Distinct roles of synapsin I and synapsin II during neuronal development

Molecular Medicine

Volumn 4, Issue 1, 1998, Pages 22-28

  Ferreira, Adriana ^a,b,d   Chin, Lih Shen ^c   Li, Lian ^c   Lanier, Lorene M ^c   Kosik, Kenneth S ^b   Greengard, Paul ^c  

^a NORTHWESTERN UNIVERSITY   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

^c ROCKEFELLER UNIVERSITY   (United States)

^d Searle Building ^*  (United States)

Author keywords

[No Author keywords available]

Indexed keywords

SYNAPSIN I; SYNAPSIN II;

ACTIN FILAMENT; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN SIZE; BRAIN WEIGHT; CONTROLLED STUDY; CYTOSKELETON; IMMUNOCYTOCHEMISTRY; MOUSE; NERVE CELL DIFFERENTIATION; NERVE FIBER GROWTH; NEUROTRANSMITTER RELEASE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; SYNAPSE; SYNAPSE VESICLE;

EID: 0031917238     PISSN: 10761551     EISSN: None     Source Type: Journal    
DOI: 10.1007/bf03401726     Document Type: Article

References (23)

1. Sudhof TC, Czernik AJ, Kao H, Takei K, Johnston PA, Horiuchi A, Wagner M, Kanazir SD, Perin MS, De Camilli P, Greengard P. (1989) Synapsins: Mosaic of shared and individual domains in a family of synaptic vesicle phosphoproteins. Science 245: 1474-1480.
2. Greengard P, Valtorta F, Czernik AJ, Benfenati F. (1993) Synaptic vesicle phosphoproteins and regulation of synaptic function. Science 259: 780-785.
3. Pieribone VA, Shupliakov O, Brodin L, Hilfiker-Rothenfluh S, Czernik AJ, Greengard P. (1995) Distinct pools of synaptic vesicles in neurotransmitter release. Nature 375: 493-497.
4. Li L, Chin L, Shupliakov O, Brodin L, Sihra T, Hvalby Ø, Jensen V, Zieng D, McNamara JO, Greengard P, Andersen P. (1995) Impairment of synaptic vesicle clustering and of synaptic transmission, and increased seizure propensity, in synapsin I-deficient mice. Proc. Natl. Acad. Sci. U.S.A. 92: 9235-9239.
5. Rosahl TW, Spillane D, Missler M, Herz J, Selig D, Wolff JR, Hammer RE, Malenka RC, Südhof TC. (1995) Essential functions of synapsin I and II in synaptic vesicle regulation. Nature 375: 488-493.
6. Takei Y, Harada A, Takeda S, Kobayashi K, Terada S, Noda T, Takahashi T, Hirokawa N. (1995) Synapsin I deficiency results in the structural change in the presynaptic terminals in the murine nervous system. J. Cell Biol. 131: 1789-1800.
7. Lu B, Greengard P, Poo MM. (1992) Exogenous synapsin I promotes functional maturation of developing neuromuscular synapses. Neuron 8: 521-529.
8. Schaeffer E, Alder J, Greengard P, Poo MM. (1994) Exogenous synapsin I promotes functional maturation of developing neuromuscular synapses. Proc. Natl. Acad. Sci. U.S.A. 91: 3882-3886.
9. Valtorta F, Iezzi N, Benfenati F, Lu B, Poo M-M, Greengard P. (1995) Accelerated structural maturation induced by synapsin I at developing neuromuscular synapses of Xenopus laevis. Eur. J. Neurosci. 7: 261-270.
10. Han HQ, Nichols RA, Rubin MR, Bahler M, Greengard P. (1991) Induction of formation of presynaptic terminals in neuroblastoma cells by synapsin IIb. Nature 349: 697-700.
11. Chin LS, Li L, Ferreira A, Kosik KS, Greengard P. (1995) Impairment of axonal development and of synaptogenesis in hippocampal neurons of synapsin I-deficient mice. Proc. Natl. Acad. Sci. U.S.A. 92: 9230-9234.
12. Ferreira A, Han HQ, Greengard P, Kosik KS. (1995) Suppression of synapsin II inhibits the formation and maintenance of synapses in hippocampal culture. Proc. Natl. Acad. Sci. U.S.A. 92: 9225-9229.
13. Ferreira A, Li L, Chin LS, Greengard P, Kosik KS. (1996) Postsynaptic element contributes to the delay in synaptogenesis in synapsin I deficient neurons. Mol. Cell. Neurosci. 8: 286-299.
14. Shupliakov O, Magarinos AM, Li L, Chin LS, Gustafsson J, McEwen BS, Pieribone V, Greengard P, Brodin L. Structural alterations in nerve terminals of synapsin-deficient mice. J. Cell Biol. (in press).
15. Goslin K, Banker GA. (1991) Rat hippocampal neurons in low-density culture. In: Banker GA, Goslin K (eds). Culturing nerve cells. MIT Press, Cambridge, MA, pp. 251-283.
16. Bottenstein JE, Sato GH. (1979) Growth of a rat neuroblastoma cell line in serum-free supplemented media. Proc. Natl. Acad. Sci. U.S.A. 76: 514-517.
17. Dotti CG, Sullivan CA, Banker GA. (1988) The establishment of polarity by hippocampal neurons in culture. J. Neurosci. 8: 1454-1468.
18. Ferreira A, Kosik KS, Greengard P, Han HQ. (1994) Aberrant neurites and synaptic vesicle protein deficiency in synapsin II-depleted neurons. Science 264: 977-979.
19. Fletcher TP, Cameron P, De Camilli P, Banker GA. (1991) The distribution of synapsin I and synaptophysin in hippocampal neurons in culture. J. Neurosci. 11: 1617-1632.
20. Mitchison T, and Kirschner M. (1988) Cytoskeletal dynamics and nerve growth. Neuron 1: 761-772.
21. Chilcote TJ, Siow YL, Schaeffer E, Greengard P, Thiel G. (1994) Synapsin IIa bundles actin filaments. J. Neurochem. 63: 1568-1571.
22. Baines AJ, Bennett V. (1986) Synapsin I is a microtubule-bundling protein. Nature 319: 145-147.
23. Petrucci TC, Morrow JF. (1991) Synapsin I: an actin-bundling protein under phosphorylation control. Biochemistry 30: 413-422.