Multiple combinations of alternatively spliced exons in rat tropomyosin-α gene mRNA: Evidence for 20 new isoforms in adult tissues and cultured cells

Archives of Biochemistry and Biophysics

Volumn 390, Issue 1, 2001, Pages 71-77

  Cooley, B C ^a   Bergtrom, G ^a  

^a MEDICAL COLLEGE OF WISCONSIN   (United States)

Author keywords

Alternative splicing; Cytoskeleton; Isoforms; L 6 cells; Rat; RT PCR; Tissue specific expression; TM ; Tropomyosin

Indexed keywords

ISOPROTEIN; MESSENGER RNA; TROPOMYOSIN;

AMINO ACID SEQUENCE; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CARBOXY TERMINAL SEQUENCE; CELL CULTURE; EXON; GENE EXPRESSION; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN LOCALIZATION; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SPLICEOSOME; TISSUE CULTURE; TISSUE DISTRIBUTION;

EID: 0035371460     PISSN: 00039861     EISSN: None     Source Type: Journal    
DOI: 10.1006/abbi.2001.2347     Document Type: Article

References (17)

1. Structure and complete nucleotide sequence of the gene encoding rat fibroblast tropomyosin 4
2. Splicing of two alternative exon pairs in beta-tropomyosin pre-mRNA is independently controlled during myogenesis
3. Four fibroblast tropomyosin isoforms are expressed from the rat a-tropomyosin gene via alternative RNA splicing and the use of two promoters
4. Splicing of two internal and four carboxyl-terminal alternative exons in nonmuscle tropomyosin 5 pre-mRNA is independently regulated during development
5. Identification of novel alternatively spliced isoforms of the tropomyosin-encoding gene, TMnm, in the rat cochlea
6. Nonmuscle and muscle tropomyosin isoforms are expressed from a single gene by alternative splicing and polyadenylation
7. The rat α-tropomyosin gene generates a minimum of six different mRNAs coding for striated, smooth, and nonmuscle isoforms by alternative splicing
8. Three novel brain tropomyosin isoforms are expressed from the rat α-tropomyosin gene through the use of alternative promoters and alternative RNA processing
9. Brain-specific tropomyosins TMBr-1 and TMBr-3 have distinct patterns of expression during development and in adult brain
10. The molecular composition of neuronal microfilaments is spatially and temporally regulated
11. α-tropomyosin gene organization
12. Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease
13. Native chicken gizzard tropomyosin is predominantly a βγ-heterodimer
14. Preferential assembly of the tropomyosin heterodimer: Equilibrium studies
15. Targeted ablation of the murine α-tropomyosin gene
16. Molecular and physiological effects of murine α-tropomyosin ablation in the mouse