Automated Parallel Solid-Phase Synthesis and Anticancer Screening of a Library of Peptide-Tethered Platinum(II) Complexes

Journal of Combinatorial Chemistry

Volumn 5, Issue 6, 2003, Pages 821-825

  Robillard, Marc S ^a   Bacac, Marina ^a   Van Den Elst, Hans ^a   Flamigni, Anna ^a   Van Der Marel, Gijs A ^a   Van Boom, Jacques H ^a   Reedijk, Jan ^a  

^a LEIDEN UNIVERSITY   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; BROMINE DERIVATIVE; CISPLATIN; N (2 AMINOETHYL)GLYCYLARGINYLGLUTAMIC ACID AMIDE DICHLOROPLATINUM; N (2 AMINOETHYL)GLYCYLARGINYLGLYCINAMIDE DICHLOROPLATINUM; N (2 AMINOETHYL)GLYCYLARGINYLPHENYLALANINAMIDE DICHLOROPLATINUM; N (2 AMINOETHYL)GLYCYLGLUTAMYLARGININAMIDE DICHLOROPLATINUM; N (2 AMINOETHYL)GLYCYLGLYCYLGLYCINAMIDE DICHLOROPLATINUM; N (2 AMINOETHYL)GLYCYLGLYCYLLYSINAMIDE DICHLOROPLATINUM; N (2 AMINOETHYL)GLYCYLLYSYLGLUTAMIC ACID AMIDE DICHLOROPLATINUM; PEPTIDE LIBRARY; PLATINUM COMPLEX; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; AUTOMATION; CANCER CELL CULTURE; CELL PROLIFERATION; COLORIMETRY; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG SCREENING; DRUG SYNTHESIS; GEL PERMEATION CHROMATOGRAPHY; HUMAN; HUMAN CELL; IC 50; IN VITRO STUDY; MASS SPECTROMETRY; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; OVARY CARCINOMA; PROTON NUCLEAR MAGNETIC RESONANCE; SOLID STATE;

CELL LINE, TUMOR; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; PEPTIDE LIBRARY; PLATINUM COMPOUNDS;

EID: 0345119092     PISSN: 15204766     EISSN: None     Source Type: Journal    
DOI: 10.1021/cc030011z     Document Type: Article

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24. 2 chromophore at -2381 ppm, demonstrating that lysine could safely be included as a library component.
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26. At this point, successful coupling of the six amino acids and compound 4 was confirmed by determining the loading of bis-glycine 5{1}, bis-phenylalanine 5{8}, bis-lysine 5{15}, bis-arginine 5{22}, bis-serine 5{29}, and bis-glutamate 5{36}.
27. Compound 1 corresponds to library member 8{19}.
28. Library 8 showed no activity in the A2780 cisplatin resistant cell line in an identical assay (data not shown).