Interleukin-4 inhibits platelet-derived growth factor-induced preadipocyte proliferation

Cytokine

Volumn 25, Issue 2, 2004, Pages 61-67

  Hua, Kunjie ^a   Deng, Jianbei ^a   Harp, Joyce B ^a  

^a IL   (United States)

Author keywords

3T3 L1 cells; AKT; IL 4 receptor; STAT3; STAT6

Indexed keywords

INTERLEUKIN 4; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PLATELET DERIVED GROWTH FACTOR; PROTEIN KINASE B; SERINE; STAT3 PROTEIN; STAT6 PROTEIN;

ADIPOCYTE; ANIMAL CELL; ARTICLE; CELL DIFFERENTIATION; CELL GROWTH; CELL LINE; CELL PROLIFERATION; CELL STRAIN 3T3; CELL TYPE; CONTROLLED STUDY; ELECTROPHORETIC MOBILITY; EMBRYO CELL; FIBROBLAST; MOUSE; NONHUMAN; PHOSPHORYLATION; PRIORITY JOURNAL; PROADIPOCYTE; PROTEIN EXPRESSION; RECEPTOR DOWN REGULATION;

EID: 0346250843     PISSN: 10434666     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cyto.2003.09.008     Document Type: Article

References (32)

1. Bachmeier M., Löffler G. Influence of growth factors on growth and differentiation of 3T3-L1 preadipocytes in serum-free conditions. Eur J Cell Biol. 68:1995;323-329.
2. Schmidt W., Poll-Jordon G., Loffler G. Adipose conversion of 3T3-L1 cells in a serum-free culture system depends on epidermal growth factor, insulin-like growth factor 1, corticosterone, and cyclic AMP. J Biol Chem. 265:1990;15489-15495.
3. Hauner H., Röhrig K., Petruschke T. Effects of epidermal growth factor (EGF), platelet-derived growth factor (PDGF) and fibroblast growth factor (FGF) on human development and function. Eur J Clin Invest. 25:1995;90-95.
4. Green H., Meuth M. An established pre-adipose cell line and its differentiation in culture. Cell. 3:1974;127-133.
5. Green H., Kehinde O. Spontaneous heritable changes leading to increased adipose conversion in 3T3 cells. Cell. 7:1976;105-113.
6. Rosen E.D., Walkey C.J., Puigserver P., Spiegelman B.M. Transcriptional regulation of adipogenesis. Genes Dev. 14:2000;1293-1307.
7. MacDougald O.A., Lane M.D. Transcriptional regulation of gene expression during adipocyte differentiation. Annu Rev Biochem. 64:1995;345-373.
8. Stephens J.M., Morrison R.F., Pilch P.F. The expression and regulation of STATs during 3T3-L1 adipocyte differentiation. J Biol Chem. 271:1996;10441-10444.
9. Stephens J.M., Morrison R.F., Wu Z., Farmer S.R. PPAR gamma ligand-dependent induction of STAT1, STAT5A, and STAT5B during adipogenesis. Biochem Biophys Res Commun. 262:1999;216-222.
10. Deng J., Hua K., Lesser S.S., Harp J.B. Activation of STAT3 during proliferative phases of 3T3-L1 adipogenesis. Endocrinology. 141:2000;2370-2376.
11. Harp J.B., Franklin D., Vanderpujie A.A., Gimble J.M. Differential expression of signal transducers and activators of transcription during human adipogenesis. Biochem Biophys Res Commun. 281:2001;907-912.
12. Deng J., Hua K., Lesser S.S., Greiner A.H., Walter A.W., Marrero M.B., et al. Interleukin-4 mediates STAT6 activation in 3T3-L1 preadipocytes but not adipocyte. Biochem Biophys Res Commun. 267:2000;516-520.
13. Ohmori Y., Hamilton T.A. STAT6 is required for the anti-inflammatory activity of interleukin-4 in mouse peritoneal macrophages. J Biol Chem. 273:1998;29202-29209.
14. Nelms K., Huang H., Ryan J., Keegan A., Paul W.E. Interleukin-4 receptor signaling mechanisms and their biological significance. Adv Exp Med Biol. 452:1998;37-43.
15. Trautmann A., Krohne G., Brocker E.B., Klein C.E. Human mast cells augment fibroblast proliferation by heterotypic cell-cell adhesion and action of IL-4. J Immunol. 160:1998;5053-5057.
16. Hawker K.M., Johnson P.R.A., Highes J.M., Black J.L. Interleukin-4 inhibits mitogen-induced proliferation of human airway smooth muscle cells in culture. Am J Physiol. 275:1998;L469-L477.
17. Huang J., Welch J.S., Ricote M., Binder C.J., Willson T.M., Kelly C., et al. Interleukin-4-dependent production of PPAR-gamma ligands in macrophages by 12/15-lipoxygenase. Nature. 400:1999;378-382.
18. Hou J., Schindler U., Henzel W.J., Ho T.C., Brasseur M., McKnight S.L. An interleukin-4-induced transcription factor: IL-4 Stat. Science. 265:1994;1701-1706.
19. Quelle F.W., Shimoda K., Thierfelder W., Fischer C., Kim A., Ruben S.M., et al. Cloning of murine Stat6 and human Stat6, Stat proteins that are tyrosine phosphorylated in responses to IL-4 and IL-3 but are not required for mitogenesis. Mol Cell Biol. 15:1995;3336-3343.
20. Friedman J. The function of leptin in nutrition, weight, and physiology. Nutr Rev. 60:2002;S1-S14.
21. Martin-Romero C., Santos-Alvarez J., Goberna R., Sanchez-Margalet V. Human leptin enhances activation and proliferation of human circulating T lymphocytes. Cell Immunol. 199:2000;15-24.
22. Lord G.M., Matarese G., Howard J.K., Baker R.J., Bloom S.R., Lechler R.I. Leptin modulates the T-cell immune response and reverses starvation-induced immunosuppression. Nature. 394:1998;897-901.
23. Farooqi I.S., Matarese G., Lord G.M., Keogh J.M., Lawrence E., Agwu C., et al. Beneficial effects of leptin on obesity, T cell hyporesponsiveness, and neuroendocrine/metabolic dysfunction of human congenital leptin deficiency. J Clin Invest. 110:2002;1093-1103.
24. Ozata M., Ozdemir I.C., Licinio J. Human leptin deficiency caused by a missense mutation: multiple endocrine defects, decreased sympathetic tone, and immune system dysfunction indicate new targets for leptin action, greater central than peripheral resistance to the effects of leptin, and spontaneous correction of leptin-mediated defects. J Clin Endocrinol Metab. 84:1999;3686-3695.
25. Patel B.K.R., Wang L.-M., Lee C.-C., Taylor W.G., Pierce J.H., LaRochelle W.J. Stat6 and Jak1 are common elements in platelet-derived growth factor and interleukin-4 signal transduction pathways in NIH 3T3 fibroblast. J Biol Chem. 271:1996;22175-22182.
26. Shigematsu S., Miller S.L., Pessin J.E. Differentiated 3T3L1 adipocytes are composed of heterogenous cell populations with distinct receptor tyrosine kinase signaling properties. J Biol Chem. 276:2001;15292-15297.
27. Quandt K., Frech K., Karas H., Wingender E., Werner T. MatInd and MatInspector - new fast and versatile tools for detection of consensus matches in nucleotide sequence data. Nucleic Acids Res. 23:1995;4878-4884.
28. Darlington G.J., Ross S.E., MacDougald O.A. The role of C/EBP genes in adipocyte differentiation. J Biol Chem. 273:1998;30057-30060.
29. Patel B.K.R., Pierce J.H., LaRochelle W.J. Regulation of interleukin 4-mediated signaling by naturally occurring dominant negative and attenuated forms of human Stat6. Proc Natl Acad Sci U S A. 95:1998;172-177.
30. Rosen E., Hsu C.-H., Wang X., Sakai S., Freeman M.W., Gonzalez F.J., et al. C/EBP induces adipogenesis through PPAR: a unified pathway. Genes Dev. 16:2002;22-26.
31. Krieger-Brauer H., Kather H. Antagonistic effects of different members of the fibroblast and platelet-derived growth factor families on adipose conversion and NADPH-dependent H2O2 generation in 3T3 L1-cells. Biochem J. 307:1995;549-556.
32. Laemmli U.K. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature. 227:1970;680-685.