No Evidence of Stimulation of Human Tumor Cell Proliferation by a Standardized Aqueous Mistletoe Extract in Vitro

Anticancer Research

Volumn 23, Issue 5 A, 2003, Pages 3801-3806

  Burger, A M ^a   Mengs, Ulrich ^b   Kelter, G ^c   Schuler J B ^c   Fiebig, H H ^c  

^a SUNNYBROOK RESEARCH INSTITUTE   (Canada)

^b Madaus AG   (Germany)

^c CHARLES RIVER LABORATORIES   (United States)

Author keywords

Adriamycin; Antiproliferative activity; Growth stimulation; Human tumor cell lines; In vitro; Mistletoe extract; Mistletoe lectin

Indexed keywords

VISCUM ALBUM EXTRACT;

AQUEOUS SOLUTION; ARTICLE; CANCER CELL CULTURE; CANCER INHIBITION; CELL LINEAGE; CELL PROLIFERATION; CELL STIMULATION; CONTROLLED STUDY; HUMAN; HUMAN CELL; IC 50; MELANOMA CELL; PRIORITY JOURNAL; REPRODUCIBILITY; STANDARDIZATION; TUMOR CELL; TUMOR GROWTH; VISCUM ALBUM;

CELL DIVISION; CELL LINE, TUMOR; GROWTH INHIBITORS; HUMANS; INHIBITORY CONCENTRATION 50; LEIOMYOSARCOMA; MELANOMA; MISTLETOE; PLANT PREPARATIONS; PLANT PROTEINS; STIMULATION, CHEMICAL; TOXINS, BIOLOGICAL; WATER;

EID: 0345305283     PISSN: 02507005     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (26)

1. Bocci V: Mistletoe (Viscum album) lectins as cytokine inducers and immunoadjuvant in tumor therapy. A review. J Biol Regul Homeost Agents 7: 1-6, 1993.
2. Stauder H and Kreuser E-D: Mistletoe extracts standardised in terms of mistletoe lectins (ML I) in oncology: current state of clinical research. Onkologie 25: 374-380, 2002.
3. Witthohn K and Schwarz T: In: Phytopharmaka V, Forschung und Klinische Anwendung, D. Loew, H. Blume, T. Dingermann (eds.), 19-26, Steinkopff Verlag, Darmstadt, 1999.
4. Franz H: Mistletoe lectins and their A and B chains. Oncology 43: 23-24, 1986.
5. Endo Y, Tsurugi K and Franz H: The site of action of the A chain of mistletoe lectin I on eukaryotic ribosomes. The RNA N-glycosidase activity of the protein. FEBS Lett 231: 378-380, 1988.
6. Barbieri L, Batelli MG and Stirpe F: Ribosome-inactivating proteins from plants. Biochim Biophys Acta 1154: 237-282, 1993.
7. Janssen O, Scheffler A and Kabelitz D: In vitro effects of mistletoe extracts and mistletoe lectins. Cytotoxicity towards tumor cells due to the induction of programmed cell death (apoptosis). Arznei.-Forsch./ Drug Res 43: 1221-1227, 1993.
8. Möckel B, Schwarz T, Zinke H et al: Effects of mistletoe lectin I on human blood cell lines and peripheral blood cells. Cytotoxicity, apoptosis and induction of cytokines. Arzneim.-Forsch./ Drug Res 47: 1145-1151, 1997.
9. Bantel H, Engels IH, Voelter W et al: Mistletoe lectin activates caspase-8/FLICE independently of death receptor signaling and enhances anticancer drug-induced apoptosis. Cancer Res 59: 2083-2090, 1999.
10. Büssing A and Schietzel M: Apoptosis-inducing properties of Viscum album L. extracts from different host trees, correlate with their content of toxic mistletoe lectins. Anticancer Res 19: 23-28, 1999.
11. Hajto T, Hostanka K, Frei K et al: Increased secretion of tumor necrosis factors alpha, interleukin 1, and interleukin 6 by human mononuclear cells exposed to beta-galactoside-specific lectin from clinically applied mistletoe extract. Cancer Res 50: 3322-3326, 1990.
12. Ribereau-Gayon G, Dumont S and Muller C: Mistletoe lectins I, II and III induce the production of cytokines by cultured human monocytes. Cancer Lett 109: 33-38, 1996.
13. Joller P W, Menrad J M, Schwarz T et al: Stimulation of cytokine production via a special standardized mistletoe preparation in an in vitro human skin bioassay. Arzneim.-Forsch./Drug Res 46: 649-653, 1996.
14. Baxevanis C N, Voutsas I F, Soler M H et al: Mistletoe lectin I-induced effects on human cytotoxic lymphocytes. I. Synergism with IL-2 in the induction of enhanced LAK cytotoxicity. Immunopharm Immunotox 20: 355-372, 1998.
15. Elsässer-Beile U, Voss M, Schühle R et al: Biological effects of natural and recombinant mistletoe lectin and an aqueous mistletoe extract on human monocytes and lymphocytes in vitro. J Clin Lab Anal 14: 255-259, 2000.
16. Mengs U, Göthel D and Leng-Peschlow E: Mistletoe extracts standardized to mistletoe lectins in oncology: review on current status of preclinical research. Anticancer Res 22: 1399-1408, 2002.
17. Burger A M, Mengs U, Schüler J B et al: Antiproliferative activity of an aqueous mistletoe extract in human tumor cell lines and xenografts in vitro. Arzneim.-Forsch./Drug Res 51: 748-757, 2001.
18. Valentiner U, Pfüller U, Baum C et al: The cytotoxic effect of mistletoe lectins I, II and III on sensitive and multidrug resistant human colon cancer cell lines in vitro. Toxicology 171: 187-199, 2002.
19. Weber K, Mengs U, Schwarz T et al: Effects of a standardized mistletoe preparation on metastatic B16 melanoma colonization in murine lungs. Arzneim.-Forsch./ Drug Res 48: 497-502, 1998.
20. Mengs U, Schwarz T, Bulitta M et al: Antitumoral effects of an intravesically applied aqueous mistletoe extract on urinary bladder carcinoma MB49 in mice. Anticancer Res 20: 3565-3568, 2000.
21. Burger A M, Mengs U, Schüler J B et al: Anticancer activity of an aqueous mistletoe extract (AME) in syngeneic murine tumor models. Anticancer Res 21: 1965-1968, 2001.
22. Gabius H-J, Darro F, Remmelink M et al: Evidence for stimulation of tumor proliferation in cell lines and histotypic cultures by clinically relevant low doses of the galactoside-binding mistletoe lectin, a component of proprietary extracts. Cancer Investigation 19: 114-126, 2001.
23. Maier G and Fiebig H-H: Absence of tumor growth stimulation in a panel of 16 human tumor cell lines by mistletoe extracts in vitro. Anti-Cancer Drugs 13: 373-379, 2002.
24. Skehan P, Storeng R, Scudiero D et al: New colorimetric cytotoxicity assay for anticancer-drug screening. J Nat Cancer Inst 82: 1107-1112, 1990.
25. Dengler W A, Schulte J, Berger D P et al: Development of a propidium iodide fluorescence assay for proliferation and cytotoxicity assays. Anticancer Drugs 6: 522-532, 1995.
26. Vang O, PiiLarsen K and Bog-Hansen TC: Lectins: Biology, Biochemistry, Clinical Biochemistry. In: TC Bog-Hansen, E van Driessche (Eds.), de Gruyter, Berlin, 637-644, 1986.