Side chain elongation causes a change from enthalpy driven to entropy driven binding in the molecular recognition of tetraanionic peptides

Chemical Communications

Volumn , Issue 15, 2000, Pages 1399-1400

  Salvatella, Xavier ^a   Peczuh, Mark W ^b   Gairí, Margarida ^a   Jain, Rishi K ^b   Sánchez Quesada, Jorge ^c   De Mendoza, Javier ^c   Hamilton, Andrew D ^b   Giralt, Ernest ^a  

^a UNIVERSITY OF BARCELONA   (Spain)

^b YALE UNIVERSITY   (United States)

^c UNIVERSIDAD AUTÓNOMA DE MADRID   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

ASPARTIC ACID; GLUTAMIC ACID; PEPTIDE HORMONE;

AMINO ACID SUBSTITUTION; ARTICLE; BINDING AFFINITY; CHEMICAL BINDING; CIRCULAR DICHROISM; ENTHALPY; HYDROGEN BOND; MOLECULAR RECOGNITION; PROTEIN CONFORMATION; PROTEIN PROTEIN INTERACTION; THERMODYNAMICS;

EID: 0034617858     PISSN: 13597345     EISSN: None     Source Type: Journal    
DOI: 10.1039/b003728l     Document Type: Article

References (16)

1. J. Janin and C. Chothia, J. Biol. Chem., 1990, 265, 16027.
2. L. Lo Conte, C. Chothia and J. Janin, J. Mol. Biol., 1999, 285, 2177.
3. M. W. Peczuh and A. D. Hamilton, Chem Rev., 2000, in press.
4. M. W. Peczuh, A. D. Hamilton, J. Sánchez-Quesada, J. de Mendoza, T. Hack and E. Giralt, J. Am. Chem. Soc., 1997, 119, 9327; T. Haack, M. W. Peczuh, X. Salvatella, J. Sánchez-Quesada, J. de Mendoza, A. D. Hamilton and E. Giralt, J. Am. Chem. Soc., 1999, 121, 11 813.
5. M. W. Peczuh, A. D. Hamilton, J. Sánchez-Quesada, J. de Mendoza, T. Hack and E. Giralt, J. Am. Chem. Soc., 1997, 119, 9327; T. Haack, M. W. Peczuh, X. Salvatella, J. Sánchez-Quesada, J. de Mendoza, A. D. Hamilton and E. Giralt, J. Am. Chem. Soc., 1999, 121, 11 813.
6. S. Padmanabhan, E. J. York, J. M. Stewart and R. L. Baldwin, J. Mol. Biol., 1996, 257, 726.
7. M. Vijayakumar, H. Qian and H.-X. Zhou, Proteins: Struct., Funct., Genet., 1999, 34, 497.
8. 100 = -40 000(1 - 2.5/n); n is the number of amide bonds].
9. 1H]-HMBC.
10. J. M. Scholtz, S. Marqusee, R. L. Baldwin, E. J. York, J. M. Stewart, M. Santoro and D. W. Bolen, Proc. Natl. Acad. Sci. USA., 1991, 88, 2854.
11. M. Berger and F. P. Schmidtchen, J. Am. Chem. Soc., 1999, 121, 9986.
12. E. Gallichio, M. M. Kubo and R. M. Levy, J. Am. Chem. Soc., 1998, 120, 4526; V. L. TlapakSimmons and G. D. Reinhart, Biophys. J., 1998, 75, 1010.
13. E. Gallichio, M. M. Kubo and R. M. Levy, J. Am. Chem. Soc., 1998, 120, 4526; V. L. TlapakSimmons and G. D. Reinhart, Biophys. J., 1998, 75, 1010.
14. H. Qian, J. Chem. Phys., 1998, 109, 10015.
15. A. A. Bogan and K. S. Thorn, J. Mol. Biol., 1998, 280, 1.
16. Binding constants fittings were made using either the CD titration curves or the enthalpy evolution curves. In the first case the fittings were done by non-linear regression analysis (C. S. Wilcox in Frontiers in Supramolecular Chemistry and Photochemistry, eds. H. J. Schneider and H. Durr, VCH, Weinheim, 1990, pp. 123-143) and in the latter using Microcal Origin software.