Induction of GADD Gene Expression by Phenethylisothiocyanate in Human Colon Adenocarcinoma Cells

Journal of Cellular Biochemistry

Volumn 90, Issue 6, 2003, Pages 1128-1139

  Powolny, Anna ^a   Takahashi, Keiko ^a   Hopkins, Robin G ^a   Loo, George ^a  

^a UNIVERSITY OF NORTH CAROLINA AT GREENSBORO   (United States)

Author keywords

Apoptosis; GADD153; Isothiocyanates; Phenethylisothiocyanate

Indexed keywords

ACETYLCYSTEINE; DACTINOMYCIN; GROWTH ARREST AND DNA DAMAGE INDUCIBLE PROTEIN 45; MESSENGER RNA; MUTANT PROTEIN; PHENETHYL ISOTHIOCYANATE; PHOSPHATIDYLSERINE; PROTEIN P53; REACTIVE OXYGEN METABOLITE; SINGLE STRANDED DNA;

APOPTOSIS; ARTICLE; ATTENUATION; CANCER CELL DESTRUCTION; CARCINOMA CELL; CELL SHAPE; CELL STRUCTURE; CHROMATIN CONDENSATION; COLON ADENOCARCINOMA; CONTROLLED STUDY; DNA MICROARRAY; DNA STRAND BREAKAGE; GENE; GENE CLUSTER; GENE EXPRESSION REGULATION; GENE INDUCTION; HUMAN; HUMAN CELL; INTESTINE CELL; INTRACELLULAR TRANSPORT; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN TRANSPORT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TRANSCRIPTION INITIATION; UPREGULATION;

ACETYLCYSTEINE; ADENOCARCINOMA; ANTICARCINOGENIC AGENTS; ANTIGENS, DIFFERENTIATION; APOPTOSIS; CCAAT-ENHANCER-BINDING PROTEINS; CELL CYCLE PROTEINS; CELL LINE, TUMOR; CELL SIZE; COLONIC NEOPLASMS; DACTINOMYCIN; DNA DAMAGE; GENE EXPRESSION REGULATION; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; ISOTHIOCYANATES; NUCLEIC ACID SYNTHESIS INHIBITORS; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PROTEINS; RNA, MESSENGER; TRANSCRIPTION FACTOR CHOP; TRANSCRIPTION FACTORS; TUMOR SUPPRESSOR PROTEIN P53;

EID: 0345305862     PISSN: 07302312     EISSN: None     Source Type: Journal    
DOI: 10.1002/jcb.10733     Document Type: Article

References (37)

1. Abcouwer SF, Schwarz C, Meguid RA. 1999. Glutamine deprivation induces the expression of GADD45 and GADD153 primarily by mRNA stabilization. J Biol Chem 274:28645-28651.
2. Block G, Patterson B, Subar A. 1992. Fruits, vegetables, and cancer prevention: A review of epidemiological evidence. Nutr Cancer 18:1-29.
3. Bruhat A, Jousse C, Wang XZ, Ron D, Ferrara M, Fafournoux P. 1997. Amino acid limitation induces expression of CHOP, a CCAAT/enhancer binding protein-related gene, at both transcriptional and posttranscriptional levels. J Biol Chem 272:17588-17593.
4. Carlson SG, Fawcett TW, Bartlett JD, Bernier M, Holbrook NJ. 1993. Regulation of the C/EBP-related gene gadd153 by glucose deprivation. Mol Cell Biol 13:4736-4744.
5. Chen Y-R, Wang W, Kong ANT, Tan T-H. 1998. Molecular mechanisms of c-Jun N-terminal kinase-mediated apoptosis induced by anticarcinogenic isothiocyanates. J Biol Chem 273:1769-1775.
6. Chinery R, Brockman JA, Peeler MO, Shyr Y, Beauchamp RD, Coffey RJ. 1997. Antioxidants enhance the cytotoxicity of chemotherapeutic agents in colorectal cancer: A p53-independent induction of p21WAF1/CIP1 via C/EBPbeta. Nat Med 3:1233-1241.
7. Conn KJ, Gao WW, Ullman MD, McKeon-O'Malley C, Eisenhauer PB, Fine RE, Wells JM. 2002. Specific upregulation of GADD153/CHOP in 1-methyl-4-phenylpyridinium-treated SH-SY5Y cells. J Neurosci Res 68:755-760.
8. Coultas L, Strasser A. 2000. The molecular control of DNA damage-induced cell death. Apoptosis 5:491-507.
9. Fanzo JC, Reaves SK, Cui L, Zhu L, Wu JY, Wang YR, Lei KY. 2001. Zinc status affects p53, gadd45, and c-fos expression and caspase-3 activity in human bronchial epithelial cells. Am J Physiol Cell Physiol 281:C751-C757.
10. Fimognari C, Nusse M, Cesari R, Iori R, Cantelli-Forti G, Hrelia P. 2002. Growth inhibition, cell-cycle arrest, and apoptosis in human T-cell leukemia by the isothiocyanate sulforaphane. Carcinogenesis 23:581-586.
11. Gamet-Payrastre L, Li P, Lumeau S, Cassar G, Dupont MA, Chevolleau S, Gasc N, Tulliez J, Terce F. 2000. Sulforaphane, a naturally occurring isothiocyanate, induces cell cycle arrest and apoptosis in HT29 human colon cancer cells. Cancer Res 60:1426-1433.
12. Hecht SS. 2000. Inhibition of carcinogenesis by isothiocyanates. Drug Metab Rev 32:395-411.
13. Hollander MC, Sheikh MS, Yu K, Zhan Q, Iglesias M, Woodworth C, Fornace AJ. 2001. Activation of Gadd34 by diverse apoptotic signals and suppression of its growth inhibitory effects by apoptotic inhibitors. Int J Cancer 96:22-31.
14. Huang C, Ma W, Li J, Hecht SS, Dong Z. 1998. Essential role of p53 in phenethyl isothiocyanate-induced apoptosis. Cancer Res 58:4102-4106.
15. Kassie F, Pool-Zobel B, Parzefall W, Knasmuller S. 1999. Genotoxic effects of benzyl isothiocyanate, a natural chemopreventive agent. Mutagenesis 14:595-603.
16. Kim D-G, You K-R, Liu M-J, Choi Y-K, Won Y-S. 2002. GADD153-mediated anticancer effects of N-(4-hydroxyphenyl)retinamide on human hepatoma cells. J Biol Chem 277:38930-38938.
17. Lengwehasatit I, Dickson AJ. 2002. Analysis of the role of GADD153 in the control of apoptosis in NS0 myeloma cells. Biotechnol Bioeng 80:719-730.
18. Maytin EV, Ubeda M, Lin JC, Habener JF. 2001. Stress-inducible transcription factor CHOP/gadd153 induces apoptosis in mammalian cells via p38 kinase-dependent and -independent mechanisms. Exp Cell Res 267:193-204.
19. Mertani HC, Zhu T, Goh EL, Lee KO, Morel G, Lobie PE. 2001. Autocrine human growth hormone (hGH) regulation of human mammary carcinoma cell gene expression. Identification of CHOP as a mediator of hGH-stimulated human mammary carcinoma cell survival. J Biol Chem 276:21464-21475.
20. Miyashita T, Reed JC. 1995. Tumor suppressor p53 is a direct transcriptional activator of the human bax gene. Cell 80:293-299.
21. Miyashita T, Harigai M, Hanada M, Reed JC. 1994. Identification of a p53-dependent negative response element in the bcl-2 gene. Cancer Res 54:3131-3135.
22. Murata M, Yamashita N, Inoue S, Kawanishi S. 2000. Mechanism of oxidative DNA damage induced by carcinogenic allyl isothiocyanate. Free Radic Biol Med 28:797-805.
23. Musk SR, Johnson IT. 1993. Allyl isothiocyanate is selectively toxic to transformed cells of the human colorectal tumour line HT29. Carcinogenesis 14:2079-2083.
24. Nakamura Y, Kawakami M, Yoshihiro A, Miyoshi N, Ohigashi H, Kawai K, Osawa T, Uchida K. 2002. Involvement of the mitochondrial death pathway in chemopreventive benzyl isothiocyanate-induced apoptosis. J Biol Chem 277:8492-8499.
25. Oh-Hashi K, Maruyama W, Isobe K. 2001. Peroxynitrite induces GADD34, 45, 153 via p38 MAPK in human neuroblastoma SH-SY5Y cells. Free Radic Biol Med 30:213-221.
26. Owuor ED, Kong AN. 2002. Antioxidants and oxidants regulated signal transduction pathways. Biochem Pharmacol 64:765-770.
27. Powolny A, Xu J, Loo G. 2001. Deoxycholate induces DNA damage and apoptosis in human colon epithelial cells expressing either mutant or wild-type p53. Int J Biochem Cell Biol 33:193-203.
28. Rolli-Derkinderen M, Gaestel M. 2000. p38/SAPK2-dependent gene expression in Jurkat T cells. Biol Chem 381:193-198.
29. Sarkar D, Su ZZ, Lebedeva IV, Sauane M, Gopalkrishnan RV, Valerie K, Dent P, Fisher PB. 2002. mda-7 (IL-24) mediates selective apoptosis in human melanoma cells by inducing the coordinated overexpression of the GADD family of genes by means of p38 MAPK. Proc Natl Acad Sci USA 99:10054-10059.
30. Sheikh MS, Hollander MC, Fornace AJ, Jr. 2000. Role of Gadd45 in apoptosis. Biochem Pharm 59:43-45.
31. Talalay P, Fahe JW. 2001. Phytochemicals from cruciferous plants protect against cancer by modulating carcinogen metabolism. J Nutr 131:3027S-3033S.
32. Tong T, Fan W, Zhao H, Jin S, Fan F, Blanck P, Alomo I, Rajasekaran B, Liu Y, Holbrook NJ, Zhan Q. 2001. Involvement of the MAP kinase pathways in induction of GADD45 following UV radiation. Exp Cell Res 269:64-72.
33. Wang XW, Zhan Q, Coursen JD, Khan MA, Kontny HU, Yu L, Hollander MC, O'Connor PM, Fornace AJ, Jr., Harris CC. 1999. GADD45 induction of a G2/M cell cycle checkpoint. Proc Natl Acad Sci USA 96:3706-3711.
34. Xia Y, Wong NS, Fong WF, Tideman H. 2002. Upregulation of GADD153 expression in the apoptotic signaling of N-(4-hydroxyphenyl)retinamide (4HPR). Int J Cancer 102:7-14.
35. Xiao D, Singh SV. 2002. Phenethyl isothiocyanate-induced apoptosis in p53-deficient PC-3 human prostate cancer cell line is mediated by extracellular signal-regulated kinases. Cancer Res 62:3615-3619.
36. Yu R, Mandlekar S, Harvey KJ, Ucker DS, Kong ANT. 1998. Chemopreventive isothiocyanates induce apoptosis and caspase-3-like protease activity. Cancer Res 58:402-408.
37. Zhan Q, Lord KA, Alamo I, Jr., Hollander MC, Carrier F, Ron D, Kohn KW, Hoffman B, Liebermann DA, Fornace AJ, Jr. 1994. The gadd and MyD genes define a novel set of mammalian genes encoding acidic proteins that synergistically suppress cell growth. Mol Cell Biol 14:2361-2371.