Left-right asymmetry: Notch acts upstream of Nodal;Mise en place de l'asymétrie droite-gauche: Notch et Nodal dans le nœud embryonnaire

Medecine/Sciences

Volumn 19, Issue 12, 2003, Pages 1188-1190

  Vincent, Stéphane ^a  

^a UNIVERSITÉ DE LYON   (France)

Author keywords

[No Author keywords available]

Indexed keywords

CELL PROTEIN; DELTA SERRATA LAG2 PROTEIN; MEMBRANE RECEPTOR; NOTCH RECEPTOR; PROTEIN LEFTY1; PROTEIN NODAL; TRANSFORMING GROWTH FACTOR BETA; UNCLASSIFIED DRUG;

ALLELE; CELL COMPARTMENTALIZATION; CELL POLARITY; DROSOPHILA; EMBRYO DEVELOPMENT; GENE EXPRESSION REGULATION; GENE MUTATION; HUMAN; LIGAND BINDING; NOTE; PROTEIN DOMAIN; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION; SOMITE;

EID: 0346216872     PISSN: 07670974     EISSN: None     Source Type: Journal    
DOI: 10.1051/medsci/200319121188     Document Type: Note

References (11)

1. Hamada H, Meno C, Watanabe D, Saijoh Y. Establishment of vertebrate left-right asymmetry. Nat Rev Genet 2002; 3: 103-13.
2. Przemeck GK, Heinzmann U, Beckers J, Hrabe de Angelis M. Node and midline defects are associated with left-right development in Delta1 mutant embryos. Development 2003; 130: 3-13.
3. Krebs LT, Iwai N, Nonaka S, et al. Notch signaling regulates left-right assymmetry determination by inducing Nodal expression. Genes Dev 2003; 17: 1207-12.
4. Raya A, Kawakami Y, Rodriguez-Esteban C, et al. Notch activity induces Nodal expression and mediates the establishment of left-right asymmetry in vertebrate embryos. Genes Dev 2003; 17: 1213-8.
5. Mumm JS, Kopan R. Notch signaling: from the outside in. Dev Biol 2000; 228: 151-65.
6. Brennan J, Norris DP, Robertson EJ. Nodal activity in the node governs left-right asymmetry. Genes Dev 2002; 16: 2339-44.
7. Saijoh Y, Oki S, Ohishi S, Hamada H. Left-right patterning of the mouse lateral plate requires nodal produced in the node. Dev Biol 2003; 256: 160-72.
8. Yamamoto M, Mine N, Mochida K, et al. Nodal signaling induces the midline barrier by activating Nodal expression in the lateral plate. Development 2003; 130: 1795-804.
9. Norris DP, Robertson EJ, Asymmetric and node-specific nodal expression patterns are controlled by two distinct cis-acting regulatory elements. Genes Dev 1999; 13: 1575-88.
10. Adachi H, Saijoh Y, Mochida K, et al. Determination of left/right asymmetric expression of nodal by a left side-specific enhancer with sequence similarity to a lefty-2 enhancer. Genes Dev 1999; 13: 1589-600.
11. Zhang N, Gridley T. Defects in somite formation in lunatic fringe-deficient mice. Nature 1998; 394: 374-7.