Regulation of conjunctival goblet cell secretion by Ca2+ and protein kinase C

Experimental Eye Research

Volumn 71, Issue 6, 2000, Pages 619-628

  Dartt, Darlene A ^a   Rios, Jose R ^a   Kanno, Harumi ^a   Rawe, Ian M ^a   Zieske, James D ^a   Ralda, Nereida ^a   Hodges, Robin R ^a   Zoukhri, Driss ^a  

^a SCHEPENS EYE RESEARCH INSTITUTE   (United States)

Author keywords

Eye; Glycoprotein; Ionophore; Mucus; Muscarinic agonists; Phorbol esters; Signal transduction

Indexed keywords

CALCIUM ION; CALMODULIN; CHELERYTHRINE; CHOLINERGIC RECEPTOR STIMULATING AGENT; DIACYLGLYCEROL; GLYCOPROTEIN; INOSITOL 1,4,5 TRISPHOSPHATE; IONOMYCIN; N (6 AMINOHEXYL) 1 NAPHTHALENESULFONAMIDE; N (6 AMINOHEXYL) 5 CHLORO 1 NAPHTHALENESULFONAMIDE; N [2 [[N [3 (4 CHLOROPHENYL) 2 PROPENYL] N METHYLAMINO]METHYL]PHENYL] N (2 HYDROXYETHYL) 4 METHOXYBENZENESULFONAMIDE; PHORBOL 13 ACETATE 12 MYRISTATE; PHOSPHOLIPASE C; PROTEIN KINASE C; PROTEIN KINASE INHIBITOR; STAUROSPORINE;

ANIMAL TISSUE; ARTICLE; CALCIUM CELL LEVEL; CELL SECRETION; CHELATION; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ASSAY; ENZYME LOCALIZATION; ENZYME REGULATION; EYE; GOBLET CELL; IMMUNOFLUORESCENCE MICROSCOPY; MALE; MUCUS SECRETION; NONHUMAN; PRIORITY JOURNAL; RAT; SIGNAL TRANSDUCTION; WESTERN BLOTTING;

EID: 0034529153     PISSN: 00144835     EISSN: None     Source Type: Journal    
DOI: 10.1006/exer.2000.0915     Document Type: Article

References (32)

1. 2+ activation of mucin secretion in airway goblet cells
2. Calcium channels and other devices for effecting stimulus-exocytosis coupling
3. Inositol trisphosphate and diacylglycerol: Two interacting second messengers
4. Inositol trisphosphate, a novel second messenger in cellular signal transduction
5. Vasoactive intestinal peptide-stimulated glycoconjugate secretion from conjunctival goblet cells
6. Structure and function of the tear film
7. PKC-Dependent stimulation of exocytosis by sulfonylureas in pancreatic β cells
8. Signal transduction, packaging and secretion of mucins
9. 2+ and PKC
10. Calcium-induced P56(Lck) phosphorylation in human T lymphocytes via calmodulin dependent kinase
11. W-5 and quin 2-AM reverse the inhibitory effect of insulin on lipolysis due to dibutyryl cAMP
12. Detection and quantification of conjunctival mucin
13. Stimulation of goblet cell mucous secretion by activation of nerves in rat conjunctiva
14. Inhibitors of calmodulin-dependent protein kinase are nonspecific blockers of voltage-dependent K+ channels in vascular myocytes
15. 2++/ calmodulin-dependent protein kinase II inhibitors KN62 and KN93, and their inactive analogues KN04 and KN92, inhibit nicotinic activation of tyrosine hydroxylase in bovine chromaffin cells
16. Anchoring proteins for protein kinase C: A means for enzyme selectivity
17. Identification of intracellular receptor proteins for activated protein kinase C
18. Protein kinase C: Structure, function and regulation
19. The molecular heterogeneity of protein kinase C and its implications for cellular regulation
20. Study of precorneal tear film thickness and structure by interferometry and confocal microscopy
21. Phosphoinositides and alpha-1 adrenergic receptors
22. 2+/calmodulin-dependent protein kinase II regulates atrial natriuretic factor gene expression in ventricular myocytes
23. Localization of protein kinase C gamma in healing rat limbal and corneal epithelia
24. Immunolocalization of muscarinic and VIP receptor subtypes and their role in stimulating goblet cell secretion
25. PICK1: A perinuclear binding protein and substrate of protein kinase C isolated by the yeast two-hybrid system
26. 2+/calmodulin kinase II inhibitor KN-62. Studies with Thyroid FRTL-5 cells
27. Secretogogue-dependent phosphorylation of phogrin, an insulin granule membrane protein tyrosine phosphatase homologue
28. Intracellular mediators of goblet cells degranulation in isolated pancreatic ducts
29. Signal transduction cascade in staurosporine-induced prostaglandin E (2) production by rat peritoneal macrophages
30. Activation of p38 and c-Jun N-terminal kinase pathways and induction of apoptosis by chelerythrine do not require inhibition of protein kinase C
31. Role of protein kinase C in cholinergic stimulation of lacrimal gland protein secretion
32. Immunolocalization of lacrimal gland PKC isoforms. Effect of phorbol esters and cholinergic agonists on their cellular distribution