High-molecular-weight tropomyosins localize to the contractile rings of dividing CNS cells but are absent from malignant pediatric and adult CNS tumors

GLIA

Volumn 42, Issue 1, 2003, Pages 25-35

  Hughes, Julie A I ^a,b   Cooke Yarborough, Claire M ^a   Chadwick, Nigel C ^a   Schevzov, Galina ^a   Arbuckle, Susan M ^a   Gunning, Peter ^a,b   Weinberger, Ron P ^a,b,c  

^a CHILDREN S HOSPITAL AT WESTMEAD   (Australia)

^b UNIVERSITY OF SYDNEY   (Australia)

^c Proteome Systems Ltd   (Australia)

Author keywords

Astrocyte; Cancer; Cell division; Cytokinesis; Cytoskeleton

Indexed keywords

ACTIN; TROPOMYOSIN;

ADULT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASTROCYTOMA; BRAIN CANCER; BRAIN INJURY; CELL CYCLE; CELL DIVISION; CELL MIGRATION; CONTROLLED STUDY; CYTOKINESIS; CYTOSKELETON; DOWN REGULATION; EMBRYO; FEMALE; GLIA CELL; HUMAN; HUMAN CELL; INFANT; MOLECULAR WEIGHT; MORPHOGENESIS; MOUSE; NERVE CELL; NEWBORN; NONHUMAN; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION;

ADULT; ANIMALS; ANIMALS, NEWBORN; ASTROCYTES; BRAIN; BRAIN NEOPLASMS; CELL DIVISION; CELLS, CULTURED; CHILD; CONTRACTILE PROTEINS; FEMALE; HUMANS; MICE; PROTEIN ISOFORMS; TROPOMYOSIN;

EID: 0345269302     PISSN: 08941491     EISSN: None     Source Type: Journal    
DOI: 10.1002/glia.10174     Document Type: Article

References (55)

1. Alaiya AA, Franzen B, Fujioka K, Moberger B, Schedvins K, Silfversvard C, Linder S, Auer G. 1997. Phenotypic analysis of ovarian carcinoma: polypeptide expression in benign, borderline and malignant tumors. Int J Cancer 73:678-683.
2. Alaiya A, Roblick U, Egevad L, Carlsson A, Franzen B, Volz D, Huwendiek S, Linder S, Auer G. 2000. Polypeptide expression in prostate hyperplasia and prostate adenocarcinoma. Anal Cell Pathol 21:1-9.
3. Alaiya AA, Oppermann M, Langridge J, Roblick U, Egevad L, Brindstedt S, Hellstrom M, Linder S, Bergman T, Jornvall H, Auer G. 2001. Identification of proteins in human prostate tumor material by two-dimensional gel electrophoresis and mass spectrometry. Cell Mol Life Sci 58:307-311.
4. Altman J, Bayer SA. 1995. Atlas of prenatal rat brain development. Boca Raton, FL: CRC Press.
5. Balasubramanian MK, Helfman DM, Hemmingsen SM. 1992. A new tropomyosin essential for cytokinesis in the fission yeast S. pombe. Nature 360:84-87.
6. Blanchoin L, Pollard TD, Hitchcock-DeGregori SE. 2001. Inhibition of the Arp2/3 complex-nucleated actin polymerization and branch formation by tropomyosin. Curr Biol 11:1300-1304.
7. Bohmer RM, Scharf E, Assoian RK. 1996. Cytoskeletal integrity is required throughout the mitogen stimulation phase of the cell cycle and mediates the anchorage-dependent expression ofcyclin D1. Mol Biol Cell 7:101-111.
8. Bouvier-Labit C, Civatte M, Bartoli C, Renaud W, Pellissier JF, Figarella-Branger D. 1999. p16INK4a and p19INK4d mRNA expression in neuroglial tumors: correlation with proliferation index. Neuropathol Appl Neurobiol 25:408-416.
9. Cheng Y, Pang JC, Ng HK, Ding M, Zhang SF, Zheng J, Liu DG, Poon WS. 2000. Pilocytic astrocytomas do not show most of the genetic changes commonly seen in astrocytomas. Histopathology 37:437-444.
10. Cho YJ, Hitchcock-DeGregori SE. 1991. Relationship between alternatively spliced exons and functional domains in tropomyosin. Proc Natl Acad Sci USA 88:10153-10157.
11. Clayton L, Johnson MH. 1998. Tropomyosin in preimplantation mouse development: identification, expression, and organization during cell division and polarization. Exp Cell Res 238:450-464.
12. Cooley BC, Bergtrom G. 2001. Multiple combinations of alternatively spliced exons in rat tropomyosin-alpha gene mRNA: evidence for 20 new isoforms in adult tissues and cultured cells. Arch Biochem Biophys 390:71-77.
13. Cooper HL, Feuerstein N, Noda M, Bassin RH. 1985. Suppression of tropomyosin synthesis, a common biochemical feature of oncogenesis by structurally diverse retroviral oncogenes. Mol Cell Biol 5:972-983.
14. Dufour C, Weinberger RP, Schevzov G, Jeffrey PL, Gunning P. 1998. Splicing of two internal and four carboxyl-terminal alternative exons in nonmuscle tropomyosin 5 pre-mRNA is independently regulated during development. J Biol Chem 273:18547-18555.
15. Ferrier R, Had L, Rabie A, Faivre-Sarrailh C. 1994. Coordinated expression offive tropomyosin isoforms and beta-actin in astrocytes treated with dibutyryl cAMP and cytochalasin D. Cell Motil Cytoskeleton 28:303-316.
16. Franzen B, Linder S, Uryu K, Alaiya AA, Hirano T, Kato H, Auer G. 1996. Expression of tropomyosin isoforms in benign and malignant human breast lesions. Br J Cancer 73:909-913.
17. Galloway PG, Likavec MJ, Perry G. 1990. Tropomyosin isoform expression in normal and neoplastic astrocytes. Lab Invest 62:163-170.
18. Gordon AM, Homsher E, Regnier. 2000. Regulation of contraction in striated muscle. Physiol Rev 80:853-924.
19. Had L, Faivre-Sarrailh C, Legrand C, Rabie A. 1993. The expression of tropomyosin genes in pure cultures ofrat neurons, astrocytes and oligodendrocytes is highly cell-type specific and strongly regulated during development. Brain Res Mol Brain Res 18:77-86.
20. Hammell RL, Hitchcock-DeGregori SE. 1997. The sequence of the alternatively spliced sixth exon of alpha-tropomyosin is critical for cooperative actin binding but not for interaction with troponin. J Biol Chem 272:22409-22416.
21. Hannan AJ, Gunning P, Jeffrey PL, Weinberger RP. 1998. Structural compartments within neurons: developmentally regulated organization of microfilament isoform mRNA and protein. Mol Cell Neurosci 11:289-304.
22. Hendricks M, Weintraub H. 1981. Tropomyosin is decreased in transformed cells. Proc Natl Acad Sci USA 78:5633-5637.
23. Hoshino T. 1992. Cell kinetics of glial tumors. Rev Neurol (Paris) 148:396-401.
24. Ichimura K, Schmidt EE, Goike HM, Collins VP. 1996. Human glioblastomas with no alterations of the CDKN2A (p16INK4A, MTS1) and CDK4 genes have frequent mutations of the retinoblastoma gene. Oncogene 13:1065-1072.
25. Ishii N, Maier D, Merlo A, Tada M, Sawamura Y, Diserens AC, Van Meir EG. 1999. Frequent co-alterations of TP53, p16/CDKN2A, p14ARF, PTEN tumor suppressor genes in human glioma cell lines. Brain Pathol 9:469-479.
26. Ishikawa R, Yamashiro S, Matsumura F. 1989. Differential modulation of actin-severing activity of gelsolin by multiple isoforms of cultured rat cell tropomyosin. Potentiation of protective ability of tropomyosins by 83-kDa nonmuscle caldesmon. J Biol Chem 264: 7490-7497.
27. Ito S, Hoshino T, Shibuya M, Prados MD, Edwards MS, Davis RL. 1992. Proliferative characteristics ofjuvenile pilocytic astrocytomas determined by bromodeoxyuridine labelling. Neurosurgery 31:413-419.
28. Jung MH, Kim SC, Jeon GA, Kim SH, Kim Y, Choi KS, Park SI, Joe MK, Kimm K. 2000. Identification of differentially expressed genes in normal and tumor human gastric tissue. Genomics 69:281-286.
29. Kleihues P, Burger PC, Scheithauer BW. 1993. The new WHO classification of brain tumors. Brain Pathol 3:255-268.
30. Leavitt J, Latter G, Lutomski L, Goldstein D, Burbeck S. 1986. Tropomyosin isoform switching in tumorigenic human fibroblasts. Mol Cell Biol 6:2721-2726.
31. Lees-Miller JP, Helfman DM. 1991. The molecular basis for tropomyosin isoform diversity. Bioessays 13:429-437.
32. Li J, Perry A, James CD, Gutmann DH. 2001. Cancer-related gene expression profiles in NF1-associated pilocytic astrocytomas. Neurology 56:885-890.
33. Lin JJ, Hegmann TE, Lin JL. 1988. Differential localization oftropomyosin isoforms in cultured nonmuscle cells. J Cell Biol 107:563-572.
34. Lin JJ, Warren KS, Wamboldt DD, Wang T, Lin JL. 1997. Tropomyosin isoforms in nonmuscle cells. Int Rev Cytol 170:1-38.
35. Moraczewska J, Nicholson-Flynn K, Hitchcock-DeGregori SE. 1999. The ends of tropomyosin are major determinants of actin affinity and myosin subfragment 1-induced binding to F-actin in the open state. Biochemistry 38:15885-15892.
36. Murovic JA, Nagashima T, Hoshino T, Edwards MS, Davis RL. 1986. Pediatric central nervous system tumors: a cell kinetic study with bromodeoxyuridine. Neurosurgery 19:900-904.
37. Nicholson-Flynn K, Hitchcock-DeGregori SE, Levitt P. 1996. Restricted expression of the actin-regulatory protein, tropomyosin, defines distinct boundaries, evaginating neuroepithelium, and choroid plexus forerunners during early CNS development. J Neurosci 16:6853-6863.
38. Novy RE, Lin JL, Lin CS, Lin JJ. 1993. Human fibroblast tropomyosin isoforms: characterization of cDNA clones and analysis of tropomyosin isoform expression in human tissues and in normal and transformed cells. Cell Motil Cytoskeleton 25:267-281.
39. Ono S, Ono K. 2002. Tropomyosin inhibits ADF/cofilin-dependent actin filament dynamics. J Cell Biol 156:1065-1076.
40. Parkins CS, Darling JL, Gill SS, Revesz Y, Thomas DG. 1991. Cell proliferation in serial biopsies through human malignant brain tumors: measurement using Ki67 antibody labelling. Br J Neurosurg 5:289-298.
41. Percival JM, Thomas G, Cock TA, Gardiner EM, Jeffrey PL, Lin JJ, Weinberger RP, Gunning P. 2000. Sorting of tropomyosin isoforms in synchronised NIH 3T3 fibroblasts: evidence for distinct microfilament populations. Cell Motil Cytoskeleton 47:189-208.
42. Pittenger MF, Kistler A, Helfman DM. 1995. Alternatively spliced exons of the beta tropomyosin gene exhibit different affinities for F-actin and effects with nonmuscle caldesmon. J Cell Sci 108:3253-3265.
43. Rautiainen E, Haapasalo H, Sallinen P, Rantala I, Helen P, Helin H. 1998. Histone mRNA in-situ hybridization in astrocytomas: a comparison with PCNA, MIB-1 and mitoses in paraffin-embedded material. Histopathology 32:43-50.
44. Satterwhite LL, Pollard TD. 1992. Cytokinesis. Curr Opin Cell Biol 4:43-52.
45. Schevzov G, Gunning P, Jeffrey PL, Temm-Grove C, Helfman DM, Lin JJ, Weinberger RP. 1997. Tropomyosin localization reveals distinct populations of microfilaments in neurites and growth cones. Mol Cell Neurosci 8:439-454.
46. Sherr CJ. 1995. D-type cyclins. Trends Biochem Sci 20:187-190.
47. Stamm S, Casper D, Lees-Miller JP, Helfman DM. 1993. Brain-specific tropomyosins TMBr-1 and TMBr-3 have distinct patterns of expression during development and in adult brain. Proc Natl Acad Sci USA 90:9857-9861.
48. Strand J, Nili M, Homsher E, Tobacman LS. 2001. Modulation of myosin function by isoform-specific properties of Saccharomyces cerevisiae and muscle tropomyosins. J Biol Chem 276:34832-34839.
49. Temm-Grove CJ, Jockusch BM, Weinberger RP, Schevzov G, Helfman DM. 1998. Distinct localizations of tropomyosin isoforms in LLCPK1 epithelial cells suggests specialized function at cell-cell adhesions. Cell Motil Cytoskeleton 40:393-407.
50. Wang FL, Wang Y, Wong WK, Liu Y, Addivinola FJ, Liang P, Chen LB, Kantoff PW, Pardee AB. 1996. Two differentially expressed genes in normal human prostate tissue and in carcinoma. Cancer Res 56:3634-3637.
51. Warren KS, Lin JL, McDermott JP, Lin JJ. 1995. Forced expression of chimeric human fibroblast tropomyosin mutants affects cytokinesis. J Cell Biol 129:697-708.
52. Weinberger RP, Henke RC, Tolhurst O, Jeffrey PL, Gunning P. 1993. Induction of neuron-specific tropomyosin mRNAs by nerve growth factor is dependent morphological differentiation. J Cell Biol 120: 205-215.
53. Weinberger R, Schevzov G, Jeffrey P, Gordon K, Hill M, Gunning P. 1996. The molecular composition of neuronal microfilaments is spatially and temporally regulated. J Neurosci 16:238-252.
54. Wessel D, Flugge UI. 1984. A method for the quantitative recovery of protein in dilute solution in the presence of detergents and lipids. Anal Biochem 138:141-143.
55. Wong K, Wessels D, Krob SL, Matveia AR, Lin JL, Soll DR, Lin JJ. 2000. Forced expression of a dominant-negative chimeric tropomyosin causes abnormal motile behaviour during cell division. Cell Motil Cytoskeleton 45:121-132.