Correlation of GDF5 and Connexin 43 mRNA Expression during Embryonic Development

Anatomical Record - Part A Discoveries in Molecular, Cellular, and Evolutionary Biology

Volumn 275, Issue 2, 2003, Pages 1117-1121

  Coleman, Cynthia M ^a,b   Loredo, Grace A ^b,e   Lo, Cecilia W ^c,d   Tuan, Rocky S ^a,b  

^a NATIONAL INSTITUTES OF HEALTH   (United States)

^b THOMAS JEFFERSON UNIVERSITY   (United States)

^c UNIVERSITY OF PENNSYLVANIA   (United States)

^d NATIONAL HEART LUNG AND BLOOD INSTITUTE   (United States)

^e VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

Chondrogenesis; Connexin 43; Growth differentiation factor 5; Heart development; Spine development; Tendon development

Indexed keywords

CONNEXIN 43; GENE PRODUCT; GROWTH DIFFERENTIATION FACTOR 5; MESSENGER RNA;

ARTICLE; BONE DEVELOPMENT; CARTILAGE; CHONDROGENESIS; CONTROLLED STUDY; EMBRYO; EMBRYO DEVELOPMENT; FETUS; GAP JUNCTION; GENE EXPRESSION REGULATION; HEART; HEART DEVELOPMENT; HUMAN; HUMAN TISSUE; LIMB DEVELOPMENT; ORGANOGENESIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; SPINE; TENDON; TISSUE DISTRIBUTION;

EID: 0345258017     PISSN: 0003276X     EISSN: None     Source Type: Journal    
DOI: 10.1002/ar.a.10125     Document Type: Article

References (31)

1. Allen F, Tickle C, Warner A. 1990. The role of gap junctions in patterning of the chick limb bud. Development 108:623-634.
2. Chang SC, Hoang B, Thomas JT, Vukicevic S, Luyten FP, Ryba NJ, Kozak CA, Reddi AH, Moos Jr M. 1994. Cartilage-derived morphogenetic proteins. New members of the transforming growth factor-beta superfamily predominantly expressed in long bones during human embryonic development. J Biol Chem 269:28227-28234.
3. Chatterjee B, Meyer RA, Loredo GA, Coleman CM, Tuan RS, Lo CW. 2003. BMP regulation of the mouse connexin-43 promoter in osteoblastic cells and embryos. Cell Adhes Commun 10:37-50.
4. Clark RT, Johnson TL, Schalet BJ, Davis L, Gaschen V, Hunziker EB, Oldberg A, Mikic B. 2001. GDF-5 deficiency in mice leads to disruption of tail tendon form and function. Connect Tissue Res 42:175-186.
5. Coelho CN, Kosher RA. 1991a. Gap junctional communication during limb cartilage differentiation. Dev Biol 144:47-53.
6. Coelho CN, Kosher RA. 1991b. A gradient of gap junctional communication along the anterior-posterior axis of the developing chick limb bud. Dev Biol 148:529-535.
7. Coleman CM, Tuan RS. 2003a. Functional role of growth/differentiation factor 5 in chondrogenesis of limb mesenchymal cells. Mech Dev 120:823-836.
8. Coleman CM, Tuan RS. 2003b. Growth/differentiation factor 5 enhances chondrocyte maturation. Dev Dyn 228:208-216.
9. Dealy CN, Beyer EC, Kosher RA. 1994. Expression patterns of mRNAs for the gap junction proteins connexin43 and connexin42 suggest their involvement in chick limb morphogenesis and specification of the arterial vasculature. Dev Dyn 199:156-167.
10. Donahue HJ. 2000. Gap junctions and biophysical regulation of bone cell differentiation. Bone 26:417-422.
11. Elmer WA, Selleck DK. 1975. In vitro chondrogenesis of limb mesoderm from normal and brachypod mouse embryos. J Embryol Exp Morphol 33:371-386.
12. Francis-West PH, Abdelfattah A, Chen P, Allen C, Parish J, Ladher R, Allen S, MacPherson S, Luyten FP, Archer CW. 1999. Mechanisms of GDF-5 action during skeletal development. Development 126:1305-1315.
13. Green CR, Bowles L, Crawley A, Tickle C. 1994. Expression of the connexin43 gap junctional protein in tissues at the tip of the chick limb bud is related to the epithelial-mesenchymal interactions that mediate morphogenesis. Dev Biol 161:12-21.
14. Gruneberg H, Lee AJ. 1973. The anatomy and development of brachypodism in the mouse. J Embryol Exp Morphol 30:119-141.
15. Hartmann C, Tabin CJ. 2001. Wnt-14 plays a pivotal role in inducing synovial joint formation in the developing appendicular skeleton. Cell 104:341-351.
16. Laird DW, Yancey SB, Bugga L, Revel JP. 1992. Connexin expression and gap junction communication compartments in the developing mouse limb. Dev Dyn 195:153-161.
17. Lecanda F, Towler DA, Ziambaras K, Cheng SL, Koval M, Steinberg TH, Civitelli R. 1998. Gap junctional communication modulates gene expression in osteoblastic cells. Mol Biol Cell 9:2249-2258.
18. Lecanda F, Warlow PM, Sheikh S, Furlan F, Steinberg TH, Civitelli R. 2000. Connexin43 deficiency causes delayed ossification, craniofacial abnormalities, and osteoblast dysfunction. J Cell Biol 151:931-944.
19. Levin M. 2002. Isolation and community: a review of the role of gap-junctional communication in embryonic patterning. J Membr Biol 185:177-192.
20. Meyer RA, Cohen MF, Recalde S, Zakany J, Bell SM, Scott Jr WJ, Lo CW. 1997. Developmental regulation and asymmetric expression of the gene encoding Cx43 gap junctions in the mouse limb bud. Dev Genet 21:290-300.
21. Mikic B, Schalet BJ, Clark RT, Gaschen V, Hunziker EB. 2001. GDF-5 deficiency in mice alters the ultrastructure, mechanical properties and composition of the Achilles tendon. J Orthop Res 19:365-371.
22. Mikic B, Battaglia TC, Taylor EA, Clark RT. 2002. The effect of growth/differentiation factor-5 deficiency on femoral composition and mechanical behavior in mice. Bone 30:733-737.
23. Owens EM, Solursh M. 1982. Cell-cell interaction by mouse limb cells during in vitro chondrogenesis: analysis of the brachypod mutation. Dev Biol 91:376-388.
24. Ruangvoravat CP, Lo CW. 1992. Connexin 43 expression in the mouse embryo: localization of transcripts within developmentally significant domains. Dev Dyn 194:261-281.
25. Shum L, Coleman CM, Hatakeyama Y, Tuan RS. 2003. Morphogenesis and dysmorphogenesis of the appendicular skeleton. Birth Defects Res-C: Embryo Today (in press).
26. Storm EE, Huynh TV, Copeland NG, Jenkins NA, Kingsley DM, Lee SJ. 1994. Limb alterations in brachypodism mice due to mutations in a new member of the TGF beta-superfamily. Nature 368:639-643.
27. Storm EE, Kingsley DM. 1996. Joint patterning defects caused by single and double mutations in members of the bone morphogenetic protein (BMP) family. Development 122:3969-3979.
28. Storm EE, Kingsley DM. 1999. GDF5 coordinates bone and joint formation during digit development. Dev Biol 209:11-27.
29. Wawersik S, Epstein JA. 2000. Gene expression analysis by in situ hybridization. In: Tuan RS, Lo CW, editors. Developmental biology protocols. Vol. III. Totowa: Humana Press, Inc. p 87-96.
30. Wolfman NM, Hattersley G, Cox K, Celeste AJ, Nelson R, Yamaji N, Dube JL, DiBlasio-Smith E, Nove J, Song JJ, Wozney JM, Rosen V. 1997. Ectopic induction of tendon and ligament in rats by growth and differentiation factors 5, 6, and 7, members of the TGF-beta gene family. J Clin Invest 100:321-330.
31. Zimmermann B, Scharlach E, Kaatz R. 1982. Cell contact and surface coat alterations of limb-bud mesenchymal cells during differentiation. J Embryol Exp Morphol 72:1-18.