A Tetraguanidinium Ligand Binds to the Surface of the Tetramerization Domain of Protein P53

Angewandte Chemie - International Edition

Volumn 43, Issue 2, 2003, Pages 196-198

  Salvatella, Xavier ^a,b,e   Martinell, Marc ^a,b   Gairí, Margarida ^a,b   Mateu, Mauricio G ^c   Feliz, Miguel ^b   Hamilton, Andrew D ^d   De Mendoza, Javier ^c   Giralt, Ernest ^a,b  

^a INSTITUTE FOR RESEARCH IN BIOMEDICINE   (Spain)

^b UNIVERSITY OF BARCELONA   (Spain)

^c UNIVERSIDAD AUTÓNOMA DE MADRID   (Spain)

^d YALE UNIVERSITY   (United States)

^e UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

Host guest systems; Ligand design; Molecular recognition; NMR spectroscopy; Proteins

Indexed keywords

DRUG INTERACTIONS; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; ONCOLOGY; PROTEINS; SALTS;

LIGANDS; TETRAMERIZATION;

BIOCHEMISTRY;

GUANIDINE DERIVATIVE; LIGAND; PROTEIN P53; TETRAGUANIDINIUM; TUMOR SUPPRESSOR PROTEIN; UNCLASSIFIED DRUG; WATER;

ARTICLE; CANCER THERAPY; HOST GUEST SYSTEM; LIGAND BINDING; MOLECULAR INTERACTION; MOLECULAR RECOGNITION; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; OLIGOMERIZATION; PROTEIN DOMAIN;

BINDING SITES; BIOPOLYMERS; GUANIDINE; LIGANDS; MODELS, MOLECULAR; PROTEIN BINDING; TUMOR SUPPRESSOR PROTEIN P53;

EID: 0345862318     PISSN: 14337851     EISSN: None     Source Type: Journal    
DOI: 10.1002/anie.200352115     Document Type: Article

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