Structural requirements for signalling and regulation of AT1-receptors

JRAAS - Journal of the Renin-Angiotensin-Aldosterone System

Volumn 2, Issue SUPPL. 1, 2001, Pages

  Hunyady, László ^a   Gáborik, Zsuzsanna ^a   Vauquelin, Georges ^b   Catt, Kevin J ^c  

^a SEMMELWEIS UNIVERSITY OF MEDICINE   (Hungary)

^b VRIJE UNIVERSITEIT BRUSSEL   (Belgium)

^c EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT   (United States)

Author keywords

Angiotensin II; Ca2+ signal; Candesartan; G protein; Receptor internalisation; Receptor phosphorylation; Tyrosine kinase

Indexed keywords

EID: 0345893958     PISSN: 14703203     EISSN: None     Source Type: Journal    
DOI: 10.1177/14703203010020010301     Document Type: Review

References (82)

1. 1 receptor. Trends Pharmacol Sci 1996; 17:135-40.
2. Timmermans PB. Angiotensin II receptor antagonists: an emerging new class of cardiovascular therapeutics. Hypertens Res 1999; 22:147-53.
3. Jagadeesh G. Angiotensin II receptors: antagonists, molecular biology, and signal transduction. Indian J Exp Biol 1998; 36:1171-94.
4. De Gasparo M, Catt KJ, Inagami T, Wright JW, Unger T. International union of pharmacology. XXIII. The angiotensin II receptors. Pharmacol Rev 2000; 52:415-72.
5. Goodfriend TL, Elliott ME, Catt KJ. Drug therapy - Angiotensin receptors and their antagonists. N Engl J Med 1996; 334:1649-54.
6. Dostal DE. The cardiac renin-angiotensin system: novel signaling mechanisms related to cardiac growth and function. Regul Pept 2000; 91:1-11.
7. Eguchi S, Inagami T. Signal transduction of angiotensin II type 1 receptor through receptor tyrosine kinase. Regul Pept 2000; 91:13-20.
8. Haendeler J, Berk BC. Angiotensin II mediated signal transduction. Important role of tyrosine kinases. Regul Pept 2000; 95:1-7.
9. Inagami T, Eguchi S, Numaguchi K et al. Cross-talk between angiotensin II receptors and the tyrosine kinases and phosphatases. J Am Soc Nephrol 1999; 10:S57-S61.
10. Griendling KK, Ushio-Fukai M. Reactive oxygen species as mediators of angiotensin II signaling. Regul Pept 2000; 91:21-7.
11. Thomas WG. Regulation of angiotensin II type 1 (AT1) receptor function. Regul Pept 1999; 79:9-23.
12. Hunyady L, Catt KJ, Clark AJ, Gáborik Z. Mechanisms and functions of AT(1) angiotensin receptor internalization. Regul Pept 2000; 91:29-44.
13. 1A) receptor endocytosis. Clin Exp Pharmacol Physiol 1996; Suppl.3:S74-S80.
14. Gáborik Z, Szaszák M, Szidonya L et al. β-arrestin-and dynamin-dependent endocytosis of the AT1 angiotensin receptor. Mol Pharmacol 2001; 59:239-47.
15. Ferguson SSG, Barak LS, Zhang J, Caron MG. G-protein-coupled receptor regulation: Role of G-protein-coupled receptor kinases and arrestins. Can J Physiol Pharmacol 1996; 74:1095-110.
16. Krupnick JG, Benovic JL. The role of receptor kinases and arrestins in G protein-coupled receptor regulation. Annu Rev Pharmacol Toxicol 1998; 38:289-319.
17. Lefkowitz RJ. G protein-coupled receptors. III. New roles for receptor kinases and beta-arrestins in receptor signaling and desensitization. J Biol Chem 1998; 273:18677-80.
18. Luttrell LM, Daaka Y, Lefkowitz RJ. Regulation of tyrosine kinase cascades by G-protein-coupled receptors. Curr Opin Cell Biol 1999; 11:177-83.
19. Bumpus FM. Mechanisms and sites of action of newer angiotensin agonists and antagonists in terms of activity and receptor. Fed Proc 1977; 36:2128-32.
20. 1 receptor. Clin Exp Pharmacol Physiol 1997;Suppl. 3:S58-S66.
21. 1 angiotensin receptor is generated by angiotensin II induction. Biochemistry 1996; 35:16435-42.
22. 1 receptor in agonist activation. J Biol Chem 1995; 270:28511-14.
23. Yamano Y, Ohyama K, Chaki S, Guo D-F, Inagami T. Identification of amino acid residues of rat angiotensin II receptor for ligand binding by site directed mutagenesis. Biochem Biophys Res Commun 1992; 187:1426-31.
24. Fierens FL, Vanderheyden PM, Gáborik Z et al. Lys199 mutation of the human angiotensin type 1 receptor differentially affects the binding of surmountable and insurmuntable non-peptide antagonists. JRAAS 2000; 1:283-87.
25. Thomas WG, Qian H, Chang CS, Karnik S. Agonist-induced phosphorylation of the angiotensin II (AT(1A)) receptor requires generation of a conformation that is distinct from the inositol phosphate-signaling state. J Biol Chem 2000; 275:2893-900.
26. 1 receptor. J Biol Chem 1999; 274:7103-10.
27. 1 receptor activation is dependent upon two juxtaposed asparagine residues on transmembrane helices III and VII. J Biol Chem 1997; 272:4245-51.
28. 1A angiotensin II receptor induces its constitutive activation. J Biol Chem 1997; 272:1822-26.
29. 1 ligands: Susceptibility to receptor mutations. Mol Pharmacol 1997; 51:301-11.
30. 1 angiotensin receptor function on adjacent asparagine residues in the seventh transmembrane helix. Mol Pharmacol 1998; 54:427-34.
31. 1). Biochemistry 1998; 37:15791-8.
32. Joseph MP, Maigret B, Bonnafous JC, Marie J, Scheraga HA. A computer modeling postulated mechanism for angiotensin II receptor activation. J Protein Chem 1995; 14:381-98.
33. Böhm SK, Grady EF, Bunnett NW. Regulatory mechanisms that modulate signalling by G-protein-coupled receptors. Biochem J 1997;322:1-18.
34. Barak LS, Tiberi M, Freedman NJ, Kwatra MM, Lefkowitz RJ, Caron MG. A highly conserved tyrosine residue in G protein-coupled receptors is required for agonist-mediated β2-adrenergic receptor sequestration. J Biol Chem 1994; 269:2790-5.
35. Ferguson SSG, Ménard L, Barak LS, Koch WJ, Colapietro AM, Caron MG. Role of phosphorylation in agonist-promoted β2-adrenergic receptor sequestration - Rescue of a sequestration-defective mutant receptor by βARK1. J Biol Chem 1995; 270:24782-9.
36. nY motif present in the gastrin-releasing peptide receptor is not a general sequestration sequence. J Biol Chem 1994; 269:21755-62.
37. Hunyady L, Bor M, Baukal AJ, Balla T, Catt KJ. A conserved NPLFY sequence contributes to agonist binding and signal transduction but is not an internalization signal for the type 1 angiotensin II receptor. J Biol Chem 1995; 270:16602-09.
38. nY motif of the human angiotensin II type 1 receptor is involved in mediating signal transduction but is not essential for internalization. Mol Pharmacol 1996; 49:89-95.
39. Monnot C, Bihoreau C, Conchon S, Curnow KM, Corvol P, Clauser E. Polar residues in the transmembrane domains of the type 1 angiotensin II receptor are required for binding and coupling - Reconstitution of the binding site by co-expression of two deficient mutants. J Biol Chem 1996; 271:1507-13.
40. 1B receptors: Pharmacological and functional requirements. FEBS Lett 1994; 349:365-70.
41. Crozat A, Penhoat A, Saez JM. Processing of angiotensin II (A-II) and (Sar1,AlaS)A-II by cultured bovine adrenocortical cells. Endocrinology 1986; 118:2312-18.
42. Hunyady L, Merelli F, Baukal AJ, Balla T, Catt KJ. Agonist-induced endocytosis and signal generation in adrenal glomerulosa cells. A potential mechanism for receptor-operated calcium entry. J Biol Chem 1991; 266:2783-8.
43. Tarasova NI, Stauber RH, Choi JK et al. Visualization of G protein-coupled receptor trafficking with the aid of the green fluorescent protein - Endocytosis and recycling of cholecystokinin receptor type A. J Biol Chem 1997; 272:14817-24.
44. Hunyady L, Baukal AJ, Balla T, Catt KJ. Independence of type 1 angiotensin II receptor endocytosis from G protein coupling and signal transduction. J Biol Chem 1994; 269:24798-804.
45. 1A angiotensin receptor plays a key role in G protein coupling specificity and transduction of the mitogenic signal. J Biol Chem 1997; 272:25566-72.
46. Ohyama K, Yamano Y, Chaki S, Kondo T, Inagami T. Domains for G-protein coupling in angiotensin II receptor type I: Studies by site-directed mutagenesis. Biochem Biophys Res Commun 1992; 189:677-83.
47. q coupling by the use of receptor chimeras. J Biol Chem 1995; 270:16677-82.
48. 1 angiotensin receptor. Proc Natl Acad Sci USA 1996; 93:10040-5.
49. 1 angiotensin receptor is dependent on adjacent apolar residues in the carboxyl terminus of the third cytoplasmic loop. J Biol Chem 2000; 275:15782-8.
50. Sano T, Ohyama K, Yamano Y et al. A domain for G protein coupling in carboxyl-terminal tail of rat angiotensin II receptor type 1A. J Biol Chem 1997; 272:23631-6.
51. 1A angiotensin receptor. FEBS Lett 1998; 428:147-51.
52. Miura S, Zhang J, Karnik SS. Angiotensin II type 1 receptor-function affected by mutations in cytoplasmic loop CD. FEBS Lett 2000; 470:331-5.
53. Chaki S, Guo D-F, Yamano Y et al. Role of carboxyl tail of the rat angiotensin II type 1A receptor in agonist-induced internalization of the receptor. Kidney Int 1994; 46:1492-5.
54. Hunyady L, Bor M, Balla T, Catt KJ. Critical role of a conserved intramembrane tyrosine residue in angiotensin II receptor activation. J Biol Chem 1995; 270:9702-05.
55. Lapone SA, Roy SF, Escher E, Guillemette G, Leduc R. Essential role of leucine222 in mediating signal transduction of the human angiotensin II type 1 receptor. Receptors Channels 1998; 5:103-12.
56. 1A receptor activates transcription factor-Stat91 and/or a related protein. J Biol Chem 1994; 269:31443-9.
57. 1 receptor. Nature 1995; 375:247-50.
58. 1 receptor. J Biol Chem 1997; 272:23382-8.
59. 1 receptor. J Biol Chem 1998; 273:7703-08.
60. Ali MS, Schieffer B, Delafontaine P, Bernstein KE, Ling BN, Marrero MB. Angiotensin II stimulates tyrosine phosphorylation and activation of insulin receptor substrate 1 and protein-tyrosine phosphatase ID in vascular smooth muscle cells. J Biol Chem 1997; 272:12373-9.
61. 1 angiotensin receptor. J Biol Chem 1994; 269:31378-82.
62. Schmitz U, Ishida T, Ishida M et al. Angiotensin II stimulates p21-activated kinase in vascular smooth muscle cells: role in activation of JNK. Circ Res 1998; 82:1272-8.
63. Haendeler J, Ishida M, Hunyady L, Berk BC. The third cytoplasmic loop of the angiotensin II type 1 receptor exerts differential effects on extracellular signal-regulated kinase (ERK1/ERK2) and apoptosis via Ras-and Rap1-dependent pathways. Circ Res 2000; 86:729-36.
64. Luttrell LM, Ferguson SS, Daaka Y et al. Beta-arrestin-dependent formation of beta2 adrenergic receptor-Src protein kinase complexes [see comments]. Science 1999; 283:655-61.
65. Ma YC, Huang J, Ali S, Lowry W, Huang XY. Src tyrosine kinase is a novel direct effector of G proteins. Cell 2000; 102:635-46.
66. Dikic I, Tokiwa G, Lev S, Courtneidge SA, Schlessinger J. A role for Pyk2 and Src in linking G-protein-coupled receptors with MAP kinase activation. Nature 1996; 383:547-50.
67. Prenzel N, Zwick E, Daub H et al. EGF receptor transactivation by G-protein-coupled receptors requires metalloproteinase cleavage of proHB-EGF. Nature 1999; 402:884-8.
68. Bishop AL, Hall A. Rho GTPases and their effector proteins. Biochem J 2000; 348:241-55.
69. Seasholtz TM, Majumdar M, Brown JH. Rho as a mediator of G protein-coupled receptor signaling. Mol Pharmacol 1999; 55:949-56.
70. 2+ channels in rat portal vein myocytes. J Biol Chem 1997; 272:23180-5.
71. Yamakawa T, Tanaka S, Numaguchi K et al. Involvement of Rho-kinase in angiotensin II-induced hypertrophy of rat vascular smooth muscle cells. Hypertension 2000; 35:313-8.
72. Mitchell R, McCulloch D, Lutz E et al. Rhodopsin-family receptors associate with small G proteins to activate phospholipase D. Nature 1998; 392:411-4.
73. -4 of the rat angiotensin II receptor confers changes in antagonist affinities and abolishes G-protein coupling. Proc Natl Acad Sci USA 1993; 90:5133-7.
74. Hunyady L, Tian Y, Sandberg K, Balla T, Catt KJ. Divergent conformational requirements for angiotensin II receptor internalization and signaling. Kidney Int 1994; 46:1496-8.
75. 1A receptor in CHO-K1 cells.The carboxyl-terminal region directs agonist-induced internalization but not receptor signaling or desensitization. J Biol Chem 1995; 270:207-13.
76. 1A receptor. Eur J Pharmacol Mol Pharmacol 1995; 291:135-41.
77. 1A receptor transduces an amplified ANG II signal. Am J Physiol Endocrinol Metab 1998; 274:E336-E345.
78. Thomas WG, Baker KM, Motel TJ, Thekkumkara TJ. Angiotensin II receptor endocytosis involves two distinct regions of the cytoplasmic tail. A role for residues on the hydrophobic face of a putative amphipathic helix. J Biol Chem 1995; 270:22153-9.
79. Smith RD, Hunyady L, Olivares-Reyes JA, Mihalik B, Jayadev S, Catt KJ. Agonist-induced phosphorylation of the angiotensin AT1a receptor is localized to a serine/threonine-rich region of its cytoplasmic tail. Mol Pharmacol 1998; 54:935-41.
80. 1A) receptor carboxyl terminus:A role in receptor endocytosis. Mol Endocrinol 1998; 12:1513-24.
81. Palczewski K, Kumasaka T, Hori T et al. Crystal structure of rhodopsin: A G protein-coupled receptor. Science 2000; 289:739-45.
82. 1 receptor-expressing Chinese hamster ovary cells. J Am Soc Nephrol 1999; 10:S15-S17.