Measurement of strain-dependent toxicity in the indene bioconversion using multiparameter flow cytometry

Biotechnology and Bioengineering

Volumn 81, Issue 4, 2003, Pages 405-420

  Amanullah, A ^a,c   Hewitt, C J ^b   Nienow, A W ^b   Lee, C ^c   Chartrain, M ^c   Buckland, B C ^c   Drew, S W ^c   Woodley, J M ^a  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

^b UNIVERSITY OF BIRMINGHAM   (United Kingdom)

^c MERCK RESEARCH LABORATORIES   (United States)

Author keywords

Flow cytometry; HIV protease inhibitor; Indene bioconversion; Strain selection; Substrate, product, and by product toxicity

Indexed keywords

BIOMASS; CELLS; OXYGEN; PHYSIOLOGY; SYNTHESIS (CHEMICAL); TOXICITY;

STRAIN-DEPENDENT TOXICITY;

BIOTECHNOLOGY;

INDENE DERIVATIVE; PROTEINASE; PROTEINASE INHIBITOR;

ARTICLE; BACTERIAL STRAIN; BIOMASS; BIOTRANSFORMATION; BREATHING; CELL FUNCTION; CELL MEMBRANE; CELL VIABILITY; CONTROLLED STUDY; ESCHERICHIA COLI; FLOW CYTOMETRY; GRAM NEGATIVE BACTERIUM; HUMAN IMMUNODEFICIENCY VIRUS; MEASUREMENT; MEMBRANE DEPOLARIZATION; MEMBRANE POTENTIAL; NONHUMAN; OPTICAL DENSITY; OXYGEN CONSUMPTION; PSEUDOMONAS PUTIDA; RHODOCOCCUS;

BIOREACTORS; CATALYSIS; CELL DIVISION; CELL MEMBRANE; DOSE-RESPONSE RELATIONSHIP, DRUG; ESCHERICHIA COLI; FLOW CYTOMETRY; INDENES; MEMBRANE POTENTIALS; OXYGEN; PSEUDOMONAS PUTIDA; RHODOCOCCUS; SENSITIVITY AND SPECIFICITY; SPECIES SPECIFICITY;

ESCHERICHIA COLI; NEGIBACTERIA; POSIBACTERIA; PSEUDOMONAS; PSEUDOMONAS PUTIDA; RHODOCOCCUS;

EID: 0346036070     PISSN: 00063592     EISSN: None     Source Type: Journal    
DOI: 10.1002/bit.10479     Document Type: Article

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