of CD19 and activation of phosphatidylinositol 3-kinase. Eur. J. Immunol. 28, 3003-3016.
62. Venkataraman, C., Muthusamy, N., Muthukkumar, S., and Bondada, S. (1998b). Activation of lyn, blk, and btk but not syk in CD72-stimulated B lymphocytes. J. Immunol. 160, 3322-3329.
63. Vikis, H. G., Li, W., He, Z., and Guan, K. L. (2000). The semaphorin receptor plexin-B1 specifically interacts with active Rac in a ligand-dependent manner. Proc. Natl. Acad. Sci. USA 97, 12457-12462.
64. Von Hoegen, I., Nakayama, E., and Parnes, J. R. (1990). Identification of a human protein homologous to the mouse Lyb-2 B cell differentiation antigen and sequence of the corresponding cDNA. J. Immunol. 144, 4870-4877.
65. Wang, X., Kumanogoh, A., Watanabe, C., Shi, W., Yoshida, K., and Kikutani, H. (2001). Functional soluble CD100/Sema4D released from activated lymphocytes: possible role in normal and pathologic immune responses. Blood 97, 3498-3504.
66. Watanabe, C., Kumanogoh, A., Shi, W., Suzuki, K., Yamada, S., Okabe, M., Yoshida, K., and Kikutani, H. (2001). Enhanced immune responses in transgenic mice expressing a truncated form of the lymphocyte semaphorin CD100. J. Immunol. 167, 4321-4328.
67. Winberg, M. L., Noordermeer, J. N., Tamagnone, L., Comoglio, P. M., Spriggs, M. K., Tessier-Lavigne, M., and Goodman, C. S. (1998). Plexin A is a neuronal semaphorin receptor that controls axon guidance. Cell 95, 903-916.
68. Xu, X., Ng, S., Wu, Z. L., Nguyen, D., Homburger, S., Seidel-Dugan, C., Ebens, A., and Luo, Y. (1998). Human semaphorin K1 is glycosylphosphatidylinositol-linked and defines a new subfamily of viral-related semaphorins. J. Biol. Chem. 273, 22428-22434.
69. Yakura, H., Kawabata, I., Ashida, T., Shen, F. W., and Katagiri, M. (1986). A role for Lyb-2 in B cell activation mediated by a B cell stimulatory factor. J. Immunol. 136, 1475-1481.
70. Yakura, H., Shen, F. W., Bourcet, E., and Boyse, E. A. (1982). Evidence that Lyb-2 is critical to specific activation of B cells before they become responsive to T cell and other signals. J. Exp. Med. 155, 1309-1316.
71. Yamada, A., Kubo, K., Takeshita, T., Harashima, N., Kawano, K., Mine, T., Sagawa, K., Sugamura, K., and Itoh, K. (1999). Molecular cloning of a glycosylphosphatidyhnositol-anchored molecule CDw108. J. Immunol. 162, 4094-4100.
72. Yu, H. H., and Kolodkin, A. L. (1999). Semaphorin signaling: a little less per-plexin. Neuron 22, 11-14.