Vernalization requires epigenetic silencing of FLC by histone methylation

Nature

Volumn 427, Issue 6970, 2004, Pages 164-167

  Bastow, Ruth ^a   Mylne, Joshua S ^a   Lister, Clare ^a   Lippman, Zachary ^b   Martienssen, Robert A ^b   Dean, Caroline ^a  

^a JOHN INNES CENTRE   (United Kingdom)

^b Watson School of Biological Sciences   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALKYLATION; DNA; GENES; PLANTS (BOTANY); PROTEINS;

VERNALIZATION;

GENETIC ENGINEERING;

DNA BINDING PROTEIN; HISTONE; HISTONE H3; PROTEIN VNR2; PROTEIN VRN1; UNCLASSIFIED DRUG;

FLOWERING; PROTEIN; VERNALIZATION; WINTER;

ARABIDOPSIS; ARTICLE; CHROMATIN; COLD EXPOSURE; DOWN REGULATION; EPIGENETICS; FLC GENE; FLOWERING; GENE ACTIVITY; GENE LOCUS; GENETIC CODE; HUMAN; METHYLATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN MODIFICATION; REPRESSOR GENE; SEQUENCE HOMOLOGY; VERNALIZATION; WINTER;

ARABIDOPSIS; ARABIDOPSIS PROTEINS; CARRIER PROTEINS; CHROMATIN; CHROMATIN ASSEMBLY AND DISASSEMBLY; COLD; DNA-BINDING PROTEINS; FLOWERS; GENE EXPRESSION REGULATION, PLANT; GENE SILENCING; GENES, PLANT; HISTONES; MADS DOMAIN PROTEINS; METHYLATION; MUTATION; NUCLEAR PROTEINS; REPRESSOR PROTEINS; SEASONS; ZINC FINGERS;

ANIMALIA; ARABIDOPSIS; EMBRYOPHYTA;

EID: 0345826148     PISSN: 00280836     EISSN: None     Source Type: Journal    
DOI: 10.1038/nature02269     Document Type: Article

References (29)

1. Sheldon, C. C. et al. The FLF MADS box gene: a repressor of flowering in Arabidopsis regulated by vernalization and methylation. Plant Cell 11, 445-458 (1999).
2. Michaels, S. D. & Amasino, R. M. FLOWERING LOCUSC encodes a novel MADS domain protein that acts as a repressor of flowering. Plant Cell 11, 949-956 (1999).
3. Gendall, A. R., Levy, Y. Y., Wilson, A. & Dean, C. The VERNALIZATION 2 gene mediates the epigenetic regulation of vernalization in Arabidopsis. Cell 107, 325-335 (2001).
4. Levy, Y. Y., Mesnage, S., Mylne, J. S., Gendall, A. R. & Dean, C. Multiple roles of Arabidopsis VRN1 in vernalization and flowering time control. Science 297, 243-246 (2002).
5. Cao, R. et al. Role of histone H3 lysine 27 methylation in Polocomb-group silencing. Science 298, 1039-1043 (2002).
6. Muller, J. et al. Histone methyltransferase activity of a Drosophila Polycomb group repressor complex. Cell 111, 197-208 (2002).
7. Rea S. et al. Regulation of chromatin structure by site-specific histone H3 methyltransferases. Nature 406, 593-599 (2000).
8. Henderson, I., Shindo, C. & Dean, C. The need for winter in the switch to flowering. Annu. Rev. Genet. 37, 371-392 (2003).
9. Kobayashi, Y., Kaya, H., Goto, K., Iwabuchi, M. & Araki, T. A pair of related genes with antagonistic roles in mediating flowering signals. Science 286, 1960-1962 (1999).
10. Kardailsky, I. et al. Activation tagging of the floral inducer FT. Science 286, 1962-1965 (1999).
11. Samach, A. et al. Distinct roles of CONSTANS target genes in reproductive development of Arabidopsis. Science 288, 1613-1616 (2000).
12. Lee, H. et al. The AGAMOUS-LIKE 20 MADS domain protein integrates floral inductive pathways in Arabidopsis. Genes Dev. 14, 2366-2376 (2000).
13. Hepworth, S. R., Valverde, F., Ravenscroft, D., Mouradov, A. & Coupland, G. Antagonistic regulation of flowering-time gene SOCI by CONSTANS and FLC via separate promoter motifs. EMBO J. 21, 4327-4337 (2002).
14. Burn, I. E., Bagnall, D. J., Metzger, I. D., Dennis, E. S. & Peacock, W. J. DNA methylation, vernalization, and the initiation of flowering. Proc. Natl Acad. Sci. USA 90, 287-291 (1993).
15. Chandler, J., Wilson, A. & Dean, C. Arabidopsis mutants showing an altered response to vernalization. Plant J. 10, 637-644 (1996).
16. Birve, A. et al. Su(z)12, a novel Drosophila Polycomb group gene that is conserved in vertebrates and plants. Development 128, 3371-3379 (2001).
17. Fischle, W., Wang, Y. & Allis, C. Binary switches and modification cassettes in histone biology and beyond. Nature 425, 475-479 (2003).
18. Czermin, B. et al. Drosophila enhancer of Zeste/ESC complexes have a histone H3 methyltransferase activity that marks chromosomal Polycomb sites. Cell 111, 185-196 (2002).
19. Kuzmichev, A., Nishioka, K., Erdjument-Bromage, H., Tempst, P. & Reinberg, D. Histone methyltransferase activity associated with a human multiprotein complex containing the Enhancer of Zeste protein. Genes Dev. 16, 2893-2905 (2002).
20. Bannister, A. J. et al. Selective recognition of methylated lysine 9 on histone H3 by the HP1 chromo domain. Nature 410, 120-124 (2001).
21. Lachner, M., O'Carroll, D., Rea, S., Mechtler, K. & Jenuwein, T. Methylation of histone H3 lysine 9 creates a binding site for HP1 proteins. Nature 410, 116-120 (2001).
22. Jenuwein, T. & Allis, C. D. Translating the histone code. Science 293, 1074-1080 (2001).
23. Sims, R. I. III, Nishioka, K. & Reinberg, D. Histone lysine methylation: a signature for chromatin function. Trends Genet. 19, 629-639 (2003).
24. Gazzani, S., Gendall, A. R., Lister, C. & Dean, C. Analysis of the molecular basis of flowering time variation in Arabidopsis accessions. Plant Physiol. 132, 1107-1114 (2003).
25. Michaels, S. D., He, Y., Scortecci, K. C. & Amasino, R. M. Attenuation of FLOWERING LOCUS C activity as a mechanism for the evolution of a summer-annual flowering behavior in Arabidopsis. Proc. Natl Acad. Sci. USA 100, 10102-10107 (2003).
26. Gendrel, A.-V., Lippman, Z., Yordan, C., Colot, V. & Martienssen, R. A. Dependence of heterochromatic histone H3 methylation patterns on the Arabidopsis gene DDMI. Science 297, 1871-1873 (2002).
27. Sheldon, C. C., Conn, A. B., Dennis, E. S. & Peacock, W. J. Different regulatory regions are required for the vernalization-induced repression of FLOWERING LOCUS C and for the epigenetic maintenance of repression. Plant Cell 14, 2527-2537 (2002).
28. Rigaut, G. et al. A generic protein purification method for protein complex characterization and proteome exploration. Nature Biotechnol. 17, 1030-1032 (1999).
29. Goodrich, J. & Tweedie, S. Remembrance of things past: chromatin remodeling in plant development. Annu. Rev. Cell Dev. Biol. 18, 707-746 (2002).