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Volumn 21, Issue 4, 2003, Pages 277-292

CVT-510: A Selective A1 Adenosine Receptor Agonist

Author keywords

Adenosine; Adenosine receptors; Antiarrhythmics; Arrhythmia; Cardiovascular diseases; CVT 510 ; Tachycardia, supraventricular

Indexed keywords

2 [4 (2 CARBOXYETHYL)PHENETHYLAMINO]ADENOSINE 5' (N ETHYLCARBOXAMIDE); ADENOSINE; ADENOSINE A1 RECEPTOR; ADENOSINE A1 RECEPTOR AGONIST; ADENOSINE A2A RECEPTOR; ADENOSINE A2B RECEPTOR; ADENOSINE A3 RECEPTOR; AMINOPHYLLINE; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; CALCIUM CHANNEL BLOCKING AGENT; CVT 2759; DILTIAZEM; ISOPRENALINE; LIGAND; N(G) METHYLARGININE; NUCLEOSIDE; RADIOLIGAND; RECEPTOR SUBTYPE; TECADENOSON; UNCLASSIFIED DRUG; VERAPAMIL;

EID: 0346158489     PISSN: 08975957     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1527-3466.2003.tb00122.x     Document Type: Review
Times cited : (19)

References (70)
  • 1
    • 0028892557 scopus 로고
    • Role of nitric oxide in adenosine receptor-mediated relaxation of porcine coronary artery
    • Abebe W, Hussain T, Olanreqaju H, Mustafa SI. Role of nitric oxide in adenosine receptor-mediated relaxation of porcine coronary artery. Am J Physiol 1995;269:H1672-H1678.
    • (1995) Am J Physiol , vol.269
    • Abebe, W.1    Hussain, T.2    Olanreqaju, H.3    Mustafa, S.I.4
  • 2
    • 0023780277 scopus 로고
    • Ionic mechanisms of adenosine actions in pacemaker cells from the rabbit heart
    • Belardinelli L, Giles WR, West A. Ionic mechanisms of adenosine actions in pacemaker cells from the rabbit heart. J Physiol 1988;405:615-633.
    • (1988) J Physiol , vol.405 , pp. 615-633
    • Belardinelli, L.1    Giles, W.R.2    West, A.3
  • 3
    • 0020759724 scopus 로고
    • Isolated atrial myocytes: Adenosine and acetylcholine increase potassium conductance
    • Belardinelli L, Isenberg G. Isolated atrial myocytes: adenosine and acetylcholine increase potassium conductance. Am J Physiol 1983;244:H734-H737.
    • (1983) Am J Physiol , vol.244
    • Belardinelli, L.1    Isenberg, G.2
  • 4
    • 0342440735 scopus 로고
    • Adenosine regulation of cardiac electrical activity
    • Zipes DP, Jalife J, Eds. Philadelphia: WB Saunders Co
    • Belardinelli L, Wu S-N, Visentin S. Adenosine regulation of cardiac electrical activity. In: Zipes DP, Jalife J, Eds. Cardiac electrophysiology: From cell to bedside. Philadelphia: WB Saunders Co, 1990; 344-353.
    • (1990) Cardiac Electrophysiology: From Cell to Bedside , pp. 344-353
    • Belardinelli, L.1    Wu, S.-N.2    Visentin, S.3
  • 5
    • 0028910425 scopus 로고
    • Ionic basis of the electrophysiological actions of adenosine on cardiomyocytes
    • Belardinelli L, Shryrock JC, Song Y, Wang D, Srinivas M. Ionic basis of the electrophysiological actions of adenosine on cardiomyocytes. FASEB J 1995;9:359-365.
    • (1995) FASEB J , vol.9 , pp. 359-365
    • Belardinelli, L.1    Shryrock, J.C.2    Song, Y.3    Wang, D.4    Srinivas, M.5
  • 6
    • 0022968939 scopus 로고
    • Cardiovascular effects of adenosine infusion in man and their modulation by dipyridamole
    • Biaggioni I, Onrot J, Hollister A, Robertson D. Cardiovascular effects of adenosine infusion in man and their modulation by dipyridamole. Life Sci 1986;39:2229-2236.
    • (1986) Life Sci , vol.39 , pp. 2229-2236
    • Biaggioni, I.1    Onrot, J.2    Hollister, A.3    Robertson, D.4
  • 8
    • 0024473768 scopus 로고
    • 1 adenosine receptors in atrial and ventricular myocardium from disease human hearts
    • 1 adenosine receptors in atrial and ventricular myocardium from disease human hearts. Circ Res 1989;65:1201-1211.
    • (1989) Circ Res , vol.65 , pp. 1201-1211
    • Bohm, M.1    Pieske, B.2    Ungerer, M.3    Erdmann, E.4
  • 10
    • 0025103219 scopus 로고
    • Role of adenosine in pathogenesis of anginal pain
    • Crea F, Pupita G, Galassi AR, et al. Role of adenosine in pathogenesis of anginal pain. Circulation 1990;81:164-172.
    • (1990) Circulation , vol.81 , pp. 164-172
    • Crea, F.1    Pupita, G.2    Galassi, A.R.3
  • 12
    • 0025345730 scopus 로고
    • Adenosine for paroxysmal supraventricular tachycarida: Dose ranging and comparison with verapamil. Assessment in placebo-controlled, multicenter trials
    • The Adenosine for PSVT Study Group
    • DiMarco JP, Miles W, Akhtar M, et al. Adenosine for paroxysmal supraventricular tachycarida: Dose ranging and comparison with verapamil. Assessment in placebo-controlled, multicenter trials. The Adenosine for PSVT Study Group. Ann Intern Med 1990;113:104-10.
    • (1990) Ann Intern Med , vol.113 , pp. 104-110
    • DiMarco, J.P.1    Miles, W.2    Akhtar, M.3
  • 13
    • 0003349952 scopus 로고
    • Adenosine and digoxin
    • Zipes DP, Jalife J, Eds. Philadelphia: WB Saunders Co
    • DiMarco JP. Adenosine and digoxin. In: Zipes DP, Jalife J, Eds. Cardiac electrophysiology: From cell to bedside. Philadelphia: WB Saunders Co, 1990;933-938.
    • (1990) Cardiac Electrophysiology: From Cell to Bedside , pp. 933-938
    • DiMarco, J.P.1
  • 14
    • 84940815279 scopus 로고
    • The physiological activity of adenine compounds with especial reference to their action on the mammalian heart
    • Drury AN, Szent-Geörgyi A. The physiological activity of adenine compounds with especial reference to their action on the mammalian heart. J Physiol 1929;68:213-237.
    • (1929) J Physiol , vol.68 , pp. 213-237
    • Drury, A.N.1    Szent-Geörgyi, A.2
  • 15
    • 0141715360 scopus 로고    scopus 로고
    • A randomized, double-blind, placebo-controlled study of intravenous Tecadenoson in patients with PSVT undergoing an electrophysiologic study: Trial to Evaluate the Management of PSVT during Electrophysiologic Study with Tecadenoson (TEMPEST)
    • Abstract
    • Ellenbogen K and the TEMPEST Study Group from the Medical College of Virginia, Richmond. A randomized, double-blind, placebo-controlled study of intravenous Tecadenoson in patients with PSVT undergoing an electrophysiologic study: Trial to Evaluate the Management of PSVT during Electrophysiologic Study with Tecadenoson (TEMPEST). Circulation 2002;106:2986A (Abstract).
    • (2002) Circulation , vol.106
    • Ellenbogen, K.1
  • 16
    • 0347539686 scopus 로고    scopus 로고
    • TEMPEST (Trial to Evaluate the Management of PSVT [Paroxysmal Supraventricular Tachycardia] during Electrophysiology)
    • Abstract
    • Ellenbogen K. TEMPEST (Trial to Evaluate the Management of PSVT [Paroxysmal Supraventricular Tachycardia] during Electrophysiology). Clin Cardiol 2003;26:100-101 (Abstract).
    • (2003) Clin Cardiol , vol.26 , pp. 100-101
    • Ellenbogen, K.1
  • 17
    • 0028176297 scopus 로고
    • cAMP and beta gamma subunits of heterotrimeric G proteins stimulate the mitogen-activated protein kinase pathway in COS-7 cells
    • Faure M, Voyno-Yasenetskaya TA, and Bourne HR. cAMP and beta gamma subunits of heterotrimeric G proteins stimulate the mitogen-activated protein kinase pathway in COS-7 cells. J Biol Chem 1994;269:7851.
    • (1994) J Biol Chem , vol.269 , pp. 7851
    • Faure, M.1    Voyno-Yasenetskaya, T.A.2    Bourne, H.R.3
  • 18
    • 0028972108 scopus 로고
    • 2B receptors evoke interleukin-8 secretion in human mast cells. An enprofylline-sensitive mechanism with implications for asthma
    • 2B receptors evoke interleukin-8 secretion in human mast cells. An enprofylline-sensitive mechanism with implications for asthma. J Clin Invest 1995;96:1979-1986.
    • (1995) J Clin Invest , vol.96 , pp. 1979-1986
    • Feoktistov, I.1    Biaggioni, I.2
  • 19
    • 0037382360 scopus 로고    scopus 로고
    • 1 adenosine receptor agonist, antagonizes catecholamine-induced lipolysis without cardiovascular effects in awake rats
    • 1 adenosine receptor agonist, antagonizes catecholamine-induced lipolysis without cardiovascular effects in awake rats. J Pharmacol Exp Ther 2003;305:225-231.
    • (2003) J Pharmacol Exp Ther , vol.305 , pp. 225-231
    • Fraser, H.1    Gao, Z.2    Ozeck, M.J.3    Belardinelli, L.4
  • 20
    • 0035209620 scopus 로고    scopus 로고
    • International union of pharmacology. XXV. Nomenclature and classification of adenosine receptors
    • Fredholm BB, Ijzerman AP, Jacobson KA, Klotz K, Linden J. International union of pharmacology. XXV. Nomenclature and classification of adenosine receptors. Pharmacol Rev 2001;53:527-557.
    • (2001) Pharmacol Rev , vol.53 , pp. 527-557
    • Fredholm, B.B.1    Ijzerman, A.P.2    Jacobson, K.A.3    Klotz, K.4    Linden, J.5
  • 22
    • 0034725754 scopus 로고    scopus 로고
    • Differential expression of a(2a), A(1)-adenosine and D(2)-dopamine receptor genes in rat peripheral arterial chemoreceptors during postnatal development
    • Gauda EB, Northington FJ, Linden J, Rosin DL. Differential expression of a(2a), A(1)-adenosine and D(2)-dopamine receptor genes in rat peripheral arterial chemoreceptors during postnatal development. Brain Res 2000;872:1-10.
    • (2000) Brain Res , vol.872 , pp. 1-10
    • Gauda, E.B.1    Northington, F.J.2    Linden, J.3    Rosin, D.L.4
  • 23
    • 0029069676 scopus 로고
    • Adenosine-induced vasodilation: Receptor characterization in pulmonary circulation
    • Haynes J, Obiako B, Thompson WJ, Downey J. Adenosine-induced vasodilation: Receptor characterization in pulmonary circulation. Am J Physiol 1995;268:H1872-H1868.
    • (1995) Am J Physiol , vol.268
    • Haynes, J.1    Obiako, B.2    Thompson, W.J.3    Downey, J.4
  • 24
    • 0034978548 scopus 로고    scopus 로고
    • Functional and molecular characterization of receptor subtypes mediating coronary microvascular dilation to adenosine
    • Hein TW, Wang W, Zoghi B, Muthuchamy M, Kuo L. Functional and molecular characterization of receptor subtypes mediating coronary microvascular dilation to adenosine. J Mol Cell Cardiol 2001; 33:271-282.
    • (2001) J Mol Cell Cardiol , vol.33 , pp. 271-282
    • Hein, T.W.1    Wang, W.2    Zoghi, B.3    Muthuchamy, M.4    Kuo, L.5
  • 25
    • 0026634634 scopus 로고
    • Adenosine versus verapamil in the treatment of supraventricular tachycardia: A randomized double-crossover trial
    • Hood MA, Smith WM. Adenosine versus verapamil in the treatment of supraventricular tachycardia: A randomized double-crossover trial. Am Heart J 1993;125:1543-1549.
    • (1993) Am Heart J , vol.125 , pp. 1543-1549
    • Hood, M.A.1    Smith, W.M.2
  • 26
    • 0037180526 scopus 로고    scopus 로고
    • Response to adenosine differentiates focal from macroreentrant atrial tachycardia
    • Iwai S, Markowitz SM, Stein K et al. Response to adenosine differentiates focal from macroreentrant atrial tachycardia. Circulation 2002;106:2793-2799.
    • (2002) Circulation , vol.106 , pp. 2793-2799
    • Iwai, S.1    Markowitz, S.M.2    Stein, K.3
  • 28
    • 0030614436 scopus 로고    scopus 로고
    • 2 receptor activation attenuates reperfusion injury by inhibiting neutrophil accumulation, superoxide generation and coronary endothelial adherence
    • 2 receptor activation attenuates reperfusion injury by inhibiting neutrophil accumulation, superoxide generation and coronary endothelial adherence. J Pharmacol Exp Ther 1997;280:301-309.
    • (1997) J Pharmacol Exp Ther , vol.280 , pp. 301-309
    • Jordan, J.E.1    Zhao, Z.-Q.2    Sato, H.3    Taft, S.4    Vinten-Johansen, J.5
  • 30
    • 0022515173 scopus 로고
    • + channels by adenosine in isolated atrial cells: Involvement of GTP-binding proteins
    • + channels by adenosine in isolated atrial cells: Involvement of GTP-binding proteins. Pflüger's Arch 1986;407:264-274.
    • (1986) Pflüger's Arch , vol.407 , pp. 264-274
    • Kurachi, Y.1    Kakajima, T.2    Sugimoto, T.3
  • 31
    • 0022496352 scopus 로고
    • Adenosine-sensitive ventricular tachycardia: Evidence suggesting cyclic AMP-mediated triggered activity
    • Lerman BB, Belardinell L, West GA, Berne RM, Dimarco JP. Adenosine-sensitive ventricular tachycardia: Evidence suggesting cyclic AMP-mediated triggered activity. Circulation 1986;74:270-280.
    • (1986) Circulation , vol.74 , pp. 270-280
    • Lerman, B.B.1    Belardinell, L.2    West, G.A.3    Berne, R.M.4    Dimarco, J.P.5
  • 32
    • 0023187936 scopus 로고
    • Differential electrophysiological properties of decremental retrograde pathways in short RP' tachycardia
    • Lerman BB, Greenberg M, Overhold ED, et al. Differential electrophysiological properties of decremental retrograde pathways in short RP' tachycardia. Circulation 1987;76:21-31.
    • (1987) Circulation , vol.76 , pp. 21-31
    • Lerman, B.B.1    Greenberg, M.2    Overhold, E.D.3
  • 33
    • 0024246222 scopus 로고
    • Antiadrenergic effects of adenosine on His-Purkinje automaticity: Evidence for accentuated antagonism
    • Lerman BB, Wesley RC, DiMarco JP, Haines DE, Berlardinelli L. Antiadrenergic effects of adenosine on His-Purkinje automaticity: Evidence for accentuated antagonism. J Clin Invest 1988;82:2127-2135.
    • (1988) J Clin Invest , vol.82 , pp. 2127-2135
    • Lerman, B.B.1    Wesley, R.C.2    DiMarco, J.P.3    Haines, D.E.4    Berlardinelli, L.5
  • 34
    • 0025819251 scopus 로고
    • Cardiac electrophysiology of adenosine: Basic and clinical concepts
    • Lerman BB, Belardinelli L. Cardiac electrophysiology of adenosine: Basic and clinical concepts. Circulation 1991;83:1499-1509.
    • (1991) Circulation , vol.83 , pp. 1499-1509
    • Lerman, B.B.1    Belardinelli, L.2
  • 37
    • 0032836645 scopus 로고    scopus 로고
    • Characterization of human A(2B) adenosine receptors: Radioligand binding, western blotting, and coupling to G(q) in human embryonic kidney 293 cells and HMC-1 mast cells
    • Linden J, Thai T, Figler H, Jin X, Robeva AS. Characterization of human A(2B) adenosine receptors: Radioligand binding, western blotting, and coupling to G(q) in human embryonic kidney 293 cells and HMC-1 mast cells. Mol Pharmacol 1999;56:705-713.
    • (1999) Mol Pharmacol , vol.56 , pp. 705-713
    • Linden, J.1    Thai, T.2    Figler, H.3    Jin, X.4    Robeva, A.S.5
  • 39
    • 0028533861 scopus 로고
    • 1 receptor blockade on glomerular hemodynamics: Involvement of renin-angiotensin system
    • 1 receptor blockade on glomerular hemodynamics: Involvement of renin-angiotensin system. Am J Physiol 1994;267:F504-F510.
    • (1994) Am J Physiol , vol.267
    • Munger, K.A.1    Jackson, E.K.2
  • 41
    • 0003224190 scopus 로고    scopus 로고
    • 1 adenosine receptor agonist, is associated with fewer arrhythmias than adenosine
    • Abstract
    • 1 adenosine receptor agonist, is associated with fewer arrhythmias than adenosine. Circulation 2001;104:2317A (Abstract).
    • (2001) Circulation , vol.104
    • Niazi, I.1    Bhanson, T.D.2    Lanzerotti, C.3
  • 42
  • 44
    • 0033939473 scopus 로고    scopus 로고
    • Distinct cardioprotective effects of adenosine mediated by differential coupling of receptor subtypes to phospholipases C and D
    • Parsons M, Young L, Lee JE, Jacobson KA, Liang BT. Distinct cardioprotective effects of adenosine mediated by differential coupling of receptor subtypes to phospholipases C and D. FASEB J 2000;14:1423-1431.
    • (2000) FASEB J , vol.14 , pp. 1423-1431
    • Parsons, M.1    Young, L.2    Lee, J.E.3    Jacobson, K.A.4    Liang, B.T.5
  • 45
    • 0035989842 scopus 로고    scopus 로고
    • Adenosine-receptor subtypes: Their relevance to adenosine-mediated responses in asthma and chronic obstructive pulmonary disease
    • Polosa R. Adenosine-receptor subtypes: Their relevance to adenosine-mediated responses in asthma and chronic obstructive pulmonary disease. Eur Respir J 2002;20:488-496.
    • (2002) Eur Respir J , vol.20 , pp. 488-496
    • Polosa, R.1
  • 48
    • 0027337474 scopus 로고
    • 3 adenosine receptor is the unique adenosine receptor which facilitates release of allergic mediators in mast cells
    • 3 adenosine receptor is the unique adenosine receptor which facilitates release of allergic mediators in mast cells. J Biol Chem 1993;268:16887-16890.
    • (1993) J Biol Chem , vol.268 , pp. 16887-16890
    • Ramkumar, V.1    Stiles, G.L.2    Beaven, M.A.3    Ali, H.4
  • 49
    • 0036973951 scopus 로고    scopus 로고
    • Adenosine receptors in the nervous system: Pathophysiological implications
    • Ribeiro JA, Sebastio AM, de Mendonca A. Adenosine receptors in the nervous system: Pathophysiological implications. Progr Neurobiol 2003;68:377-392.
    • (2003) Progr Neurobiol , vol.68 , pp. 377-392
    • Ribeiro, J.A.1    Sebastio, A.M.2    De Mendonca, A.3
  • 54
    • 0030198589 scopus 로고    scopus 로고
    • Adenosine: Potential modulator for vasovagal syncope
    • Shen WK, Hammill SC, Munger TM, et al. Adenosine: Potential modulator for vasovagal syncope. J Am Coll Cardiol 1996;28:146-154.
    • (1996) J Am Coll Cardiol , vol.28 , pp. 146-154
    • Shen, W.K.1    Hammill, S.C.2    Munger, T.M.3
  • 55
    • 0030847083 scopus 로고    scopus 로고
    • Adenosine and adenosine receptors in the cardiovascular system: Biochemistry, physiology and pharmacology
    • Shryock JC, Belardinelli L. Adenosine and adenosine receptors in the cardiovascular system: Biochemistry, physiology and pharmacology. Am J Cardiol 1997;79(12A):2-10.
    • (1997) Am J Cardiol , vol.79 , Issue.12 A , pp. 2-10
    • Shryock, J.C.1    Belardinelli, L.2
  • 56
    • 0347539685 scopus 로고    scopus 로고
    • Adenosine and cardiac arrhythmias
    • Burnstock G, Dobson JG, Liang BT, Linden J, eds. Norwell: Kluwer Academic Publishers Group
    • Slotwiner DJ, Lerman, BB. Adenosine and cardiac arrhythmias. In: Burnstock G, Dobson JG, Liang BT, Linden J, eds. Cardiovascular biology of purines. Norwell: Kluwer Academic Publishers Group, 1998;126-142.
    • (1998) Cardiovascular Biology of Purines , pp. 126-142
    • Slotwiner, D.J.1    Lerman, B.B.2
  • 57
    • 0032589142 scopus 로고    scopus 로고
    • 1 adenosine receptor agonist (CVT-510) with diltiazem for slowing of AV nodal conduction in guinea-pig
    • 1 adenosine receptor agonist (CVT-510) with diltiazem for slowing of AV nodal conduction in guinea-pig. Br J Pharmacol 1999; 126:137-146.
    • (1999) Br J Pharmacol , vol.126 , pp. 137-146
    • Snowdy, S.1    Liang, H.X.2    Blackburn, B.3
  • 58
    • 0028985715 scopus 로고
    • 2b adenosine receptor mediates cAMP responses to adenosine receptor agonists in human intestinal epithelia
    • 2b adenosine receptor mediates cAMP responses to adenosine receptor agonists in human intestinal epithelia. J Biol Chem 1995;270:2387-2394.
    • (1995) J Biol Chem , vol.270 , pp. 2387-2394
    • Strohmeier, G.R.1    Reppert, S.M.2    Lencer, W.I.3    Madara, J.L.4
  • 63
    • 9544240496 scopus 로고
    • F) in single rabbit atrioventricular nodal myocytes
    • Abstract
    • F) in single rabbit atrioventricular nodal myocytes. FASEB J 1984;8:A611 (Abstract).
    • (1984) FASEB J , vol.8
    • Wang, D.1    Belardinelli, L.2
  • 64
    • 0030737752 scopus 로고    scopus 로고
    • Adenosine as an antiarrhythmic agent
    • Wilbur SL, Marchlinski FE. Adenosine as an antiarrhythmic agent. Am J Cardiol 1997;79(12A): 30-37.
    • (1997) Am J Cardiol , vol.79 , Issue.12 A , pp. 30-37
    • Wilbur, S.L.1    Marchlinski, F.E.2
  • 67
    • 0034749394 scopus 로고    scopus 로고
    • Pharmokinetic-pharmacodynamic modeling of the antilipolytic effects of an adenosine receptor agonist in healthy volunteers
    • Zannikos PN, Rohatagi S, Jensen BK. Pharmokinetic-pharmacodynamic modeling of the antilipolytic effects of an adenosine receptor agonist in healthy volunteers. J Clin Pharmacol 2001;41:61-69.
    • (2001) J Clin Pharmacol , vol.41 , pp. 61-69
    • Zannikos, P.N.1    Rohatagi, S.2    Jensen, B.K.3
  • 69
    • 0035985608 scopus 로고    scopus 로고
    • CVT-510 CV Therapeutics
    • Zaza A. CVT-510 CV Therapeutics. Curr Opin Invest Drugs 2002;3:96-100.
    • (2002) Curr Opin Invest Drugs , vol.3 , pp. 96-100
    • Zaza, A.1
  • 70
    • 0033799652 scopus 로고    scopus 로고
    • Antagonism of the positive dromotropic effect of isoproterenol by adenosine: Role of nitric oxide, cGMP-dependent cAMP-phosphodiesterase and protein kinase G
    • Zima A, Martynyuk AE, Seubert CN et al. Antagonism of the positive dromotropic effect of isoproterenol by adenosine: Role of nitric oxide, cGMP-dependent cAMP-phosphodiesterase and protein kinase G. J Mol Cell Cardiol 2000;32:1609-1619.
    • (2000) J Mol Cell Cardiol , vol.32 , pp. 1609-1619
    • Zima, A.1    Martynyuk, A.E.2    Seubert, C.N.3


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