Pre-natal Origins of Childhood Leukemia

Reviews in Clinical and Experimental Hematology

Volumn 7, Issue 3, 2003, Pages 233-245

  Greaves, Mel ^a  

^a INSTITUTE OF CANCER RESEARCH   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ACUTE LYMPHOBLASTIC LEUKEMIA; ACUTE MYELOBLASTIC LEUKEMIA; CELL CLONE; CHILD; CHILDHOOD LEUKEMIA; CHIMERA; CHROMOSOME TRANSLOCATION; FUSION GENE; HEMATOPOIESIS; HUMAN; INFANT; LEUKEMIA CELL; PRENATAL PERIOD; REVIEW;

CHILD; CHROMOSOMES, HUMAN; FEMALE; HUMANS; LEUKEMIA; LEUKEMIA, LYMPHOCYTIC, ACUTE; PREGNANCY; TRANSLOCATION, GENETIC;

EID: 0345763041     PISSN: 11270020     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (76)

1. Kersey JH. Fifty years of studies of the biology and therapy of childhood leukemia. Blood, 90: 4243-4251, 1997.
2. Biondi A, Cimino G, Pieters R, et al. Biological and therapeutic aspects of infant leukemia. Blood, 96: 24-33, 2000.
3. th Henderson ES, Lister TA, Greaves MF (eds). Philadelphia, Saunders, 2002.
4. Greaves MF, Colman SM, Beard MEJ, et al. Geographical distribution of acute lymphoblastic leukaemia subtypes: second report of the collaborative group study. Leukemia, 7: 27-34, 1993.
5. UK Childhood Cancer Study Investigators. The United Kingdom Childhood Cancer Study: objectives, materials and methods. Br J Cancer, 82: 1073-1102, 2000.
6. Doll R and Wakeford R. Risk of childhood cancer from fetal irradiation. Brit J Radiol, 70: 130-139, 1997.
7. Sande JE, Arceci RJ, Lampkin BC. Congenital and neonatal leukemia. Sem Perinatol, 23: 274-285, 1999.
8. Ridge SA, Cabrera ME, Ford AM, et al. Rapid intraclonal switch of lineage dominance in congenital leukaemia with a MLL gene rearrangement. Leukemia, 9: 2023-2026, 1995.
9. Hunger SP, McGavran L, Meltesen L, et al. Oncogenesis in utero: fetal death due to acute myelogenous leukaemia with an MLL translocation. Br J Haematol, 103: 539-542, 1998.
10. Smith MA, Chen T, Simon R. Age-specific incidence of acute lymphoblastic leukemia in U.S. children: in utero initiation model. J Natl Cancer Inst, 89: 1542-1544, 1997.
11. Ford AM, Ridge SA, Cabrera ME, et al. In utero rearrangements in the trithorax-related oncogene in infant leukaemias. Nature, 363: 358-360, 1993.
12. Ford AM, Bennett CA, Price CM, et al. Fetal origins of the TEL-AML1 fusion gene in identical twins with leukemia. Proc Natl Acad Sci, USA 95: 4584-4588, 1998.
13. Wiemels JL, Ford AM, Van Wering ER, et al. Protracted and variable latency of acute lymphoblastic leukemia after TEL-AML1 gene fusion in utero. Blood 94: 1057-1062, 1999.
14. Wiemels JL, Cazzaniga G, Daniotti M, et al. Prenatal origin of acute lymphoblastic leukaemia in children. Lancet, 354: 1499-1503, 1999.
15. Maia AT, Ford AM, Jalali GR, et al. Molecular tracking of leukemogenesis in a triplet pregnancy. Blood, 98: 478-482, 2001.
16. Zuna J, Muzikova K, Ford AM, et al. Prenatal, clonal origin of acute lymphoblastic leukaemia in triplets. Leuk Lymphoma, in press.
17. Kempski H, Mensa-Bonsu KA, Kearney L, et al. Prenatal chromosomal diversification of leukemia in monozygotic twins. Genes Chromosomes Cancer, 37: 406-411, 2003.
18. Maia AT, van der Velden VHJ, Harrison CJ, et al. Pre-natal origin of hyperdiploid acute lymphoblastic leukemia in identical twins. Leukemia, 17: 2202-2206, 2003.
19. Ford AM, Pombo-de-Oliveira MS, McCarthy KP, et al. Monoclonal origin of concordant T-cell malignancy in identical twins. Blood, 89: 281-285, 1997.
20. Gale KB, Ford AM, Repp R, et al. Backtracking leukemia to birth: identification of clonotypic gene fusion sequences in neonatal blood spots. Proc Natl Acad Sci USA, 94: 13950-13954, 1997.
21. Wiemels JL, Xiao Z, Buffler PA, et al. In utero origin of t(8;21) AML1-ETO translocations in childhood acute myeloid leukemia. Blood, 99: 3801-3805, 2002.
22. Hjalgrim LL, Madsen HO, Melbye M, et al. Presence of clone-specific markers at birth in children with acute lymphoblastic leukaemia. Br J Cancer, 87: 994-999, 2002.
23. McHale CM, Wiemels JL, Zhang L, et al. Prenatal origin of childhood acute myeloid leukemias harboring chromosomal rearrangements t(15;17) and inv(16). Blood, 101: 4640-4641, 2003.
24. Fasching K, Panzer S, Haas OA, et al. Presence of clone-specific antigen receptor gene rearrangements at birth indicates an in utero origin of diverse types of early childhood acute lymphoblastic leukemia. Blood, 95: 2722-2724, 2000.
25. Yagi T, Hibi S, Tabata Y, et al. Detection of clonotypic IgH and TCR rearrangements in the neonatal blood spots of infants and children with B-cell precursor acute lymphoblastic leukemia. Blood, 96: 264-268, 2000.
26. Taub JW, Konrad MA, Ge Y, et al. High frequency of leukemic clones in newborn screening blood samples of children with B-precursor acute lymphoblastic leukemia. Blood, 99: 2992-2996, 2002.
27. McHale CM, Wiemels JL, Zhang L, et al. Prenatal origin of TEL-AML1-positive acute lymphoblastic leukemia in children born in California. Genes Chromosomes Cancer, 37: 36-43, 2003.
28. Panzer-Grümayer ER, Fasching K, Panzer S, et al. Nondisjunction of chromosomes leading to hyperdiploid childhood B-cell precursor acute lymphoblastic leukemia is an early event during leukemogenesis. Blood, 100: 347-349, 2002.
29. Maia AT, Tussiwand R, Cassaniga G, et al. Identification of pre-leukaemic precursors of hyperdiploid ALL in cord blood. Genes Chromosomes Cancer, in press.
30. Mori H, Colman SM, Xiao Z, et al. Chromosome translocations and covert leukemic clones are generated during normal fetal development. Proc Natl Acad Sci USA, 99: 8242-8247, 2002.
31. Senator H. Zur Kenntniss der Leukämie und Pseudoleukämie im Kindesalter. Berliner Klinische Wochenschrift, 35: 533-536, 1882.
32. Greaves M, Maia AT, Wiemels JL, et al. Leukemia in twins: lessons in natural history. Blood, 102: 2321-2333, 2003.
33. Cooke GS and Hill AVS. Genetics of susceptibility to human infectious disease. Nat Rev Genet, 2: 967-977, 2001.
34. MacMahon B and Levy MA. Prenatal origin of childhood leukemia. N Engl J Med, 270: 1082-1085, 1964.
35. Wolman IJ. Parallel responses to chemotherapy in identical twin infants with concordant leukemia. Journal of Pediatrics, 60: 91-96, 1962.
36. Clarkson B and Boyse EA. Possible explanation of the high concordance for acute leukaemia in monozygotic twins. Lancet, i: 699-701, 1971.
37. Strong SJ and Corney G. The Placenta in Twin Pregnancy. Oxford, Pergamon Press, 1967.
38. Hilton HB, Lewis IC, Trowell HR. C group trisomy in identical twins with acute leukemia. Blood, 35: 222-226, 1970.
39. Chaganti RSK, Miller DR, Meyers PA, et al. Cytogenetic evidence of the intrauterine origin of acute leukemia in monozygotic twins. N Engl J Med, 300: 1032-1034, 1979.
40. Hartley SE and Sainsbury C. Acute leukaemia and the same chromosome abnormality in monozygotic twins. Hum Genet, 58: 408-410, 1981.
41. Wiemels JL and Greaves M. Structure and possible mechanisms of TEL-AML1 gene fusions in childhood acute lymphoblastic leukemia. Cancer Res, 59: 4075-4082, 1999.
42. Greaves MF and Wiemels J. Origins of chromosome translocations in childhood leukaemia. Nat Rev Cancer, 3: 639-649, 2003.
43. Wiemels JL, Leonard B, Wang Y, et al. Site-specific translocation and evidence of post-natal origin of the t(1;19) E2A-PBX1 translocation in childhood acute lymphoblastic leukemia. Proc Natl Acad Sci USA, 99: 15101-15106, 2003.
44. Maia AT, Koechling J, Corbett R, et al. Duration of post-natal latency in childhood leukaemia. Genes Chromosomes Cancer, in press.
45. Yuan Y, Zhou L, Miyamoto T, et al. AML1-ETO expression is directly involved in the development of acute myeloid leukemia in the presence of additional mutations. Proc Natl Acad Sci USA, 98: 10398-10403, 2001.
46. Andreasson P, Schwaller J, Anastasiadou E, et al. The expression of ETV6/CBF2 (TEL/AML1) is not sufficient for the transformation of hematopoietic cell lines in vitro or the induction of hematologic disease in vivo. Cancer Genet Cytogenet, 130: 93-104, 2001.
47. Raimondi SC. Cytogenetics of acute leukemias. In: Childhood Leukemias. Edited Pui C-H (ed.), Cambridge, Cambridge University Press, 1999.
48. Gilliland DG and Griffin JD. The roles of FLT3 in hematopoiesis and leukemia. Blood, 100: 1532-1542, 2002.
49. Strick R, Strissel PL, Borgers S, et al. Dietary bioflavonoids induce cleavage in the MLL gene and may contribute to infant leukemia. Proc Natl Acad Sci USA, 97: 4790-4795, 2000.
50. Wiemels JL, Pagnamenta A, Taylor GM, et al. A lack of a functional NAD(P)H:quinone oxidoreductase allele is selectively associated with pediatric leukemias that have MLL fusions. Cancer Res, 59: 4095-4099, 1999.
51. Smith MT, Wang Y, Skibola CF, et al. Low NAD(P)H: quinone oxidoreductase activity is associated with increased risk of leukemia with MLL translocations in infants and children. Blood, 100: 4590-4593, 2002.
52. Alexander FE, Patheal SL, Biondi A, et al. Transplacental chemical exposure and risk of infant leukaemia with MLL gene fusion. Cancer Res 61: 2542-2546, 2001.
53. Greaves MF. Speculations on the cause of childhood acute lymphoblastic leukemia. Leukemia, 2: 120-125, 1988.
54. Maris JM and Denny CT. Focus on embryonal malignancies. Cancer Cell, 2: 447-450, 2002.
55. Thompson JR, Fitz Gerald P, Willoughby MLN, et al. Maternal folate supplementation in pregnancy and protection against acute lymphoblastic leukaemia in childhood: a case-control study. Lancet 358: 1935-1940, 2001.
56. Wiemels JL, Smith RN, Taylor GM, et al. Methylene tetrahydrofolate reductase (MTHFR) polymorphisms and risk of molecularly defined subtypes of childhood acute leukemia. Proc Natl Acad Sci USA, 98: 4004-4009, 2001.
57. Greaves MF. Aetiology of acute leukaemia. Lancet, 349: 344-349, 1997.
58. van Steensel-Moll HA, Valkenburg HA, van Zanen GE. Childhood leukemia and infectious diseases in the first year of life: a register-based case/ control study. Am J Epidemiol, 124: 590-594, 1986.
59. Neglia JP, Linet MS, Xhu X-O, et al. Patterns of infection and day care utilization and risk factors of childhood acute lymphoblastic leukemia. Br J Cancer, 82: 234-240, 2000.
60. McKinney PA, Juszczak E, Findlay E, et al. Pre- and perinatal risk factors for childhood leukaemia and other malignancies: a Scottish case control study. Br J Cancer, 80: 1844-1851, 1999.
61. Chan LC, Lam TH, Li CK, et al. Is the timing of exposure to infection a major determinant of acute lymphoblastic leukaemia in Hong Kong? Paediatr Perinatal Epidemiol, 16: 154-165, 2002.
62. Westergaard T, Andersen PK, Pedersen JB, et al. Birth characteristics, sibling patterns, and acute leukemia risk in childhood: a population-based cohort study. J Natl Cancer Inst, 89: 939-947, 1997.
63. Dockerty JD, Draper G, Vincent T, et al. Case-control study of parental age, parity and socioeconomic level in relation to childhood cancers. Int J Epidemiol, 30: 1428-1437, 2001.
64. Petridou E, Kassimos D, Kalmanti M, et al. Age of exposure to infections and risk of childhood leukaemia. Br J Med, 307: 774, 1993.
65. Infante-Rivard C, Fortier I, Olsen E. Markers of infection, breast-feeding and childhood acute lymphoblastic leukaemia. Br J Cancer, 83: 1559-1564, 2000.
66. Perrillat F, Clavel J, Auclerc MF, et al. Daycare, early common infections and childhood acute leukaemia: a multicentre French case-control study. Br J Cancer, 86: 1064-1069, 2002.
67. Ma X, Buffler PA, Selvin S, et al. Daycare attendance and risk of childhood acute lymphoblastic leukaemia. Br J Cancer, 86: 1419-1424, 2002.
68. Greaves M. Molecular genetics, natural history and the demise of childhood leukaemia. Eur J Cancer, 35: 173-185, 1999.
69. Wills-Karp M, Santeliz J, Karp CL. The germ-less theory of allergic disease: revisiting the hygiene hypothesis. Nat Rev, 1: 69-75, 2001.
70. The EURODIAB Substudy 2 Study Group. Infections and vaccinations are risk factors for childhood Type I (insulin-dependent) diabetes mellitus: a multicentre case-control investigation. Diabetologia, 43: 47-53, 2000.
71. Taylor GM, Dearden S, Ravetto P, et al. Genetic susceptibility to childhood common acute lymphoblastic leukaemia is associated with polymorphic peptide-binding pocket profiles in HLk-DPB1*0201. Hu Mol Genet, 11: 1585-1597, 2002.
72. Guthrie R and Susi A. A simple phenylalanine method for the detection of phenylketonuria in large populations of new-born infants. Pediatric, 32: 338-341, 1963.
73. Jinks DC, Minter M, Tarver DA, et al. Molecular genetic diagnosis of sickle cell disease using dried blood specimens on blotters used for newborn screening. Hum Genet, 81: 363-366, 1989.
74. Comeau AM, Hsu H-W, Schwerzler M, et al. Identifying human immunodeficiency virus infection at birth: application of polymerase chain reaction to Guthrie cards. J Pediatr, 123: 252-258, 1993.
75. Biernaux C, Loos M, Sels A, et al. Detection of major bcr-abl gene expression at a very low level in blood cells of some healthy individuals. Blood, 86: 3118-3122, 1995.
76. Bose S, Deininger M, Gora-Tybor J, et al. The presence of typical and atypical BCR-ABL fusion genes in leukocytes of normal individuals: biologic significance and implications for the assessment of minimal residual disease. Blood, 92: 3362-3367, 1998.