Moderate Controlled Cortical Contusion in Pigs: Effects on Multi-Parametric Neuromonitoring and Clinical Relevance

Journal of Neurotrauma

Volumn 20, Issue 12, 2003, Pages 1293-1305

  Alessandri, Beat ^a   Heimann, Axel ^a   Filippi, Ronald ^a   Kopacz, Laszlo ^a   Kempski, Oliver ^a  

^a JOHANNES GUTENBERG UNIVERSITY   (Germany)

Author keywords

Controlled cortical impact; Microdialysis; Monitoring; Pig; ptiO2

Indexed keywords

GLUCOSE; GLUTAMIC ACID; LACTIC ACID; PYRUVIC ACID;

ACID BASE BALANCE; ADOLESCENT; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN BLOOD FLOW; BRAIN CONTUSION; BRAIN INJURY; BRAIN OXYGEN CONSUMPTION; BRAIN WATER; CLINICAL PRACTICE; CONTROLLED STUDY; GLUCOSE BRAIN LEVEL; INTRACRANIAL PRESSURE; LACTATE BLOOD LEVEL; MALE; MICRODIALYSIS; NONHUMAN; SWINE;

EID: 0345731380     PISSN: 08977151     EISSN: None     Source Type: Journal    
DOI: 10.1089/089771503322686094     Document Type: Article

References (58)

1. ADAMS, J.H., DOYLE, D., GRAHAM, D.I., et al. (1985). The contusion index: a reappraisal in human and experimental non-missile head injury. Neuropathol. Appl. Neurobiol. 11, 299-308.
2. ALBERICO, A.M., WARD, J.D., CHOI, S.C., et al. (1987). Outcome after severe head injury. Relationship to mass lesions, diffuse injury, and ICP course in pediatric and adult patients. J. Neurosurg. 67, 648-656.
3. ALESSANDRI, B., and BULLOCK, R. (1998). Glutamate and its receptors in the pathophysiology of brain and spinal cord injuries. Prog. Brain Res. 116, 303-330.
4. ALESSANDRI, B., DOPPENBERG, E., BULLOCK, R., et al. (1999). Glucose and lactate metabolism after severe human head injury: influence of excitatory neurotransmitters and injury type. Acta Neurochir. Suppl. (Wien) 75, 21-24.
5. ALESSANDRI, B., DOPPENBERG, E., ZAUNER, A., et al. (1999). Evidence for time-dependent glutamate-mediated glycolysis in head-injured patients: a microdialysis study. Acta Neurochir. Suppl. (Wien) 75, 25-28.
6. ALESSANDRI, B., LANDOLT, H., LANGEMANN, H., et al. (1996). Application of glutamate in the cortex of rats: a microdialysis study. Acta Neurochir. Suppl. (Wien) 67, 6-12.
7. ANDERSEN, B.J., and MARMAROU, A. (1992). Posttraumatic selective stimulation of glycolysis. Brain Res. 585, 184-189.
8. BARBIRO-MICAHELY, E., and MAYEVSKY, A. (2001). Multiparametric monitoring of brain under elevated intracranial pressure in a rat model. J. Neurotrauma 18, 711-725.
9. 2 in traumatic brain injury: effect of cerebral hypoxia on outcome. Acta Neurochir. Suppl. (Wien) 71, 153-156.
10. BASKAYA, M.K., RAO, A.M., DOGAN, A., et al. (1997). The biphasic opening of the blood-brain barrier in the cortex and hippocampus after traumatic brain injury in rats. Neurosci. Lett. 226, 33-36.
11. BERGSNEIDER, M., HOVDA, D.A., LEE, S.M., et al. (2000). Dissociation of cerebral glucose metabolism and level of consciousness during the period of metabolic depression following human traumatic brain injury. J. Neurotrauma 17, 389-401.
12. BERGSNEIDER, M., HOVDA, D.A., SHALMON, E., et al. (1997). Cerebral hyperglycolysis following severe traumatic brain injury in humans: a positron emission tomography study. J. Neurosurg. 86, 241-251.
13. BOUMA, G.J., MUIZELAAR, J.P., STRINGER, W.A., et al. (1992) Ultra-early evaluation of regional cerebral blood flow in severely head-injured patients using xenon-enhanced computerized tomography. J. Neurosurg. 77, 360-368.
14. BRODHUN, M., FRITZ, H., WALTER, B., et al. (2001). Immunomorphological sequelae of severe brain injury induced by fluid-percussion in juvenile pigs-effects of mild hypothermia. Acta Neuropathol. (Berl.) 101, 424-434.
15. BRYAN, R.M., JR., CHERIAN, L., and ROBERTSON, C. (1995). Regional cerebral blood flow after controlled cortical impact injury in rats. Anesth. Analg. 80, 687-695.
16. BULLOCK, R., ZAUNER, A., MYSEROS, J.S., et al. (1995). Evidence for prolonged release of excitatory amino acids in severe human head trauma. Relationship to clinical events. Ann. NY Acad. Sci. 765, 290-298.
17. BULLOCK, R., ZAUNER, A., TSUJI, O., et al. (1995). Patterns of excitatory amino acid and ionic flux after severe human head trauma. in: T. Tsubokawa, A. Marmarou, C. Robertson, et al. (eds.), Neuromonitoring in the Intensive Care Unit: Microdialysis, Jugular Venous Oximetry, Near-Infrared Spectroscopy. Springer-Verlag: Tokyo, pps. 64-71.
18. BULLOCK, R., ZAUNER, A., WOODWARD, J.J., et al. (1998). Factors affecting excitatory amino acid release following severe human head injury. J. Neurosurg. 89, 507-518.
19. CLAUSEN, T., ZAUNER, A., LEVASSEUR, J.E., et al. (2001). Induced mitochondrial failure in the feline brain: implications for understanding acute post-traumatic metabolic events. Brain Res. 908, 35-48.
20. CZOSNYKA, M., SMIELEWSKI, P., KIRKPATRICK, P., et al. (1997). Continuous assessment of the cerebral vasomotor reactivity in head injury. Neurosurgery 41, 11-19.
21. 2-reactivity after severe head injury. Acta Neurochir. (Wien) 138, 425-434.
22. DIXON, C.E., CLIFTON, G.L., LIGHTHALL, J.W., et al. (1991). A controlled cortical impact model of traumatic brain injury in the rat. J. Neurosci. Methods 39, 253-262.
23. DUHAIME, A.C., MARGULIES, S.S., DURHAM, S.R., et al. (2000). Maturation-dependent response of the piglet brain to scaled cortical impact. J. Neurosurg. 93, 455-462.
24. DURHAM, S.R., RAGHUPATHI, R., HELFAER, M.A., et al. (2000). Age-related differences in acute physiologic response to focal traumatic brain injury in piglets. Pediatr. Neurosurg. 33, 76-82.
25. FELIX, B., LEGER, M.E., ALBE-FESSARD, D., et al. (1999). Stereotaxic atlas of the pig brain. Brain Res. Bull. 49, 1-137.
26. FRAY, A.E., FORSYTH, R.J., BOUTELLE, M.G., et al. (1996). The mechanisms controlling physiologically stimulated changes in rat brain glucose and lactate: a microdialysis study. J. Physiol. 496, 49-57.
27. GOODMAN, J.C., GOPINATH, S.P., VALADKA, A.B., et al. (1996). Lactic acid and amino acid fluctuations measured using microdialysis reflect physiological derangements in head injury. Acta Neurochir. Suppl. (Wien) 67, 37-39.
28. GOODMAN, J.C., VALADKA, A.B., GOPINATH, S.P., et al. (1999a). Simultaneous measurement of cortical potassium, calcium, and magnesium levels measured in head injured patients using microdialysis with ion chromatography. Acta Neurochir. Suppl. (Wien) 75, 35-37.
29. GOODMAN, J.C., VALADKA, A.B., GOPINATH, S.P., et al. (1999b). Extracellular lactate and glucose alterations in the brain after head injury measured by microdialysis. Crit. Care Med. 27, 1965-1973.
30. HILLERED, L., PERSSON, L., PONTEN, U., et al. (1990). Neurometabolic monitoring of the ischaemic human brain using microdialysis. Acta Neurochir. (Wien) 102, 91-97.
31. KATAYAMA, Y., BECKER, D.P., TAMURA, T., et al. (1990). Massive increases in extracellular potassium and the indiscriminate release of glutamate following concussive brain injury. J. Neurosurg. 73, 889-900.
32. KEMPSKI, O., VON ANDRIAN, U., SCHURER, L., et al. (1990). Intravenous glutamate enhances edema formation after a freezing lesion. Adv. Neurol. 52, 219-223.
33. 2-monitoring in comatose patients: implications for therapy. Neurol. Res. 19, 233-240.
34. KOCHANEK, P.M., MARION, D.W., ZHANG, W., et al. (1995). Severe controlled cortical impact in rats: assessment of cerebral edema, blood flow, and contusion volume. J. Neurotrauma 12, 1015-1025.
35. KROPPENSTEDT, S.N., SCHNEIDER, G.H., THOMALE, U.W., et al. (1998). Protective effects of aptiganel HCl (Cerestat) following controlled cortical impact injury in the rat. J. Neurotrauma 15, 191-197.
36. KROPPENSTEDT, S.N., STROOP, R., KERN, M., et al. (1999). Lubeluzole following traumatic brain injury in the rat. J. Neurotrauma 16, 629-637.
37. LANDOLT, H., LANGEMANN, H., MENDELOWITSCH, A., et al. (1994). Neurochemical monitoring and on-line pH measurements using brain microdialysis in patients in intensive care. Acta Neurochir. Suppl. (Wien) 60, 475-478.
38. LEVASSEUR, J.E., ALESSANDRI, B., REINERT, M., et al. (2000). Fluid percussion injury transiently increases then decreases brain oxygen consumption in the rat. J. Neurotrauma 17, 101-112.
39. MEIXENSBERGER, J., KUNZE, E., BARCSAY, E., et al. (2001). Clinical cerebral microdialysis: brain metabolism and brain tissue oxygenation after acute brain injury. Neurol. Res. 23, 801-806.
40. NARAYAN, R.K., MICHEL, M.E., ANSELL, B., et al. (2002). Clinical trials in head injury. J. Neurotrauma 19, 503-557.
41. PALMER, A., MARION, D., BOTSCHELLER, M., et al. (1993). Traumatic brain injury-induced excitotoxicity assessed in a controlled cortical impact model. J. Neurochem. 61, 2015-2024.
42. REINERT, M., KHALDI, A., ZAUNER, A., et al. (2000). High level of extracellular potassium and its correlates after severe head injury: relationship to high intracranial pressure. J. Neurosurg. 93, 800-807.
43. ROS, J., PECINSKA, N., ALESSANDRI, B., et al. (2001). Lactate reduces glutamate-induced neurotoxicity in rat cortex. J. Neurosci. Res. 66, 790-794.
44. SCHRODER, M.L., MUIZELAAR, J.P., BULLOCK, M.R., et al. (1995). Focal ischemia due to traumatic contusions documented by stable xenon-CT and ultrastructural studies. J. Neurosurg. 82, 966-971.
45. STOCCHETTI, N., PENNY, K.I., DEARDEN, M., et al. (2001). Intensive care management of head-injured patients in Europe: a survey from the European brain injury consortium. Intens. Care Med. 27, 400-406.
46. UNTERBERG, A., KIENING, K., SCHMIEDEK, P., et al. (1993). Long-term observations of intracranial pressure after severe head injury. The phenomenon of secondary rise of intracranial pressure. Neurosurg. (Balt.) 32, 17-24.
47. UNTERBERG, A.W., SAKOWITZ, O.W., SARRAFZADEH, A.S., et al. (2001). Role of bedside microdialysis in the diagnosis of cerebral vasospasm following aneurysmal subarachnoid hemorrhage. J. Neurosurg. 94, 740-749.
48. VAJKOCZY, P., ROTH, H., HORN, P., et al. (2000). Continuous monitoring of regional cerebral blood flow: experimental and clinical validation of a novel thermal diffusion microprobe. J. Neurosurg. 93, 265-274.
49. VALADKA, A.B., GOODMAN, J.C., GOPINATH, S.P., et al. (1998a). Comparison of brain tissue oxygen tension to microdialysis-based measures of cerebral ischemia in fatally head-injured humans. J. Neurotrauma 15, 509-519.
50. 2 to outcome after severe head injury. Crit. Care Med. 26, 1576-1581.
51. VAN DEN BRINK, W.A., VAN SANTBRINK, H., STEYERBERG, E.W., et al. (2000). Brain oxygen tension in severe head injury. Neurosurgery 46, 868-876.
52. VAN SANTBRINK, H., MAAS, A.I., and AVEZAAT, C.J. (1996). Continuous monitoring of partial pressure of brain tissue oxygen in patients with severe head injury. Neurosurgery 38, 21-31.
53. VATH, A., MEIXENSBERGER, J., DINGS, J., et al. (2000). Prognostic significance of advanced neuromonitoring after traumatic brain injury using neural networks. Zentralbl. Neurochir. 61, 2-6.
54. VERWEIJ, B.H., MUIZELAAR, J.P., VINAS, F.C., et al. (1997). Mitochondrial dysfunction after experimental and human brain injury and its possible reversal with a selective N-type calcium channel antagonist (SNX-111). Neurol. Res. 19, 334-339.
55. 2, pH, and temperature monitoring: evaluation in the feline brain. Neurosurgery 37, 1168-1176.
56. ZAUNER, A., CLAUSEN, T., ALVES, O.L., et al. (2002). Cerebral metabolism after fluid-percussion injury and hypoxia in a feline model. J. Neurosurg. 97, 643-649.
57. ZAUNER, A., DOPPENBERG, E., WOODWARD, J.J., et al. (1997a). Multiparametric continuous monitoring of brain metabolism and substrate delivery in neurosurgical patients. Neurol. Res. 19, 265-273.
58. ZAUNER, A., DOPPENBERG, E.M., WOODWARD, J.J., et al. (1997b). Continuous monitoring of cerebral substrate delivery and clearance: initial experience in 24 patients with severe acute brain injuries. Neurosurgery 41, 1082-1091.