A comparison of an AI adenosine receptor agonist (CVT-510) with diltiazem for slowing of AV nodal conduction in guinea-pig

British Journal of Pharmacology

Volumn 126, Issue 1, 1999, Pages 137-146

  Snowdy, Stephen ^a   Liang, Hui Xiu ^a   Blackburn, Brent ^a   Lum, Robert ^b   Nelson, Marek ^c   Wang, Lisa ^d   Pfister, Miirg ^a   Sharma, Bhavender P ^a   Wolff, Andrew ^b   Belardinelli, Luiz ^c  

^a UNIVERSITY OF FLORIDA COLLEGE OF MEDICINE   (United States)

^b CV THERAPEUTICS INC   (United States)

^c ROCHE BIOSCIENCE   (United States)

^d Telik Inc   (United States)

Author keywords

Action potential; Adenosine; Adenosine agonist; AV node; Coronary vasodilation; Diltiazem; Re entry; Supraventricular tachycardia; Ventricular contractility

Indexed keywords

ADENOSINE; ADENOSINE 5' (N ETHYLCARBOXAMIDE); ADENOSINE RECEPTOR; CALCIUM CHANNEL BLOCKING AGENT; DILTIAZEM; DRUG DERIVATIVE; FURAN DERIVATIVE; N-(3-TETRAHYDROFURANYL)-6-AMINOPURINE RIBOSIDE; TECADENOSON; VASODILATOR AGENT; ADENOSINE A1 RECEPTOR AGONIST; UNCLASSIFIED DRUG;

ACTION POTENTIAL; ANESTHESIA; ANIMAL; ARTICLE; BINDING COMPETITION; BLOOD PRESSURE; COMPARATIVE STUDY; CORONARY ARTERY BLOOD FLOW; CORONARY BLOOD VESSEL; DOSE RESPONSE; DRUG EFFECT; DRUG POTENTIATION; FEMALE; GUINEA PIG; HEART ATRIOVENTRICULAR NODE; HEART ATRIUM; HEART ATRIUM FUNCTION; HEART LEFT VENTRICLE FUNCTION; HEART MUSCLE CONDUCTION SYSTEM; HEART RATE; HEART VENTRICLE; IN VITRO STUDY; INTRAVENOUS DRUG ADMINISTRATION; MALE; METABOLISM; PHYSIOLOGY; SWINE; VASODILATATION; ANIMAL EXPERIMENT; ANIMAL TISSUE; ATRIOVENTRICULAR CONDUCTION; DRUG POTENCY; HEART LEFT VENTRICLE PRESSURE; HEART MUSCLE POTENTIAL; HIS BUNDLE; ISOLATED HEART; MEAN ARTERIAL PRESSURE; NONHUMAN; PR INTERVAL; PRIORITY JOURNAL;

ACTION POTENTIALS; ADENOSINE; ADENOSINE-5'-(N-ETHYLCARBOXAMIDE); ANESTHESIA; ANIMALS; ATRIAL FUNCTION; ATRIOVENTRICULAR NODE; BINDING, COMPETITIVE; BLOOD PRESSURE; CALCIUM CHANNEL BLOCKERS; CORONARY CIRCULATION; CORONARY VESSELS; DILTIAZEM; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; FURANS; GUINEA PIGS; HEART ATRIA; HEART CONDUCTION SYSTEM; HEART RATE; HEART VENTRICLES; INJECTIONS, INTRAVENOUS; MALE; RECEPTORS, PURINERGIC P1; SWINE; VASODILATION; VASODILATOR AGENTS; VENTRICULAR FUNCTION, LEFT;

EID: 0032589142     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0702287     Document Type: Article

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