Role of Cys221 and Asn116 in the zinc-binding sites of the Aeromonas hydrophila metallo-β-lactamase

Cellular and Molecular Life Sciences

Volumn 60, Issue 11, 2003, Pages 2501-2509

  Vanhove, M ^a,e   Zakhem, M ^a   Devreese, B ^b   Franceschini, N ^c   Anne, C ^a   Bebrone, C ^a   Amicosante, G ^c   Rossolini, G M ^d   Van Beeumen, J ^b   Frere J M ^a   Galleni, M ^a  

^a UNIVERSITY OF LIÈGE   (Belgium)

^b GHENT UNIVERSITY   (Belgium)

^c Università di L'Aquila   (Italy)

^d UNIVERSITY OF SIENA   (Italy)

^e Building 22   (Belgium)

Author keywords

lactam resistance; Enzyme kinetics; Metallo lactamases; Site directed mutagenesis; Zinc binding sites

Indexed keywords

ASPARAGINE; BACTERIAL ENZYME; BETA LACTAMASE; CYSTEINE; MUTANT PROTEIN; ZINC ION;

AEROMONAS HYDROPHILA; ARTICLE; BINDING SITE; CATALYSIS; HYDROLYSIS; MUTATION; NONHUMAN; SITE DIRECTED MUTAGENESIS;

AEROMONAS HYDROPHILA; ASPARAGINE; BACTERIAL PROTEINS; BASE SEQUENCE; BETA-LACTAMASES; BINDING SITES; CYSTEINE; KINETICS; MOLECULAR SEQUENCE DATA; STRUCTURE-ACTIVITY RELATIONSHIP; ZINC;

AEROMONAS; AEROMONAS HYDROPHILA; BACTERIA (MICROORGANISMS);

EID: 0345256373     PISSN: 1420682X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00018-003-3092-x     Document Type: Article

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