Ca2+/calmodulin-mediated neurotransmitter release and neurobehavioural deficits following lead exposure

Cell Biochemistry and Function

Volumn 21, Issue 4, 2003, Pages 345-353

  Gill, K D ^a   Gupta, Vandana ^a   Sandhir, Rajat ^a,b  

^a POSTGRADUATE INSTITUTE OF MEDICAL EDUCATION AND RESEARCH   (India)

^b PANJAB UNIVERSITY   (India)

Author keywords

Acetylcholine; Behaviour; Brain; Calcium; Calmodulin; Lead; Neurotransmitter; Synaptic vesicles

Indexed keywords

ACETYLCHOLINE; CALCIUM ION; CALMODULIN; CYCLIC AMP PHOSPHODIESTERASE; LEAD; NEUROTRANSMITTER; 3',5' CYCLIC NUCLEOTIDE PHOSPHODIESTERASE; AGENTS INTERACTING WITH TRANSMITTER, HORMONE OR DRUG RECEPTORS; CALCIUM;

ACETYLCHOLINE RELEASE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; COGNITIVE DEFECT; CONTROLLED STUDY; ENZYME ACTIVITY; IN VITRO STUDY; IN VIVO STUDY; LEAD POISONING; MALE; MOTOR DYSFUNCTION; NEUROTOXICITY; NEUROTRANSMITTER RELEASE; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; RAT; SYNAPSE VESICLE; ANIMAL; COGNITION; DRUG EFFECT; METABOLISM; MOTOR ACTIVITY; PHOSPHORYLATION; SECRETION; SYNAPSE; WISTAR RAT;

ANIMALIA;

3',5'-CYCLIC-NUCLEOTIDE PHOSPHODIESTERASE; ACETYLCHOLINE; ANIMALS; CALCIUM; CALMODULIN; COGNITION; LEAD; MALE; MOTOR ACTIVITY; NEUROTRANSMITTER AGENTS; PHOSPHORYLATION; RATS; RATS, WISTAR; SYNAPSES;

EID: 0345687163     PISSN: 02636484     EISSN: None     Source Type: Journal    
DOI: 10.1002/cbf.1030     Document Type: Article

References (50)

1. Banks EC, Ferretti LE, Shucard DW. Effects of low level lead exposure on cognitive function in children: a review of behavioral, neuropsychological and biological evidence. Neurotoxicology 1997; 18: 237-281.
2. Goyer R. Lead toxicity: from overt to subclinical to subtle health effects. Environ Health Persp 1990; 86: 177-181.
3. Simons TJ. Lead-calcium in cellular lead toxicity. Neurotoxicology 1993; 203: 121-127.
4. Godwin HA. The biological chemistry of lead. Curr Opin Chem Biol 2001; 5: 223-227.
5. Goldsein GW. Evidence that lead acts as a calcium substitute in second messenger metabolism. Neurotoxicology 1993; 14: 97-101.
6. Kern M, Wisniewski CL, Audesirk G. Inorganic lead and calcium interact positively in activation of calmodulin. Neurotoxicology 2000; 21: 353-363.
7. Toscano CD, Schann FA. Lead-induced activation of protein kinase C in rat cortical synaptosomes. Ann NYAcad Sci 2000; 919: 309-311.
8. Sandhir R, Gill KD. Alterations in calcium homeostasis on lead exposure in rat synaptosomes. Mol Cell Biochem 1994; 131: 25-33.
9. Richardt G, Federolf G, Habermann E. The interaction of aluminium and other metal ions with calcium, calmodulin dependent phosphodiesterase. Arch Toxicol 57: 257-259.
10. Byrne JH, Kandel ER. Presynaptic facilitation revisited: state and time dependence. J Neurosci 1996; 6: 425-435.
11. 2+ microdomains: new tools for understanding their roles in neurotransmitter release. Neuron 1998; 20: 389-399.
12. Schiavo G, Stenbeck G. Molecular analysis of neurotransmitter release. Essays Biochem 1998; 22: 29-42.
13. Publicover SJ. Calmodulin synchronous and asynchronous release of neurotransmitter. Comp Biochem Physiol 1985; 82A: 7-11.
14. Sudhof TC. The synaptic vesicle cascade: a cascade of protein-protein interactions. Nature 1995; 375: 645-653.
15. Ferreira A, Chin LS, Lanier LM, Kosik KS, Greengard P. Distinct roles of synapsin I and synapsin II during neuronal development. Mol Med 1998; 4: 22-28.
16. Everitt BJ, Robbins TW. Central cholinergic systems and cognition. Annu Rev Psychol 1977; 48: 649-684.
17. Cory-Slechta DA. Relationship between lead-induced learning impairments and changes in dopaminergic, cholinergic and glutaminergic neurotransmitter functions. Annu Rev Pharmacol Toxicol 1995; 35: 391-415.
18. Glowinski J, Iverson L L. Regional studies of catecholamines in rat brain-I. J Neurochem 1966; 66: 655-659.
19. Egrie JC, Campbell JA, Flangas AL. Regional cellular, subcellular distribution of calcium activated cyclic nucleotide phosphodiesterase and calcium dependent regulator in porcine brain. J Neurochem 1977; 28: 1207-1213.
20. 2+ dependent phosphodiesterase. Meth Enzymol 1983; 102: 39-47.
21. Delorenzo RJ, Freedman SD. Calcium dependent phosphorylation of synaptic vesicle proteins and its possible role in mediating neurotransmitter release and vesicle function. Biochem Biophys Res Commun 1977; 77: 1036-1043.
22. Jones LR, Simmerman HKB, Wilson WW, Gurd FRN, Wegener AD. Purification and characterization of phospholamban from canine sarcoplamic reticulum. J Biol Chem 1985; 260: 7721-7730.
23. Delorenzo RJ, Freedman SD. Possible role of calcium dependent protein phosphorylation in mediating neurotransmitter release and anticonvulsant action. Epilepsia 1977; 18: 357-365.
24. Whittaker VP. Synaptosomes. In Handbook of Neurochemistry, Lajtha A (ed.). Plenum Publishing Corp: New York, 1969; 327-364.
25. Evenson MA, Anderson CT. Ultramicroanalysis for copper, cadmium and zinc in human liver tissues by use of atomic absorption spectrophotometery. Clin Chem 1975; 21: 537-543.
26. Lowry OH, Rosebrough NJ, Farr AL, Randall RJ. Protein measurement with the Folinphenol reagent. J Biol Chem 1951; 193: 265-275.
27. Reddy DS, Kulkarni SK. Role of GABA-A and mitochondrial diazepam binding inhibitor receptors in the antistress activity of neurosteroids in mice. Psychopharmacology 1996; 128: 280-292.
28. Dews PB. Measurements of influence of drugs on voluntary activity in mice. Br J Pharmacol 1953; 8: 46-48.
29. Kaplan M, Murphy SD. Effect of acrylamide on rotarod performance and sciatic nerve β-glucuronidase of rats. Toxicol Appl Pharmacol 1972; 22: 259-268.
30. Sole E, Ballabriga A, Dominguez C. Zinc-protoporphyrin determination as a screening test for lead exposure in childhood. Bull Environ Contam Toxicol 2000; 65: 285-292.
31. 2+/calmodulin dependent protein kinase. Neurochem Res 1993; 18: 65-77.
32. Rosahl TW, Spillane D, Missler M, et al. Essential functions of synapsin I and II in synaptic vesicle regulation. Nature 1995; 375: 488-493.
33. Chin D, Means AR. Calmodulin: a prototypical calcium sensor. Trends Cell Biol 2000; 10: 322-328.
34. 2+ ATPase activity: calmodulin involvement. Mol Cell Biochem 1989; 89: 87-93.
35. Li L, Chin LS, Shupliakov O, et al. Impairment of synaptic vesicle clustering and of synaptic transmission, and increased seizure propensity, in synapsin I deficient mice. Proc Natl Acad Sci USA 1995; 92: 9235-9239.
36. Lisman J, Schulman H, Cline H. The molecular basis of calmodulin kinase II function in synaptic and behavioral memory. Nature Rev Neurosci 2002; 3: 175-190.
37. 32P into nuclear protein of rat brain. Pharmacol Biochem Behav 1980; 12: 481-486.
38. Tomsig JL, Suszkiw JB. Extracellular mechanisms of lead induced norepinephrine release from bovine chromaffin cells. Am J Physiol 1993; 265: C1630-C1636.
39. Bressler JP, Belloni-Olive L, Forman S, Goldstein GW. Distinct mechanisms of neurotransmitter release from PC12 cells exposed to lead. J Neurosci Res 1996; 46: 678-685.
40. Bouton CM, Frelin LP, Forde CE, Godwin HA, Persner J. Synaptotagmin I is a molecular target for lead. J Neurochem 2001; 76: 1724-1735.
41. Atchison WD, Narahasi T. Mechanism of action of lead on neuromuscular junctions. Neurotoxicology 1984; 5: 267-282.
42. Audesirk G. Effect of lead exposure on physiology of neurons. Prog Neurobiol 1985; 24: 199-231.
43. Sun X, Tian X, Suszkiw JB. Reduced vesicular acetylcholine transporter mRNA in the rat septum following lead exposure. Neuroreport 1997; 8: 891-894.
44. Sun X, Tian X, Suszkiw JB. Reduction of choline acetyl transferase mRNA in the septum of developing rat exposed to inorganic lead. Neurotoxicology 1997; 18: 201-207.
45. Sulzer D, Piscopo I, Ungar F, Holtzman E. Lead-dependent deposits in diverse synaptic vesicles: suggestive evidence for presence of anionic binding sites. J Neurobiol 1987; 18: 467-483.
46. Anger WK. Neurobehavioral testing of chemicals: impact of recommended standards. Neurobehav Toxicol Teratol 1984; 6: 147-153.
47. Alkon DL, Amaral DG, Bear MF, et al. Learning and memory. Brain Res Rev 1991; 16: 193-220.
48. Memo M, Lucchi L, Spano PF, Trabucchi M. Dose dependent and reversible effects of lead on rat dopaminergic system. Life Sci 1980; 28: 795-799.
49. Gupta V, Gill KD. Lead and ethanol coexposure: implications on the dopaminergic system and associated behavioral functions. Pharmacol Biochem Behav 2000; 66: 465-474.
50. David O, Clark J, Voeller K. Lead and hyperactivity. Lancet ii: 1972; 900-903.